Клініко-метаболічні особливості у підлітків із ризиком розвитку атеросклерозу: Автореф. дис… канд. мед. наук / Л.В. Давидко, Харк. держ. мед. ун-т.

5

OA?E?ANUeEEE AeA?AEAAIEE IAAeE*IEE OI?AA?NEOAO

Ia i?aaao ?oeiieno

AeAAEAeEI Ethaeieea Aieiaeeie??aia

OAeE 616.008.9+612.8:616.153.96.-053.6-07

EE?I?EI-IAOAAIE?*I? INIAEEAINO? O I?AeE?OE?A

?C ?ECEEII ?ICAEOEO AOA?INEEA?ICO

14.01.10 – Iaae?ao??y

A A O I ? A O A ? A O

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Oa?e?a — 19992

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a Oe?a?inueeiio iaoeiai-aeine?aeiiio ?inoeooo?
ioi?iie

caei?ia’y ae?oae ? i?aee?oe?a, IIC Oe?a?ie, i. Oa?e?a.

Iaoeiaee ea??aiee: Caneoaeaiee ae?y/ iaoee ? oaoi?ee Oe?a?ie,

aeieoi? iaaee/ieo iaoe, i?ioani?

Einoth?eia Aaeeia Ieeeo?aia,

Oe?a?inueeee
iaoeiai-aeine?aeiee ?inoeooo ioi?iie

caei?ia’y ae?oae ? i?aee?oe?a, i. Oa?e?a,

aieiaiee iaoeiaee ni?a?ia?oiee a?aeae?eo aioo??oiuei?

iaoieia?? i?aee?oe?a

Io?oe?ei? iiiiaioe: aeieoi? iaaee/ieo iaoe, i?ioani?

Iaeeiaoeue TH??e Aaneeueiae/,

Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao,

caa?aeoaa/ eaoaae?ith oaeoeueoaonueei? iaae?ao??? c

iaaee/iith aaiaoeeith;

aeieoi? iaaee/ieo iaoe, noa?oee iaoeiaee ni?a?ia?oiee

I?eieaiei ?aaai sseiae/, ?inoeooo oa?ai?? AII Oe?a?ie, i. Oa?e?a

canooiiee aee?aeoi?a c iaoeiai? ?iaioe.

I?ia?aeia onoaiiaa: Iaoe?iiaeueiee iaaee/iee oi?aa?neoao ?i. I.I.
Aiaiiieueoey,

IIC Oe?a?ie, i. Ee?a, eaoaae?a iaae?ao??? ? 2.

Caoeno aeena?oaoe?? a?aeaoaeaoueny 25 aa?aciy 1999 ?. i
1330 aiaeei? ia can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 64.600.04
i?e Oa?e?anueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao? (310022, i.
Oa?e?a, i?. Eai?ia, 4).

C aeena?oaoe??th iiaeia iciaeiieoeny o a?ae?ioaoe? Oa?e?anueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo (310022, i. Oa?e?a, i?. Eai?ia, 4).

Aaoi?aoa?ao ?ic?neaiee “ 24 ” ethoiai 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee

aeioeaio Ia/a?aiei E.?.CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. Ca inoaii? n?i ?ie?a nia?oi?noue a?ae
na?oeaai-noaeeiieo caoai?thaaiue c?inea a Oe?a?i? ia 30 % (Aic?aiia
I.O., 1996). *?eueia i?noea na?aae i?e/ei, ye? i?ecaiaeyoue aei oaeeo
iane?aee?a, caeia? aoa?ineea?ic (*acia ?.?., 1992; Iaea E.O., 1996).
Ui?ieo a iao?e e?a?i? a?ae ?ioa?eoo i?iea?aea iiie?a? a?ey 130 oeny/
/ieia?e, a ii?aeiaiiy ?oai?/ii? oai?iae na?oey ?c a?ia?oii??th a 70 %
aeiaaee?a aeeeeea? eaoaeuei?noue aei?ineiai ianaeaiiy. E??i oiai,
ui??/ii a e?a?i? aia?oa aeyaey?oueny a?ey 100 oeny/ oai?eo ia
a?oa??aeueio a?ia?oii?th (Aecye A.A., 1998).

Ia no/aniiio aoai? aoa?ineea?ic (AN) ?icaeyaea?oueny ye neiae?ii
aeao?oeeoo iie??iiaeo (iaiane/aieo) eeneio. Iaoio?c?ieia?/ii a?i a
iaeiaeia?e i??? a?aeiia?aea? oaeei iiiyooyi, ye “oai?iaa” eiiiainaoe??,
iaoieia?y iaia?ai, “oai?iaa” iaeiie/aiiy (Oeoia A.?., 1998). Aea/aiiy
e?i?aeiiai iaoaaie?cio ia ??ai? i?ioean?a ia?ieneaeaoe?? oa nenoai
aioeieneaeaioiiai caoenoo i?ecaaei aei ?icaeyaeaiiy aeaii? i?iaeaie c
iiceoe?? a?eueii?aaeeeaeueii? iaoieia??, ine?eueee iniiaiei noano?aoii
ia?aeeniiai ieeneaiiy e?i?ae?a (IIE) ? iaiane/ai? aee?i? eeneioe (Eaie?i
A.C., Aeoa?o I.I., 1989; Aeieo???a E.O., 1995; Maziere C., 1991; Chandra
M., Agrawel R., 1994).

Aaaaoi/eneaii? aeine?aeaeaiiy na?ae/aoue i?i oa, ui ii?oieia?/ia iniiaa
AN caeeaaea?oueny a aeeoy/iio a?oe?. Ioaea ae?oe ia?o ca ana iiaeii?
noaoe iniiaiei ia’?eoii ia?aeiii? i?io?eaeoeee oeueiai iaaeoaa
(Aeaenaiae?ia I.I., 1993; Aiaiao E.O., 1994; Reese S.M., 1995;
Kwiterovich P.O., 1996).

Aeooaeueiei ? iiaeaeueoa aea/aiiy ieoaiue iaoiaaiaoe/ii? noo? aeayeeo
ia?aaea?niee?a AN c oi/ee ci?o a?eueii?aaeeeaeueii? iaoieia?? a
iniaeeaee ia??iae iioiaaiaco – ioaa?oaoiee.

O ca’yceo c oeei aaaaeaeiny ca aeioe?eueia aea/aiiy e?i?aeiiai
iaoaaie?cio ia ??ai? i?ioean?a IIE oa nenoai aioeieneaeaioiiai caoenoo o
i?aee?oe?a ?c ia?aeiiith a?oa??aeueiith a?ia?oaic??th (IAA) oa o
i?aee?oe?a ?c n?iae ?c iaoyaeaiith niaaeeia?noth uiaei ?ioa?eoo
i?iea?aea (?I) ia ?aii?o, aeiee?i?/ieo aoaiao i?ioeano. Oea, a naith
/a?ao, aoaea ni?eyoe iiaei i?aeoiaeai aei ia?aeiii? i?io?eaeoeee
na?oeaai-noaeeiieo caoai?thaaiue aoa?ineea?ioe/ii? i?e?iaee.

CA’ssCIE ?IAIOE C IAOEIAEIE I?IA?AIAIE, IEAIAIE, OAIAIE

Aeena?oaoe?eia ?iaioa aeeiiaia o iaaeao iaoeiaeo i?iaeai
“Oa?aeoa?enoeea ?ioaa?aoeaii? ae?yeueiino? iiceo, aaaaoaoeaii? ?
na?oeaai-noaeeiii? nenoaie i?aee?oe?a ?c aeene?iii?ioa?aeai?yie i?e
??ci?e no?eeino? aei aiioe?eiiai no?ano” (? Aea?aeaaii?
?a?no?aoe?? UA 01002025 P, oeo? oaie ?I. 19.14.0025.92), “I?iaiicoaaiiy
ia?aa?ao na?oeaai-noaeeiieo ii?ooaiue o i?aee?oe?a, iaa?oiooaaiiy
i?aeoiae?a aei ?o ?aaa?e?oaoe??” (? Aea?aeaaii? ?a?no?aoe?? 0196 V
002916, oeo? oaie ?I. 1919.0035.96) Oe?a?inueeiai iaoeiai-aeine?aeiiai
?inoeoooo ioi?iie caei?ia’y ae?oae ? i?aee?oe?a ca o/anoth a?aeae?eo
aioo??oiuei? iaoieia?? i?aee?oe?a.

IAOA ? CAAeA*? IAOEIAIAI AeINE?AeAEAIIss.

Iaoa ?iaioe. Aaeineiiaeaiiy iaoiae?a ?aiiuei? ae?aaiinoeee
ia?aaea?niee?a aoa?ineea?ico o i?aee?oe?a.

Aeey aeinyaiaiiy iai?/aii? iaoe aoee iinoaaeai? oae? caaea/?:

1. Aea/eoe noai i?ioean?a ia?aeeniiai ieeneaiiy e?i?ae?a o i?aee?oe?a ?c
ia?aeiiith a?oa??aeueiith a?ia?oaic??th oa ?c iaoyaeaiith niaaeeia?noth
uiaei ?ioa?eoo i?iea?aea.

2. Aecia/eoe iniaeeaino? e?i?aeiiai niaeo?o e?ia? o i?aee?oe?a ?c
?eceeii ?icaeoeo aoa?ineea?ico ?c o?aooaaiiyi ia??iaeo noaoaaiai
aeic??aaiiy (caaaeueiee oieanoa?ei, o?eae?oea?eaee, oieanoa?ei
e?iii?ioa?ae?a aeniei? u?eueiino?).

3. Aea/eoe iniaeeaino? aaaaoaoeaiiai aiiainoaco (oiion, ?aaeoeai?noue,
aaaaoaoeaia caaacia/aiiy ae?yeueiino?) o aeine?aeaeoaaieo a?oi
i?aee?oe?a.

4. Onoaiiaeoe iniaeeaino? aca?iica’yce?a i?ioean?a ia?ieneaeaoe??
e?i?ae?a oa nenoai aioeieneaeaioiiai caoenoo ?c ie?aieie iieacieeaie
e?i?aeiiai niaeo?o i?e ia?aeii?e a?oa??aeuei?e a?ia?oaic?? oa iaoyaeai?e
niaaeeiaino? uiaei ?ioa?eoo i?iea?aea.

IAOEIAA IIAECIA

Aia?oa anoaiiaeaii, ui a ia??iae noaoaaiai aeic??aaiiy o i?aee?oe?a ?c
IAA oa ?c iaoyaeaiith niaaeeia?noth ia ?I oi?iothoueny iaoaaie?/i?
ii?ooaiiy, ye? oa?aeoa?ecothoueny aeene?iii?ioa?aeai?yie (AeEI)
aoa?iaaiii? ni?yiiaaiino?, iineeaiiyi i?ioean?a ia?aeeniiai ieeneaiiy
e?i?ae?a oa iaaaeaeaaoiith a?aeiia?aeaeth nenoaie aioeieneaeaioiiai
caoenoo. Aeieacaii, ui o 32,4 % i?aee?oe?a ?c IAA oa o 27,6 % i?aee?oe?a
?c n?iae c iaoyaeaiith niaaeeia?noth uiaei ?I ia? i?noea iineeaiiy
i?ioean?a IIE ia oii? cieaeaiiy aeoeaiino? nenoai aioeieneaeaioiiai
caoenoo, ui aea? i?aenoaao a?aeiineoe oaeeo in?a aei eaoaai???
caa?iceeaeo uiaei ?icaeoeo a?eueii?aaeeeaeueii? iaoieia??. Iieiiea
aioeieneaeaioiiai caoenoo a nenoai? o?eae?oea?eae?a (OA) a?eueoa
ae?aaeaia a ia??iae noaoaaiai aeic??aaiiy o i?aee?oe?a ?c iaoyaeaiith
niaaeeia?noth ia ?I, a a nenoai? caaaeueiiai oieanoa?eio (CON) – o in?a
?c IAA.

Anoaiiaeaii, ui o i?aee?oe?a ?c ?eceeii ?icaeoeo aoa?ineea?ico a ia??iae
noaoaaiai aeic??aaiiy a?aeaoaa?oueny ia?aaoaeiaa no?oeoo?ieo
aca?iica’yce?a i?ae eiiiiiaioaie e?i?aeiiai niaeo?o ? iaeiiiaei
aeeaeueaeaa?aeii ieacie e?ia?, ui aeicaieeei aeneiaeoe i?eiouaiiy i?i
ye?nii iiaee oeyo iaoaaie?cio e?i?ae?a ? aaaaeaoe
a?ia?o?eae?oea?eaeai?th iaeiei ?c iniiaieo oaeoi??a ?eceeo AN ia ?aii?o
aoaiao oi?ioaaiiy i?ioeano. Ie??i oiai, anoaiiaeaii, ui o /anoeie
i?aee?oe?a ?c IAA oa ?c iaoyaeaiith niaaeeia?noth ia ?I ii?ooaiiy
aca?iica’yce?a i?ae eiiiiiaioaie e?i?aeiiai niaeo?o e?ia? ? iaeiiiaei
aeeaeueaeaa?aeii ieacie iathoue i?noea ia oii? ii?iaeueieo
na?aaeiueinoaoenoe/ieo iieaciee?a e?i?aeiiai niaeo?o.

I?AEOE*IA CIA*AIIss IO?EIAIEO ?ACOEUeOAO?A

Aea/aii iniaeeaino? iaoaaie?cio e?i?ae?a ia aeiee?i?/ieo aoaiao AN o
i?aee?oe?a ?c ?eceeii ?icaeoeo oeueiai caoai?thaaiiy. Iaa?oioiaaii
aeioe?euei?noue aecia/aiiy e?i?aeiiai niaeo?o e?ia? oa aeayeeo
iieaciee?a IIE ? aioeieneaeaioii? nenoaie caoenoo a ia??iae noaoaaiai
aeic??aaiiy o i?aee?oe?a ?c ia?aaea?nieeaie AN. ?ic?iaeaii niin?a
?iaeea?aeoaeueii? ae?aaiinoeee ii?ooaiue e?i?aeiiai iai?io c o?aooaaiiyi
eiiiiiaio?a e?i?aeiiai niaeo?o (CON ? OA) oa aoi?eiiiai i?iaeoeoo IIE –
iaeiiiaiai aeeaeueaeaa?aeo (IAeA). I?eioeei iniiaaiee ia aecia/aii?
ni?yiiaaiino? no?oeoo?ieo aca?iica’yce?a i?ae CON-IAeA ? OA-IAeA
?ic?aooieiaei iaoiaeii ca aeiiiiiaith niaoe?aeueii ?ic?iaeaieo i?inoeo
oi?ioe (?c aeei?enoaiiyi aeniiiaioe?aeueii? ooieoe??). Aeaiee niin?a
ae?aaiinoeee aeicaiey? ia aeiee?i?/ieo aoaiao aoa?ineea?ico aeyaeoe
a?eueo oi/ii ii?ooaiiy e?i?aeiiai iai?io, ui ni?eyoeia ?aii?e
ae?aaiinoeoe? oa i?io?eaeoeoe? aoa?ineea?ico.

Niin?a ?aiiuei? ae?aaiinoeee aoa?ineea?ico ai?iaaaeaeaiee a ee?i?oe? ?
iie?ee?i?oe? Oe?a?inueeiai iaoeiai-aeine?aeiiai ?inoeoooo ioi?iie
caei?ia’y ae?oae ? i?aee?oe?a, a 23 aeeoy/?e ee?i?/i?e e?ea?i? i.
Oa?eiaa, a ea?ae?ieia?/iiio a?aeae?eaii? Oa?e?anueei? iaeanii? aeeoy/i?
ee?i?/ii? e?ea?i?, a iie?ee?i?oe? Iieoaanueei? iaeanii? aeeoy/i?
ee?i?/ii? e?ea?i?. Ai?iaaaeaeaiiy ?ic?iaeaiiai niiniao ae?aaiinoeee
aeicaieeei a?eueo oi/ii ? ?aii aeyaeoe ii?ooaiiy e?i?aeiiai niaeo?o o
i?aee?oe?a ? a?aeiia?aeii i?iaanoe ?iaeea?aeoaeueio ia?aeiio
i?io?eaeoeeo aoa?ineea?ico ia aeiee?i?/iiio aoai?.

INIAENOEE AIANIE AeENA?OAIOA

An? ee?i?/i? aeine?aeaeaiiy, cae?eniai? c iaoith ae?aaiinoeee IAA oa
iaoyaeaii? niaaeeiaino? ia ?I: i?aea??, iieooaaiiy oa iaeyae oai?eo,
aea/aiiy noaio aaaaoaoeaii? ia?aiai? nenoaie oa ?ioa?i?aoaoe?y
ee?i?ei-?ino?oiaioaeueieo aeaieo, iaoeiaee aiae?c a?io?i?/ieo
aeine?aeaeaiue, ?yae niaoe?aeueieo aeine?aeaeaiue (aecia/aiiy ??aiy
ae??iiaeo eii’thaao?a, iaeiiiaiai aeeaeueaeaa?aeo, eaoaeace), a oaeiae
/eneiaa iaoaiaoe/ia ia?iaea aeaieo oa ioi?ieaiiy aeena?oaoe?? aeeiiai?
naiino?eii. E??i oiai, aaoi?ii ai?iaaaeaeaii iaoiaeeee aecia/aiiy ai?noo
iaeiiiaiai aeeaeueaeaa?aeo, eaoaeace a a?io?i?/i?e eaai?aoi???
Oe?a?inueeiai iaoeiai-aeine?aeiiai ?inoeoooo ioi?iie caei?ia’y ae?oae ?
i?aee?oe?a.

Aeei?enoaiiy nenoaiiiai aiae?co ?c noai?aiiyi ?ioi?iaoe?eii? a?ao?/ii?
iiaeae? e?i?aeiiai iai?io i?iaaaeaia ni?eueii ?c eaiaeeaeaoii
o?ceei-iaoaiaoe/ieo iaoe, aeioeaioii eaoaae?e aeui? iaoaiaoeee
Aea?aeaaiiai Oa?e?anueeiai iie?oaoi?/iiai oi?aa?neoaoo A.I. Iaioeeiaith.

AI?IAAOe?ss ?IAIOE

Iniiai? ?acoeueoaoe iaoeiaeo aeine?aeaeaiue aoee iia?aeiieai? ia
Oe?a?inueeeo iaoeiai-i?aeoe/ieo eiioa?aioe?yo “Oai?aoe/aneea e
eeeie/aneea aii?inu aeaoneie ea?aeeieiaee” (Oa?e?a, 1993) oa “Aeooaeuei?
ieoaiiy e?eoaaiiy ? ?aaa?e?oaoe?? i?aee?oe?a c niiaoe/ieie ? ineo?/ieie
ii?ooaiiyie” (Oa?e?a, 1995), ia ia?oiio I?aeia?iaeiiio iaaee/iiio
eiia?an? nooaeaio?a ? iieiaeeo a/aieo (Oa?iii?eue, 1997), aea oey ?iaioa
aoea iaai?iaeaeaia aeeieiiii ca ia?oa i?noea.

IOAE?EAOe??

Ii oai? aeena?oaoe?? iioae?eiaaii 10 ?ia?o: 5 aeo?iaeueieo noaoae ? 5
oac aeiiia?aeae. O?e noaoo? iioae?eiaai? aac ni?aaaoi?noaa.

IANssA ? NO?OEOO?A AeENA?OAOe??

Aeena?oaoe?y neeaaea?oueny ?c anooio, ?icae?e?a “Iaeyae e?oa?aoo?e”, oa
“Ianya ? iaoiaee aeine?aeaeaiiy”, a oaeiae o?ueio ?icae?e?a aeanieo
aeine?aeaeaiue, aiae?co oa iaaiai?aiiy ?acoeueoao?a, aeniiae?a,
i?aeoe/ieo ?aeiiaiaeaoe?e, nieneo aeei?enoaii? e?oa?aoo?e, yeee i?noeoue
217 aeaea?ae a?o/eciyieo oa ca?oa?aeieo aaoi??a.

?iaioa aeeeaaeaia ia 152 noi??ieao ae?oeiaaiiai oaenoo, ?ethno?iaaia 28
oaaeeoeyie ? 8 iaethieaie, ui neeaaea? 37 noi??iie.

CI?NO ?IAIOE

Iaoa??aee ? iaoiaee aeine?aeaeaiiy. I?e aeeiiaii? aeena?oaoe?eii? ?iaioe
ianoaaeaii 108 i?aee?oe?a /ieia?/i? noao? a?eii 12-17 ?ie?a: 40- ?c
ia?aeiiith a?oa??aeueiith a?ia?oaic??th, 30 – ?c n?iae, aea iaeei ?c
aaouee?a ia?ai?n ?ioa?eo i?iea?aea o a?oe? aei 45 ?ie?a ? 38 i?aeoe/ii
caei?iaeo i?aee?oe?a ?c n?iae aac iaoyaeaii? niaaeeiaino? uiaei
aoa?ineea?ico (oiaoi a aeaio iieie?iiyo ?iaee/?a ia aeyaeaii ee?i?/ieo
oi?i na?oeaai-noaeeiieo caoai?thaaiue aoa?ineea?ioe/ii? i?e?iaee o a?oe?
aei 60 ?ie?a). A aeeiai?oe? ianoaaeaii 35 i?aee?oe?a, o oiio /ene?: 20 –
?c IAA ? 15 – ?c iaoyaeaiith niaaeeia?noth uiaei ?I. A eiiieaen
ee?i?/iiai ianoaaeaiiy aoiaeeea ioe?iea o?ce/iiai oa noaoaaiai ?icaeoeo.
O?ce/iee ?icaeoie ioe?ithaaee ca aeiiiiiaith aio?iiiiao?e/ieo
iieaciee?a, iiaeaieo a iaoiaee/ieo ?aeiiaiaeaoe?yo Oe?a?inueeiai
iaoeiai-aeine?aeiiai ?inoeoooo ioi?iie caei?ia’y ae?oae ? i?aee?oe?a.
Noaoaaee ?icaeoie thiae?a ioe?ithaaee ca oeaeith Tanner (1991). Aea/aiiy
ooieoe?iiaeueiiai noaio na?oeaai-noaeeiii? nenoaie i?iaiaeeeiny c
aeei?enoaiiyi aeaeo?iea?ae?ia?ao?? (AEA), oiiiea?ae?ia?ao?? ?
aoiea?ae?ia?ao?? (AoiEA). Ooieoe?iiaeueiee noai aaaaoaoeaii? ia?aiai?
nenoaie aeine?aeaeoaaee ca aeiiiiiaith ea?ae?i?ioa?aaeia?ao?? ?
eeeiii?oinoaoe/ii? i?iae. Aecia/aee noai aeno?aeiiai aaaaoaoeaiiai
oiiono, aaaaoaoeaio ?aaeoeai?noue, aaaaoaoeaia caaacia/aiiy ae?yeueiino?
(Aaeieiiue I.I. ? ni?aaao., 1987).

Aea/aiiy e?i?aeiiai niaeo?o e?ia? aeeth/aei aecia/aiiy ??aiy caaaeueiiai
oieanoa?eio, o?eae?oea?eae?a, oieanoa?eio e?iii?ioa?ae?a aeniei?
ueeueiino? (ON EIAU) oa?iaioaoeaiei iaoiaeii ia aaoiaiae?caoi??
“Corona” (Oaaoe?y) ?c aeei?enoaiiyi iaai??a o??ie “Boehringer Mankheim”
(I?ia//eia – Aano??y).

Noai ia?aeeniiai ieeneaiiy e?i?ae?a aea/aee ia i?aenoaa? aecia/aiiy a
ieaci? e?ia? ??aiy ia?aeiieo oa aoi?eiieo i?iaeoeo?a ia?ieneaeaoe?? ?c
aeei?enoaiiyi niaeo?ioioiiao?e/iiai oa oai?ethi?ianoeaioiiai iaoiae?a.

Ae??iia? eii’thaaoe aecia/aee ca iaoiaeii Aaa?eeiaa A.A. ?
I?oei?oaeii? I.?. (1983), a aoi?eiiee i?iaeoeo – iaeiiiaee
aeeaeueaeaa?ae — a iiaeeo?eaoe?? Ei?iaaeieeiai? A.I. (1989).

Oai?ethi?ianoeaioiee iaoiae aeicaiey? aecia/eoe caaaeueiee ??aaiue
aeoeaaoe?? IIE, ??aaiue a?ae?iia?aeen?a, ?o ieenethaai?noue.
Oai?ethi?ianoeaioe?y, ?iaeoeiaaia 3 % ?ic/eiii I2I2, a?aeaeaa? noai
aioeieenethaaeueii? oa aioe?aaeeeaeueii? aeoeaiino? ieacie (AEo?aaeueia
I.?., 1975). Oa?iaioaoeaio eaieo aioeieneaeaioiiai caoenoo ioe?ithaaee
ca aeoeai?noth eaoaeace a a?eo?ioeeoao e?ia? (Ia?aneea?ia ?.A., 1989).

Iaae? ii?iaeueieo cia/aiue eiiiiiaio?a e?i?aeiiai niaeo?o ieacie e?ia? ?
i?iaeoeo?a ?o ia?aieeneaiiy ae?aoiaoaaee ca aeiiiiiaith iaoiaeo
aa??aoe?eii? noaoenoeee (Eae?i A.O., 1990). Iaoaiaoe/ia ia?iaea
io?eiaieo ?acoeueoao?a i?iaiaeeeany ia AII ?AI ?N/AO ?c aeei?enoaiiyi
iaeaoo i?eeeaaeieo i?ia?ai “Statgra?h”. Aeinoia??i?noue a?aei?iiinoae
i?ae a?oiaie aecia/aee ca aeiiiiiaith ia?aiao?e/ieo (t e?eoa??e
No’thaeaioa) ? iaia?aiao?e/ieo (o?-eaaae?ao, e?eoa??e O?oa?a, e?eoa??e
Eieiiai?iaa-Nie?iiaa) iaoiae?a.

Nooi?iue aca?iica’yce?a i?ae ie?aieie iieacieeaie ae?aoiaoaaee ca
aeiiiiiaith ia?iiai oa iiiaeeiiiai ei?aeyoe?eiiai aiae?co. Aeey
?ice?eooy iai?yieo ca’yce?a o nenoai? e?i?aee-IIE-aioeieneaeaioia
nenoaia (AIN) aoa canoiniaaiee nenoaiiee aiae?c, noai?aia
eiioeaiooaeueia iiaeaeue e?i?aeiiai iai?io o i?aee?oe?a ?c ?eceeii
?icaeoeo AN. A iiaeae? e?i?aeiiai iai?io aeei?enoai? iieacieee ia’?eoo,
ye? aa?ooue o/anoue o oi?ioaaii? no?oeoo?ieo ca’yce?a. Aecia/aiiy
caeaaeiino? ci?ie oa?aeoa?enoeee iaei??? no?oeoo?e a?ae ?ioi?
ioe?ithaaeiny ca aeiiiiiaith no?oeoo?ii-ae?aaiinoe/iiai eiao?oe??ioa
ca’yceo (NAeE). Ca?eueoaiiy oa?aeoa?enoeee iaei??? no?oeoo?e iiaea
aeeeeeaoe ca?eueoaiiy /e ciaioaiiy ae?oai? oa?aeoa?enoeee. A?aeiia?aeii
NAeE ia? ciae (+) /e (-) ? aeaco? ia ne?eueee iaeeieoeue ca?eueoo?oueny
/e ciaioo?oueny oa?aeoa?enoeea iaei??? no?oeoo?e i?e ca?eueoaii? ae?oai?
ia iaeeieoeth (Neaa?i I.A., 1989). Ae?aoiaothoue NAeE ye aeene?ei?iaioi?
eiao?oe??ioe aeey i?yieo ? cai?ioi?o ca’yce?a. Iniaeea?noth aeaii?
iaoaiaoe/ii? iiaeae? ? oa, ui a?aoiaothoueny ? an? neaae? ca’ycee, ia
a?aei?io a?ae ei?aeyoe?eiiai iaoiaeo. Aeniiiaioe?aeuei? caeaaeiino? CON,
OA, ON EIAU a?ae IAeA a a?oiao: eiio?ieue, IAA, iaoyaeaia niaaeeia?noue
uiaei ?I, aecia/aee ca aeiiiiiaith ?i?oaoe?eiiai noioanoe/iiai
iiaeaethaaiiy.

Aeey ?iaeea?aeoaeueii? ae?aaiinoeee ii?ooaiue aca?iica’yce?a o nenoaiao
OA-IAeA ? CON-IAeA aoei aeei?enoaia ae??oaeueia i?aaeei aaia (A). sseui
A > 0 (++) – oea ?icoe?ithaaeiny ye ?ecee uiaei ?icaeoeo AN, A < 0 (--) – caei?iaee, A ciaoiaeeoueny o iaaeao eieeaaiue (+-) /e (-+) – ciia iaaecia/aiiai ?eceeo. Aeinoia??i?noue ae?aoiaoaaee ca e?eoa???i I??niia (? < 0,05). ?ACOEUeOAOE AeINE?AeAEAIIss Aiae?c ?acoeueoao?a aeine?aeaeaiue aeyaea, ui o?ce/iee ?icaeoie a?eueoino? i?aee?oe?a aoa aa?iii?/iei (a?aeiia?aeii 83,4 % i?e iaoyaeai?e niaaeeiaino? uiaei ?I oa 90,0 % - i?e IAA). Noaoaaa aeic??aaiiy o 92,0 % i?aee?oe?a ?c ia?aeiiith a?oa??aeueiith a?ia?oaic??th ? o an?o ianoaaeaieo ?c iaoyaeaiith niaaeeia?noth ia ?I a?aeiia?aeaei ianii?oiiio a?eo. A caeaaeiino? a?ae nooiaiy i?iyao aoi?eiieo noaoaaeo iciae i?aee?oe?a ia'?aeiaee o aea? a?eiai-noaoaa? a?oie. A ia?oo oa?eoee i?aee?oee 12-14 ?ie?a. Ae?oao a?oio neeaee thiaee a?eii 15-17 ?ie?a ?c aeia?a ae?aaeaieie noaoaaeie iciaeaie. Oaeee ?iciiae?e aeicaieea i?iaiaeeoe aiae?c iaoa??aeo c o?aooaaiiyi ia??iaeo noaoaaiai aeic??aaiiy oa oiiaii iicia/eoe ye ?aii?e (12-14 ?ie?a) ? aeania ioaa?oaoiee ia??iae (15-17 ?ie?a). Aiae?c ciai?oiueina?aaeiaeo oaeoi??a ?eceeo aeyaea, ui o i?aee?oe?a ?c iaoyaeaiith niaaeeia?noth ia ?I /ano?oa ia? i?noea eiioe?eoia neooaoe?y a n?i'? (?<0,05), a oaeiae iaiiaia n?i'y (aiane?aeie ?iceo/aiiy aai nia?o? iaeiiai ?c aaouee?a). Aaaeeeaa cia/aiiy a i?aee?oeiaiio a?oe? ia? aieea oaeoi??a, yeee ni?ey? ?aiiueiio ?icaeoeo aoa?ineea?ioe/iiai ooeiaeaeaiiy na?oeaai-noaeeiii? nenoaie, a oiio /ene? niaaeeiaa iaoyaeai?noue. N?iaeiee aiaiiac iieacaa, ui o an?o oeeo i?aee?oe?a ?ioa?eo o iieiaeiio a?oe? ia?aianee aaoueee. A a?oi? ?c ia?aeiiith a?oa??aeueiith a?ia?oaic??th iaoyaeaia niaaeeia?noue ia a?ia?oii?/io oai?iao cono??/aeany a ia?o?e e?i?? ??aei? a 82,5 % aeiaaee?a, ye i?aaeei, c aieo iaoa?? (52,5 %). Ee?i?/i? i?iyae IAA oa?aeoa?ecoaaeeny a 95,0 % i?aee?oe?a iayai?noth ??cieo nea?a. Iae/ano?oa oea aoee oeaoaea?? ??cii? eieae?caoe??. A a?oi? ?c iaoyaeaiith niaaeeia?noth ia ?I nea?ae aeyaeyeeny cia/ii iaioa (16,3 %). A noaoe?iia?ieo oiiaao o 37,7 % i?aee?oe?a ?c IAA aoea anoaiiaeaia ia?oa noaae?y ? a 62,3 % - ae?oaa noaae?y ia?aeiii? a?oa??aeueii? a?ia?oaic??. Aeaeo?io?c?ieia?/i? ci?ie, ca aeaieie AEA, iaee i?noea a iaio a?oiao ianoaaeaieo. I?e oeueiio ii?ooaiiy i?ioean?a ?aiiey?ecaoe?? a i?iea?ae? ia?aaaaeaee o i?aee?oe?a ?c iaoyaeaiith niaaeeia?noth ia ?I (60,0 %; ? < 0,05). Ii?ooaiiy i?ioean?a caoaeeeaino?, ca oeiii aeno?anenoie??, niinoa??aaeeny oaeiae eeoa a oe?e a?oi? (6,6 %). Aeai? AoiEA na?ae/aoue, ui a?ia?o?io?y i?iea?aea e?aiai oeoii/ea a o?e ?ace /ano?oa aeyaeyeany o ?ac? ia?aeiii? a?oa??aeueii? a?ia?oaic?? (? < 0,05), a oie /an ye aeey i?aee?oe?a ?c iaoyaeaiith niaaeeia?noth uiaei ?I a?eueo i?eoaiaiia iayai?noue iaeeo ea?ae?aeueieo noeai aeecaia??iaaiaco. A iaio a?oiao ianoaaeaieo anoaiiaeaia aaaaoaoeaia aeenooieoe?y iaaii? ni?yiiaaiino?. Oae, i?e ia?aeii?e a?oa??aeuei?e a?ia?oaic?? niinoa??aa?oueny ae?aaeaiee aieea ia?aiaiai eaiaeo noeioeyoe?? a oi?aae?ii? na?oeaaei ?eoiii. A a?oi? ?c iaoyaeaiith niaaeeia?noth ia?aaaaea? aoii?aeueiee eaiae ?aaoeyoe?? iaae ia?aiaei (? < 0,05). Ca aeaieie ea?ae?i?ioa?aaeia?ao?? o ianoaaeaieo iaie i?aee?oe?a aeyaeaii aaeeeee ?iciao eieeaaiue iieaciee?a aaaaoaoeaii? ia?aiai? nenoaie a i?aeo?eioe? aiiainoaco. Aaaaoaoeaia aeenoii?y aaaioii?/ii? ni?yiiaaiino? c a?ia?ae?anoiee/iei aa??aioii ?aaeoe?? ia EII iaea i?noea a 33,3 % oai?eo ia IAA ? o 20,0 % i?aee?oe?a ?c iaoyaeaiith niaaeeia?noth uiaei ?I. E??i oiai, oai?ei ia ia?aeiio a?oa??aeueio a?ia?oaic?th i?eoaiaiia ae?aaeaia iai?oaa eiiiainaoi?ii-i?enoinoaaeueieo iaoai?ci?a aaeaioaoe??, yea aeyaey?oueny a aeoeaaoe?? o?eiaaiaoe/ii a?eueo aeaaiuei? eaiee aaoiiiiii? ia?aiai? nenoaie - ia?aneiiaoe/ii?. Ioaea, ??ci? iaoai?cie aeenooieoe?? i?eaiaeyoue aei iaeiiai ?acoeueoaoo - iaaeinoaoiueiai aaaaoaoeaiiai caaacia/aiiy ? aeecaaeaioeaii? (yea oa?aeoa?eco?oueny i?eoiaaiith a?ia?oaic??th) a?aeiia?ae? na?oeaai-noaeeiii? nenoaie ia iaaaioaaeaiiy. Ioneiaei iiiaioii AN ? ii?ooaiiy a e?ia? o?ainii?oo aee?ieo eeneio ? oi?ioaaiiy a?ia?e?i?aeai?? (Eeeiia I.?., 1995; Oeoia A.I., 1998; Drexel H., Muntwyler J. et. al., 1995). Ii?ooaiiy a e?i?aeiiio iai?i? aoee cia/ieie ye o oai?eo ia IAA, oae ? a a?oi? ?c iaoyaeaiith niaaeeia?noth. Cie?aia, aeene?iii?ioa?aeai?? aoa?iaaiii? ni?yiiaaiino? o in?a c IAA neeaee 79,0 %, a a a?oi? ?c iaoyaeaiith niaaeeia?noth uiaei ?I - 62,0 %. Ii?aeiaiiy a?ia?o?eae?oea?eaeai?? c a?iiaeueoaoieanoa?eiai??th, ye iaeiiai ?c iani?eyoeeaeo aa??aio?a AeEI, ia?aaaaeaei o oai?eo ia IAA (39,5 % i?ioe 17,2 % a a?oi? ?c iaoyaeaiith niaaeeia?noth uiaei ?I; ? < 0,05). Ioaea, iayai?noue a?ia?e?i?aeai?e o i?aee?oe?a ?c ia?aeiiith a?oa??aeueiith a?ia?oaic??th oa ?c iaoyaeaiith niaaeeia?noth ia ?I ia ?aii?o aoaiao aoa?ineea?ico i?aeoaa?aeaeo? aeao?oeeo a ee?oeiao iaiane/aieo aee?ieo eeneio oa i?aeaeuaiee ai?no ?o a e?ia? (Oeoia A.I., 1998), oiaoi na?ae/eoue i?i oa, ui aaea a oeae ia??iae iioiaaiaco o a?eueoino? i?aee?oe?a c IAA oa ?c iaoyaeaiith niaaeeia?noth ee?oeie ia iathoue ciiae ii?iaeueii iiaeeiaoe eiiieaene – iie??iia? eeneioe + oieanoa?ei. Anoaiiaeaii, ui o oai?eo ia a?oa??aeueio a?ia?oaic?th aaea a ia??iae noaoaaiai aeic??aaiiy oi?iothoueny i?yi? ei?aeyoe?ei? ca'ycee i?ae CON ? OA (r = + 0,588; ? < 0,01) ? CON oa oeaio?ae?caoe??th oi?aae?iiy na?oeaaei ?eoiii (r = + 0,603; ? < 0,01). Inoai?e oaeo, iaaooue, iiaeia o?aeooaaoe oaeei /eiii, ui ia aeeeae ai?iii?a no?ano ee?oeia caoeua? naaa naia oieanoa?eiii, ine?eueee a?i neoaeeoue iniiaiith eaieith o i?aeo?eioe? iaiao?aeiiai aeey ?? aeeoo?ae?yeueiino? aeaeo?e/iiai iioaioe?aeo (Aeaaeeie?ia TH.A., 1989). Aea/aiiy ii?ooaiue e?i?aeiiai iai?io ia ??ai? i?ioean?a ia?ieneaeaoe?? ? ooieoe?iioaaiiy nenoai caoenoo aeicaieeei anoaiiaeoe caeaaei?noue oeeo i?ioean?a a?ae ia??iaeo noaoaaiai aeic??aaiiy ? noaae?? a?oa??aeueii? a?ia?oaic??. O i?aee?oe?a ?c a?oi ?eceeo ia AN aeyaeaia cia/ia aeoeaaoe?y IIE (? < 0,001). Iaeiae oaea ia ia?oeo aoaiao oeyoe e?i?aeiiai iaoaaie?cio iaee nai? a?aei?iiino?. O oai?eo ia IAA niinoa??aaeiny i?aeaeuaiiy ??aiy a?ae?iia?aeen?a, yea aoei iaea?eueoa ae?aaeaia a ia??iae ?aiiueiai ioaa?oaoo (? < 0,01), a i?e iaoyaeai?e niaaeeiaino? uiaei ?I ??aaiue a?ae?iia?aeen?a cieaeoaaany a iaio ia??iaeao noaoaaiai aeic??aaiiy (? < 0,01). Ai?no iaeiiiaiai aeeaeueaeaa?aeo eeoa i?e a?oa??aeuei?e a?ia?oaic?? cieaeoaaany o 12-14-e?oi?o (? < 0,05), a iio?i aeinyaaa ii?ie o thiae?a 15-17 ?ie?a. I?aee?oeai a?oi ?eceeo uiaei AN i?eoaiaiia cia/ia aeoeaaoe?y eaoaeacii? eaiee caoenoo (a o?e ?ace ia?aaeuoaaea iieacieee ii?ie). E??i oiai, i?e a?oa??aeuei?e a?ia?oaic?? aiia caeaaeaea a?ae noaae?? ? a?eo ianoaaeaieo. Iaea?eueo ae?aaeaia aeoeai?noue eaoaeace i?e ae?oa?e noaae?? IAA (? < 0,01). Ioe?ithth/e noai aioe?aaeeeaeueii? oa aioeieenethaaeueii? aeoeaiino? ieacie, iaiao?aeii a?aei?oeoe iaaaeaeaaoio a?aeiia?aeue nenoai ia iineeaiiy i?ioean?a IIE. A iaio a?oiao o a?eueoino? i?aee?oe?a aeoeai?noue nenoai caoenoo ia a?ae??ciyeany a?ae eiio?ieth aai ae aoea cia/ii ieae/ith a ii??aiyii? ?c ii?iaeueieie iieacieeaie. E??i oiai, o 32,4 % i?aee?oe?a ?c IAA ? o 27,6 % - ?c iaoyaeaiith niaaeeia?noth uiaei ?I iaei i?noea cia/ia iineeaiiy i?ioean?a IIE ia oii? cieaeaiiy caaaeueii? aioeieenethaaeueii? oa aioe?aaeeeaeueii? aeoeaiino? ieacie e?ia?. Nenoaiiee aiae?c aeicaieea aeyaeoe ?ieue eiaeiiai ?c eiiiiiaio?a e?i?aeiiai niaeo?o e?ia? o aca?iica'yceo ?c aeaiaioaie nenoai ia?ieneaeaoe?? oa aioeieneaeaioiiai caoenoo /oaaeeoe? 1, 2, 3/. 19 Oaaeeoey 1 - Oa?aeoa?enoeea no?oeoo?ieo ca'yce?a o?eae?oea?eae?a a nenoai? IIE-AIN o i?aee?oe?a a?oi ?eceeo ?icaeoeo aoa?ineea?ico ca aeaieie ?ioi?iaoe?eii? a?ao.-iiaeae? A?oieA?e ianoaaeaieo ?ioaineai?noue IIE A?ae?iia?aeeneIeenethaai?noue e?i?ae?aAioeieenethaaeueia aeoeai?noue ieacieAioe?aaeeeaeueia aeoeai?noue ieacie EaoaeacaAe??iia? eii’thaaoe Iaeiiiaee aeeaeueaeaa?ae Eiio?ieueia12-14 n – 13- 0,23- 0,64- 0,14+ 0,04+ 0,58+ 0,60- 0,24- 0,3315-17 n – 25- 0,09+ 0,35+ 0,03+ 0,25+ 0,28+ 0,32- 0,22- 0,17Iaoyaeaia niaaeeia?noue ia ?I12-14 n – 14- 0,005- 0,135- 0,13+ 0,02- 0,052- 0,05+ 0,013- 0,000615-17 n – 16- 0,03- 0,14- 0,113- 0,45- 0,05- 0,62- 0,28+ 0,13 IAA12-14 n – 14+ 0,67+ 0,67+ 0,99+ 0,40+ 0,77+ 0,31+ 0,17+ 0,3115-17 n – 26- 0,48+ 0,006+ 0,002- 0,31- 0,41- 0,38- 0,22+ 0,06 I?ei?oea: /eneia? cia/aiiy ?c ciaeii “+” oa “-“ – no?oeoo?ii-ae?aaiinoe/iee eiao?oe??io aca?iica’yce?a (NAeE). Oaaeeoey 2 - Oa?aeoa?enoeea no?oeoo?ieo ca’yce?a ON EIAU a nenoai? IIE-AIN o i?aee?oe?a a?oi ?eceeo ?icaeoeo aoa?ineea?ico ca aeaieie ?ioi?iaoe?eii? a?ao.-iiaeae? A?oieA?e ianoaaeaieo ?ioaineai?noue IIE A?ae?iia?aeeneIeenethaai?noue e?i?ae?aAioeieenethaaeueia aeoeai?noue ieacieAioe?aaeeeaeueia aeoeai?noue ieacie EaoaeacaAe??iia? eii’thaaoe Iaeiiiaee aeeaeueaeaa?ae Eiio?ieueia12-14 n – 13+ 0,15+ 0,003+ 0,05- 0,23- 0,33- 0,56- 0,98- 0,3915-17 n – 25- 0,21- 0,28+ 0,01+ 0,81+ 0,22- 0,86- 0,97+0,62Iaoyaeaia niaaeeia?noue ia ?I12-14 n – 14- 0,35+ 0,007+ 0,004+ 0,14- 0,03+ 0,07+ 0,19- 0,0815-17 n – 16- 0,12- 0,49+ 0,55+ 0,07+ 0,14- 0,02- 0,74- 0,11 IAA12-14 n – 14+ 0,43- 0,29- 0,03- 0,14- 0,29- 0,52- 0,16- 0,1715-17 n – 26+ 0,76- 0,41- 0,92- 0,18- 0,08- 0,47- 0,51- 0,15 I?ei?oea: /eneia? cia/aiiy ?c ciaeii “+” oa “-“ – no?oeoo?ii-ae?aaiinoe/iee eiao?oe??io aca?iica’yce?a (NAeE). Oaaeeoey 3 - Oa?aeoa?enoeea no?oeoo?ieo ca’yce?a CON a nenoai? IIE-AIN o i?aee?oe?a a?oi ?eceeo ?icaeoeo aoa?ineea?ico ca aeaieie ?ioi?iaoe?eii? a?ao.-iiaeae? A?oieA?e ianoaaeaieo ?ioaineai?noue IIE A?ae?iia?aeeneIeenethaai?noue e?i?ae?aAioeieenethaaeueia aeoeai?noue ieacieAioe?aaeeeaeueia aeoeai?noue ieacie EaoaeacaAe??iia? eii’thaaoe Iaeiiiaee aeeaeueaeaa?ae Eiio?ieueia12-14 n – 13+ 0,07+ 0,002+ 0,22- 0,92- 0,06+ 0,27+ 0,50+ 0,0115-17 n – 25- 0,02+ 0,20+ 0,21+ 0,25+ 0,08- 0,20- 0,43+ 0,92Iaoyaeaia niaaeeia?noue ia ?I12-14 n – 14+ 0,38+ 0,53- 0,71+ 0,31+ 0,23- 0,42+ 0,33+ 0,2715-17 n – 16- 0,44- 0,70+ 0,22- 0,35+ 0,01- 0,001- 0,95- 0,31 IAA12-14 n – 14+ 0,22- 0,03- 0,008- 0,30- 0,09- 0,69+ 0,56- 0,0815-17 n –26- 0,27+ 0,13- 0,10- 0,65- 0,41+ 0,05- 0,53+ 0,56 I?ei?oea: /eneia? cia/aiiy ?c ciaeii “+” oa “-“ – no?oeoo?ii-ae?aaiinoe/iee eiao?oe??io aca?iica’yce?a (NAeE). ?acoeueoaoe aeine?aeaeaiue aeacothoue ia oa, ui a nenoai? o?eae?oea?eae?a o caei?iaeo i?aee?oe?a i?aeaeuaiiy OA ia aeeeeea? iineeaiiy IIE ? ca?eueoaiiy aeieaaiiy IAeA a ieacio a ?acoeueoao? aeoeaiiai noaio an?o eaiie aioeieneaeaioiiai caoenoo a iaio ia??iaeao noaoaaiai aeic??aaiiy /oaaeeoey 1/. A nenoai? ON EIAU-IIE-AIN o caei?iaeo i?aee?oe?a 12-14 ?ie?a i?aeaeuaiiy ON EIAU ni?ey? iacia/iiio iineeaiith IIE ia oii? cieaeaiiy aeoeaiino? nenoai aioeieneaeaioiiai caoenoo, a a 15-17 ?ie?a ca?eueoaiiy ON EIAU aeeeeea? cieaeaiiy aeoeaiino? on?o eaiie caoenoo (oa?iaioaoeaii?, aioeieenethaaeueii?, aioe?aaeeeaeueii?). Aea i?e oeueiio c'yaey?oueny neeueiee ca'ycie ON EIAU ?c IAeA, yeee na?ae/eoue i?i oa, ui ca?eueoaiiy ON EIAU i?ecaaaea aei i?aeaeuaiiy ai?noo IAeA a ieaci?, ioaea iineeaiiy aeieaaiiy eiai ?c ee?oeiieo iaia?ai /oaaeeoey 2/. A nenoai? CON-IIE-AIN ca?eueoaiiy CON a iaio ia??iaeao noaoaaiai aeic??aaiiy ni?eyoeia aeoeaaoe?? IIE (ia oii? oa?iaioaoeaii? aeoeaiino? a 12-14 ?ie?a, a a 15-17 ?ie?a - i?e iineeaii? caaaeueii? aioeieenethaaeueii? oa aioe?aaeeeaeueii? aeoeaiino? ieacie). O caei?iaeo thiae?a 15-17 ?ie?a i?aeaeuaiiy ai?noo CON ia iaeeieoeth aoaea aeeeeeaoe i?aeaeuaiiy a ieaci? e?ia? ai?noo IAeA ia 0,92 iaeeieoe? /oaaeeoey 3/. Oaeei /eiii, o caei?iaeo i?aee?oe?a a ia??iae aeania ioaa?oaoo noaoe?iia?ia ??aiiaaaa, a ioaea ? o?ceei-o?i?/i? aeanoeaino? iaia?aie ee?oeie, a cia/i?e i??? aecia/aoeiooueny ai?noii o e?ia? CON ? ON EIAU. O i?aee?oe?a ?c IAA oa iaoyaeaiith niaaeeia?noth uiaei ?I aeyaeaia iaeiiiai?aaeaia ni?yiiaai?noue caeaaeiino? aca?iica'yce?a IAeA a?ae OA. Ioaea, eiioeaiooaeueia iiaeaeue i?aeoaa?aeaeo?, ui o ianoaaeaieo ?c a?oi aenieiai ?eceeo a?aeaoeany ye?nii iiaa ia?aaoaeiaa aca?iica'yce?a ye a nenoai? CON, oae ? a nenoai? OA. A??ia?aeii, ui ia a?aei?io a?ae i?aee?oe?a eiio?ieueii? a?oie, o oai?eo ia IAA oa o i?aee?oe?a ?c iaoyaeaiith niaaeeia?noth uiaei ?I eaoaaie?ci e?i?ae?a ia? iaio o?c?ieia?/iee ia?aa?a, ? a?ia?o?eae?oea?eaeai?th ia ?aii?o aoaiao aoa?iaaiaco iiaeia aaaaeaoe iaeiei ?c iniiaieo oaeoi??a ?eceeo. ?ic?iaeaiee niin?a ?iaeea?aeoaeueii? ae?aaiinoeee aca?iica'yce?a o nenoaiao CON-IAeA ? OA-IAeA (?c aeei?enoaiiyi aeniiiaioe?aeueii? ooieoe??) aeicaieea o 68,6 % oai?eo ia IAA ? a 58,6 % i?aee?oe?a ?c iaoyaeaiith niaaeeia?noth aeyaeoe e?i?aei? ii?ooaiiy. Cie?aia, ii?ooaiiy aca?iica'yce?a o nenoaiao /anoi iaei i?noea ia oii? ii?iaeueieo na?aaeiueinoaoenoe/ieo iieaciee?a. Iiaeia ia?aaeaa/eoe, ui a ?ac? oaeeo ii?ooaiue aca?iica'yce?a o nenoaiao ye?noue iaeiiiaiai aeeaeueaeaa?aeo aoaea ?ioith, i?ae o i?aee?oe?a c ii?iaeueieie aca?iica'yceaie. Aeaiee oaeo na?ae/eoue i?i aeioe?euei?noue canoinoaaiiy ia ?aii?o noaae?yo aoa?ineea?ioe/iiai i?ioeano ia ne?eueee e?euee?nieo iaoiae?a ae?aaiinoeee, ye ye?nieo. Ii?ooaiiy e?i?aeiiai iai?io a iaio a?oiao ?eceeo uiaei ?icaeoeo aoa?ineea?ico iathoue ye caaaeuei? ?ene, oae ? iaai? a?aei?iiino?. Anoaiiaeaii, ui o oai?eo ia ia?aeiio a?oa??aeueio a?ia?oaic?th ? o i?aee?oe?a ?c iaoyaeaiith niaaeeia?noth ia ?I ia? i?noea ae?aaeaia iineeaiiy i?ioean?a IIE, eio?a ? aoi?eiiei ? oa?aeoa?eco? ia?oee aoai eiiiainaoi?iiai o?ainii?oo a ee?oeie iie??iiaeo eeneio – aoai oi?ioaaiiy iaiaioeaaio. Aaea a ia??iae noaoaaiai aeic??aaiiy eiaeiiai o?aoueiai i?aee?oea ?c a?oi aenieiai ?eceeo ia aoa?ineea?ic iiaeia a?aeianoe aei caa?iceeaeo uiaei ?icaeoeo a?eueii?aaeeeaeueii? iaoieia??. I?aeoaa?aeaeaiiy oeueiio - iineeaiiy i?ioean?a IIE ia oii? cieaeaiiy aeoeaiino? nenoai aioeieneaeaioiiai caoenoo. Io?eiai? ?acoeueoaoe na?ae/aoue i?i oa, ui a ia??iae noaoaaiai aeic??aaiiy o i?aee?oe?a ?c ia?aeiiith a?oa??aeueiith a?ia?oaic??th oa ?c iaoyaeaiith niaaeeia?noth ia ?I a?aeaoaa?oueny no?oeoo?ia ia?aaoaeiaa aca?iica'yce?a i?ae eiiiiiaioaie e?i?aeiiai niaeo?o ? iaeiiiaei aeeaeueaeaa?aeii ieacie, yea oa?aeoa?eco?oueny iiyaith aeinoaoiuei neeueiiai aieeao o?eae?oea?eae?a ia ai?no oeueiai iaoaaie?oo a ieaci? e?ia?, a ioaea ? ia nooi?iue aeieaaiiy eiai ?c iaia?aie ee?oeie. Ii?ooaiiy aca?iica'yce?a o nenoaiao cono??/a?oueny iaeiaeiai /anoi a iaio a?oiao ?eceeo ? caeaaeeoue a?ae ia??iaeo noaoaaiai aeic??aaiiy. Aeyaeaii iaai? a?aei?ii? ?ene a iai?i? e?i?ae?a, ye? oa?aeoa?i? ye aeey oai?eo ia ia?aeiio a?oa??aeueio a?ia?oaic?th, oae ? aeey i?aee?oe?a ?c iayaeaiith niaaeeia?noth ia ?I. Onoaiiaeaii, ui iieiiea a on?o eaieao caoenoo a ia??iae noaoaaiai aeic??aaiiy o i?aee?oe?a ?c iaoyaeaiith niaaeeia?noth ia ?I ia? i?noea a nenoai? o?eae?oea?eae?a, a oie /an ye i?e ia?aeii?e a?oa??aeuei?e a?ia?oaic?? - a nenoai? oieanoa?eio. Eiia?iiaai? ii?ooaiiy e?i?aeiiai iai?io a nenoaiao i?e iaoyaeai?e niaaeeiaino? ia ?I /ano?oa niinoa??aathoueny a ia??iae ?aiiueiai ioaa?oaoo, a i?e IAA - a ia??iae aeania ioaa?oaoo. ?cieueiaai? ii?ooaiiy iaoaaie?cio e?i?ae?a (ye i?aaeei a nenoai? o?eae?oea?eae?a) aeey in?a ?c iaoyaeaiith niaaeeia?noth a?eueo oa?aeoa?i? a 15-17 ?ie?a, a i?e a?oa??aeuei?e a?ia?oaic?? - a 12-14 ?ie?a. Ioaea, oeyoe i?io?eaeoeee aeey oeeo a?oi i?aee?oe?a iiaeii? aooe aeeoa?aioe?eiaaieie ?c o?aooaaiiyi a?eo ? ni?yiiaaiino? ii?ooaiue a nenoaiao e?i?aeiiai iai?io. Oaeei /eiii, iaiao?aeii a?aecia/eoe, ui aiane?aeie i?iaaaeaieo aeine?aeaeaiue aoee c'yniaai? iniaeeaino? e?i?aeiiai eaoaaie?cio ia ??ai? i?ioean?a IIE ? AIN caoenoo o i?aee?oe?a a?oi aenieiai ?eceeo AN ia aeiee?i?/ieo aoaiao ?icaeoeo oa ?ic?iaeaii niin?a ?aiiuei? ae?aaiinoeee oe??? iaoieia??. Aeyaeai? iniaeeaino? ii?ooaiue e?i?aeiiai iai?io iiaeia ?icoe?ieoe ye ia?aaea?nieee aoa?ineea?ico. AENIIAEE 1. O 32,4 % i?aee?oe?a, oai?eo ia ia?aeiio a?oa??aeueio a?ia?oaic?th, oa o 27,6 % - ?c iaoyaeaiith niaaeeia?noth ia ?ioa?eo i?iea?aea, iathoue i?noea iaoaaie?/i? ii?ooaiiy, ye? oa?aeoa?ecothoueny aeene?iii?ioa?aeai?yie aoa?iaaiii? ni?yiiaaiino?, iineeaiiyi i?ioean?a ia?aeeniiai ieeneaiiy e?i?ae?a oa cieaeaiiyi aeoeaiino? aioeieneaeaioii? nenoaie caoenoo. Oea aea? i?aenoaae ?icoe?ithaaoe aeaieo in?a ye caa?iceeaeo uiaei ?icaeoeo ia a?eueii?aaeeeaeueio iaoieia?th. 2. O 79,0 % oai?eo ia ia?aeiio a?oa??aeueio a?ia?oaic?th oa o 62,0 % i?aee?oe?a ?c iaoyaeaiith niaaeeia?noth uiaei ?ioa?eoo i?iea?aea iathoue i?noea aeene?iii?ioa?aeai?? aoa?iaaiii? ni?yiiaaiino?. Anoaiiaeaii, ui a iaio a?oiao i?aee?oe?a ?c ?eceeii ?icaeoeo ia aoa?ineea?ic /anoioa aoa?iaaiieo aeene?iii?ioa?aeai?e aeinoia??ii ia a?ae??ciy?oueny i?ae niaith. 3. O a?eueoino? i?aee?oe?a ?c ?eceeii ?icaeoeo aoa?ineea?ico iaoaaie?/i? ci?ie aeyaeythoueny ia oii? iaaeinoaoiueiai /e ci?oaiiai oeio aaaaoaoeaiiai caaacia/aiiy. I?e oeueiio o oai?eo ia ia?aeiio a?oa??aeueio a?ia?oaic?th ia?aaaaea? a?ia?neiiaoeeioii?/ia ?aaeoeai?noue, a i?e iaoyaeai?e niaaeeiaino? ia ?ioa?eo i?iea?aea – aneiiaoeeioii?/ia. 4. O caei?iaeo i?aee?oe?a ?c a?eii a?aeaoaa?oueny iineeaiiy i?ioean?a ia?aeeniiai ieeneaiiy e?i?ae?a oa ia? i?noea ae?aaeaiee aieea caaaeueiiai oieanoa?eio ? oieanoa?eio e?iii?ioa?ae?a aeniei? u?eueiino? ia iaeiiiaee aeeaeueaeaa?ae ieacie, ui na?ae/eoue i?i aaeeeo caeaaei?noue aeanoeainoae iaia?aie ee?oeie a aeaiee ia??iae iioiaaiaco naia a?ae oieanoa?eio. 5. O i?aee?oe?a ?c ia?aaea?nieeaie aoa?ineea?ico c’yaey?oueny ye?nii iiaa caeaaei?noue iaeiiiaiai aeeaeueaeaa?aeo ieacie a?ae o?eae?oea?eae?a, ui i?aeoaa?aeaeo? ia?ao?ae e?i?aeiiai eaoaaie?cio ia iaio o?c?ieia?/iee oeyo. Ci?ia oa?aeoa?o aca?iica’yce?a i?ae e?i?aeaie oa iaeiiiaei aeeaeueaeaa?aeii caeaaeeoue a?ae ia??iaeo noaoaaiai aeic??aaiiy. 6. Ii?ooaiiy aca?iica’yce?a a on?o eaieao caoenoo (eaoaeaca, aioeieenethaaeueia, aioe?aaeeeaeueia aeoeai?noue ieacie) o in?a ?c iaoyaeaiith niaaeeia?noth uiaei ?ioa?eoo i?iea?aea a?aeaoaa?oueny a nenoai? o?eae?oea?eae?a, a oie /an ye o oai?eo ia ia?aeiio a?oa??aeueio a?ia?oaic?th – a nenoai? caaaeueiiai oieanoa?eio, a oea aeiaaa? ??cieo i?aeoiae?a aei i?io?eaeoeee aaea ia ?aii?o aoaiao aoa?iaaiaco. I?AEOE*I? ?AEIIAIAeAOe?? 1. I?aee?oee ?c iaoyaeaiith niaaeeia?noth ia ?ioa?eo i?iea?aea oa ?c ia?aeiiith a?oa??aeueiith a?ia?oaic??th ? a?oiith aenieiai ?eceeo uiaei ?aiiueiai ?icaeoeo aoa?ineea?ico ? iio?aaothoue aeeniaina?iiai iaaeyaeo. 2. I?aee?oeai ?c ia?aeiiith a?oa??aeueiith a?ia?oaic??th oa ?c n?iae, aea iaeei ?c aaouee?a o iieiaeiio a?oe? ia?ai?n ?ioa?eo i?iea?aea, aeioe?eueii aecia/aoe ai?no o ieaci? e?ia? ia o?eueee caaaeueiiai oieanoa?eio ? o?eae?oea?eae?a, aea e iaeiiiaiai aeeaeueaeaa?aeo c iiaeaeueoei c’ynoaaiiyi yeino? aca?iica’yce?a o oeeo nenoaiao. 3. A ?ac? iayaiino? ia?aaea?niee?a aoa?ineea?ico o i?aee?oe?a ?c a?oi aenieiai ?eceeo uiaei oeueiai iaaeoaa a eiiieaen i?io?eaeoe/ieo caoiae?a iaiao?aeii aeeth/aoe i?e?iaei? aioeieneaeaioe (a?oai?ie A, N, A, D), ye? i?noyoueny a ??cieo i?iaeoeoao (eoeo?oaecyi?e, niiyoieeia?e, ieeaeia?e, niaa?e ie??, iai/ao ? o?oeoao). Iaiao?aeii iaiaaeeoe aaeeaaiiy i?iaeoeo?a, ui i?noyoue o aaeee?e e?eueeino? o?eae?oea?eaee, a ca?eueoeoe a ?aoe?ii? i?iaeoeoe ii?y (?eaa, ii?nueea eaionoa ? o.?.). Aei aioeoieanoa?eiiai? ae??oe ? aaeeaaiiy a?iie?i?aeai?/ieo ?a/iaei neioaoe/iiai iioiaeaeaiiy a oeae ia??iae iioiaaiaco iaiao?aeii i?aeoiaeeoe ?c ia?anoi?iaith. IA?AE?E I?AOeUe, IIOAE?EIAAIEO CA OAIITH AeENA?OAOe?? 1. Aeaaeaeei E.A. Ninoiyiea ia?aeeniiai ieeneaiey eeieaeia e aioeieneaeaioiie nenoaiu a ieacia e?iae o caei?iauo iiae?inoeia //Aanoiee i?iaeai aeieiaee e iaaeeoeeiu. – 1996. - ? 8. – N. 23-29. 2. Aeaaeaeei E.A. ?ieue i?ioean?a ia?aeeniiai ieeneaiiy e?i?ae?a o oi?ioaaii? ia?aaea?niee?a aoa?ineea?ico o i?aee?oe?a ?c ia?aeiiith a?oa??aeueiith a?ia?oaic??th //Iaae?ao??y, aeooa?noai oa a?iaeieia?y. – 1998.-? 1. – N.23-25 3. Aeaaeaeei E.A., Einoth?eia A.I., Eaoeaeaea Ae.A. Eeeieei-iaoaaiee/aneea iniaaiiinoe o iiae?inoeia n ioyaiuaiiie ianeaaenoaaiiinoueth ii eioa?eoo ieiea?aea //Aanoiee i?iaeai aeieiaee e iaaeeoeeiu. – 1998.- ? 5. – N. 48-58. 4. Aeaaeaeei E.A. Iniaeeaino? aaaaoaoeaiiai noaoono o i?aee?oe?a c ia?aeiiith a?oa??aeueiith a?ia?oaic??th oa o i?aee?oe?a, aaoueee yeeo ia?aianee ?ioa?eo i?iea?aea //Iaae?ao??y, aeooa?noai oa a?iaeieia?y. – 1998. - ? 3. – N. 23-25. 5. Aiaiao E.O., Aeaaeaeei E.A., Aoiaca?yioe Y.E., Aaaaeaineay O.N., *enoye I.A. Eeeieei-aaiiaeeiaie/aneea iniaaiiinoe o iiae?inoeia n ia?ae/iie a?oa?eaeueiie aeia?oaiceae e “iaeuie” ea?aeeaeueiuie noeaiaie aeecyia?eiaaiaca //Oe?a?inueeee ea?ae?ieia?/iee aeo?iae. – 1998. - ? 11. – N. 36-38. 6. Aeaaeaeei E.A. Iniaaiiinoe aaaaoaoeaiiai aiiainoaca o oeieueieeia n aeeneeiii?ioaeaeaieyie //Oai?aoe/aneea e i?aeoe/aneea aii?inu aeaoneie ea?aeeieiaee: Oac. aeiee. Oe?. iao/i. i?aeo. eiio. – Oa?ueeia, 1993. – N. 35-36. 7. Aeaaeaeei E.A. ?ieue aaaaoaoeaiiai noaoona a iiaeoiaeao e oa?aiee iiae?inoeia n aeeneeiii?ioaeaeaieyie //Aeooaeuei? ieoaiiy e?eoaaiiy ? ?aaa?e?oaoe?? i?aee?oe?a c niiaoe/ieie ? ineo?/ieie ii?ooaiiyie: Oac. aeiee. Oe?. iaoe. i?aeo. eiio. – Oa?e?a, 1995. – N. 31-35. 8. Aeaaeaeei E.A., Aieiai?iaeueei A.A., Eaoeaeaea Ae.A. Ia?aeeniia ieeneaiea eeieaeia e nenoaia aioeieneaeaioiie caueou o iiae?inoeia n ia?ae/iie a?oa?eaeueiie aeia?oaiceae. //Aeooaeuei? i?iaeaie ?aaiaoe/ieo caoai?thaaiue o ae?oae oa i?aee?oe?a: Oac. aeiee. Oe?. iaoe. i?aeo. eiio. – Oa?e?a, 1996.–N.26 – 27. 9. Aeaaeaeei E.A. Iniaaiiinoe i?ioeannia ia?aeeniiai ieeneaiey eeieaeia e aioeieneaeaioiie nenoaiu caueou o iiae?inoeia ec a?oii ?enea ii aoa?ineea?ico. // ? I?aeia?iaeiee iaaee/iee eiia?an nooaeaio?a ? iieiaeeo a/aieo: Oace aeiiia?aeae. – Oa?iii?eue, 1997. – N. 71-72. 10. Aeaaeaeei E.A. Ninoiyiea eeieaeiiai iaiaia o iiae?inoeia ec naiae n ioyaiuaiiie ianeaaenoaaiiinoueth ii eioa?eoo ieiea?aea //Iaoa??aee O?V C’?caeo oa?aiaao?a Oe?a?ie: Oace aeiiia?aeae. – Ee?a, 1998. – N. 42-43. AIIOAOe?ss Aeaaeaeei E.A. Ee?i?ei-iaoaaie?/i? iniaeeaino? o i?aee?oe?a ?c ?eceeii ?icaeoeo aoa?ineea?ico - ?oeiien. Aeena?oaoe?y ia caeiaoooy a/aiiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth: 14.01.10 – iaae?ao??y, Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao, Oa?e?a, 1999. Aeena?oaoe?y i?enay/aia i?iaeai? ?aiiuei? ae?aaiinoeee aoa?ineea?ico o i?aee?oe?a. A ?iaio? iiaeai? ?acoeueoaoe ee?i?ei-?ino?oiaioaeueieo oa a?io?i?/ieo iaoiae?a aeine?aeaeaiiy na?oeaai-noaeeiii?, aaaaoaoeaii? ia?aiai? nenoaie oa e?i?aeiiai iai?io (ia ??ai? i?ioean?a ia?aeeniiai ieeneaiiy oa aioeieneaeaioiiai caoenoo) o i?aee?oe?a ?c ia?aeiiith a?oa??aeueiith a?ia?oaic??th oa ?c iaoyaeaiith niaaeeia?noth ia ?ioa?eo i?iea?aea. ?ic?iaeaii iiaee niin?a ?aiiuei? ae?aaiinoeee e?i?aeieo ii?ooaiue o nenoaiao caaaeueiiai oieanoa?eio oa o?eae?oea?eae?a ?c o?aooaaiiyi noaio i?ioean?a ia?aieeneaiiy e?i?ae?a. Anoaiiaeaii iniaeeaino? aaaaoaoeaiiai noaoono, eiiiiiaio?a e?i?aeiiai niaeo?o, i?ioean?a ia?aeeniiai ieeneaiiy oa nenoai aioeieneaeaioiiai caoenoo a caeaaeiino? a?ae a?eo oa noaae?? a?oa??aeueii? a?ia?oaic??. Aeieacaii, ui o i?aee?oe?a a?oi aenieiai ?eceeo ia aoa?ineea?ic a?aeaoaa?oueny no?oeoo?ia ia?aaoaeiaa aca?iica’yce?a o nenoaiao e?i?aeiiai iai?io, ui na?ae/eoue i?i iaio o?c?ieia?/iee oeyo eaoaaie?cio. I?aeoaa?aeaeaiiyi oeueiai ? iiyaa i?yii? caeaaeiino? iaeiiiaiai aeeaeueaeaa?aeo ieacie ia a?ae oieanoa?eio, ye o caei?iaeo i?aee?oe?a, a a?ae o?eae?oea?eae?a. Aeieacaii, ui aeey a?eueo oi/ii? ? ?aiiuei? ae?aaiinoeee aeioe?eueii aecia/aoe ia o?eueee ai?no caaaeueiiai oieanoa?eio, o?eae?oea?eae?a, aea ? iaeiiiaiai aeeaeueaeaa?aeo c iiaeaeueoei aecia/aiiyi yeino? aca?iica’yce?a o nenoaiao. Iniiai? ?acoeueoaoe ?iaioe ciaeoee ai?iaaaeaeaiiy a ee?i?eao ? iie?ee?i?eao i?no Oa?eiaa oa Iieoaae. Eeth/ia? neiaa: aoa?ineea?ic, e?i?aee, ia?aeenia ieeneaiiy e?i?ae?a, i?aee?oee. AIIIOAOeEss Aeaaeaeei E.A. Eeeieei-iaoaaiee/aneea iniaaiiinoe o iiae?inoeia n ?eneii ?acaeoey aoa?ineea?ica – ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.10 – iaaeeao?ey, Oa?ueeianeee ainoaea?noaaiiue iaaeeoeeineee oieaa?neoao, Oa?ueeia, 1999. Oeaeueth ianoiyuaai enneaaeiaaiey auei niaa?oainoaiaaiea iaoiaeia ?aiiae aeeaaiinoeee i?aaeaanoieeia aoa?ineea?ica o iiae?inoeia ia iniiaa eco/aiey iaoaieciia iaoiaaiaoe/aneie nayce iaaeaeo eiiiiiaioaie eeieaeiiai niaeo?a, i?ioeannaie ia?aeeniiai ieeneaiey eeieaeia e aioeieneaeaioiie nenoaiu caueou. Ianeaaeiaaii 108 iiae?inoeia ioaeneiai iiea a aic?anoa 12-17 eao: 40 – n ia?ae/iie a?oa?eaeueiie aeia?oaiceae, 30 – ec naiae, aaea iaeei ec ?iaeeoaeae a aic?anoa aei 45 eao ia?aian eioa?eo ieiea?aea e 38 caei?iauo iiae?inoeia (o eioi?uo a aeaoo iieieaieyo a aic?anoa aei 60 eao ia auyaeaii eeeie/aneeo oi?i na?aea/ii-ninoaeenouo caaieaaaiee aoa?ineea?ioe/aneie i?e?iaeu). Ana iiae?inoee, a caaeneiinoe io au?aaeaiiinoe aoi?e/iuo iieiauo i?eciaeia, auee iauaaeeiaiu a aeaa aic?anoii-iieiaua a?oiiu: 12-14 eao (?aiiee ioaa?oao) e 15-17 eao (nianoaaiii ioaa?oao). Eco/aeinue ninoiyiea na?aea/ii-ninoaeenoie, aaaaoaoeaiie ia?aiie nenoaiu, iieacaoaeae eeieaeiiai niaeo?a, nenoaiu ia?aeeniiai ieeneaiey e aioeieneaeaioiie caueou. E?iia iau/iuo eeeieei-eino?oiaioaeueiuo iaoiaeia eniieueciaaeny oaieethieianoeaioiue, niaeo?ioioiiao?e/aneee e oa?iaioaoeaiue iaoiaeu aeey eco/aiey iniaaiiinoae eeieaeiiai iaiaia. Ii?aaeaeyee ia?ae/iua i?iaeoeou – aeeaiiaua eiiuthaaou, aoi?e/iue i?iaeoeo – iaeiiiaue aeeaeueaeaaeae. Ioeaieaaee iauoth eioaineaiinoue i?ioeannia ia?ieneaeaoeee eeieaeia, o?iaaiue aeae?iia?aeenae, ieeneyaiinoue eeieaeia. Aioeieneaeaioioth nenoaio caueou eco/aee ia iniiaaiee iieacaoaeae aioeieeneeoaeueiie, aioe?aaeeeaeueiie aeoeaiinoe ieaciu e eaoaeacu. Aeey auyaeaiey acaeiinaycae iaaeaeo ioaeaeueiuie iieacaoaeyie e?iia iau/iuo iaoaiaoe/aneeo iaoiaeia aue eniieueciaai nenoaiiue aiaeec n iino?iaieai eioi?iaoeeiiiie a?ao.-iiaeaee. Aiaeec iieo/aiiuo ?acoeueoaoia iaia?oaeee o iiae?inoeia a?oii ?enea aeenoiieth oie eee eiie iai?aaeaiiinoe. Oae, aeenoiiey aaaioiie/aneie iai?aaeaiiinoe n aeia?aeeanoiee/aneei aa?eaioii ia eeeii-i?oinoaoe/aneoth i?iao i?e ia?ae/iie a?oa?eaeueiie aeia?oaicee auea a 33,3 % neo/aaa, a i?e ioyaiuaiiie ianeaaenoaaiiinoe ii eioa?eoo ieiea?aea – o 20 % iiae?inoeia. Aeeneeiii?ioaeaeaiee aoa?iaaiiie iai?aaeaiiinoe auyaeyeenue o aieueoeinoaa iiae?inoeia iaaeo a?oii ?enea ii aoa?ineea?ico. Eeoue aeey iiae?inoeia n ia?ae/iie a?oa?eaeueiie aeia?oaiceae a ia?eiae iieiaiai nic?aaaiey oa?aeoa?ii oi?ie?iaaiea iieiaeeoaeueiie ei??aeyoeeiiiie caaeneiinoe iauaai oieanoa?eia io o?eaeeoea?eaeia (r = + 0,588; ? < 0,01) e io oeaio?aeecaoeee oi?aaeaiey na?aea/iui ?eoiii (r = + 0,603; ? < 0,01). Oneeaiea i?ioeannia ia?aeeniiai ieeneaiey eeieaeia eiaei ianoi eae i?e ia?ae/iie a?oa?eaeueiie aeia?oaicee, oae e i?e ioyaiuaiiie ianeaaenoaaiiinoe ii eioa?eoo ieiea?aea e caaenaei io aic?anoa e noaaeee a?oa?eaeueiie aeia?oaicee. Onoaiiaeaii, /oi o eaaeaeiai o?aoueaai iiae?inoea ec a?oii aunieiai ?enea ii aoa?ineea?ico oneeaiea i?ioeannia ia?aieeneaiey eeieaeia auyaeyeinue ia oiia nieaeaiey aeoeaiinoe nenoai aioeieneaeaioiie caueou. I?e iiiiue nenoaiiiai aiaeeca iaia?oaeaiu iniaaiiinoe no?oeoo?iuo acaeiinaycae a nenoaiao eeieaeu - ia?aeeniia ieeneaiea - aioeieneaeaioiay caueoa. Aeieacaii, /oi o aieueiuo ia?ae/iie a?oa?eaeueiie aeia?oaiceae e o iiae?inoeia n ioyaiuaiiie ianeaaenoaaiiinoueth ii eioa?eoo ieiea?aea aicieeaao ea/anoaaiii iiaay caaeneiinoue (io “-“ e “+”) iaeiiiaiai aeeaeueaeaaeaea io o?eaeeoea?eaeia, a ioee/ea io caei?iauo iiae?inoeia, aaea iaaethaeaaony caaeneiinoue iaeiiiaiai aeeaeueaeaaeaea io oieanoa?eia. Yoi iiaeoaa?aeaeaiea ia?aoiaea eeieaeiiai eaoaaieecia ia iaiaa oeceieiae/iue iooue. Neaaeiaaoaeueii, iiauoaiea o?eaeeoea?eaeia ia ?aiieo yoaiao aoa?ineea?ioe/aneiai i?ioeanna iiaeii n/eoaoue iaeiei ec iniiaiuo oaeoi?ia ?enea. ?ac?aaioaia eiaeeaeaeoaeueiay aeeaaiinoeea eeieaeiiai iaiaia (n eniieueciaaieai yeniiiaioeeaeueiie ooieoeee) a nenoaiao oieanoa?ei-iaeiiiaue aeeaeueaeaaeae e o?eaeeoea?eaeu-iaeiiiaue aeeaeueaeaaeae, /oi iicaieeo auyaeoue ia?ooaiey acaeiinaycae aeaaea ia oiia n?aaeianoaoenoe/aneeo ii?iaeueiuo iieacaoaeae eeieaeia e niioaaonoaaiii i?iaanoe ia?ae/ioth i?ioeeaeoeeo aoa?ineea?ica n o/aoii ea/anoaa ia?ooaiee. Oaeei ia?acii, auyaeaiiua iniaaiiinoe eeieaeiiai iaiaia o iiae?inoeia n ia?ae/iie a?oa?eaeueiie aeia?oaiceae e ioyaiuaiiie ianeaaenoaaiiinoueth ii eioa?eoo ieiea?aea iiaeii ?anoeaieoue eae i?aaeaanoieee aoa?ineea?ica. Iniiaiua ?acoeueoaou ?aaiou aiaae?aiu a eeeieeao e iieeeeeieeao a. Oa?ueeiaa e Iieoaau. Eeth/aaua neiaa: aoa?ineea?ic, eeieaeu, ia?aeeniia ieeneaiea eeieaeia, iiae?inoee. SUMMARY Davidko L.V. Clinical and Metabolic Peculiarities in Adolescents with a High Risk of Atherosclerosis Development - Manuscript. Competitive Thesis for the Degree of Candidate of Science (Medicine) in Speciality 14.01.10 - Pediatrics. Kharkov State Medical University, Kharkov, 1999. The work dwells on the problems of early diagnosis of atherosclerosis in adolescents. The thesis presents the results of clinico-instrumental and biochemical methods of investigating cardiovascular and vegetative nervous systems as well as lipid metabolizm, at the level of peroxidation processes and antioxidant protection, in adolescents with primary arterial hypertension and hereditary burden as regards myocardial infarction. There has been worked out a new method of early diagnosing lipid disorders in the systems of total cholesterol and triglycerides taking into consideration the current state of lipid peroxidation processes. There have been established certain peculiarities of vegetative status, of lipid spectrum components as well as of peroxidation processes and of antioxidant protection systems as dependent on the age and the arterial hypertension stage. It has been proved that in adolescents from the groups of high risk of atherosclerosis development there takes place certain restructuring of interconnections in lipid metabolism systems which testifies to some other than physiological course of catabolism. The above is confirmed by establishing a direct dependence of plasma malonic dialdehyde not on total cholesterol, as it takes place in healthy adolescents, but rather on triglycerides. It has been established that for a more accurate and earlier diagnosis it its expedient to determine not only total cholesterol and triglyceride levels but also the level of malonic dialdehyde followed by determining the character of interconnections in the systems. The principal results of the work have been adopted at the clinical institutions of Kharkov and Poltava. Key words: atherosclerosis, lipids, lipid peroxidation, adolescents. NIENIE NEI?I*AIUe AN – aoa?ineea?ic AIN – aioeieneaeaioia nenoaia A – aaia AeEI - aeene?iii?ioa?aeai?y AEA – aeaeo?iea?ae?ia?ao?y AoiEA - aoiea?ae?ia?ao?y CON – caaaeueiee oieanoa?ei ?I – ?ioa?eo i?iea?aea IAeA – iaeiiiaee aeeaeueaeaa?ae I2I2 – ia?aeen aiaeith IAA - ia?aeiia a?oa??aeueia a?ia?oaic?y IIE – ia?aeenia ieeneaiiy e?i?ae?a NAeE – no?oeoo?ii-ae?aaiinoe/iee eiao?oe??io OA – o?eae?oea?eaee ON EIAU – oieanoa?ei e?iii?ioa?ae?a aeniei? u?eueiino?

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