Клініко-імунологічна та імуногенетична характеристика дітей з різними формами туберкульозу і корекція імунологічних порушень: Автореф. дис… д-ра мед

?INOEOOO OOEC?AO??? ? IOEUeIIIIEIA??

?I. O.A.ssIIANUeEIAI AII OE?A?IE

A?EIAI?OeAAA IEUeAA ?AAI?AIA

OAeE 616-002.5-053.2-085.281.32/37:612.112.017.1.575:616-092.9-07

EE?I?EI-?IOIIEIA?*IA OA ?IOIIAAIAOE*IA oa?aeoa?enoeea Ae?OAE C
??CIEIE OI?IAIE OOAA?EOEUeICO ? ei?aeoe?y ?ioiieia?/ieo ii?ooaiue

14.01.26 – ooec?ao??y

AAOI?AOA?AO

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

aeieoi?a iaaee/ieo iaoe

Ee?a – 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a Aei?i?iiao?ianuee?e aea?aeaai?e iaaee/i?e aeaaeai??
IIC Oe?a?ie.

Iaoeiaee eiinoeueoaio: aeieoi? iaaee/ieo iaoe, i?ioani?

Eino?ii?ia A?eoi??y
Iaae?aia,

?inoeooo ooec?ao??? ?
ioeueiiiieia?? ?i. O.A.ssiianueeiai

AII Oe?a?ie, caa?aeoth/a
a?aeae?eaiiyi ooec?iiaae?ao???

Io?oe?ei? iiiiaioe: aeieoi? iaaee/ieo iaoe, i?ioani?

Iaianthe Ieaen?e Aa?oieii?eiae/,

Iaaee/iee ?inoeooo Oe?a?inueei? anioe?aoe?? ia?iaeii? iaaeeoeeie,
i?ioani? eaoaae?e ooec?ao???;

aeieoi? iaaee/ieo iaoe, i?ioani?

N??aiei ??eia Ieaenaiae??aia,

Oa?e?anueeee ?inoeooo oaeineiiaeaiiy e?ea??a IIC Oe?a?ie, caa?aeoth/a
eaoaae?ith aeeoy/i? ooec?ao??? ? ioeueiiiieia??;

aeieoi? iaaee/ieo iaoe, i?ioani?

Oaeuei?i Ieaenaiae? Naio?eiae/,

Caii??cueeee ?inoeooo oaeineiiaeaiiy e?ea??a IIC Oe?a?ie, caa?aeoth/ee
eaoaae?ith ooec?ao??? oa ioeueiiiieia??.

I?ia?aeia onoaiiaa: Iaoe?iiaeueiee iaaee/iee oi?aa?neoao
?i.I.I.Aiaiiieueoey, eaoaae?a ooec?ao??? c eo?nii ioeueiiiieia??.

Caoeno a?aeaoaeaoueny » 29 » /a?aiy 1999?. i 10-00 aiaeei? ia
can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae26.552.01 i?e ?inoeooo?
ooec?ao??? ? ioeueiiiieia?? ?i.O.A.ssiianueeiai AII Oe?a?ie (252110,
i.Ee?a, INI-680, oca?c I?ioan?a y?,7).

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? ?inoeoooo ooec?ao???
? ioeueiiiieia?? ?i.O.A.ssiianueeiai AII Oe?a?ie (i.Ee?a, oca?c I?ioan?a
y?, 7).

Aaoi?aoa?ao ?ic?neaiee » 25 » o?aaiy 1999?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee
AE.A.Aaaioe?aa

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. C?inoaiiy caoai?thaaiino? oa nia?oiino? a?ae
ooaa?eoeueico ca inoaii?e /an i?eaaei aei oiai, ui ooaa?eoeueic a
Oe?a?i? noaiiaeoue caa?ico iaoe?iiaeuei?e aaciaoe? (TH.?.Oauaiei, 1995;
TH.?.Oauaiei, A.I.Iaeueiee, 1998; A.I.Eino?ii?ia, 1995, 1998).

Ai?aeneooaoe?y c ooaa?eoeueico a oe?eiio, caoai?thaai?noue i?aee?oe?a ?
aei?ineeo cia/iith i??ith aecia/athoueny ia?aianaiei o aeeoeinoa?
ia?aeiiei i?ioeanii ? ye?noth eiai aee?eoaaiiy, ine?eueee iaa?oue
i?i?iaeuei? caeeoeia? ci?ie ia?aeiiiai aaiaco ? aeaea?aeii aiaeiaaiii?
?a?ioaeoe?? o i?aee?oe?a oa aei?ineeo (A.A.Oiiaiei, 1997; E.A.Ieoeineay,
1998; TH.?.Oauaiei, 1998).

Na?aae iaeaaaeeea?oeo caaaeaiue, ae??oaiiy yeeo ia?aaeaa/a?
iaoe?iiaeueia i?ia?aia ai?ioueae c ooaa?eoeueicii, — caaaeaiiy
oaeineiiaeaiiy ?nioth/eo ? ?ic?iaee iiaeo cania?a ae?aaiinoeee,
e?eoaaiiy ? i?io?eaeoeee ooaa?eoeueico, ?ic?iaee ? canoinoaaiiy o
ooec?ao??? noaiaea?o?a ? oaoiieia?e, aaeaioiaaieo aei i?aeia?iaeieo
noaiaea?o?a.

Aaaeeeaa ?ieue ?ioiii? nenoaie o ?icaeoeo ? ia?aa?ao ooaa?eoeueico ia
aeeeeea? noii?a?a (I.I.Aaa?aao e niaao., 1980, 1984, 1992;
E.O.*a?iooaiei, E.N.Eiainiaa, 1981; E.O.*a?iooaiei, 1993, 1998). ??aaiue
oa aeeaeia ?ioiiae?aaiinoeee a aeaiee /an cia/iith i??ith caeaaeaoue
a?ae oiai, iane?eueee oe?iei a i?e aeei?enoiaothoueny iiiieeiiaeuei?
aioeo?ea (Ae.A.Noaoaie, TH.A.Aaeueoeuaa, 1996).

O oie aea /an o ooec?iiaae?ao??? caeeoathoueny iaii?aoeueiaaieie
ieoaiiy, iiaycai? c aea/aiiyi iiioeyoe?e oa noaiiioeyoe?e
?ioiieiiiaoaioieo ee?oei e?ia?, ??aiy i?ioeooaa?eoeueicieo aioeo?e ?c
canoinoaaiiyi oaeeo aenieiniaoeeo?/ieo oaoiieia?e, ye iiiieeiiaeuei?
aioeo?ea. Iii?oi?eia noaio ?ioi?oaoo o ae?oae, oai?eo ia ooaa?eoeueic, ?
aaaeeeaith oiiaith ia?eoeaii? ioe?iee aoaeoeaiino? e?eoaaiiy, oei
a?eueoa, ui o ae?oae /ano?oa a?aenooi? aeanoea? aei?ineei e?eoa???
aeeiai?ee i?ioeano: cae?eooy ii?iaeiei ?iciaaeo ? i?eieiaiiy
aaeoa??iaeae?eaiiy.

Aaiaoe/ia noeeuei?noue i?aai?cio aei caoai?thaaiue, iniaeeaino? ?o
ia?aa?ao a cia/i?e i??? aecia/athoueny aioeaaiiei neeaaeii eiai oeaiei
(E.Ae.Na?iaa, A.I.Oaaaeei, 1988), oiio a inoaii? ?iee aaeeeiai
i?aeoe/iiai cia/aiiy noaee iaaoaaoe aeine?aeaeaiiy aioeaai?a aieiaiiai
eiiieaeno a?noinoi?niino? (HLA), ui aa?ooue aaciina?aaeith o/anoue o
?icaeoeo ?ioiii? a?aeiia?ae? (J.D.Dasgupta et al., 1990; A.I.Ae?aiiee,
A.I.Aeecee, 1990; A.A.sscaeianeee, 1991, 1997).

A oiiaao c?inoaiiy caoai?thaaiino? ooaa?eoeueicii, iaiaaeaieo
iiaeeeainoae ?aioaaiieia?/iiai ianoaaeaiiy ae?oae, aieeao iani?eyoeeaeo
ciai?oi?o oaeoi??a aea/aiiy aaiaoe/ieo ia?ea??a noeeueiino? aei
ooaa?eoeueico, aacoiiaii, ia? aaaeeeaa i?aeoe/ia cia/aiiy, aeicaiey?
?iaeea?aeoae?coaaoe aeeniaina?ia niinoa?aaeaiiy ? e?eoaaeueio oaeoeeo.
A?aeiiino? i?i ?iciiae?eaiiy aioeaai?a a?noinoi?niino? o ae?oae c
??cieie i?iyaaie ooaa?eoeueico, ye? i?iaeeaathoue a Oe?a?i?, a?aenooi?.
Caeeoathoueny iaii?aoeueiaaieie i?iaeaie niieo/aiino? ??cieo eaiie
?ioi?oaoo oa ?o aca?iicayceo c aaiaoe/ieie oaeoi?aie.

O oie aea /an iniaeeaino? ?ioiieia?/ii? nenoaie i?aai?cio, ui ?inoa,
aeiaaathoue aeeeth/ii ?aoaeueiiai i?aeai?o cania?a ?ioiiei?aeoe??,
?ic?iaee ?iaeea?aeoaeueieo iieacaiue aei ?o canoinoaaiiy, iiooeo cania?a
i?e?iaeiiai iioiaeaeaiiy c aeanoeainoyie aaeaioiaai?a. Oaeei /eiii,
iia??oaiiy a Oe?a?i? ai?aeai?ieia?/ii? neooaoe?? c ooaa?eoeueico,
cieaeaiiy aoaeoeaiino? e?eoaaiiy, neeaaei?noue ae?aaiinoeee oa e?eoaaiiy
ooaa?eoeueico o ae?oae i?eaaee aei iaiao?aeiino? iiooeo aaiaoe/ieo
ia?ea??a /ooeeaino? ? ?acenoaioiino? aei ooaa?eoeueico, aeine?aeaeaiiy
?ioiieia?/ieo iaoai?ci?a ?aae?caoe?? aaiaoe/ii? noeeueiino? aei
caoai?thaaiiy, aea/aiiy iaoio?c?ieia?/ieo iniaeeainoae ia?aa?ao
ooaa?eoeueico ? iiaeeeainoae oaiioei?/ii? ei?aeoe?? ?ioiieia?/ieo
ii?ooaiue ?c aaeeaaiiyi iiaeo ?ioiiaeoeaieo i?aia?ao?a ??ciiai
iioiaeaeaiiy ? iaoai?cio ae?? c iaoith i?aeaeuaiiy aoaeoeaiino?
e?eoaaiiy, ? aecia/eee aeooaeuei?noue aeine?aeaeaiue, ui i?iaiaeeeeny,
oa ?ioa?an aei aea/aiiy aeaii? i?iaeaie.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Aeine?aeaeaiiy
aeeiioaaeenue ia eaoaae?? ooec?ao??? Aei?i?iiao?ianueei? aea?aeaaii?
iaaee/ii? aeaaeai??. Aeena?oaoe?y ? o?aaiaioii eiiieaenieo oai:
«Aeeoa?aioe?eiaai? iaoiaee o?i?ii?io?eaeoeee o ae?oae a?oi ?eceeo ii
caoai?thaaiith ooaa?eoeueicii», ? aea?ae?a?no?aoe?? 01.88.0086827;
«Aea/eoe i?e/eiii-iane?aeeia? caycee aeeiai?ee caoai?thaaiino?,
oai?iaeeaino?, nia?oiino? oa aeayeeo ?ioeo iieaciee?a
?iciianthaeaeaiino? ooaa?eoeueico a Oe?a?i?; ?ic?iaeoe 10-??/iee
iaoeiai-iaa?oioiaaiee i?iaiic ? oeyo aieeao ia oeth iaaeoao. ?ic?iaeoe
iia? iaoiaee ?aiiuei? ae?aaiinoeee ? i?io?eaeoeee ooaa?eoeueico oa
iniiai? iai?yiee ia?niaeoeaieo iaoeiaeo aeine?aeaeaiue o ooec?ao???»,
?0192U010901, oeo? NO.393.

Iaoa ?iaioe. Aeaoe eiiieaenio ee?i?/io, ?ioiieia?/io ? ?ioiiaaiaoe/io
(HLA) oa?aeoa?enoeeo ??cieo aa??aio?a ia?aa?ao ooaa?eoeueico o ae?oae ?
ee?i?ei-iaoiaaiaoe/ia iaa?oiooaaiiy canoinoaaiiy ??cieo ?ioiio?iiieo
i?aia?ao?a aeey i?aeaeuaiiy aoaeoeaiino? e?eoaaiiy.

Caaaeaiiy aeine?aeaeaiiy:

1. I?iaanoe aiae?c iniaeeainoae ee?i?/iiai ia?aa?ao ??cieo i?iya?a
ooaa?eoeueico o ae?oae o c?noaaeaii? c ?acoeueoaoaie aea/aiiy
?ioiieia?/ii? ?aaeoeaiino?: iiioeyoe?eiiai oa noaiiioeyoe?eiiai neeaaeo
?ioiieiiiaoaioieo ee?oei, ooieoe?iiaeueii? aeoeaiino? e?ioioeeo?a,
aoii?aeueieo oaeoi??a oa ooieoe?iiaeueii? aeoeaiino? oaaioeeooth/eo
ee?oei e?ia?.

2. Aea/eoe aaiaoe/i? ia?ea?e HLA ??cieo i?iya?a ooaa?eoeueico o
ae?oae oa ?o aca?iicaycie c iniaeeainoyie ?ioiii? a?aeiia?ae?.

3. Aea/eoe i?iaiinoe/io oe?ii?noue oaeoi??a ?eceeo (aaiaoe/ieo ?
ciai?oi?o) o ?icaeoeo ooaa?eoeueico o ae?oae.

4. Aea/eoe ee?i?ei-?ioiieia?/io aoaeoeai?noue ??cieo aeae?a e?eoaaiiy
(o?i?ioa?ai??, o?i?ioa?ai?? o ii?aeiaii? c ?ioiiaeoeaieie i?aia?aoaie —
oeiiaaiii, a?inii?eiii) o ae?oae, oai?eo ia ooaa?eoeueic, ? aeaoe
iaoiaaiaoe/ia iaa?oiooaaiiy ?o canoinoaaiiy.

5. Aea/eoe iniaeeaino? ?ioii?aaa?e?oaoe?? i?e ??cieo aeaeao e?eoaaiiy o
caeaaeiino? a?ae aeo?aeiiai noaio ?ioi?oaoo ? aeeiai?eo niieo/aiino?
?ioiieia?/ieo iciae o i?ioean? e?eoaaiiy.

6. Aea/eoe aoaeoeai?noue canoinoaaiiy o?oii?aia?aoo “A?aaoii” ie?aii ? o
ii?aeiaii? c aioeaaeoa??aeueieie i?aia?aoaie ia ?ioiieia?/io
?aaeoeai?noue ? ooaa?eoeueicia caiaeaiiy o aenia?eiaio? c o?aooaaiiyi
aaiaoe/ii iaoiiaeaii? iiiceoii? /ooeeaino? aei ooaa?eoeueicii?
?ioaeoe??.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Iaea?aeaii iia? aeai?, ye?
aeaoaeueii oa?aeoa?ecothoue noai ?ioi?oaoo o ae?oae c ??cieie i?iyaaie
ooaa?eoeueico (iniaeeaino? aeni?an?? aioeaai?a ?ioiieiiiaoaioieo ee?oei
— CD3, CD4, CD8, CD38, CD22, HLA, DR, niieo/ai?noue ee?oeiieo,
aoii?aeueieo oaeoi??a, iieaciee?a ooieoe?iiaeueii? aeoeaiino?
e?ioioeeo?a ? oaaioeeoa?ii? caeaoiino? ee?oei), ui iioe?ththoue oyao i?i
?ieue oaeoi??a i?aeee?oeiii? eiiia?aoe?? ? iaoai?cie ?ioiiiaoiaaiaco
??cieo aa??aio?a ia?aa?ao ooaa?eoeueico, aeathoue ciiao iiynieoe
iniaeeaino? ee?i?/iiai ia?aa?ao oeeo oi?i c oi/ee ci?o aaeaeaaoiino?
?ioiii? a?aeiia?ae?.

Aia?oa o ae?oae, ye? i?iaeeaathoue a Oe?a?i?, aecia/aii aaiaoe/i?
ia?ea?e HLA noeeueiino? aei ?icaeoeo ooaa?eoeueico ? ia?aoiaeo
ia?aeiiiai i?ioeano o aoi?eiiee, a oaeiae aea/aii aca?iicaycie i?ae
aaiaoe/ieie ? ciai?oi?ie oaeoi?aie, ui i?aeaeuothoue ?ecee caoai?thaaiiy
ooaa?eoeueicii.

Aia?oa aea/aii aieea aaeoa??aeueiiai i?aia?aoo — a?inii?eio — ia ia?aa?a
ooaa?eoeueiciiai i?ioeano ? ?ioiieia?/io ?aaeoeai?noue o oai?eo ia
ooaa?eoeueic, iaa?oioiaaii iieacaiiy aei aaeeaaiiy oa cai?iiiiiaaii
noaio i?eeiio i?aia?aoo o oai?eo ia ooaa?eoeueic ae?oae. Iieacaii, ui
i?aia?ao iie?ioo? ia?aiinei?noue ? i?aeaeuo? aoaeoeai?noue o?i?ioa?ai??.

Aia?oa aoei aea/aii iniaeeaino? ?ioii?aaa?e?oaoe?? i?e ??cieo aeaeao
ao?iiaoiaaiaoe/ii? oa?ai?? o ae?oae, oai?eo ia ooaa?eoeueic, o
caeaaeiino? a?ae aeo?aeiiai noaio ?ioiieia?/ii? ?aaeoeaiino?, a naia —
iai?aaeaiino? ae??; oaeaeeino? a?aeiiaeaiiy ?ioiieia?/ieo ia?aiao??a, a
oaeiae a?ae aaiaoe/ieo oaeoi??a nenoaie HLA.

Aia?oa aeaii e?euee?nio ioe?ieo neee aieeao () ??cieo aeae?a e?eoaaiiy
(o?i?ioa?ai??, o?i?ioa?ai?? o ii?aeiaii? c oeiiaaiii, a?inii?eiii) ia
ee?oeii? ? aoii?aeuei? ia?aiao?e ?ioi?oaoo, ui aeicaieeei ?ic?iaeoe
?aeiiaiaeaoe?? ii aeeoa?aioe?eiaaiiio aaeeaaiith cacia/aieo
?ioiiaeoeaieo i?aia?ao?a.

Aia?oa, a oiiaao aenia?eiaioo, iieacaii aoaeoeai?noue canoinoaaiiy
eiiieaeniiai o?oii?aia?aoo “A?aaoii” o ei?aeoe?? ii?ooaiue ?ioi?oaoo ?
ae?? ia ooaa?eoeueicia caiaeaiiy c o?aooaaiiyi ??cii?, aaiaoe/ii
iaoiiaeaii?, /ooeeaino? aei ooaa?eoeueicii? ?ioaeoe??.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. I?iaaaeaiee ee?i?/iee
aiae?c ??cieo i?iya?a ooaa?eoeueico o ae?oae o ii??aiyii? c eiiieaeniith
ioe?ieith noaio ?ioiieia?/ii? ?aaeoeaiino? (iiioeyoe?eiiai oa
noaiiioeyoe?eiiai neeaaeo ? ooieoe?iiaeueii? aeoeaiino? e?ioioeeo?a,
noaio aoii?aeueieo oaeoi??a, ooieoe?iiaeueii? aeoeaiino? oaaioeeooth/eo
ee?oei) aeicaieea aeae?eeoe ee?i?ei-?ioiieia?/i? iniaeeaino? ??cieo oi?i
ooaa?eoeueico ? aeyaeoe eaiee, ye? iio?aaothoue ?ioiiei?aeoe??.

Iieacaii, ui o ae?oae c ii/aoeiaeie i?iyaaie ooaa?eoeueicii? ?ioaeoe?? ?
iaeeie oi?iaie ooaa?eoeueico aioo??oiueia?oaeieo e?ioaoe/ieo aoce?a
/ano?oa a?aenooi? iciaee ae?eniiai ?ioiiaeao?oeeoo (aeieaaea
?aoeaioi?iiai aia?aoo e?ioioeeo?a iii??ii ae?aaeaia ? eiiiaino?oueny
aeoeaaoe??th niaoeeo?/ii? eaiee ee?oeiiiai ?ioi?oaoo) ? iieacaiiy aeey
i?ecia/aiiy ?ioiiiiaeoeyoi??a o ieo iaiaaeai?.

?acoeueoaoe ee?i?ei-?ioiieia?/ieo c?noaaeaiue aeicaieeee ?aeiiaiaeoaaoe
aeey aeei?enoaiiy o i?aeoeoe? ?ioiieia?/i? ia?aiao?e ae?aaeaiino?
ooaa?eoeueiciiai i?ioeano, a naia: aeoeaaoe?y noi?ani?ii-oeeoioiene/ii?
eaiee (CD8) ia oii? iecueeeo iieaciee?a ee?oeiiiai ?ioi?oaoo (CD3, CD4,
CD4/CD8, A-?OE, Aa-?OE, ?AOE) ooai?ththoue iaoiaaiaoe/iee oii aeey
?icaeoeo ae?aaeaieo oi?i caoai?thaaiiy.

Iieacaii, ui HLA oeioaaiiy iiaea aooe aeei?enoaii o yeino?
ne?ei?iaiai-ai iaoiaeo i?iaiico ?iia??iino? ?icaeoeo ooaa?eoeueico o
ae?oae (aeiiicieia?/ii? ae?aaiinoeee) ? iiaeeeaino? ia?aoiaeo ia?aeiiiai
ooaa?eoeueico o aoi?eiiee.

?ic?iaeai? ia?eoeai? e?eoa??? aeicaieythoue noi?ioaaoe a?oie c aenieei
a?aeiiniei ?eceeii caoai?thaaiiy ooaa?eoeueicii, ?iaeea?aeoae?coaaoe
aeeniaina?ia niinoa?aaeaiiy ? oa?aiaaoe/io oaeoeeo aeey oaeeo ae?oae.

I?iaaaeaia a ?iaio? aea/aiiy niieo/aiino? i?ae iaeiieiaiieie ia?aiao?aie
(ai?noii O- ? A-e?ioioeeo?a), ui aecia/athoueny ??cieie iaoiaeaie (ca
aeiiiiiaith iiiieeiiaeueieo aioeo?e ? iaoiaeaie ?icaoeiooai?aiiy)
iieacaei, ui iaoiaee iathoue naiino?eia cia/aiiy ? aeicaieythoue iiai?oa
oa?aeoa?ecoaaoe noai ?ioi?oaoo.

Iaaaaeai? e?euee?ni? ia?aiao?e neee ae?? ??cieo aeae?a e?eoaaiiy
(o?i?ioa?ai??, o?i?ioa?ai?? o ii?aeiaii? c oeiiaaiii, a?inii?eiii) ia
??ci? eaiee ?ioi?oaoo o oai?eo ia ooaa?eoeueic () aeathoue ciiao e?ea?th
cae?enithaaoe aeeoa?aioe?eiaaia i?ecia/aiiy ei?aeoi??a.

Cai?iiiiiaaia aeey i?aeoe/iiai aeei?enoaiiy i?iaiinoe/ia iiaeaeue
aoaeoeaiino? ?ioiio?i?ioa?ai??, yea iieacaea, ui ?acoeueoaoe e?eoaaiiy
ae?oae, oai?eo ia ooaa?eoeueic, a cia/i?e i??? caeaaeaoue a?ae
aeo?aeiiai noaio ?ioi?oaoo ? iin?enoaa aaiaoe/ieo oaeoi??a HLA.

Aeaii ee?i?ei-iaoiaaiaoe/ia iaa?oiooaaiiy canoinoaaiiy aaeoa??aeueiiai
i?aia?aoo a?inii?eio, cai?iiiiiaaia ? ai?iaaaeaeaia a ee?i?oe? aoaeoeaia
noaia eiai aaeeaaiiy oai?eie ia ooaa?eoeueic ae?oueie. Iaoiaeeea
canoinoaaiiy a?inii?eio aeicaiey? ?icoe?eoe iiaeeeaino? iaoiaaiaoe/ii?
oa?ai?? c aeei?enoaiiyi i?aia?aoo c aaaaoinoi?iiiueith iiceoeaiith
ae??th ia ooaa?eoeueiciee i?ioean oa ?ioiieia?/io ?aaeoeai?noue ?
a?aoiao? ?aaeuei? iiaeeeaino? e?eoaaeueii-i?io?eaeoe/ieo caeeaae?a on?o
??ai?a.

?acoeueoaoe aenia?eiaioaeueieo aeine?aeaeaiue ii aea/aiith ae??
eiiieaeniiai o?oii?aia?aoo “A?aaoii” ia ?ioiieia?/io ?aaeoeai?noue ?
ooaa?eoeueicia caiaeaiiy a?aee?eaathoue ia?niaeoeao aeei?enoaiiy iiaiai
aoaeoeaiiai ?ioiiei?eaoth/iai caniao o ee?i?oe? ooaa?eoeueico.

Ai?iaaaeaeaiiy ?acoeueoao?a aeine?aeaeaiiy a i?aeoeeo. Aeaeai?
iaoiaee/i? ?aeiiaiaeaoe??: “?ioa?iiioeyoe?ei? ci?ie no?oeoo?e
i?aaenoaaieoeoaa ?ioiieiiiaoaioieo ee?oei a ia?eoa?e/i?e e?ia? ae?oae,
ui oai??thoue ia aino?? ?ioaeoe?eii-caiaeuei? caoai?thaaiiy
a?iioieaaaiaai? nenoaie oa ooaa?eoeueic eaaai?a” (1997),
“?ioiiae?aaiinoeea a iaae?ao??? ? ?ioiiei?aeoe?y i?e ?ani??aoi?i?e
iaoieia?? o ae?oae» (1997); ?ioi?iaoe?ei? eenoe: “Canoinoaaiiy
?ioiiaaiaoe/ieo aeine?aeaeaiue aeey aeyaeaiiy noeeueiino? aei ?icaeoeo
ooaa?eoeueico o ae?oae” (1995); “Canoinoaaiiy oeiiaaio o eiiieaeni?e
oa?ai?? ae?oae, oai?eo ia ooaa?eoeueic” (1995).

?aeiiaiaeaoe??, aeeeaaeai? a iaoiaee/ieo iin?aieeao, ?ioi?iaoe?eieo
eenoao, aeiaoiaeao, ai?iaaaeaeai? a i?aeoeeo Aei?i?iiao?ianueeiai
iaeaniiai e?eoaaeueii-i?io?eaeoe/iiai ia?aeiaiiy “Ooec?ao??y”,
Aei?i?iiao?ianueeiai i?nueeiai i?ioeooaa?eoeueiciiai aeeniaina?o,
Aei?i?iiao?ianueeeo ooaa?eoeueicieo naiaoi???a ?5 oa ?7, ?inoeoooo
ooec?ao??? oa ioeueiiiieia?? AII Oe?a?ie, Aei?i?iaeca?aeeinueeiai
i?nueeiai i?ioeooaa?eoeueiciiai aeeniaina?o, Aei?i?iaeca?aeeinueei?
i?nueei? aeeoy/i? e?ea?i? ? aeeoy/iai ooanaiaoi??th, a oaeiae a o/aiaee
i?ioean Aei?i?iiao?ianueei? aea?aeaaii? iaaee/ii? aeaaeai??.

Iniaenoee aianie caeiaoaa/a. Aeena?oaio noai?eea iaoiaee/io iniiao
?iaioe, aaeaeaaoio iao? ? caaaeaiiyi aeine?aeaeaiiy. Cae?enithaaea
ee?i?/iee i?aea?? oai?eo, aeeiai?/ia niinoa?aaeaiiy ca ieie o i?ioean?
e?eoaaiiy (ee?i?/iee iaeyae, i?ecia/aiiy ?ioiieia?/ieo oa ?ioeo aeae?a
ianoaaeaiiy, ?ioiieia?/ieo i?aia?ao?a), caa?? e?ia?.

Inai?ea ?ioiieia?/i? iaoiaee aeine?aeaeaiiy a ?ioiieia?/i?e eaai?aoi???
Iineianueeiai IAe? ooaa?eoeueico (caa. — ae.i.i. A.I.Aieiaeeie?nueeee),
?ioiiaaiaoe/i? — a ?ioiieia?/i?e eaai?aoi??? Oeaio?aeueiiai IAe?
ooaa?eoeueico AII ?in?? (caa. — ae.i.i.A.?.Eeoaeiia) ? ai?iaaaeeea ?o a
?iaioo a?aeiia?aeieo eaai?aoi??e i.Aei?i?iiao?ianueea.

I?iaiaeeea aenia?eiaioaeuei? aeine?aeaeaiiy a Oeaio?? ii aeiee?i?/iiio
aea/aiith iiaeo e?ea?nueeeo i?aia?ao?a Iineianueeiai IAe? ooaa?eoeueico
IIC ?in?? i?ae ea??aieoeoaii ? ca o/anoth ea??aieea Oeaio?o — e.i.i.
A.A.Nieieiai?, ae.i.i. ?.I.Naeeoeueei?, ae.i.i. I.I.A?a/iai?.

Naiino?eii i?iaiaeeea aiae?c ?acoeueoao?a ee?i?/ieo ? eaai?aoi?ieo
aeine?aeaeaiue, iiooe iaoeiai? e?oa?aoo?e.

Aaoi? aeneiaeth? aeeaieo iiaeyeo ca eiinoeueoaoeaio aeiiiiiao i?e aeai??
oaie ? ia aoaiao ?iaioe iaoeiaiio eiinoeueoaioo ae.i.i., i?io.
A.I.Eino?ii?i?e, /e.ei?. AII Oe?a?ie, i?io. E.O.*a?iooaiei, e.i.i.
I.A.Aea?ea/, ae.i.i. A.ss.*aieeinueeiio, ae.i.i., i?io. I.I.Eino?ii?io,
aeaae. IAI ? AII Oe?a?ie, ae.i.i., i?io. A.A.Nie?iiao, ae.i.i.
I.?.Aaaoo?iao, ae.i.i., i?io. A.ss.Aa?aa?oo.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iniiai? ?acoeueoaoe ?iaioe
i?aaenoaaeai? oa iaaiai?ai? ia eiioa?aioe?yo ? c?caeao:
iaoeiai-i?aeoe/i?e eiioa?aioe??, i?enay/ai?e 75-??//th
Aei?i?iiao?ianueeiai iaaee/iiai ?inoeoooo (Aei?i?iiao?ianuee, 1991);
i?ae?aa?iiaeuei?e eiioa?aioe?? «Nioe?aeueii-ai?aeai?ieia?/i? i?iaeaie
ooaa?eoeueico a oa?eoi??yo E?aeiuei? I?aii/?» (sseoonuee, 1992);
tha?eaei?e eiioa?aioe?? IAe? ooec?ao??? oa ioeueiiiieia?? ?i.
O.A.Ae?iiaa (Oaoeaio, 1992); XI c?cae? e?ea??a-ooec?ao??a (Eai?ia?aae,
1992); iaoeiai-i?aeoe/ieo eiioa?aioe?yo «Aeooaeuei? ieoaiiy iaaeeoeeie
oa a?ieia??» (Aei?i?iiao?ianuee, 1992, 1993, 1995, 1997); ? c?cae?
ooec?ao??a ? ioeueiiiieia?a Oe?a?ie (A?iieoey, 1993); IX c?cae? aeeoy/eo
e?ea??a Oe?a?ie (Iaeana, 1993); iaoeiai-i?aeoe/i?e eiioa?aioe??
«Iioeiaeuei? caniae oa iaoiaee ?ioiiei?eaoth/i?, i?ioecaiaeueii? oa
i?ioei?e?iaii? oa?ai?? (Oa?e?a, 1993); iaoeiai-i?aeoe/i?e eiioa?aioe??
«Aeooaeuei? ieoaiiy i?e?ia?ieia??, ai?aeai?ieia?? oa ?ioiieia??
?ioaeoe?eieo caoai?thaaiue (Oa?e?a, 1993); Iaoe?iiaeueieo eiia?anao ii
oai?iaao i?aai?a aeeoaiiy (Iineaa, 1994, 1995, 1997, 1998); O?? c?cae?
ooec?ao??a (Na?aoia, 1994); iaoeiai-i?aeoe/i?e eiioa?aioe?? «Aeieia?y oa
caei?iay» (E?eaee ??a, 1994); ? Iaoe?iiaeueiiio c?cae? oa?iaeieia?a
Oe?a?ie (Oa?e?a, 1995); eiioa?aioe?? «?aaa?e?oaoe?y o iaae?ao???»
(Oa?iii?eue, 1995); ?? I?aeia?iaei?e eiioa?aioe?? «O?aioe?y oa Oe?a?ia,
iaoeiai-i?aeoe/iee aeina?ae o eiioaeno? ae?aeiao iaoe?iiaeueieo
eoeueoo?» (Aei?i?iiao?ianuee, 1995); iaoeiai-i?aeoe/i?e eiioa?aioe??
«Iaoeia? aeinyaiaiiy oa i?iaeaie ae?iaieoeoaa e?ea?nueeeo cania?a»
(Oa?e?a, 1995); eiioa?aioe?? «Aeooaeuei? ieoaiiy iaiaaeeeaiaioiciiai
e?eoaaiiy caoai?thaaiue i?aai?a aeeoaiiy, na?oeaai-noaeeiii? oa ia?aiai?
nenoaie» (sseoa, 1996); O??? c?cae? ooec?ao??a (Eaoa?eiao?a, 1997);
Conference on Global Lung Health (Paris, France, 1997); ?? c?cae?
ooec?ao??a oa ioeueiiiieia?a Oe?a?ie (Ee?a, 1998); ? Iaoe?iiaeueiiio
eiia?an? Oe?a?ie ii ?ioiieia??, aea?aieia?? oa ?ioii?aaa?e?oaoe??
(Aeoooa, 1998); i?aeeaoaae?aeueiiio nai?ia?? eaoaae? ooec?ao???,
oaeoeueoaonueei? iaae?ao??? ? aeeoy/eo ?ioaeoe?eieo oai?ia oa
Oeaio?aeueii? iaoeiai-aeine?aeii? eaai?aoi??? Aei?i?iiao?ianueei?
aea?aeaaii? iaaee/ii? aeaaeai?? (Aei?i?iiao?ianuee, 1998).

Ioae?eaoe??. Iaoa??aee aeena?oaoe?eiiai aeine?aeaeaiiy aeeeaaeai? o 65
ioae?eaoe?yo: noaoae o iaoeiaeo aeaeaiiyo — 16, aeaiiiiaaieo ?oeiien?a —
3, iaoiaee/ieo ?aeiiaiaeaoe?e — 2, ?ioi?iaoe?eieo eeno?a — 2, iaoa??ae?a
c?cae?a oa eiioa?aioe?e — 39, iaoaio?a ia aeiaoiaee — 3.

Ianya oa no?oeoo?a aeena?oaoe??. Aeena?oaoe?eia ?iaioa aeeeaaeaia ia
325 noi??ieao iaoeiiieno ? neeaaea?oueny ?c anooio, iaeyaeo e?oa?aoo?e,
5 ?icae?e?a aeanieo niinoa?aaeaiue, caeeth/aiiy, aeniiae?a oa nieneo
e?oa?aoo?e, yeee i?noeoue 386 aeaea?ae. ?iaioa ?ethno?iaaia 68
oaaeeoeyie oa 28 ?enoieaie.

Iniiaiee ci?no

Iaoa??aee oa iaoiaee aeine?aeaeaiue

Aeey ae??oaiiy iinoaaeaieo caaaeaiue iaie ianoaaeaii 368 ae?oae o a?oe?
a?ae 6 aei 13 ?ie?a c ??cieie i?iyaaie ooaa?eoeueicii? ?ioaeoe??
(oeii/ee?a — 191, ae?a/aoie — 177): 59 — c ?aii?i ia??iaeii ia?aeiii?
ooaa?eoeueicii? ?ioaeoe??; 87 — ?io?eiaai? ooaa?eoeueicii c
ia?inoath/eie ooaa?eoe?iiaeie ?aaeoe?yie; 54 — c ia?aeiiei
ooaa?eoeueiciei eiiieaenii; 119 — c ooaa?eoeueicii aioo??oiueia?oaeieo
e?ioaoe/ieo aoce?a; 11 — c ?io?eueo?aoeaiei ooaa?eoeueicii, 7 — c
aeenai?iiaaiei ooaa?eoeueicii, 5 — c aiaieuaaei ooaa?eoeueicii, 13 — c
ooaa?eoeueiciei ieaa?eoii, 1 — c o?a?icii-eaaa?iiciei ooaa?eoeueicii, 12
— ?io?eiaai? ooaa?eoeueicii c aino?ith ianiaoeeo?/iith iiaaiii??th.

Eiio?ieueio a?oio aeey ii??aiyiiy ?acoeueoao?a ?ioiieia?/ieo
aeine?aeaeaiue neeaee 42 ia?io?eiaai? ooaa?eoeueicii aeeoeie, aeey
?ioiiaaiaoe/ieo aeine?aeaeaiue — 183 caei?ia? iniae, ui iaoeathoue ia
oa?eoi??? Aei?i?iiao?ianueei? iaeano?.

On? ae?oe aoee ianoaaeai? a oiiaao noaoe?iia?o oa naiaoi??th ?c
canoinoaaiiyi iaiayceiaeo, aeiaeaoeiaeo oa oaeoeueoaoeaieo iaoiae?a
aeine?aeaeaiiy. Ia?eoii niaoe?aeueieo ?ia?o noaee ?ioiieia?/i? oa
?ioiiaaiaoe/i? aeine?aeaeaiiy.

Aeey ioe?iee ?ioiieia?/ii? ?aaeoeaiino? aaeeaaany eiiieaen iaoiae?a, ye?
aeicaieythoue ioe?ieoe noai O- ? A- nenoaie ?ioi?oaoo ? oaaioeeoa?io
ooieoe?th ee?oei (a oe?eiio 33 a?aeiinieo ? aaniethoieo cia/aiiy
iieaciee?a ?ioi?oaoo).

Aeey aea/aiiy no?oeoo?ieo ? ooieoe?iiaeueieo iniaeeainoae
?ioiieiiiaoaioieo ee?oei ia?eoa?e/ii? e?ia? oai?eo (iiioeyoe?e ?
noaiiioeyoe?e) aeei?enoiaoaaee iaoiae iai?yii? ?ioiioethi?anoeaioe?? ?c
aaeeaaiiyi oaoiieia?? oa iiiieeiiaeueieo aioeo?e na??? ?EI ae?iaieoeoaa
“Iaaeaeiniaeo?” (i.Iineaa). Aecia/aee ai?no CD3-, CD4-, CD8-, CD38-,
CD22- HLA-DR-ee?oei ? aaee/eio ?ioii?aaoeyoi?iiai ?iaeaeno CD4/CD8.
Aea/aiiy O-nenoaie ?ioi?oaoo aeeth/aei oaeiae i?ae?aooiie e?eueeino?
O-e?ioioeeo?a iaoiaeii niiioaiiiai ?icaoeiooai?aiiy (A-?OE), I.Bash et
al. (1969), (Aa-?OE) ca iaoiaeii I.Wybren, H.Furlenberg (1973), aea/aiiy
ooieoe?iiaeueii? aeoeaiino? e?ioioeeo?a o ?aaeoe?? aeanoii?
o?ainoi?iaoe?? (?AOE) c o?oiaaiaaethoeiii (OAA) oa ooaa?eoe?iii (IIAe-E)
iaoiaeii I.Bash, K.Hirshorn (1963) o iiaeeo?eaoe?? E.O.*a?iooaiei oa
E.N.Eiainiai? (1978), ?a?no?aoe?th i?ie?oa?aoeaii? a?aeiia?ae?
e?ioioeeo?a — ii aeeth/aiith o AeIE I3-oei?aeeio ?aae?iiao?e/iei
iaoiaeii i?e ?ieoaaoe?? c OAA oa IIAe-E.

Oa?aeoa?enoeeo A-nenoai ?ioi?oaoo aeiiiaithaaee aecia/aiiyi e?eueeino?
A-e?ioioeeo?a ca aeiiiiiaith oanoo eiiie?iaioa?iiai ?icaoeiooai?aiiy
(A.I.*a?aaeaaa, 1976), ??aiy ne?iaaoeiaeo ?ioiiaeiaoe?i?a A, M, G
(G.Manchini et al., 1965) oa oee?eoethth/eo ?ioiieo eiiieaen?a (Oe?E)
iaoiaeii naeaeoeaii? i?aoeei?oaoe?? eiiieaen?a aioeaai-aioeo?ea o
?ic/ei? iie?aoeeaiae?eieth (I.Iaiueoeeia, 1987). Aeey aecia/aiiy ai?noo
i?ioeooaa?eoeueicieo aioeo?e aeei?enoiaoaaee oano-nenoaio “Aioeooa” aeey
i?iaaaeaiiy oaa?aeioaciiai ?ioiioa?iaioiiai aiae?co ae?iaieoeoaa IAe?
ooaa?eoeueico IIC ?in??. Aioeaaiiee iaoa??ae, aaeeoee aeey
nainea?e?caoe?? ieaioao?a, aoa io?eiaiee ?c noaiaea?oieo ooai?a
i?eiaaeoa??e ooaa?eoeueico, ye? caciaee -ii?ii?iaiiy oa oeueo?acaoeiai?
aeac?ioaa?aoe??. ?a?no?aoe?y ?acoeueoao?a aeeiioaaeanue ia iaeaaeiaii?
“?ioiioa?iaioia eaai?aoi??y JFCO” o??ie “Eaaioae”.

Oanoe, ui oa?aeoa?ecothoue oaaioeeoa?io caeaoi?noue ee?oei, aeeth/aee:
INO-oano (niiioaiiee oa ?iaeoeiaaiee IIAe-E), i?ae?aooiie i?ioeaio?a
oaaioeeooth/eo iaeo?io?e?a (IO), oaaioeeoa?iiai /enea (O*).

Niaoeeo?/io ?aaeoeai?noue oa?aeoa?ecoaaee oaeiae ca aeiiiiiaith
iieacieea ooeiaeaeoaaiino? iaeo?io?e?a III c IIAe-E ca A.A.O?aaee?iei
(1985).

Aecia/aiiy aioeaai?a aieiaiiai eiiieaeno a?noinoi?niino? (HLA)
i?iaiaeeeinue ca aeiiiiiaith noaiaea?oiiai i?e?ie?ioioeeoioiene/iiai
oanoo P.Terasaki c aeei?enoaiiyi oeioth/eo iaiaeae ?in?enueeiai IAe?
aaiaoieia?? ? o?ainooc?ieia??, ui neeaaeathoueny c 120 aioene?iaaoie aei
56 aioeaai?a HLA (aei 17 aioeaai?a HLA eieono A, 33 aioeaai?a eieono A
oa 6 aioeaai?a eieono N).

Ca?aeii c caaaeaiiyie aeine?aeaeaiiy aoea aea/aia ee?i?/ia oa
?ioiieia?/ia aoaeoeai?noue o?aaeeoe?eii? o?i?ioa?ai?? (40 oai?eo),
o?i?ioa?ai?? o ii?aeiaii? c oeiiaaiii (36 in?a) ? a?inii?eiii (38
oai?eo), oiaoi ?ioii?aaeoeaieie i?aia?aoaie ??ciiai iioiaeaeaiiy oa
iaoai?cio ae??. Iaoiaeeea e?eoaaiiy ia?aaeaa/aea i?ecia/aiiy aaeaeaaoii?
iaeiioeiii? o?i?ioa?ai?? oai?ei on?o a?oi. Oeiiaai i?ecia/aee o a?eia?e
aeic? a/i ca noaiith: 5 aei?a aaaaeaiiy — 3 aei? ia?a?ae — 3 aei?
aaaaeaiiy — 3 aei? ia?a?ae — 2 aei? aaaaeaiiy (eo?n 16 aei?a).

Aaaaoinoi?iii? iiceoeai? iaoiaaiaoe/i? aoaeoe aaeoa??aeueiiai i?aia?aoo
?c nai?io?oieo aaeoa??e — a?inii?eio, ye? ? iieacaiiyi aei i?ecia/aiiy
oai?ei ia ooaa?eoeueic (i?aia?ao ia? aeac?ioieneeaoe?eio,
i?ioecaiaeueio, i?ioeaea?a?/io ae?th, eiio aeanoeaee aoaeo o?aineieaoe??
— i?iieea? a ina?aaeie o?aaeaiiy ??cii? eieae?caoe?? ? ia? oai
aioeaaeoa??aeueio oa i?ioecaiaeueio ae?th, i?iaeoeo? e?cioeei, ?iaeoeo?
ae?iaeaiiy aiaeiaaiiiai ?ioa?oa?iio, aeoeao? iae?ioaae, neioaco?
ai?iieeneioe, aa?a o/anoue o i?ioeanao o?aaeaiiy oeyoii ae?iaeaiiy
oa?iaio?a, ii?iae?co? eeoeiao oei?o, ni?ey? aeaaaeaiith aaaeeeo iaoae?a
oiui) (A.A.Nie?iia, N.?.?aciee,1992) niiioeaee ian aei aea/aiiy
ee?i?ei-?ioiieia?/ii? aoaeoeaiino? eiai aaeeaaiiy o ii??aiyii? c
o?aaeeoe?eiith o?i?ioa?ai??th oa o?i?ioa?ai??th o ii?aeiaii? c oei?/iei
?ioiiiiaeoeyoi?ii — oeiiaaiii ? aecia/aiiy iieacaiiy aei i?ecia/aiiy
eiai o oai?eo ia ooaa?eoeueic. A?inii?ei i?ecia/aee ai?iaeiaae 5 aei?a c
?ioa?aaeii a 3 aei? i?ioyaii 21 aeiy: ii 1 aeic? 2 ?ace ia aeaiue ca 30
oa. aei ?ae?.

Aoaeoeai?noue e?eoaaiiy ioe?ithaaee c o?aooaaiiyi aeeiai?ee ee?i?/ii?
neiioiiaoeee ? ?acoeueoao?a eiiieaeniiai ?ioiieia?/iiai ianoaaeaiiy.
?ioiieia?/i? aeine?aeaeaiiy i?iaiaeeeenue i?e iaaeoiaeaeaii?, /a?ac 1,5
(i?ney eo?no ?ioiioa?ai??), 3, 6 oa 9 i?nyoe?a e?eoaaiiy.

A inoaii? ?iee oaaao aeine?aeiee?a i?eaa?oathoue i?aia?aoe ?ineeiiiai
iioiaeaeaiiy ye ?ioiiei?eaoth/? caniae. Iaii?aoeueiaaieie caeeoathoueny
ieoaiiy ae?? o?oioa?ai?? ia ooaa?eoeueicia caiaeaiiy, iai?aaeai?noue
?ioiiiiaeoethth/i? ae?? o caeaaeiino? a?ae aaiaoe/ii? oa?aeoa?enoeee
/ooeeaino? aei ooaa?eoeueicii? ?ioaeoe?? oa aeice o?oii?aia?aoo. Oea
niiioeaei ian a iaaeao caaaeaiue aeaiiai aeine?aeaeaiiy i?iaanoe
aea/aiiy ae?? o?oii?aia?aoo “A?aaoii”.

O aenia?eiaioaeuei?e /anoei? ?iaioe aoei aea/aii ae?th eiiieaeniiai
o?oii?aia?aoo “A?aaoii”, iaea?aeaiiai c 27 e?ea?nueeeo ?ineei (i?aia?ao
ia ia? aiaeia?a), ia ?ioiio nenoaio oa ooaa?eoeueicia caiaeaiiy c
o?aooaaiiyi aaiaoe/ii iaoiiaeaii? noeeueiino? aei ooaa?eoeueico.
Aeine?aeaeaiiy aoei i?iaaaeaii ia 42 a?eeo aacii?iaeieo ieoao,
ca?aaeaieo i?eiaaeoa??yie ooaio BOV, oa 91 ieo? c iiiceoiith /ooeea?noth
aei i?eiaaeoa??e ooaa?eoeueico (39 ieoae Black oa 52 ieo? F1-a?a?eae
CBA/C57Bl6), ca?aaeaieo i?eiaaeoa??yie ooaio H37Rv. Iana oaa?ei
noaiiaeea 20-22 a.

O aenia?eiaio? aoee aeei?enoai? oae? iaoiaee:

a) iaoio?c?ieia?/i? (ca?aaeaiiy oaa?ei, aaaaeaiiy e?ea?nueeeo cania?a);

a) ?ioiieia?/i? (e?euee?nia ioe?iea iiioeyoe?eiiai neeaaeo e?ioioeeo?a a
i?aaiao ?ioiii? nenoaie, ioe?iea oaaioeeoa?ii? aeoeaiino? ee?oeiieo
aeaiaio?a ia?eoa?e/ii? e?ia?);

a) iaoiii?oieia?/i? (a?noieia?/iee aiae?c aioo??oi?o i?aai?a, ioe?iea
?iaeaeno o?aaeaiiy);

a) i?e?ia?ieia?/i? (n?yiiy oa ethi?ianoeaioia i?e?ineii?y in?aeaiiy
aioo??oi?o i?aai?a).

N?yiiy IAO i?iaiaeeeiny ia na?aaeiaeua Eaaaiooaeia-E?inaia, O?ia oa A-6.
Ioe?iea aeyaeaiiy i?eiaaeoa??aeueii? iiioeyoe?? cae?enithaaeanue ca
aaeueiith nenoaiith: c eiaeii? a?oie aiae?coaaeenue 3 oaa?eie ii 4
i?aaiao (eaaai?, naeac?iea, ia/?iea, e?ioaoe/i? aocee), anueiai o a?oi?
i?iaiaeeeinue 12 n?yiue oa 12 ethi?ianoeaioieo i?e?ineii?e (e?euee?noue
iiceoeaieo aiae?c?a ?icoe?ithaaeanue ye e?euee?noue aae?a).

Ioe?iea ai?noo A-e?ioi?aeieo aeaiaio?a o naeac?ioe? oa e?ioaoe/ieo
aoceao i?iaiaeeeanue iaoiaeii i?yii? ?ioiioethi?anoeaioe?? (ia
i?aaeiaoiiio nee? a i?e?iyieao c iie?e?ceiii L c aeei?enoaiiyi nooi?
ethi?ioth/i? ne?iaaoee e?ieeea i?ioe aeiaoe?i?a a?ei? ieo?).

Iaoaiaoe/ia caaacia/aiiy ?iaioe cae?enithaaeinue ia IAII ?N 386 c
aeei?enoaiiyi iaai?o iaoiae?a (aeey e?euee?nieo oa ye?nieo ia?aiao??a),
ye? aeicaieythoue aeaoe ??ciinoi?iiith oa ia?eoeaio oa?aeoa?enoeeo
?acoeueoaoai aeine?aeaeaiiy (aeei?enoaii iaeao i?ia?ai aeey
iaaeeei-a?ieia?/ieo aeine?aeaeaiue -BMDP). Ie??i caaaeueiii?eeiyoeo
iieaciee?a (na?aaeiueia?eoiaoe/ia cia/aiiy (I), na?aaeiueieaaae?aoe/ia
a?aeoeeaiiy (), iiieeea na?aaeiuei? a?eoiaoe/ii? (m), t- e?eoa??e
Nouethaeaioa, iaia?aiao?e/i? e?eoa??? O?oa?a, A?eeieniia-Iaiia-O?oi?),
canoiniaoaaee aeenia?n?eiee aiae?c, yeee aeicaiey? ioe?ieoe neeo ae??
??cieo oaeoi??a ia ?acoeueoaoeaio iciaeo (). I?e aea/aii? noaoenoe/iiai
cayceo i?ae yaeuaie canoiniaoaaeanue e?i?eia ei?aeyoe?y, a oaeiae
iaia?aiao?e/i? e?eoa??? niieo/aiino? (2-e?eoa??e, eiao?oe??io I??niia oa
?i.). Aeey i?iaiicoaaiiy aoaeoeaiino? e?eoaaiiy aeei?enoaii
aeene?ei?iaioiee aiae?c. Eiiieaen aaiaoeei-noaoenoe/ieo iaoiae?a
aeeth/aa aiae?c ?iciiae?eaiiy aioeaai?a HLA, oaiioei?a ? aaieioei?a oa
a??ia?aei?noue ?o a?aei?iiinoae o ii??aithaaieo a?oiao, neeo anioe?aoe??
i?ae aioeaaiii oa oai?iaith — e?eoa??e a?aeiiniiai ?eceeo (RR). Aeey
i?iaiicoaaiiy iniaeeainoae ia?aa?ao caoai?thaaiiy c o?aooaaiiyi
aaiaoe/ieo ia?ea??a aeei?enoaii aiae?c Aaeueaea.

Iniiai? ?acoeueoaoe aeine?aeaeaiiy

A oiiaao no/aniiai iaoiii?oico ooaa?eoeueico o ae?oae ana a?eueoiai
cia/aiiy iaaoaa? cynoaaiiy iioaioe?eii? aeoeaiino? ooaa?eoeueicii?
?ioaeoe?? i?e “a??aaeo” oa o in?a, aeaaii ?io?eiaaieo (?.I.N??aiei,
1992, 1998). Iniaeeai aaaeeeaa cia/aiiy oae? aeine?aeaeaiiy iathoue o
ae?oae c a?ia?/ooeea?noth aei ooaa?eoe?io, o yeeo ?ecee caoai?thaaiiy
ooaa?eoeueicii o 2-10 ?ac?a aeuee, i?ae o ae?oae ?c neaaeeie oa
iii??ieie ?aaeoe?yie.

Aiae?c ee?i?ei-?ioiieia?/ieo oa?aeoa?enoee ae?oae a?oie i?aeaeuaiiai
?eceeo caoai?thaaiiy ooaa?eoeueicii c a?ia?a?a??th ia ooaa?eoe?i (o
36,3% ianoaaeaieo aoei cao?eniaaii a??aae ooaa?eoe?iiaeo ?aaeoe?e, o
63,7% aeaai?noue ?io?eoaaiiy noaiiaeea 1,5-6 ?ie?a ? i?e/eiith
ianoaaeaiiy noaei ia?inoaiiy ooaa?eoe?iiai? /ooeeaino?) aeyaea oae?
iaoyaeoth/? ia?aa?a ooaa?eoeueicii? ?ioaeoe?? oaeoi?e, ye aeaoaeoe
aaeoeeiaoe?? oa ?aaaeoeeiaoe?? AOeAE (17,8%), o?i?ii?io?eaeoeee oa
ianoaaeaiiy o ?io?eiaaieo c ieioeeo ?ie?a (68,5%), oneeaaeiaiee ia?aa?a
?aaeoe?? Iaioo (iae?ic, e?ioaai?o — 17,8%), eiioaeo c oai?eie ia
ooaa?eoeueic (16,1%), /ano? i?inooaei? caoai?thaaiiy (23,3%). I?e
ia?eoeaiiio iaeyae? oa?aeoa?iith iciaeith caeeoa?oueny ?aaeoe?y c aieo
ia?eoa?e/ieo aoce?a.

Na?aae eieaeueieo oi?i ooaa?eoeueico o ae?oae iae/ano?oa cono??/a?oueny
ooaa?eoeueic aioo??oiueia?oaeieo e?ioaoe/ieo aoce?a. Oey a?oia
iaiaeii??aeia ca ee?i?ei-?aioaaiieia?/ieie i?iyaaie. Iniaeea? o?oaeiiu?
aeey ae?aaiinoeee noaiiaeyoue iae? oi?ie caoai?thaaiiy. I?ae iaoei
niinoa?aaeaiiyi ciaoiaeeeinue 43 aeeoe-ie c iaeeie oi?iaie
a?iioiaaeai?oo, ui noaiiaeei 36% an?o ianoaaeaieo oai?eo ia ooaa?eoeueic
aioo??oiueia?oaeieo e?ioaoe/ieo aoce?a. *a?ac i?eoiaaiee ia?aa?a
caoai?thaaiiy iiieeee o ae?aaiinoeoe? ia aeiaini?oaeueiiio aoai?
noaiiaeee 72,1%. A?eueo?noue oeeo oai?eo (83,8%) aaaaeaeenue
?io?eiaaieie c ??ciei no?ieii aeaaiino?. O 69,8% ae?oae i?ioean
ae?aaiinoiaaii o no?iee, aeecuee? aei ?aiiueiai ia??iaeo ia?aeiiiai
?io?eoaaiiy. Eiioaeo c oai?ei ia ooaa?eoeueic i?e ?aoaeueiiio iieooaaii?
anoaiiaeaii o 48,8%. Ia?aaaaeio a?eueo?noue oai?eo (41,8%) aeyaeaii i?e
ianoaaeaii? i?ney ieaiiai? ooaa?eoe?iiae?aaiinoeee, 20,9% — i?e
ianoaaeaii? c i?eaiaeo eiioaeoo ? 20,9% — c i?eaiaeo ooa?io?eoaaiiy. Aei
iie?ee?i?ee c ??cieie nea?aaie caa?ioeinue 16,4% oai?eo. O a?eueoino?
ae?oae aoee i?neyi?euaii? AOeAE-ciaee (65,1%). Oa?aeoa?iei aeey oe???
a?oie oai?eo noaa iaeineiioiiiee (60,5%) oa aacneiioiiiee ia?aa?a
caoai?thaaiiy oa ae?acia ia?eoa?e/ia i?e?iiie?aaeai?y. Cia/io
ae?aaiinoe/io oe?ii?noue noaiiaeee ?acoeueoaoe i?iae Iaioo c 2OA, yea
aoea ae?aaeaiith (11ii oa a?eueoa), a a?ia?a?a?/ia /ooeea?noue aei
ooaa?eoe?io iaea i?noea o o?aoeie oai?eo. Iae/ano?oa cono??/aeinue
o?aaeaiiy e?ioaoe/ieo aoce?a a?iioiioeueiiiaeueii? a?oie (86%).
Niinoa??aaeenue ia?aaaaeii iaeiia?/i? i?ioeane.

Na?aae aia?oa aeyaeaieo oai?eo ia eieaeuei? oi?ie ooaa?eoeueico 79,5%
noaiiaeee ae?oe c ee?i?/ii ae?aaeaieie oi?iaie caoai?thaaiiy.
Ia?aaaaeieie caeeoaeenue ooaa?eoeueic aioo??oiueia?oaeieo e?ioiaoce?a (o
81,6% — ?io?eueo?aoeaia, o 18,4% — ooii?icia oi?ie) oa ia?aeiiee
ooaa?eoeueiciee eiiieaen. Oneeaaeiaiee ia?aa?a ia?aeiieo oi?i
ae?aaiinoiaaii o 15,4%. Oa?aeoa?iith iniaeea?noth oe??? a?oie ae?oae
noaei oeacaiiy ia eiioaeo c oai?ei ia ooaa?eoeueic (53,3%), /anoi
a?aenooi?noue i?euaiiiai AOeAE-ciaeo (33,3%) aai iae? eiai ?ici??e
(32,4%), iani?eyoeeaee i?aii?a?aeiee oii (60,5%), ae?aaeaia aai
a?ia?a?a?/ia ?aaeoe?y Iaioo (75,3%), a?aeiinii ??aeea aeyaeyiiy IAO
(4,8%). Aiae?c aiaiianoe/ieo oa ee?i?ei-?aioaaiieia?/ieo aeaieo
aeicaieea o 12 (5,7%) ae?oae, ia?aaaaeii i?aioaa?oaoiiai a?eo,
ae?aaiinooaaoe aoi?eii? oi?ie ooaa?eoeueico.

?ioiieia?/i? aeine?aeaeaiiy, i?iaaaeai? o ae?oae c ??cieie i?iyaaie
ooaa?eoeueicii? ?ioaeoe??, iieacaee, ui cia/aiiy aaaaoueio ?ioiieia?/ieo
ia?aiao??a oa?aeoa?ecothoueny nooo?aeie ?iaeea?aeoaeueieie eieeaaiiyie,
o cayceo c /ei ci?ie na?aaei?o cia/aiue iieaciee?a, iacaaaeath/e ia
i/aaeaeio ??cieoeth, iathoue oa?aeoa? oaiaeaioe?? ? /anoi a??ia?aeii ia
a?ae??ciythoueny. Iaeiae a oe?eiio ii ?yaeo ia?aiao??a aaeaeiny
i?inoaaeeoe ? caaaeuei? caeiiii??iino? oa iniaeeaino?, oa?aeoa?i? aeey
eiaeii? ie?aii? a?oie ianoaaeaieo (?en.1, 2, 3).

A on?o a?oiao aeyaeai? a?aeoeeaiiy o aeaeyae? cieaeaiiy c??eeo
CD3-e?ioioeeo?a oa oaeia?ieo/?iaeoeoth/eo ee?oei (CD4). Iaeneiaeueiee
aeaoaeo oeeo ee?-oei iaa i?noea o ae?oae, oai?eo ia aino?o iiaaiii?th,
?io?eiaaieo ooaa?eoeueicii, iiaeeeai, ca ?aooiie ye ianiaoeeo?/iiai
eaaaiaaiai i?ioeano, oae ? aeiaeaoeiai? ae?? ooaa?eoeueicii? ?ioaeoe??:
CD3 (38,001,78)%, (0,950,04)A/e; CD4 (22,002,68)%, (0,550,07)A/e, i?e
ii?i? — (65,623,21)%, (1,940,09)A/e oa (39,002,12)%, (1,150,06)A/e,
a?aeiia?aeii, ?<0,001. Iiia?aaei?ie ca nooiaiai i?eai?/aiiy oeeo eaiie ?ioi?oaoo yaeyeenue: a?oia oai?eo ?c aoi?eiieie oi?iaie ooaa?eoeueico - CD3 (42,253,31)%, (1,190,09)A/e, p<0,001 oa CD4 (29,432,96)%, (0,830,08)A/e, p<0,02; ae?aaeaieie oi?iaie ia?aeiiiai ooaa?eoeueico - CD3 (46,674,12)%, (1,290,11) A/e; CD4 (28,242,84)%, (0,780,07) A/e, p<0,002; ae?oe c a?ia?a?a??th ia ooaa?eoe?i - CD3 (52,273,22)%, p<0,01, (1,720,01)A/e, p=0,1; CD4 (30,852,77)%, p<0,02, (1,020,09)A/e, p>0,05.
I?i?iaeuei? ci?ie a?aecia/aeenue o oai?eo ia iae? oi?ie a?iioiaaeai?oo:
CD3 (58,243,16)%, (1,920,1)A/e, p>0,05; CD4 (32,122,18)%, p<0,02, (1,000,07)A/e, p<0,05, o yeeo a?eueo aeaiiino?aoeaiei aeyaeeinue cieaeaiiy ?ioii?aaoeyoi?iiai ?iaeaeno (CD4/CD8 - 1,490,09, i?e ii?i? - 1,770,08, p<0,01). Na?aaeiy e?euee?noue ee?oei ?ioi? noaiiioeyoe?? aeoeaieo e?ioioeeo?a - noi?ani?ieo/oeeoioiene/ieo ee?oei o a?oiao ia?aaaaeii aa??thaaea a iaaeao ii?ie. Eeoa o oai?eo aoi?eiieie oi?iaie ooaa?eoeueico a?aei?/aeanue iii?oia aeoeaaoe?y noi?ani?ii? eaiee: CD8 - (26,321,22)%, p<0,01, (0,750,03)A/e, p<0,05 i?e ii?i? - (22,061,82)%, (0,650,05)A/e. C?inoaiiy ooieoe?iiaeueii? aeoeaiino? noi?ani?ieo O-ee?oei iaiaaeoaaei ?icaeoie aaeaeaaoii? ?ioiii? a?aeiia?ae? ?, iiaeeeai, noaei iaei??th c i?e/ei aiaeiaaiii? ?a?ioaeoe??. Oa?aeoa?iei aeey an?o ianoaaeaieo a?oi noaei cieaeaiiy ni?aa?aeiioaiiy CD4/CD8. O ae?oae c ii/aoeiaeie i?iyaaie ? ia?aeiieie oi?iaie ooaa?eoeueico oaea cieaeaiiy aoei iaoiiaeaia ia?aaaaeii ciaioaiiyi iiioeyoe?? oaeia?ieo/?iaeoeoth/eo ee?oei. O oai?eo aoi?eiieie oi?iaie ciaioaiiy ?iaeaeno aoei iiaycaii ia o?eueee c cacia/aiei iaoai?ciii, a ? c c?inoaiiyi e?eueeino? e?ioioeeo?a, yeei aeanoeaa noi?ani?ii-oeeoioiene/ia aeoeai?noue (CD4/CD8 - 1,180,09, p<0,001). Cia/ieo ?ica?aeiinoae o aeni?an?? ia?ea??a iieiaeeo i?ie?oa?oth/eo ee?oei o ae?oae ianoaaeaieo a?oi ie ia aeyaeee. Iaeiae o ii??aiyii? c ii?iith ai?no CD38-ee?oei aoa i?aeaeuaiei o ae?oae c ae?aaeaieie oi?iaie ooaa?eoeueico oa i?e ianiaoeeo?/iiio o?aaeaii? eaaai?a: CD38 - (16,451,56)%, ?<0,02; (0,410,04)A/e, p>0,05 i?e ii?i? — (12,190,96)%,
(0,360,03)A/e. Ia iiaeia aeeeth/eoe, ui iaeei ?c iaoai?ci?a oeueiai
yaeua — oea aieea aaeoa??aeueieo oienei?a, aioeaai?a oa i?iaeoeo?a, ui
ooai?ththoueny o i?ioean? o?aaeaiiy eaaaiaai? oeaieie, ia
?ioiieiiiaoaioio nenoaio, ? ca?eueoaiiy ee?oei oeueiai ?yaeo na?ae/eoue
i?i aeoeaaoe?th ?ioiii? a?aeiia?ae?.

?acoeueoaoe ?ici?ciaaaiiy A-ee?oei c aeei?enoaiiyi eeanoa?a
aeeoa?aioe?thaaiiy CD22 aeyaeee o a?eueoino? a?oi eeoa oaiaeaioe?th aei
?o c?inoaiiy. E?euee?noue ee?oei c aeni?aniaaieie ia ieo aioeaaiaie
HLA-DR aeinoaoiuei ??cieeanue. Iaea?eueo? na?aaei? cia/aiiy iieaciee?a
aoee o ae?oae c ii/aoeiaeie i?iyaaie — HLA-DR (18,502,14)%, p<0,05, (0,610,07)A/e, p<0,01, i?e ii?i? - (12,441,78)%, (0,370,05)A/e) oa iaeeie oi?iaie ooaa?eoeueico - HLA-DR (13,811,76)%, (0,460,06)A/e, ?>0,05. I?e ae?aaeaieo i?iyaao caoai?thaaiiy aeni?an?y oeeo aioeaai?a ia
ee?oeiao cieaeoaaeanue. A?aoiaoth/e ?ieue aioeaai?a HLA-DR, iiaeia
i?eionoeoe, ui i?eai?/aiiy ?o aeni?an?? i?eaiaeeoue aei ii?ooaiiy
i?ioean?a ?aaoeyoe?? ?ioiii? a?aeiia?ae? oa ni?ey? ?icaeoeo aeeaieeo
no?oeoo?ieo oa ooieoe?iiaeueieo ci?i o ?ioii?e nenoai?.

E?euee?noue O-e?ioioeeo?a, ui ianooue ia iiaa?oi? ?aoeaioi?e aei
a?eo?ioeeo?a aa?aia, aecia/a?oueny o oano? A-?OE oa Aa-?OE, ?
ooieoe?iiaeueia aeoeai?noue ee?oei ca ?acoeueoaoaie ?AOE oa ?iaeaenii
noeioeyoe?? (ii aeeth/aiith 3I-oei?aeeio o i?ie?oa?oaaeuei? e?ioioeeoe)
c OAA oa IIAe-E aoee iaeneiaeueii i?eai?/ai? o oai?eo ia aoi?eii? oi?ie
ooaa?eoeueico, oiae? ye o oai?eo c ii/aoeiaeie i?iyaaie oa iaeeie
oi?iaie ooaa?eoeueico aioo??oiueia?oaeieo e?ioiaoce?a iii??iee
e?euee?niee aeao?oeeo iiioeyoe?e oa noaiiioeyoe?e O-e?ioioeeo?a nooo?ai
ia a?aeaeaaany ia ?o ooieoe?iiaeuei?e aeoeaiino? ? a?aeaoaaany ia oii?
aeniei? niaoeeo?/ii? ?aaeoeaiino?: ?AOE c IIAe-E — (5,760,43)%, p<0,001; ?iaeaen noeioeyoe?? c IIAe-E - 3,120,22, p<0,05 i?e ii?i? - 1,760,16 oa 1,710,08, a?aeiia?aeii. Aeenooieoe?y aoii?aeueii? eaiee ?ioi?oaoo iaea i?noea i?aeoe/ii a on?o a?oiao, ia?o ca ana oea noinoaaeinue ??aiy niaoeeo?/ieo aioeo?e oa Oe?E, ye? /?oei ei?aethaaee c oyaee?noth caoai?thaaiiy oa o oai?eo aoi?eiieie oi?iaie aeinyaaee iaea?eueoeo cia/aiue: ?OA - (1,170,07)iae., p<0,001; Oe?E - (72,003,27)iae., p<0,001 i?e ii?i? - (0,210,02)iae. oa (20,311,36)iae., a?aeiia?aeii. O a?eueoino? ianoaaeaieo, iacaeaaeii a?ae oi?ie ooaa?eoeueico, /enaeuei?noue oaaioeeooth/eo ee?oei (IO) oa ?o iiaeeiaeueia caeaoi?noue (O*) a?aeiinii /anoeiie eaoaeno ci?ithaaeanue iacia/ii. O oie aea /an niinoa??aaeanue aeoeaaoe?y eeniacaeaaeieo iaoai?ci?a aaeoa?eoeeaeiino? oaaioeeooth/eo ee?oei, yea ?a?no?o?oueny o oanoao INO niiio. ? INO c IIAe-E. Oaeei /eiii, o ae?oae c ii/aoeiaeie i?iyaaie oa iaeeie oi?iaie ooaa?eoeueico ? oai?eo c ee?i?/ii ae?aaeaieie i?iyaaie ia?aeiiiai oa aoi?eiiiai ooaa?eoeueico niinoa??aathoueny ??ci? aa??aioe ?ioiieia?/ii? iaaeinoaoiino?. O ia?oeo, iii??iee e?euee?niee aeao?oeeo oa cieaeaiiy ooieoe?iiaeueii? aeoeaiino? O-e?ioioeeo?a ia ianiaoeeo?/iee i?oiaai eiiiainothoueny iineeaiiyi a?aeiia?aeii? ?aaeoe?? ia niaoeeo?/iee aeey ooaa?eoeueico aioeaai IIAe-E. Oaea caaeainiaaia ?aaeoe?y ?ioiii? nenoaie i?eaiaeeoue aei a?aeiaaeiaoaaiiy niaoeeo?/iiai i?ioeano, ?icaeoeo i?i?iaeueieo eieaeueieo ci?i aac ae?aaeaii? ?ioieneeaoe?? oa aioeaaiai??. O ae?oaeo, ? iciaee ae?eniiai ?ioiiaeao?oeeoo o aeaeyae? cieaeaiiy ye ianiaoeeo?/ieo, oae ? niaoeeo?/ieo iieaciee?a O-ee?oeiiiai ?ioi?oaoo ia oii? aenieiai ??aiy niaoeeo?/ieo aioeo?e. Aeai?, iaea?aeai? iaie o ?acoeueoao? ?ioiiaaiaoe/iiai ianoaaeaiiy, na?ae/aoue i?i iaiaeii??aei?noue aioeaaiii? HLA-oa?aeoa?enoeee ae?oae c ??cieie oi?iaie ooaa?eoeueicii? ?ioaeoe??, ui aeaco? ia aaiaoe/io aeaoa?i?iiaai?noue iie?ii?o?cio iaoiaaiaco oa ee?i?/ieo i?iya?a ooaa?eoeueico o ae?oae a?ae noaio ia?aaeoai?iae aei ?icaeoeo eieaeueieo oi?i. Aeinoia??ia i?aeaeuaiiy /anoioe no??aaeueiino? aeayeeo aioeaai?a HLA o ae?oae, ?io?eiaaieo oa oai?eo ia ooaa?eoeueic, aeicaieeei aeae?eeoe ia?ea?e ??cieo aa??aio?a ia?aa?ao ooaa?eoeueiciiai i?ioeano oa aecia/eoe a?aeiiniee ?ecee ?icaeoeo cacia/aieo noai?a, a oaeiae ?iia??i?noue ia?aoiaeo ia?aeiiiai ooaa?eoeueico o aoi?eiiee. Cieaeaia no??aaeuei?noue aecia/aieo HLA-aioeaai?a o caei?iaeo /e a iaei?e ?c ii??aithaaieo a?oi ?io?eiaaieo oa oai?eo ia ooaa?eoeueic ae?oae ia aeeeth/a? ?o ?ie? o iaoai?ciao ?acenoaioiino? aei ?io?eoaaiiy oa caoai?thaaiiy ooaa?eoeueicii ? ia?aoiaeo iaei??? oi?ie a ?ioo. Iiooe HLA-niaoeeo?/iinoae, ui anioe?ththoueny c ooaa?eoeueicii, iieacaa a??ia?aeia c?inoaiiy /anoioe no??aaeueiino? aioeaai?a HLA-A7 ? ii?aeiaiue HLA-A2A11, A2A7, A3A9, A7N4 o ae?oae c ?aii?i ia??iaeii ia?aeiii? ooaa?eoeueicii? ?ioaeoe??, aioeaai?a HLA-A52, aaieioeiieo niieo/aiue HLA-A2A52, A3A52, A9A13, A9N4, A10N4, A52N4 o in?a ?c c?inoath/ith ooaaea?a??th. No?ee?noue aei ?io?eoaaiiy oa caoai?thaaiiy anioe?thaaeanue ?c oaiioeiii HLA-A1A2. Ia?ea?aie ia?aeiiiai ooaa?eoeueiciiai eiiieaeno i?aaenoaaeeenue aioeaaie HLA-A3, A11, A24 oa aaieioeii? niieo/aiiy HLA-A3A7, A3N4, A24A35, ooaa?eoeueico aioo??oiueia?oaeieo e?ioaoe/ieo aoce?a - aioeaaie HLA-A27, HLA-A1A9, A9A8, A9N1, A15A27, aoi?eiiiai eaaaiaaiai ooaa?eoeueico - HLA-A3, HLA-A2A12, A3A7, A3A15. Aa??thth/e iaoiaee/ieie i?eeiiaie, aaeaeiny iieacaoe, ui aioeaai HLA-A3 ? ia?ea?ii eieaeueiiai ooaa?eoeueico c ia?aaaaeiei o?aaeaiiyi eaaaiaai? oeaieie, a aioeaai HLA-A3 oa aaieioei HLA-A2A12 i?aeaeuothoue ?ecee ia?aoiaeo ia?aeiieo oi?i o aoi?eii?. Iaea?aeai? iaie aeai? na?ae/aoue i?i caeaaei?noue ee?i?/iiai iie?ii?o?cio ia?aeiiiai oa aoi?eiiiai ooaa?eoeueico o ae?oae a?ae aioeaaiii? no?oeoo?e oeaiei i?aai?cio, a iaoaiaoe/iee aiae?c iieacaa, ui aeai? ia?ea?e iiaeooue aooe aeei?enoai? a yeino? aeiaeaoeiaeo e?eoa???a ?eceeo ?icaeoeo ooaa?eoeueiciiai i?ioeano oa aeicaieythoue i?iaiicoaaoe iiaeeea?noue ?icaeoeo oiai /e ?ioiai ee?i?ei-iaoiaaiaoe/iiai aa??aioo ooaa?eoeueico. Aiae?c oaii- oa aaieioeiieo niieo/aiue HLA-aioeaai?a iieacaa, ui i?e ??cieo ee?i?/ieo aa??aioao ooaa?eoeueico cono??/athoueny ia o?eueee aeyaeai? i?e naiino?eiiio aiae?c? ie?ai? aioeaaie HLA, a e iia? aioeaaie, ye? ia iathoue naiino?eiiai “iaeiie/aiiy”. Iacaaaeath/e ia a?eueo ??aeeo no??aaeuei?noue ?yaeo niieo/aiue aioeaai?a o ii??aiyii? c ?o naiino?eiei i?aaenoaaieoeoaii, aeaye? c ieo i?aeaeuothoue ?ecee ?icaeoeo ooaa?eoeueico, ui aeaco? ia aaaeeea?noue aea/aiiy oaii- oa aaieioei?a HLA ? ? aeiaeaoeiaei i?aeoaa?aeaeaiiyi aaiaoe/iiai iie?ii?o?cio ??cieo oi?i ooaa?eoeueico. Aeei?enoaiiy iaiaeii??aeii? iine?aeiaii? i?ioeaaeo?e Aaeueaea c iaoith aeae?eaiiy oaeoi??a ?eceeo, ye? a?ae?a?athoue ae??oaeueio ?ieue o ?icaeoeo caoai?thaaiiy, iieacaei, ui aeiaeai ?c i?iaiinoe/ii iani?eyoeeaeo aaiaoe/ieo (HLA) oaeoi??a ? ciai?oi?o oaeoi??a ?eceeo ia ia? naiino?eiiai cia/aiiy (ca aaee/eiith ae?aaiinoe/iiai eiao?oe??ioa ia aeinyaa? ii?iaiai? aaee/eie) ? eeoa ae?y ciai?oi?o oaeoi??a (eiioaeo c oai?ei ia ooaa?eoeueic, a?aenooi?noue AOeAE-ciaeo) o in?a c aaiaoe/iith noeeuei?noth noai?th? oiiae aeey ?? ?aae?caoe?? ? i?ecaiaeeoue aei ?icaeoeo ooaa?eoeueico. Aea/aiiy anioe?aoe?? i?ae aaiaoe/ieie ia?ea?aie HLA ? iieacieeaie ee?oeiiiai oa aoii?aeueiiai ?ioi?oaoo aeyaeei a?aei?iiino? o /anoio? no??aaeueiino? ?yaeo aioeaai?a o oai?eo c i?aeaeuaieie oa cieaeaieie ia?aiao?aie ?ioi?oaoo. Oei ?ioiii? a?aeiia?ae?, ye a?eueo neeaaeia ?aaeoe?y i?aai?cio, eiio?ieth?oueny a?eueoith e?euee?noth aaiaoe/ieo iaoai?ci?a (HLA), i?ae ecieueiaaia ci?ia oiai /e ?ioiai ?ioiieia?/iiai ia?aiao?a, ui na?ae/eoue i?i aaiaoe/iee iie?ii?o?ci oei?a ?ioiii? a?aeiia?ae?. Oaeei /eiii, iiaeia c?iaeoe aeniiaie, ui HLA-oeioaaiiy ? aaeaeaaoiei ?ino?oiaioii aeey aea/aiiy iniaeeainoae ia?aa?ao ooaa?eoeueico, ne?ei?iaiaei iaoiaeii aeey aeyaeaiiy a?oi i?aeaeuaiiai ?eceeo caoai?thaaiiy ooaa?eoeueicii, a?aee?eaa? ia?niaeoeao aeey iiaeo i?aeoiae?a aei i?io?eaeoeee oa e?eoaaiiy ooaa?eoeueico, ?iaeea?aeoae?caoe?? aeeniaina?iiai niinoa?aaeaiiy oa e?eoaaeueii? oaeoeee. O ?iaio? aeaoaeueii aea/aia ee?i?/ia oa ?ioiieia?/ia (naiino?eii oa o ii??aiyeueiiio ieai?) aoaeoeai?noue o?aaeeoe?eii? o?i?ioa?ai?? (eiio?ieueia a?oia), a oaeiae eiiieaenii? o?i?ioa?ai?? o ii?aeiaii? c oeiiaaiii (?-iniiaia a?oia) oa a?inii?eiii (??-iniiaia a?oia) - ?ioiiaeoeaieie i?aia?aoaie ??ciiai iioiaeaeaiiy oa iaoai?cio ae??. Aeine?aeaeaiiy iieacaee, ui aaeeaaiiy aea/aieo ?ioiiaeoeaieo i?aia?ao?a o iieacaieo aeiaaeeao i?aeaeuoaaei aoaeoeai?noue o?i?ioa?ai??. Ii??aithaaeueiee aiae?c ii ie?aieo neiioiiao aeyaea, ui ?iaiethoe?y ?ioieneeaoe?eiiai neiae?iio o oai?eo, ui iaea?aeoaaee a?inii?ei, aeia?aaeaeaea oaeo ye o eiio?ieuei?e a?oi?, oae ? o aeiaaeeo aaeeaaiiy oeiiaaio. Aei 3-o i?nyoe?a e?eoaaiiy o aeiaaeeo aaeeaaiiy a?inii?eio neiioiie ?ioieneeaoe?? a?ae?eoee o 78%, a aei 6-oe i?nyoe?a - iaeaea o an?o oai?eo (98%), oiae? ye o eiio?ieuei?e a?oi? oea a?aeaoaaeiny o 42% ? 73%, a i?e aaeeaaii? oeiiaaio - o 61% ? 76% a?aeiia?aeii. Iii?oia iie?ioaiiy aiaoeoo, ca?eueoaiiy iane o?ea o oeo, ooi iaea?aeoaaa a?inii?ei, i/aaeaeii, iiaeia iiynieoe ye aeac?ioieneeaoe?eiith ae??th i?aia?aoo, oae ? eiai iiceoeaiei aieeaii ia a?aeiiaeaiiy eeoeiai? oei?e, oa?iaioaoeaia ia?ao?aaethaaiiy ?ae? oa iai?ii? i?ioeane. Iii?oii? ??cieoe? o oa?i?iao e?ea?aeaoe?? eaoeth, ia?eooi?ieo ? aoneoeueoaoeaieo neiioii?a eieaeueiiai i?ioeano aeyaeoe ia aaeaeiny. Ii?iae?caoe?y e?eueeino? e?ioioeeo?a a?eueo aoaeoeaii a?aeaoaaeany o ?-iniiai?e a?oi?, ii?iae?caoe?y OIA oa e?ea?aeaoe?y aeeni?ioa?iai?? aoea i?eaeecii iaeiaeiaith a iaio iniiaieo a?oiao ? aeaui oiia?eueiaiith o eiio?ieuei?e. Iniiai? ?aioaaiieia?/i? iciaee aoaeoeaiiai e?eoaaiiy o aeaeyae? iiaiiai ? cia/iiai ?icniieooaaiiy a?aei?/aeenue o iniiai?e-?, o iniiai?e-?? oa eiio?ieuei?e a?oi? o 56%, 64% oa 47,5% a?aeiia?aeii. I/aaeaeii, iiceoeaia aeeiai?ea eieaeueiiai i?ioeano o oai?eo, ye? iaea?aeoaaee a?inii?ei, iiaycaia ia o?eueee c eiai ?ioiiiiaeoethth/ith ae??th, a e c aoaeoii o?aineieaoe?? - i?iieeiaiiyi a ina?aaeie o?aaeaiiy aoaeue-yei? eieae?caoe?? c i?ioecaiaeueiith ae??th, aeae?eaiiyi oa?iaio?a, ui ni?ey? e?auiio i?iieeiaiith o?i?ii?aia?ao?a o ina?aaeie o?aaeaiiy. Aa?oi oaaae, ui o aeiaaeeo aaeeaaiiy a?inii?eio nooo?ai cieaeoaaeanue /anoioa oiene/ieo oa aea?a?/ieo oneeaaeiaiue o?i?ioa?ai??. Aiae?c ?ioiieia?/ii? aoaeoeaiino? ??cieo aeae?a e?eoaaiiy i?iaiaeeany o aeae?eueea aoai?a: aea/aeanue aeeiai?ea na?aaeiueia?oiiaeo cia/aiue iieaciee?a, iniaeeaino? aieeao ?ioiiaeoeaieo i?aia?ao?a o caeaaeiino? a?ae aeo?aeiiai ??aiy iniiaieo ia?aiao??a ?ioi?oaoo, a naia - iai?aaeai?noue oe??? ae?? oa no?iee ?ioii?aaa?e?oaoe??, aecia/aany iieaciee neee aieeao i?iaiaeeieo aeae?a oa?ai?? ia ??ci? eaiee ?ioi?oaoo, aea/aeanue niieo/ai?noue ?ioiieia?/ieo iciae oa ?? ci?ie o i?ioean? e?eoaaiiy, i?iaiaeeeanue iiaoaeiaa i?iaiinoe/ii? iiaeae? aoaeoeaiino? e?eoaaiiy, ui aeicaiey? aea?aoe ?c aaeeei? e?eueeino? ee?i?ei-?ioiieia?/ieo oa ?ioiiaaiaoe/ieo ia?aiao??a iaea?eueo cia/ou?, ye? eiaeothoue iiceoeaiee aoaeo i?aia?aoo. Ii??aithaaeueiee aiae?c aeeiai?ee iieaciee?a ?ioi?oaoo i?e ??cieo aeaeao e?eoaaiiy (?en. 4, 5) iieacaa, ui o oai?eo, ye? iaea?aeoaaee a?inii?ei, /a?ac 1,5 i?nyoe? e?eoaaiiy ee?oeii? ia?aiao?e i?aeaeuoaaeenue a?eueoa, i?ae o oeo, ui iaea?aeoaaee o?eueee o?i?ii?aia?aoe, aea aeaui iaioa, i?ae o aeiaaeeo aaeeaaiiy oeiiaaio. O oai?eo eiio?ieueii? a?oie, iacaeaaeii a?ae aeo?aeiiai i?eai?/aiiy O-e?ioioeeo?a, aei iiiaioo iiaoi?iiai aeine?aeaeaiiy ia niinoa??aaeinue c?inoaiiy iieaciee?a O-ee?oeiiiai ?ioi?oaoo, ui, ?iia??ii, iiaycaii c aeieaaeith ?aoeaioi??a e?ioioeeo?a iaaeeeoeii oee?eoethth/eo aioeaai?a, ye? ooai?ththoueny o ?acoeueoao? caaeaae? IAO a ia??iae ?ioaineaii? o?i?ioa?ai??, ?ioiiaeai?aneaiith ae??th ao?io?iiii? oa?ai??. *a?ac o?e i?nyoe? o oai?eo, ye? iaea?aeoaaee a?inii?ei, iieacieee aoee nooo?ai aeueie, i?ae i?e ?cieueiaai?e o?i?ioa?ai??, ? aeueie, i?ae /a?ac 1,5 i?nyoe? e?eoaaiiy, oiae? ye o oai?eo, ui iaea?aeoaaee oeiiaai, /a?ac 3 i?nyoe? e?eoaaiiy iieacieee caeeoaeenue oeie ae, ui e /a?ac 1-1,5 i?nyoe? oa?ai??, aai iaee oaiaeaioe?th aei cieaeaiiy. Oiaoi o oai?eo, ye? io?eiothoue a?inii?ei, ?aea ieaaia iinooiiaa c?inoaiiy iieaciee?a ee?oeiiiai ?ioi?oaoo, oiae? ye o oai?eo, ui io?eioaaee oeiiaai, i?ney iii?oiiai i?aeaeuaiiy /a?ac 1,5 i?nyoe? ianoa? aeayea noaa?e?caoe?y aai iaa?oue iacia/ia aeai?an?y c ianooiiei c?inoaiiyi aei 6-oe i?nyoe?a e?eoaaiiy, oiaoi ia? i?noea oaeeaiiae?aia aeeiai?ea iieaciee?a, ui aea/athoueny. Aea/aiiy aoaeoeaiino? e?eoaaiiy a caeaaeiino? a?ae aeo?aeiiai noaio ?ioi?oaoo iieacaei, ui o oai?eo c ae?aaeaiei i?eai?/aiiyi ee?oeiiiai ?ioi?oaoo o aeiaaeeo aaeeaaiiy oeiiaaio niinoa??aa?oueny oaiaeaioe?y aei iiaeaeueoiai i?eai?/aiiy ?ioi?oaoo. O oai?eo, ye? io?eioaaee a eiiieaeni?e oa?ai?? a?inii?ei, i?aeoe/ii ia niinoa??aaeinue i?eai?/oth/i? ae?? i?aia?aoo iaa?oue i?e aeo?aeii ??cei cieaeaieo iieacieeao. Oaeaee?noue ?ioii?aaa?e?oaoe?? oaeiae caeaaeaea a?ae nooiaiy i?eai?/aiiy ?ioi?oaoo. Ii??aiyeueiee aiae?c na?aaei?o cia/aiue ?ioiieia?/ieo ia?aiao??a a i?ioean? e?eoaaiiy /anoi aoa ia iieaciaei /a?ac ?o ae?aaeai? ?iaeea?aeoaeuei? eieeaaiiy. Iaea?eueo iai/ii i?iaeaiiino?oaaee iiaeeeaino? ae?? ??cieo aeae?a e?eoaaiiy ia ?ioi?oao ?acoeueoaoe aeenia?n?eiiai aiae?co, ye? aeicaieeee ioe?ieoe ia eeoa a??ia?aei?noue, a e neeo oe??? ae?? ia ??ci? eaiee ?ioi?oaoo. ?acoeueoaoe oaeiai aiae?co iieacaee, ui an? aeaee e?eoaaiiy aieeaaee ia /eneaii? ia?aiao?e ?ioi?oaoo, i?e/iio ii ?yaeo iieaciee?a oey ae?y aoea iaeiiiai?aaeaiith, iaeiae neea ?? aoea ??ciith. Iaea?eueo ae?aaeaio ae?th ia ai?no e?ioioeeo?a ? iniaeeai O-ee?oeiiee eiiiiiaio iaea o?i?ioa?ai?y o ii?aeiaii? c oeiiaaiii. Iieacieee neee ae?? () aeyaeeenue cia/ieie ? aenieia??ia?aeieie: aeey A-?OE (%) - 0,56910,0198 (?<0,0001), CD3 (%) - 0,70420,0138 (?<0,0001), CD4 (%) - 0,5968 0,0281 (?<0,0001). Aeeth/aiiy o eiiieaenio oa?ai?th a?inii?eio oaeiae aeinoia??ii aieeaaei ia oe? ia?aiao?e, iaeiae neea eiai aoea ieae/ith: (0,36210,0160, ?<0,0001; 0,61210,0091, ?<0,0001; 0,50930,0136, ?<0,0001 a?aeiia?aeii). Aieea ??cieo aeae?a e?eoaaiiy ia ai?no A-e?ioioeeo?a (AAN-?OE, CD22) aoa iacia/iei. O a?eueo?e i??? a?i aoa ae?aaeaiee o oai?eo, ye? io?eioaaee a?inii?ei (0,19840,0214, ?<0,01; 0,28360,0246, ?<0,05). Ae?y a?ii?aia?aoo ia ai?no ?ioiiaeiaoe?i?a aoea oi/ ? iaaenieith, aea a?eueo ae?aaeaiith o ii??aiyii? c ?ioeie aeaeaie e?eoaaiiy, eiai aieea ia ??aaiue Oe?E oa niaoeeo?/ieo aioeo?e aoa aeineoue neeueiei ? ia?aaaaeaa oaeee o a?oiao, ye? ii??aithaaeeny (0,41120,0169, ?<0,0001; 0,40390,0157, ?<0,0001). I/aaeaeii, aoaeo a?inii?eio iaoiiaeaiee ciaioaiiyi aioeaaiai??, o oiio /ene? e niaoeeo?/ii?, ui i?eaiaeeoue aei cieaeaiiy ??aiy Oe?E oa aioeaaiiiai noeioeo aeey neioaco aioeo?e aei IAO. Neea ae?? e?eoaaiiy, ui i?iaiaeeeinue, ia ooieoe?iiaeueio aeoeai?noue e?ioioeeo?a o oai?eo, ye? iaea?aeoaaee oeiiaai oa a?inii?ei, aoea i?eaeecii iaeiaeiaith (aeey ?AOE c OAA - 0,44090,0238, ?<0,001; 0,41280,0294, ?<0,001; aeey ?AOE c IIAe-E - 0,32120,0246, ?<0,001; 0,30190,0261, ?<0,002 a?aeiia?aeii) ? cia/ii aeuith, i?ae i?e cae/aei?e o?i?ioa?ai??. Aaeeaaiiy a?inii?eio a yeino? caniao iaoiaaiaoe/ii? oa?ai?? iii?oii aieeioei ia aioo??oiueiee?oeiiee eeniacaeaaeiee iaoaaie?ci ? iiaeeiaeueio caeaoi?noue oaaioeeo?a (INO niiio. - 0,33560,0194, ?<0,002; INO c IIAe-E - 0,31120,0249, ?<0,001; IO - 0,32420,0214, ?<0,02; O* - 0,39240,0226, ?<0,01), i?e/iio neea oaei? ae?? aeyaeeany aeuith, i?ae o ?ac? cae/aeii? o?i?ioa?ai?? oa o?i?ioa?ai?? o ii?aeiaii? c oeiiaaiii, oi/a na?aaei? cia/aiiy iieaciee?a o i?ioean? e?eoaaiiy ci?ithaaeeny iaei ? ia a?ae??ciyeeny i?ae niaith o a?oiao, ui ii??aithaaeeny. C iaoith aea/aiiy oa?aeoa?o aca?iicayceo i?ae iieacieeaie ?ioiieia?/ii? ?aaeoeaiino? ie i?iaaee aeine?aeaeaiiy niieo/aiino? iciae ??cieie iaoiaeaie. sse?niee oa e?euee?niee aiae?c aca?iicayce?a ?ioiieia?/ieo ia?aiao??a o ae?oae c ??cieie oi?iaie ooaa?eoeueico i?iaeaiiino?oaaa ??ciiiai?oi?noue iaoiaaiaoe/ieo iaoai?ci?a, ye? eaaeaoue a iniia? ooaa?eoeueiciiai i?ioeano. I?e ooieoe?iiaeueiiai iai?oaeaiiy ?ioiii? nenoaie i?eiaaeaa ia aeoeaiee ia??iae caoai?thaaiiy. E?euee?noue cayce?a ciaioeeanue o iai?yieo cieaeaiiy aeoeaiino? i?ioeano. O oiae? e?eoaaiiy a?aei?/aeinue ciaioaiiy e?eueeino? oa ci?ia iai?aaeaiino? cayce?a, iaeiae o aeiaei?e c a?oi ie ia aeyaeee a?aeiiaeaiiy oa?aeoa?o cayce?a, a?aeiia?aeieo caei?ia?e a?oi?. Iaaia “ii?o?aoia” noiae?noue niieo/aiino? ?ioiieia?/ieo iciae o oai?eo ia aeoeaiee ooaa?eoeueic oa c ?aii?i ia??iaeii ia?aeiii? ooaa?eoeueicii? ?ioaeoe?? noaea iaoiaaiaoe/iei i?aeoaa?aeaeaiiyi aeaieo ee?i?/ieo niinoa?aaeaiue i?i oa, ui ae?oe c a?ia?a?a??th ia ooaa?eoe?i noaiiaeyoue a?oio i?aeaeuaiiai ?eceeo ?icaeoeo eieaeueiiai ooaa?eoeueico. O ae?oae c ??cieie i?iyaaie ooaa?eoeueico aoa i?yiee caycie i?ae e?euee?noth c??eeo e?ioioeeo?a oa ?o ooieoe?iiaeueiith aeoeai?noth (ii ?AOE c OAA). Aaee/eia eiao?oe??io?a niieo/aiino? eieeaaeanue o aeinoaoiuei oe?ieeo iaaeao - a?ae 0,11 aei 0,75, oiaoi aeieaaea (ao?aoa) ?aoeaioi??a O-e?ioioeeoaie ae?? ia ee?oeii? ooieoe??. O oai?eo iaeeie oi?iaie a?iioiaaeai?oo aeyaeaia iaa?iaia caeaaei?noue i?ae iieacieeaie ianiaoeeo?/ii? oa niaoeeo?/ii? aeoeaiino? O-e?ioioeeo?a (-0,31), oiaoi cieaeaiiy ianiaoeeo?/ii? aeoeaiino? noi?iaiaeaeo?oueny o ieo aeoeaaoe??th niaoeeo?/ii? a?aeiia?ae?. O oai?eo c ae?aaeaieie oi?iaie caoai?thaaiiy ia?a?nii i?yiee caycie i?ae iieacieeaie (0,42) o i?ioean? e?eoaaiiy ci?ith?oueny ? oaeiae iaaoaa? iaa?iaiiai oa?aeoa?o (-0,42). Iacaaaeath/e ia iaaiee ia?aeae?ci aeeiai?ee na?aaei?o cia/aiue iieaciee?a O- oa A-e?ioioeeo?a, ui aecia/athoueny iaoiaeaie ?icaoeiooai?aiiy oa ca aeiiiiiaith iiiieeiiaeueieo aioeo?e (A-?OE oa CD3-e?ioioeeoe, AAN-?OE oa CD22-ee?oei), ana?aaeei? a?oi ie ia aeyaeee /?oei? ei?aeyoe?? i?ae oeeie iieacieeaie, ui, i/aaeaeii, iiaycaii c oei, ui aeine?aeaeoaaeenue ??ci? ?aoeaioi?e, a ?o ao?aoa (aeieaaea) a?aeaoaa?oueny ia neio?iiii, oiaoi aeacai? iaoiaee iathoue naiino?eia cia/aiiy oa aeiiiaiththoue iaeei iaeiiai. Caaaeaiiyi aenia?eiaioaeueieo aeine?aeaeaiue aoea ioe?iea ae?? i?aia?aoo “A?aaoii” ia ?ioiieia?/io nenoaio oa ooaa?eoeueiciee i?ioean, a oiio /ene? o oaa?ei c i?ioeeaaeiith, aaiaoe/ii iaoiiaeaiith - iiiceoiith /ooeea?noth aei i?eiaaeoa??e ooaa?eoeueico. Ia?oee aoai aeine?aeaeaiue i?iaaaeaii ia 42 a?eeo aacii?iaeieo ieoao, ye? aoee ?iciiae?eai? ia 6 a?oi: eiio?ieueia; ca?aaeai? oaa?eie c aaeeaaiiyi aioeaaeoa??aeueieo i?aia?ao?a; ca?aaeai? oaa?eie c aaeeaaiiyi “A?aaoiio-1” (10ie/ea); c aaeeaaiiyi “A?aaoiio-2” (1 ie/ea); ca?aaeai? oaa?eie c aaaaeaiiyi aioeaaeoa??aeueieo i?aia?ao?a (AAI) oa “A?aaoiio-1”; ca?aaeai? oaa?eie c aaeeaaiiyi aioeaaeoa??aeueieo i?aia?ao?a oa “A?aaoiio-2”. Ca?aeii c iaea?aeaieie aeaieie, canoinoaaiiy “A?aaoiio” ni?eyei ciaioaiith i?e?iaii? iiioeyoe?? (iniaeeai ae?aaeaiee oeae aoaeo i?e ii?aeiaiiio aaeeaaii? AAI oa “A?aaoiio”), ciaioaiith caiaeueieo i?iya?a o aioo??oi?o i?aaiao, i?aeaeuaiith ??aiy A-e?ioi?aeii? iiioeyoe?? o naeac?ioe? oa e?ioaoe/ieo aoceao, iineeaiith aeoeaiino? a?eueii?aaeeeaeueieo i?ioean?a o ee?oeiao ia?eoa?e/ii? e?ia? (oai?ethi?ianoeaioe?y ee?oeiieo aeaiaio?a ia?eoa?e/ii? e?ia?, ye niiioaiia, oae ? ?iaeoeiaaia ANG i?ae ae??th “A?aaoiio”, ie?aii ? a niieo/aii? c aioeaaeoa??aeueieie i?aia?aoaie iineethaaeanue o 10-50 ?ac?a, iniaeeai o a?oiao oaa?ei, yeei aaiaeeany “A?aaoii-2”). Ae?oaee aoai aeine?aeaeaiue aeeiiaii ia e?i?eieo ieoao c iiiceoiith /ooeea?noth aei i?eiaaeoa??e ooaa?eoeueico (Black-6 oa F1-a?a?eae/N57A86). ?iciiae?e ieoae o eiaei?e c iiiceoieo a?oi a caeaaeiino? a?ae oa?aeoa?o oa?ai??, ui i?iaiaeeeanue, aoa aiaeia?/iei, ye ? ia ia?oiio aoai? aenia?eiaioo. Anoaiiaeai? a?aei?iiino? o ae?? i?aia?ao?a naiino?eii oa i?e ii?aeiaiiio aaeeaaii? ia iano aioo??oi?o i?aai?a oa ?iaeaen o?aaeaiiy o aenia?eiaioaeueieo oaa?ei, ye? a?ae??ciythoueny no?ee?noth aei ooaa?eoeueicii? ?ioaeoe??. I?e?ia?ieia?/i? aeine?aeaeaiiy iieacaee, ui aioeaaeoa??aeuei? i?aia?aoe ie?aii ? a ii?aeiaii? c “A?aaoiiii” cia/ii ciaioothoue /enaeuei?noue i?eiaaeoa??e o i?aeaeine?aeieo oaa?ei, i?e/iio a?eueo iii?oiee oeae aieea o no?eeeo aei ooaa?eoeueico oaa?ei. O aenia?eiaio? a?aei?/aany iiaiee ca?a ?acoeueoao?a ca aeaiia aeei?enoaieie iaoiaeaie aeine?aeaeaiiy - ethi?ianoeaioii? i?e?ineii?? iace?a a?aeaeoe?a oa aen?a?a aioo??oi?o i?aai?a. “A?aaoii” nooo?ai ci?iea iiioeyoe?eiee neeaae e?ioioeeo?a ?ioiieiiiaoaioieo i?aai?a ? oa?aeoa? ieenii-a?aeiiaethaaeueieo i?ioean?a o eaeeioeeoao ia?eoa?e/ii? e?ia?, i?e/iio oe? ci?ie caeaaeaee ye a?ae aeice i?aia?aoo, oae ? a?ae aaiaoe/ii? /ooeeaino? i?aai?cio aei i?eiaaeoa??aeueii? ?ioaeoe??. Ia iniia? iaea?aeaieo ?acoeueoao?a aenia?eiaioo aoee c?iaeai? caeeth/aiiy:  “A?aaoii” iaeei ? c AAI cae?enith? cia/iee aieea ia caiaeaiiy (ciaioo?oueny iana aioo??oi?o i?aai?a oa ?iaeaen o?aaeaiiy). Iniaeeai ae?aaeaiee oeae aieea o /ooeeaeo aei ooaa?eoeueico oaa?ei.  “A?aaoii”, ye naiino?eii, oae ? o ii?aeiaii? c AAI, ca?eueoo? ai?no A-e?ioi?aeii? iiioeyoe?? o naeac?ioe? oa e?ioaoe/ieo aoceao o aacii?iaeieo ? /ooeeaeo aei ooaa?eoeueico oaa?ei. O no?eeeo e?i?e ieoae nooi?iue aieeao ia ai?no A-e?ioi?aeieo aeaiaio?a o naeac?ioe? iacia/iee ? aeinoia??ii ae?aaeaiee o e?ioaoe/ieo aoceao.  “A?aaoii” naiino?eii ? o ii?aeiaii? c AAI i?aeaeuo? i?ioeaio O-e?ioi?aeieo aeaiaio?a o naeac?ioe? oa e?ioaoe/ieo aoceao o /ooeeaeo aei ooaa?eoeueico ieoae ? cia/ii cieaeo? eiai o no?eeeo oaa?ei.  “A?aaoii” o ii?aeiaii? c AAI ?aaoeth? ieenii-a?aeiiai? i?ioeane a ?ioiieiiiaoaioieo ee?oeiao e?ia? (ca aeaieie aea/aiiy INO-oanoo, oai?ethi?ianoeaioe??).  Iaoiii?oieia?/i? aeine?aeaeaiiy iieacaee, ui aaeeaaiiy “A?aaoiio” caaacia/o? ciaioaiiy iane eaaai?a, ia/?iee, naeac?iee, a oaeiae nooiaiy aeenai?iaoe?? ooaa?eoeueiciiai caiaeaiiy o /ooeeaeo aei ooaa?eoeueico ieoae, ni?ey? iiaiiio ?o aee?eoaaiith. Iineeaiiy oeueiai aoaeoo a?aei?/a?oueny i?e ii?aeiaiiio aaeeaaii? “A?aaoiio” c aioeaaeoa??aeueieie i?aia?aoaie. Ae?y “A?aaoiio” ia ooaa?eoeueicia caiaeaiiy o no?eeeo aei ooaa?eoeueico ieoae ia? aiaeia?/iee oa?aeoa?.  “A?aaoii” ia? iiooaei? ?ioiiiiaeoethth/? aeanoeaino?. Aaeeaaiiy ii?aeiaii? oa?ai?? (AAI oa “A?aaoii”) cia/ii ciaioo? i?e?iaio iiioeyoe?th a i?aai?ci? i?aeaeine?aeieo oaa?ei oa ci?ith? oa?aeoa? ia?aa?ao ooaa?eoeueiciiai i?ioeano aae aei aee?eoaaiiy. Iai?aaeai?noue, nooi?iue ?ioiiei?aeoe?? oa aoaeoeai?noue e?eoaaiiy caeaaeaoue a?ae aaiaoe/ii? oa?aeoa?enoeee, /ooeeaino? aei i?eiaaeoa??aeueii? ?ioaeoe??. AENIIAEE 1. Ooaa?eoeueic o ae?oae oe?eueiiai a?eo o a?eueoino? aeiaaee?a ia? ni?eyoeeaee ia?aa?a c ia?aaaaeaiiyi iaoneeaaeiaieo ? iaeeo oi?i caoai?thaaiiy oa noeeuei?noth aei a?aeiaaeiaoaaiiy i?ioeano. Iniaeeaino? ee?i?/iiai ia?aa?ao ei?aeththoue c? nooiaiai ae?aaeaiino? ?ioiieia?/ieo ii?ooaiue oa oa?aeoa?ii ?ioiii? a?aeiia?ae?. 2. O ae?oae c ii/aoeiaeie i?iyaaie oa iaeeie oi?iaie ooaa?eoeueico aioo??oiueia?oaeieo e?ioiaoce?a, ye i?aaeei, ia oii? iacia/iiai cieaeaiiy ianiaoeeo?/ieo iieaciee?a ee?oeiiiai ?ioi?oaoo (ca ??aiai CD3- CD4-e?ioioeeo?a, A-?OE, Aa-?OE, ?AOE c OAA, ?iaeaeno noeioeyoe?? ii aeeth/aiith 3I-oei?aeeio) a?aei?/a?oueny aeoeaaoe?y niaoeeo?/ii? O-ee?oeiii? eaiee (?AOE oa ?iaeaen noeioeyoe?? c IIAe-E), oiaoi ?aaeoe?y ?ioiii? nenoaie ia? caaeainiaaiee oa?aeoa?, ni?eyth/e a?aeiaaeiaoaaiith aiaieua caiaeaiiy, ? oai?? /ano?oa ia iio?aaothoue ?ioiiei?aeoe??. Aeniiaie i?aeoaa?aeaeo?oueny ?acoeueoaoaie aea/aiiy niieo/aiino? ?ioiieia?/ieo iciae. 3. O oai?eo ia ee?i?/ii ae?aaeai? oi?ie ooaa?eoeueico i?aai?a aeeoaiiy (ia?aeii? oa aoi?eii?) ? iciaee ae?eniiai ee?oeiiiai ?ioiiaeao?oeeoo, ye? aeyaeythoueny o aeinoia??iiio cieaeaii? u?eueiino? iiaa?oiaaeo aioeaai?a ?ioiieiiiaoaioieo ee?oei (CD3, CD4, ?aoeaioi??a aei a?eo?ioeeo?a aa?aia), cieaeaii? ?ioii?aaoeyoi?iiai ?iaeaeno (CD4/CD8) oa i?ie?oa?aoeaii? a?aeiia?ae? e?ioioeeo?a ia OAA oa IIAe-E. I?e ae?aaeaieo ci?iao o eaaaiyo ia? i?noea i?aeaeuaiiy aeni?an?? aioeaai?a-ia?ea??a iieiaeeo ee?oei (CD38). O oai?eo ia aoi?eii? oi?ie a?aeaoaa?oueny aeoeaaoe?y noi?ani?ii-oeeoioiene/ii? eaiee ?ioi?oaoo (CD8), ui noai?th? iaoiaaiaoe/i? ia?aaeoiiae aeey aiaeiaaiii? ?a?ioaeoe??. 4. O ae?oae, ?io?eiaaieo oa oai?eo ia ooaa?eoeueic, o a?eueoino? aeiaaee?a a?aenooi? nooo?a? e?euee?ni? ci?ie /enea A-e?ioioeeo?a (CD22 ? AAN-?OE). Ooieoe?iiaeueia ia?aaoaeiaa aoii?aeueiiai ?ioi?oaoo i?aeoaa?aeaeo?oueny ia?aaaaeii o aeaeyae? iii?oiiai i?aeaeuaiiy neioaco niaoeeo?/ieo aioeo?e (ca aeaieie ?OA) ? ooai?aiiy Oe?E, ??aaiue yeeo ei?aeth? c ae?aaeai?noth niaoeeo?/iiai i?ioeano. I?aeaeuaiiy ooieoe?iiaeueii? aeoeaiino? oaaioeeooth/eo ee?oei aeieoiaioo?oueny o aeaeyae? aeoeaaoe?? eeniacaeaaeieo iaoai?ci?a aaeoa?eoeeaeiino? ee?oei ye o niiioaiiiio INO-oano?, oae ? a ?iaeoeiaaiiio IIAe-E. *enaeuei?noue oaaioeeooth/eo ee?oei oa ?o iiaeeiaeueia caeaoi?noue uiaei /anoeiie eaoaeno (IO, O*) nooo?ai ia ci?iththoueny. 5. I?iaiinoe/ii iani?eyoeeaeie a ieai? oyaeeino? ia?aa?ao ooaa?eoeueiciiai i?ioeano o ae?oae ? ia?aeiii iecuee? cia/aiiy iieaciee?a CD3-, CD4-e?ioioeeo?a, A-?OE, Aa-?OE, CD4/CD8, ?AOE c OAA ? IIAe-E, i?aeaeuaiiy ??aiy aeni?an?? CD8-aioeaai?a oa aenieee ai?no niaoeeo?/ieo aioeo?e ? Oe?E. 6. O ae?oae c ??cieie i?iyaaie ooaa?eoeueicii? ?ioaeoe?? aeyaeai? ??ci? ii?ooaiiy niieo/aiino? ?ioiieia?/ieo iciae, ui na?ae/eoue i?i iie?ii?o?ci ?ioiiiaoiaaiaco ooaa?eoeueico. I?e ooieoe?iiaeueii? aeoeaiino? aca?iicayce?a i?eiaaea? ia aeoeaiee ia??iae caoai?thaaiiy. E?euee?noue ?o ciaioo?oueny o iai?yieo cieaeaiiy aeoeaiino? i?ioeano, aea ia a?aeiiaeth?oueny aei ??aiy caei?iaeo in?a o i?ioean? e?eoaaiiy. 7. I?ae /an ioe?iee ee?i?ei-?ioiieia?/ii? aoaeoeaiino? ?ioiiei?eaoth/i? oa?ai?? o ae?oae, oai?eo ia ooaa?eoeueic, aeeiai?ea na?aaei?o cia/aiue ?ioiieia?/ieo iieaciee?a /anoi ? iaei?ioi?iaoeaiith /a?ac ae?aaeai? ?iaeea?aeoaeuei? eieeaaiiy. Eiiieaeniee iaoaiaoe/iee aiae?c (aeenia?n?eiee, aeene?ei?iaioiee iaoiaee, aea/aiiy niieo/aiino? iciae, aiae?c ?ioiieia?/ieo ia?aiao??a o caeaaeiino? a?ae aeo?aeiiai ??aiy) aeicaieea aeyaeoe iniaeeaino? ??cieo aeae?a ?ioiiei?eaoth/i? oa?ai?? oa i?iaiicoaaoe aoaeoeai?noue e?eoaaiiy a caeaaeiino? a?ae aeo?aeiiai noaio ?ioi?oaoo ? aaiaoe/ieo (HLA) iciae. 8. I?e i?ecia/aii? o eiiieaeni?e oa?ai?? oai?ei ia ooaa?eoeueic ae?oyi oeiiaaio ne?ae a?aoiaoaaoe aeo?aeiee noai ee?oeiiiai ?ioi?oaoo. Iaea?eueo aoaeoeaia canoinoaaiiy i?aia?aoo i?e iii??iiio i?eai?/aii? O-ee?oeiiiai ?ioi?oaoo. I?e ae?aaeaiiio i?eai?/aii? (>20%) iiaeeeaa
iiaeaeueoa cieaeaiiy aeni?an?? e?ioioeeoa?ieo aioeaai?a (CD3, CD4).

9. Ee?i?ei-?ioiieia?/ia aoaeoeai?noue canoinoaaiiy a?inii?eio o
eiiieaeni?e oa?ai?? oai?eo ia ooaa?eoeueic ae?oae i?iyaey?oueny o
i?enei?aii? ?iaiethoe?? ?ioieneeaoe?eiiai neiae?iio, ca?eueoaii?
e?eueeino? oai?eo c iiaiei oa cia/iei ?icniieooaaiiyi ?io?eueo?aoeaieo
ci?i, i?io?eaeoeoe? iia?/ii? ae?? o?i?ii?aia?ao?a, ei?aeoe??
?ioiieia?/ieo ii?ooaiue ??ciiai nooiaiy ae?aaeaiino?.

10. Canoinoaaiiy oeiiaaio a eiiieaeni?e oa?ai?? ae?oae, oai?eo ia
ooaa?eoeueic, cieaeo? /anoioo aea?a?/ieo ?aaeoe?e o 2,6 ?ace (?<0,05) oa i?aeoe/ii ia aieeaa? ia /anoioo oiene/ieo oneeaaeiaiue. A?inii?ei ciaioo? /anoioo oiene/ieo ?aaeoe?e a 2,9 ?ace (p<0,05) oa caiia?aa? ?icaeoeo aea?a?/ieo oneeaaeiaiue. 11. Aenia?eiaioaeueia aea/aiiy aoaeoeaiino? canoinoaaiiy eiiieaeniiai o?oii?aia?aoo "A?aaoii" iieacaei, ui "A?aaoii" ia? aaeee? ?ioiiiiaeoethth/? aeanoeaino?. Canoinoaaiiy ii?aeiaii? oa?ai?? (aioeaaeoa??aeuei? i?aia?aoe ? "A?aaoii") cia/ii ciaioo? i?e?iaio iiioeyoe?th a i?aai?ci? i?aeaeine?aeieo oaa?ei oa ci?ith? oa?aeoa? ia?aa?ao ooaa?eoeueiciiai i?ioeano (ciaioo?oueny iana aioo??oi?o i?aai?a oa ?iaeaen o?aaeaiiy) aei aee?eoaaiiy aeeth/ii. Iai?aaeai?noue ? nooi?iue ?ioiiei?aeoe??, aoaeoeai?noue e?eoaaiiy caeaaeaoue a?ae aaiaoe/ii? oa?aeoa?enoeee /ooeeaino? aei i?eiaaeoa??aeueii? ?ioaeoe??. 12. ?ioiiaaiaoe/iee aiae?c HLA-niaoeeo?/iinoae o ae?oae, ?io?eiaaieo oa oai?eo ia ooaa?eoeueic, aeyaea anioe?aoe?th HLA-aioeaai?a c iniaeeainoyie ia?aa?ao ooaa?eoeueiciiai i?ioeano (aaiaoe/iee iie?ii?o?ci ??cieo ee?i?ei-iaoiaaiaoe/ieo aa??aio?a ooaa?eoeueico). Aaiaoe/ii iaoiiaeaia ?acenoaioi?noue aei ?icaeoeo ooaa?eoeueico anioe?eiaaia c iayai?noth o oaiioei? aioeaai?a HLA-A1 oa HLA-A1A2. 13. Aeey ae?oae c ii/aoeiaeie i?iyaaie ooaa?eoeueicii? ?ioaeoe?? oa?aeoa?ia i?aeaeuaia /anoioa no??aaeueiino? aioeaai?a HLA-N4, A7, A52, oaiioei?a HLA-A2A11, A3A9, aaieioeiieo niieo/aiue HLA-A2A7, A7N4, A2A52, A3A52, A9A13, A9N4, A10N4, A52N4. ?ioi?iaoeaieie ia?ea?aie aaiaoe/ii? noeeueiino? aei ?icaeoeo ia?aeiiiai ooaa?eoeueiciiai eiiieaeno ? aioeaaie HLA-A3, A11, A24, HLA aaieioeie - A3A7, A3N4, A24A35, ooaa?eoeueico aioo??oiueia?oaeieo e?ioiaoce?a - HLA-A27, niieo/aiiy aioeaai?a HLA-A1A9, A9A8, A9N1, A15A27, aoi?eiiiai ooaa?eoeueico - HLA-A3, HLA-A2A12, A3A7, A3A15. Iin?enoai aioeaai?a HLA-A3, aaieioeio HLA-A9A12 i?aeaeuo? ?ecee ia?aoiaeo ia?aeiieo oi?i o aoi?eii?. 14. HLA-oeioaaiiy ? aaeaeaaoiei ?ino?oiaioii aeey aea/aiiy iniaeeainoae ia?aa?ao ooaa?eoeueiciiai i?ioeano oa ne?ei?iaiaei iaoiaeii aeey aeyaeaiiy a?oi i?aeaeuaiiai ?eceeo ?icaeoeo ooaa?eoeueico, ui aeicaiey? ?iaeea?aeoae?coaaoe aeeniaina?ia niinoa?aaeaiiy oa oa?aiaaoe/io oaeoeeo. NIENIE INIIAIEO I?AOeUe, ssE? IIOAE?EIAAI? CA OAIITH AeENA?OAOe?? 1. Aeia?a?ae/aneay /oanoaeoaeueiinoue o aeaoae e ooaa?eoeeio /A.A.Aea?ea/, I.E.Aaeiai?oeaaa, A.O.Eaieaeaineay, AE.A.Iaeyoaaneay //Ooaa?eoe?c.- E.:Caei?iay, 1992.-N.63-65. 2. A?eiai?oeaaa I.?. ?ioiiaaiaoe/i? iieacieee o ae?oae, oai?eo ia ooaa?eoeueic //E?ea?nueea ni?aaa.- 1995.- ?7/8.- N.92-93. 3. Aaeiai?oeaaa I.E. Eiioiieiae/aneea e eiioiiaaiaoe/aneea enneaaeiaaiey o aeaoae n aunieie /oanoaeoaeueiinoueth e ooaa?eoeeio // Aanoi. i?iae. nia?ai. iaaeeoeeiu.- 1995.-?7.- N.105-108. 4. Aaeiai?oeaaa I.E. Eiioiiaaiaoe/aneay oa?aeoa?enoeea aeaoae, aieueiuo eieaeueiuie oi?iaie ooaa?eoe?ca // Aanoi. i?iae. nia?ai. iaaeeoeeiu.- 1995.-?7.- N.102-104. 5. Aaeiai?oeaaa I.E. Iniaaiiinoe eiioiiiaoiaaiaca ?acee/iuo oi?i ooaa?eoe?ca o aeaoae // Aanoi. i?iae. aeieiaee e iaaeeoeeiu.- 1997.-?4.- N.67-70. 6. Aaeiai?oeaaa I.E. Eeeieei-eiioiieiae/aneay oa?aeoa?enoeea ooaa?eoe?c-iie eioieneeaoeee o aeaoae //Aanoi. i?iae. aeieiaee e iaaeeoeeiu.-1997.-?4.-N.59-63. 7. Aaeiai?oeaaa I.E. Iieacaiey e iacia/aieth oeiiaaia o aieueiuo ooaa?eoe?cii aeaoae // Aanoi. i?iae. aeieiaee e iaaeeoeeiu.- 1997.-?4.- N.64-66. 8. A?eiai?oeaaa I.?. Canoinoaaiiy ?ioiioa?iaioiiai aiae?co aeey aeeoa?aioe?aeueii? ae?aaiinoeee ooaa?eoeueico oa ianiaoeeo?/ieo iiaaiii?e o ae?oae //Iaae?ao??y, aeooa?noai oa a?iaeieia?y.- 1997.- ?6.- N.30-31. 9. Aaeiai?oeaaa I.E. Eiioiieiae/aneay e eiioiiaaiaoe/aneay oa?aeoa?enoeea aeaoae n ?acee/iuie oi?iaie ooaa?eoe?ca //Oe?.ioeueiiiie. aeo?i.- 1998.- ?1.- N.62-64. 10. A?eiai?oeaaa I.?. Aeeoa?aioe?eia canoinoaaiiy ?ioiiaeoeaieo i?aia?ao?a o oai?eo ia ooaa?eoeueic //Iaaee/i? ia?niaeoeae.- 1998.-?2.- N.81-83. 11. E?eaeai?anueeee Ae.A., Eino?ii?ia A.I., A?eiai?oeaaa I.?. Aieea o?oioa?ai?? ia ooaa?eoeueicia caiaeaiiy ? ?ioi?oao a aenia?eiaio? //Iaaee/i? ia?niaeoeae.- 1998.- ?3.- N.51-52. 12. A?eiai?oeaaa I.?. Aieea aaiaoe/ieo oaeoi??a ia ?ioiieia?/io ?aaeoeai?noue oa oa?aeoa? oa/?? ooaa?eoeueico o ae?oae //Iaae?ao??y, aeooa?noai ? a?iaeieia?y.- 1998.- ?4.- N.24-26. 13. A?eiai?oeaaa I.?. Ooaa?eoe?iii?iaieaoe?ei? oanoe o ae?oae c iaeiae?aaeaieie oi?iaie ooaa?eoeueico //I?aeoe/ia iaaeeoeeia.- 1998.- ?5/6.-N.34-35. 14. Eino?ii?ia A.I., Aea?ea/ I.A., A?eiai?oeaaa I.?. Aea/aiiy ?iciiae?eo aioeaai?a a?noinoi?niino? aeey aeae?eaiiy a?oi i?aeaeuaiiai ?eceeo ?icaeoeo ooaa?eoeueico o ae?oae //I?aeoe/ia iaaeeoeeia.- 1998.-?5/6.-N.31-32. 15. Aaeiai?oeaaa I.E. Iiioeyoeeiiiue e noaiiioeyoeeiiiue ninoaa eeioioeeoia ia?eoa?e/aneie e?iae o aeaoae eioeoee?iaaiiuo ooaa?eoe?cii //Aano. i?iae. aeieiaee e iaaeeoeeiu.- 1998.-?6.- N.89-93. 16. Aaeiai?oeaaa I.E. I?eiaiaiea eiioiiaeoeaiuo i?aia?aoia a ea/aiee aieueiuo ooaa?eoe?cii aeaoae //Aanoi. i?iae. aeieiaee e iaaeeoeeiu.- 1998.-?12.- N.73-76. 17. Iao. 20870A. Oe?a?ia. A61A 5/00. Niin?a ae?aaiinoeee caoai?thaaiue eaaaiue /Aeoiaaiaoeue A.Ae., A?eiai?oeaaa I.?., Eino?ii?ia A.I., Aea?ea/ I.A., Oaeaiooa O.I., TH??a ?.I. (Oe?a?ia); Aei?i?iiao?. aea?ae.iaae.aeaaeai?y.- ?96041693; Cayae. 29.04.96.- 2n. //I?iieneiaa aeani?noue: Io?oe?eiee athe.- 1998.-?3.-N.3.1.23. 18. Iao. 20905A. Oe?a?ia. A61E 31/00. Niin?a e?eoaaiiy ooaa?eoeueico /E?eaeai?anueeee Ae.A., Eino?ii?ia A.I., Aea?ea/ I.A., Aeoiaaiaoeue A.Ae., A?eiai?oeaaa I.?., TH??a ?.I., Aaaoo?ia I.?. (Oe?a?ia); Aei?i?iiao?. aea?ae.iaae.aeaaeai?y.- ?96041696; Cayae. 29.04.96.- 1n. //I?iieneiaa aeani?noue: Io?oe?eiee athe.- 1997.-?6.-N.3.1.42. 19. Iao. 22854A. Oe?a?ia. A61E 31/00. Niin?a aecia/aiiy ?iaeea?aeoaeueii? /ooeeaino? aei e?ea?nueeeo i?aia?ao?a / TH??a ?.I., A?eiai?oeaaa I.?., Aeoiaaiaoeue A.Ae., Aa?aiaiei E.I. (Oe?a?ia); Aei?i?iiao?. aea?ae.iaae.aeaaeai?y.- ?96041694; Cayae. 29.04.96.- 2n. //I?iieneiaa aeani?noue: Io?oe?eiee athe. - 1998. - ?3. -N.3.1.61. 20. Aiaeec eeeieei-?aioaaiieiae/aneeo i?iyaeaiee e ninoiyiey eiioieoaoa o aeaoae n iaeuie oi?iaie ooaa?eoeaca aioo?ea?oaeiuo eeioaoe/aneeo oceia /Eino?iieia A.I., Aaeiai?oeaaa I.E.; Aeiai?iiao?. iaae. aeaaeaiey.-Aeiai?iiao?iane, 1993.-9n. - Aeai. a III "Nithciaaeeioi?i", ?23409. 21. Ninoiyiea eiioieoaoa o aeaoae n aia?aua auyaeaiiie aeia?a?aeae ia ooaa?eoeei /E?uaeaiianeee Ae.A., Aaeiai?oeaaa I.E., Aea?ea/ A.A., Eaieaeaineay A.O.; Aeiai?iiao?. iaae. aeaaeaiey.-Aeiai?iiao?iane, 1993.-11n. - Aeai. a III "Nithciaaeeioi?i", ?23410. 22. Eeeie/aneay oa?aeoa?enoeea e ia?ooaiey eiioieoaoa i?e au?aaeaiiuo oi?iao aioo?ea?oaeiiai ooaa?eoeaca o aeaoae /Aaeiai?oeaaa I.E.; Aeiai?iiao?. iaae. aeaaeaiey.-Aeiai?iiao?iane, 1993.-11n. - Aeai. a III "Nithciaaeeioi?i", ?23411. 23. Aea?ea/ A.A., Aaeiai?oeaaa I.E., Eaieaeaineay A.O. Eiioiieiae/aneay ?aaeoeaiinoue e iieacaoaee eeieiiaaiaca o aeaoae n iaeuie oi?iaie ooaa?eoeaca aioo?ea?oaeiuo eeioaoe/aneeo oceia //O? nuacae a?a/ae-ooeceao?ia: Na.-?acthia.- E., 1992.- N.126. 24. Aaeiai?oeaaa I.E. Eiioiieiae/aneea e aaiaoe/aneea ia?aeeaee o aeaoae aieueiuo ooaa?eoeacii i?aaiia aeuoaiey //O?? nuacae ooeceao?ia: Na.-?acthia.- Na?aoia, 1994.- N.140. 25. E?uaeaiianeee Ae.A., Eiaeooei I.TH., Aaeiai?oeaaa I.E. I?eiaiaiea aaeoa?eaeueiuo i?aia?aoia a ea/aiee aieueiuo ooaa?eoeacii //O??? nuacae ooeceao?ia: Na. - ?acthia.- Aeaoa?eiao?a, 1997.- N.32. 26. Aaeiai?oeaaa I.E. Eiioiiaaiaoe/aneea ia?ea?u ?acee/iuo i?iyaeaiee ooaa?eoeaca o aeaoae //Iaoa??aee iaoeiaeo i?aoeue ?? c?caeo ooec?ao??a ? ioeueiiiieia?a Oe?a?ie.- E., 1998.-N.60. 27. E?uaeaiianeee Ae.A., Aaeiai?oeaaa I.E., Auoiaaiaoe A.Ae. Eciaiaiea iiioeyoeeiiiiai e noaiiioeyoeeiiiiai ninoaaa eeioioeeoia o aeaoae n ia/aeueiuie i?iyaeaieyie ooaa?eoeaca //Iaoa??aee iaoeiaeo i?aoeue ?? c?caeo ooec?ao??a ? ioeueiiiieia?a Oe?a?ie.- E., 1998.-N.68. 28.Aaeiai?oeaaa I.E. Eco/aiea eiaeeaeaeoaeueiie /oanoaeoaeueiinoe in vitro e eiioiiaeoeaiui i?aia?aoai //8-e Iaoeeiiaeueiue eiia?ann ii aieaciyi i?aaiia aeuoaiey: Na. ?acthia.- I., 1998.- N.211. A?eiai?oeaaa I.?. Ee?i?ei-?ioiieia?/ia oa ?ioiiaaiaoe/ia oa?aeoa?enoeea ae?oae c ??cieie oi?iaie ooaa?eoeueico ? ei?aeoe?y ?ioiieia?/ieo ii?ooaiue. - ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy aeieoi?a iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.26 - ooec?ao??y.- ?inoeooo ooec?ao??? oa ioeueiiiieia?? AII Oe?a?ie, Ee?a, 1999. Aeena?oaoe?y i?enay/aia ieoaiiyi ee?i?/iiai ia?aa?ao, ?ioiiiaoiaaiaco oa ?ioiiei?aeoe??, aaiaoe/iei (HLA) oa?aeoa?enoeeai ??cieo oi?i ooaa?eoeueico o ae?oae. Io?eiai? aeai?, ye? aeaoaeueii oa?aeoa?ecothoue noai ?ioi?oaoo i?e ??cieo i?iyaao ooaa?eoeueico o ae?oae: iniaeeaino? aeni?an?? aioeaai?a ?ioiieiiiaoaioieo ee?oei - CD3, CD4, CD8, CD38, CD22, HLA-DR oa ?i., niieo/ai?noue ee?oeiieo oa aoii?aeueieo /eiiee?a, iieaciee?a ooieoe?iiaeueii? aeoeaiino? e?ioioeeo?a ? oaaioeeooth/eo ee?oei e?ia?. Aia?oa o ae?oae, ye? iaoeathoue a Oe?a?i?, aeyaeai? aaiaoe/i? ia?ea?e HLA noeeueiino? aei ooaa?eoeueico. ?ic?iaeaia iaoaiaoe/ia iiaeaeue i?iaiico ?iia??iino? ?icaeoeo ooaa?eoeueico a caeaaeiino? a?ae aaiaoe/ieo oa ciai?oi?o /eiiee?a. O ee?i?oe? oa aenia?eiaio? iieacaia aoaeoeai?noue canoinoaaiiy ?ioiiaeoeaieo i?aia?ao?a ??ciiai iioiaeaeaiiy oa iaoai?cio ae?? - oeiiaaio, a?inii?eio, a?aaoiio. Aeaii ee?i?ei-iaoiaaiaoe/ia iaa?oiooaaiiy aeey aeeoa?aioe?eiaaiiai ?o i?ecia/aiiy, cai?iiiiiaai? noaie canoinoaaiiy. ?acoeueoaoe aeine?aeaeaiiy oni?oii aeei?enoiaothoueny a ?iaio? ?yaeo niaoe?ae?ciaaieo aeeoy/eo caeeaae?a. Eeth/ia? neiaa: ooaa?eoeueic o ae?oae, ?ioiiee noaoon, nenoaia HLA, ?ioiiei?aeoe?y, aenia?eiaio. Belogortseva O.I. Clinico-immunologic and immunogenetic characteristic of children with various forms of tuberculosis and correction of immunologic disorders. - Manuscript. Dissertation for the degree of Doctor of Medicine, Speciality 14.01.26 - Phthisiology. - Academy of Medical Sciences of Ukraine, The Institute of Phthisiology and Pulmonology, Kiev, 1999. The dissertation deals with the problems of clinical course, immunopathogenesis and immunocorrection, genetic (HLA) characteristics of various forms of tuberculosis in children. Findings received give a detailed characteristic of the immunity status of children with various manifestations of tuberculosis: peculiarities of expression of antigenes of immunocompetent cells - ND3, ND4, ND8, ND38, ND22, HLA-DR and others; interrelation of cellular and humoral factors, of indices of functional activity of lymphocytes and of blood phagocytosing cells. HLA genetic markers of tuberculosis predisposition have been for the first time identified in children living in Ukraine. Mathematic model of prognosis of tuberculosis development probability depending on genetic and external factors has been worked out. Efficiency of immunoactive preparations of various origin and various mechanism of action (tymogen, biosporin, vivaton) was demonstrated both clinically and experimentally; clinico-pathogenetic substantiation of their usage was given and administration schemes were proposed. Results of the investigation are being successfully put into practice by a number of specialized children health care institutions. Key words: Tuberculosis in children, immunity status, HLA system, immunocorrection, experiment. Aaeiai?oeaaa I.E. Eeeieei-eiioiieiae/aneay e eiioiiaaiaoe/aneay oa?aeoa?enoeea aeaoae n ?acee/iuie oi?iaie ooaa?eoeaca e ei??aeoeey eiioiieiae/aneeo ia?ooaiee.- ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie aeieoi?a iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.26 - ooeceao?ey.- Einoeooo ooeceao?ee e ioeueiiiieiaee AII Oe?aeiu, Eeaa, 1999. I?aaenoaaeaiu aeaiiua eeeie/aneiai ianeaaeiaaiey 368 aeaoae oeieueiiai aic?anoa n ia/aeueiuie i?iyaeaieyie e eieaeueiuie oi?iaie ia?ae/iiai e aoi?e/iiai ooaa?eoeaca. I?aaeiaoii niaoeeaeueiuo enneaaeiaaiee noaee eiioiieiae/aneea e eiioiiaaiaoe/aneea enneaaeiaaiey. Eiio?ieueioth a?oiio aeey n?aaiaiey ?acoeueoaoia eiioiieiae/aneeo enneaaeiaaiee ninoaaeee 42 iaeioeoee?iaaiiuo ooaa?eoeacii ?aaaiea, aeey eiioiiaaiaoe/aneeo - 183 /aeiaaea. Aeey ioeaiee eiioiieiae/aneie ?aaeoeaiinoe i?eiaiyeny eiiieaen iaoiaeia, iicaieythueo ioeaieoue ninoiyiea O- e A-nenoai eiioieoaoa e ooieoeeth oaaioeeoe?othueo eeaoie (a iauae neiaeiinoe 33 iieacaoaey eiioieoaoa). A ?aaioa eniieueciaaiu nia?aiaiiua iaoiaeu eiioiiaeeaaiinoeee: ii?aaeaeaiea iiioeyoeee e noaiiioeyoeee eiioiieiiiaoaioiuo eeaoie n iiiiuueth iiiieeiiaeueiuo aioeoae, eiioiioa?iaioiue aiaeec, HLA-oeie?iaaiea ii 56 aioeaaiai eieonia A, B, C e ae?. A yenia?eiaioaeueiie /anoe auei eco/aii aeeyiea eiiieaeniiai oeoii?aia?aoa "Aeaaoii", iieo/aiiiai ec 27 eaea?noaaiiuo ?anoaiee (i?aia?ao ia eiaao aiaeiaia), ia eiioiioth nenoaio e ooaa?eoeaciia ainiaeaiea n o/aoii aaiaoe/anee iaoneiaeaiiie i?aae?aniieiaeaiiinoe e ooaa?eoeaco. A yenia?eiaioa auee eniieueciaaiu iaoioeceieiae/aneea, eiioiieiae/aneea, iaoiii?oieiae/aneea, iee?iaeieiae/aneea iaoiaeu. ?acoeueoaou ianeaaeiaaiey aeaoae, aieueiuo ooaa?eoeacii, iieacaee, /oi o aeaoae oeieueiiai aic?anoa a aieueoeinoaa neo/aaa eiaao ianoi aeaaii?eyoiia oa/aiea caaieaaaiey n i?aiaeaaeaieai iaineiaeiaiiuo e iaeuo oi?i. Iniaaiiinoe eeeie/aneiai oa/aiey ei??aee?otho ni noaiaiueth au?aaeaiiinoe eiioiieiae/aneeo ia?ooaiee e oa?aeoa?ii eiioiiiai ioaaoa. I?iaaaeaiiue eeeie/aneee aiaeec ?acee/iuo i?iyaeaiee ooaa?eoeaca o aeaoae a niiinoaaeaiee n eiiieaeniie ioeaieie ninoiyiey eiioiieiae/aneie ?aaeoeaiinoe (iniaaiiinoyie yeni?annee aioeaaiia eiioiieiiiaoaioiuo eeaoie - CD3, CD4, CD8, CD38, HLA-DR e ae?., nii?yaeaiiinoueth eeaoi/iuo e aoii?aeueiuo oaeoi?ia, iieacaoaeae ooieoeeiiaeueiie aeoeaiinoe eeioioeeoia e oaaioeeoe?othueo eeaoie) iicaieee auaeaeeoue eeeieei-eiioiieiae/aneea iniaaiiinoe ?acee/iuo oi?i ooaa?eoeaca e auyaeoue caaiuey, o?aaothuea eiioiiei??aeoeee. Iieacaii, /oi o aeaoae n ia/aeueiuie i?iyaeaieyie e iaeuie oi?iaie ooaa?eoeaca /aua ionoonoaotho i?eciaee enoeiiiai eiioiiaeaoeoeeoa (aeieaaea ?aoeaioi?iiai aiia?aoa eeioioeeoia oia?aiii au?aaeaia e eiiiaine?oaony aeoeaaoeeae niaoeeoe/aneiai eeaoi/iiai eiioieoaoa) e iieacaiey aeey iacia/aiey eiioiiei??aeoi?ia o ieo ia?aie/aiu. I?iaiinoe/anee iaaeaaii?eyoiie a ieaia oyaeanoe niaoeeoe/aneiai i?ioeanna yaeyaony aeoeaaoeey noi?anni?ii-oeeoioiene/aneiai caaia eiioieoaoa (CD8) ia oiia ieceeo iieacaoaeae eeaoi/iiai eiioieoaoa (CD3, CD4, CD4/CD8, A-?IE, Aa-?IE, ?AOE), nicaeathuea iaoiaaiaoe/aneee oii aeey ?acaeoey au?aaeaiiuo oi?i caaieaaaiey. Aia?aua o aeaoae, i?iaeeaathueo ia Oe?aeia, ii?aaeaeaiu aaiaoe/aneea ia?ea?u HLA i?aae?aniieiaeaiiinoe e ?acaeoeth ooaa?eoeaca e ia?aoiaea ia?ae/iiai i?ioeanna ai aoi?e/iue, a oaeaea eco/aia acaeiinaycue iaaeaeo aaiaoe/aneeie e aiaoieie oaeoi?aie, iiauoathueie ?ene caaieaaaiey ooaa?eoeacii. Iieacaii, /oi HLA oeie?iaaiea iiaeao auoue eniieueciaaii a ea/anoaa ne?eieiaiaiai iaoiaea i?iaiica ?acaeoey ooaa?eoeaca o aeaoae. ?ac?aaioaiiua iauaeoeaiua e?eoa?ee iicaieytho noi?ie?iaaoue a?oiiu n aunieei ioiineoaeueiui ?eneii caaieaaaiey ooaa?eoeacii, eiaeeaeaeoaeece?iaaoue aeeniaina?iia iaaethaeaiea e ea/aaioth oaeoeeo. I?aaenoaaeaiu ?acoeueoaou eco/aiey eeeie/aneie e eiioiieiae/aneie yooaeoeaiinoe ?acee/iuo aeaeia eiioiiei??aae?othuae oa?aiee. Aia?aua o aieueiuo ooaa?eoeacii aue i?eiaiai aaeoa?eaeueiue i?aia?ao - aeinii?ei, aeaii eeeieei-iaoiaaiaoe/aneia iainiiaaiea e aai eniieueciaaieth, i?aaeeiaeaia yooaeoeaiay noaia i?eiaiaiey. Iaoiaeeea i?eiaiaiey aeinii?eia iicaieyao ?anoe?eoue aiciiaeiinoe iaoiaaiaoe/aneie oa?aiee e o/eouaaao ?aaeueiua aiciiaeiinoe ea/aaiuo o/?aaeaeaiee anao o?iaiae. I?aaeeiaeaia aeey i?aeoe/aneiai eniieueciaaiey i?iaiinoe/aneay iiaeaeue yooaeoeaiinoe eiioiioeieioa?aiee, iieacaaoay, /oi ?acoeueoaou ea/aiey aieueiuo ooaa?eoeacii aeaoae a cia/eoaeueiie ia?a caaenyo io enoiaeiiai ninoiyiey eiioieoaoa e aeeyiey aaiaoe/aneeo oaeoi?ia HLA. I?aaenoaaeaiu eiee/anoaaiiua ia?aiao?u neeu aeeyiey i?iaiaeeiuo aeaeia ea/aiey (oeieioa?aiee, oeieioa?aiee a ni/aoaiee n oeiiaaiii, aeinii?eiii) ia ?acee/iua caaiuey eiioieoaoa o aieueiuo ooaa?eoeacii, eioi?ua iicaieytho a?a/o inouanoaeyoue aeeooa?aioee?iaaiiia iacia/aiea eiioiiei??aeoi?ia. Yenia?eiaioaeueiia eco/aiea yooaeoeaiinoe i?eiaiaiey oeoii?aia?aoa "Aeaaoii" iieacaei, /oi i?aia?ao iaeaaeaao iiuiuie eiioiiiiaeoee?othueie naienoaaie. I?eiaiaiea ni/aoaiiie oa?aiee (aioeaaeoa?eaeueiua i?aia?aou e "Aeaaoii") cia/eoaeueii oiaiueoaao iee?iaioth iiioeyoeeth a i?aaiecia iiaeiiuoiuo aeeaioiuo e eciaiyao oa?aeoa? oa/aiey ooaa?eoeaciiai i?ioeanna (oiaiueoaaony ianna aioo?aiieo i?aaiia e eiaeaen ii?aaeaiey) aieioue aei ecea/aiey. Iai?aaeaiiinoue e noaiaiue eiioiiei??aeoeee, yooaeoeaiinoue ea/aiey caaenyo io aaiaoe/anee iaoneiaeaiiie /oanoaeoaeueiinoe e ieeiaaeoa?eaeueiie eioaeoeee. Eeth/aaua neiaa: ooaa?eoeac o aeaoae, eiioiiue noaoon, nenoaia HLA, eiioiiei??aeoeey, yenia?eiaio.

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