Хроноритми функцій щитовидної залози, екскреторної функції нирок у хворих на дифузний токсичний зоб та гіпотиреоз: Автореф. дис… канд. мед. наук / Н

?INOEOOO AIAeIE?EIIEIA?? OA IAI?IO ?A*IAEI

?I. A.I.EII?NA?AIEA AII OE?A?IE

E?EAE* Iaoae?y A?eoi??aia

OAeE
616.441-002-073.66

O?iii?eoie ooieoe?? ueoiaeaeii? caeice, aene?aoi?ii? ooieoe?? ie?ie
o oai?eo ia aeeoociee oiene/iee cia oa a?iioe?aic

14.01.14 — aiaeie?eiieia?y

A a o i ? a o a ? a o

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Ee?a — 1998

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia a Aoeiaeinuee?e aea?aeaai?e iaaee/i?e aeaaeai?? IIC
Oe?a?ie ia eaoaae?? ee?i?/ii? ?ioiieia??, aea?aieia?? oa aiaeie?eiieia??

Iaoeia? ea??aieee(

Aeieoi? iaaee/ieo iaoe, i?ioani? I?oae Aaneeue Iaaeiae/,

Aoeiaeinueea aea?aeaaia iaaee/ia aeaaeai?y, caa?aeoaa/ eaoaae?e
iaaee/ii? a?ieia?? oa aaiaoeee

Aeieoi? iaaee/ieo iaoe, i?ioani? Ie?eiee Aaea??e Aiaoie?eiae/,

?inoeooo aiaeie?eiieia?? oa iai?io ?a/iaei ?i. A.I.Eii?na?aiea AII
Oe?a?ie, caa?aeoaa/ a?aeae?eo caaaeueii? aiaeie?eiii? iaoieia??

Io?oe?ei? iiiiaioe:

Aeieoi? iaaee/ieo iaoe, i?ioani?, /e.-ei?aniiiaeaio AII Oe?a?ie

Aiooaei Ian?e Aieiaeeie?iae/, ?inoeooo aiaeie?eiieia?? oa iai?io ?a/iaei
?i. A.I.Eii?na?aiea AII Oe?a?ie, caa?aeoaa/ eaai?aoi??? ooieoe?iiaeueii?
ae?aaiinoeee

Eaiaeeaeao iaaee/ieo iaoe Naa?ai Ieaia Aaea???aia, Oe?a?inueeee
iaoeiai-i?aeoe/iee oeaio? aiaeie?eiii? o??o?a?? ? o?ainieaioaoe??
i?aai?a oa oeaiei, caa?aeoaa/ a?aeae?eo ee?i?/ii? aiaeie?eiieia??

I?ia?aeia onoaiiaa: Euea?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao,
eaoaae?a aiaeie?eiieia??.

Caoeno a?aeaoaeaoueny (17( eenoiiaaea 1998 ?. i 1300 aiae. ia
can?aeaii? niaoe?ae?ciaaii? A/aii? ?aaee Ae.26.558.01 c aiaeie?eiieia??
a ?inoeooo? aiaeie?eiieia?? oa iai?io ?a/iaei ?i. A.I. Eii?na?aiea AII
Oe?a?ie (254114, Ee?a-114, aoe. Aeoai?iaenueea 69)

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? ?inoeoooo
aiaeie?eiieia?? oa iai?io ?a/iaei ?i. A.I. Eii?na?aiea AII Oe?a?ie
(254114, Ee?a-114, aoe. Aeoai?iaenueea 69)

Aaoi?aoa?ao ?ic?neaiee ( 13 ( aeiaoiy 1998 ?.

A/aiee nae?aoa? niaoe?ae?ciaaii? a/aii?

?aaee, aeieoi? a?ieia?/ieo iaoe
E.I.Eaeeinueea

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue ?iaioe: Oee?eaaeiaii? ?eoie aeeiiothoue aaaeeeao
ooieoeith neio?iiicaoei? oiciieiai/ieo i?ioeania. ?o ia?aiao?e iiaeooue
aooe naiinoieiith oa?aeoa?enoeeith oiciieiai/iiai noaio i?aaiicio. A
inoaii? ?iee, o ca’yceo c aeieia?/ii-iani?eyoeeaeie oiiaaie aeiae?eey,
c??n ??aaiue aiaeie?eiieo caoai?thaaiue, iniaeeai iaoieia?? ueoiaeaeii?
caeice (I.A.Aiooaei oa ni?aao., 1994, A.A.Ie?eiee, 1997). Oiio
i?iaaaeaiiy o?iiia?ieia?/ieo aeine?aeaeaiue a aiaeie?eiieia?? iaaoaa?
iniaeeai? aeooaeueiino? (O.E.Eiia?ia, 1989). Iaeiie/aii aaaaoi
na?ae/aiue uiaei aea/aiiy a?i?eoi?a ai?iiiaeueii? aeoeaiino? ?yaeo caeic
aiaeie?eiii? nenoaie, a naia a?iio?ca (A.A.Ie?eiee oa ni?aaao., 1997,
H.de Boer et al, 1989), iaaeie?iee?a ( M.Vance, 1989), noaoaaeo caeic
(S.Dias et al., 1989), oeoeiiiae?aiiai o?ea (A.I.I?oae, 1985,
D.Cardinali, 1989) oa ?io?. I?ioa, o?iii?eoie ueoiaeaeii? caeice,
o?iiiae?aaiinoeea oa o?iiioa?iaeieia?y ?? caoai?thaaiue aea/ai?
iaaeinoaoiuei, a ?nioth/? aeai? a?ae??ciythoueny aaeeeith
aa??aaaeuei?noth.

Caaaeueiia?aeiii, ui ie?eai aeanoeaa iaeaieueo /ioea ?eoii/ia
aeiyeueiinoue a i?aai?ci?, oiio aecia/aiiy ?a/iaei, ui aene?aoothoueny
ieie, aeicaiey? io?eiaoe oyao i?i ?eoii/io i?aaiicaoeith ?icieo nenoai
(O.E.Eiia?ia, 1989). Aieueoinoue aaoi?ia aeieoee aeniiaeo, ui ?iaioa
ie?ie a?aeaeca?eaeth? ooieoe?th ?aaoeyoi?ieo nenoai (A.Ae.Neaiooeei,
A.A.Iaoeineee, 1982, I.E.Aneaiyi e niaao., 1989). Aeaneio?iiic
o?c?ieia?/ieo nenoai i?aaiicio aeyaey?oueny ia ?aiiio noaaeiyo
caoai?thaaiiy i cia/ii ia?aaeo? ii?oieiai/iei ciiiai. Oe?ai?aeii ai?iiie
ni?e/eiythoue i?yio aeith ia ie?ee, ia ui aeaco? iayaiinoue a ieo
niaoeeoi/ieo ?aoeaioi?ia aei oe?ieneio oa o?eeiaeoe?iiiio
(I.H.Oppenheimer, 1983, L.D.Kohn et al., 1985). I?ioa, ie ia cono??/aee
aeaieo i?i no?oeoo?io i?aai?caoe?th o?iii?eoi?a aene?aoi?ii? ooieoe??
ie?ie o oai?eo c ii?ooaiiyi ooieoe?? ueoiaeaeii? caeice.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie: Aeena?oaoe?y ? o?aaiaioii
ieaiiaiai iaoeiaiai aeine?aeaeaiiy Aoeiaeinueei? aea?aeaaii? iaaee/ii?
aeaaeai?? “Aeine?aeeoe aieea e?ia?/ii? nenoaie iiceo oa aae?aia?a?/ieo
no?oeoo? ia ii?oiooieoe?iiaeueiee noai aiaeie?eiieo i?aai?a c iaoith
anoaiiaeaiiy aca?iica’yce?a i?ae ieie a caeaaeiino? a?ae a?eo oa
a?ieia?/ieo ?eoi?a” (iiia? aea?aeaaii? ?a?no?aoe?? 01.9.10010096 a?ae
19.04.1991?.)

Iaoa ?iaioe: Aeyaeoe iniaeeaino? o?iii?eoi?a ooieoe?? ueoiaeaeii?
caeice, o?iii?eoi?a aene?aoi?ii? ooieoe?? ie?ie o oai?eo ia aeeoociee
oiene/iee cia ? a?iioe?aic oa ?o aca?iica’ycie.

Caaaeaiiy aeine?aeaeaiiy:

1. Anoaiiaeoe iniaeeaino? oee?eaae?aiieo ?eoi?a ooieoe?? ueoiaeaeii?
caeice i?e aeeoociiio oiene/iiio cia? oa a?iioe?aic?.

2. Aea/eoe noai aene?aoi?ii? ooieoe?? ie?ie o oai?eo ia aeeoociee
oiene/iee cia ? a?iioe?aic.

3. Aeine?aeeoe o?iii?eoie aene?aoi?ii? ooieoe?? ie?ie o iaoe??io?a c
ii?ooaiiyi ooieoe?? ueoiaeaeii? caeice.

4. Aeyaeoe iiaeeeaee aieea o?iii?eoi?a ooieoe?? ueoiaeaeii? caeice ia
o?iii?eoie aene?aoi?ii? ooieoe?? ie?ie a ii?i? ? i?e iaoieia??
ueoiaeaeii? caeice.

5. ?ic?iaeoe i?eioeeie o?iiiae?aaiinoeee aeine?aeaeaiiy ai?noo
oe?ai?aeieo ai?iii?a o oai?eo c ii?ooaiiyi ooieoe?? ueoiaeaeii? caeice.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a: Aeyaeaiee aeaneio?iiic
ooieoe?? ueoiaeaeii? caeice i?e ?? iaoieia??, ia i?aenoaa? /iai aia?oa
?ic?iaeai? ?aeiiaiaeaoe?? uiaei o?iiiae?aaiinoeee aeeoociiai oiene/iiai
ciao oa a?iioe?aico.

Aia?oa aeine?aeaeaii o?iii?eoie aene?aoi?ii? ooieoe?? ie?ie o oai?eo ia
aeeoociee oiene/iee cia ? a?iioe?aic. Anoaiiaeaii, ui i?e ii?ooaii?
ooieoe?? ueoiaeaeii? caeice oee?eaae?aiiee ?eoi aene?aoi?ii? ooieoe??
ie?ie ci?ith? naith no?oeoo?o. Aeiaaaeaii aieea o?iii?eoi?a ooieoe??
ueoiaeaeii? caeice ia o?iii?eoie aene?aoi?ii? ooieoe?? ie?ie.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a: Ia i?aenoaa? aeine?aeaeaiiy
oee?eaae?aiieo ?eoi?a ooieoe?? ueoiaeaeii? caeice, o?iii?eoi?a
aene?aoi?ii? ooieoe?? ie?ie o oai?eo ia aeeoociee oiene/iee cia ?
a?iioe?aic iaoeiai iaa?oioiaai?, ?ic?iaeai? ? ai?iaaaeaeai? a i?aeoeeo
i?eioeeie o?iiiae?aaiinoeee ii?ooaiue ooieoe?? ueoiaeaeii? caeice.

Iniiai? iaoeia? iieiaeaiiy, ui aeianai? ia caoeno:

O?iii?eoie ooieoe?? ueoiaeaeii? caeice aieeaathoue ia oee?eaae?aii?
?eoie aene?aoi?ii? ooieoe?? ie?ie.

O iaoe??io?a c aeeoociei oiene/iei ciaii a?aeaoaa?oueny cnoa ae?ioac
ai?noo oe?ai?aeieo ai?iii?a a ne?iaaooe? e?ia? a a?e aeaiieo ? aa/??i?o
aiaeei, aeoiaey/e c /iai caa?? e?ia? aeey i?iaaaeaiiy oeeo
aeine?aeaeaiue a?eueo aeioe?eueii i?iaiaeeoe a ae?oa?e iieiaei? aeiy.

O oai?eo ia a?iioe?aic ae?ioace ai?noo oe?ai?aeieo ai?iii?a a
ne?iaaooe? e?ia? i?eiaaeathoue ia ?aieiaee, aaoeoace — ia aeaiiee
ia??iae aeiae, ia i?aenoaa? /iai ?o aeine?aeaeaiiy e?aua i?iaiaeeoe
aaeaiue.

Oee?eaae?aii? ?eoie aene?aoi?ii? ooieoe?? ie?ie o oai?eo ia aeeoociee
oiene/iee cia ? a?iioe?aic ci?iththoue naith no?oeoo?o ? iiaeooue
aeei?enoiaoaaoenue ye naiino?ei? ae?aaiinoe/i? oanoe.

Iniaenoee aianie iiooeoaa/a: Aaoi?ii naiino?eii i?iaaaeaii
aeine?aeaeaiiy oee?eaae?aiieo ?eoi?a ooieoe?? ueoiaeaeii? caeice oa
aene?aoi?ii? ooieoe?? ie?ie, noaio aiaeii-nieueiai? ??aiiaaae o oai?eo
ia aeeoociee oiene/iee cia oa a?iioe?aic, aeeiiaia noaoenoe/ia ia?iaea ?
iaoeiaa ?ioa?i?aoaoe?y io?eiaieo aeaieo.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??: Iniiai? iieiaeaiiy
aeiiia?aeaeenue ia iaoeiai-i?aeoe/i?e eiioa?aioe?? “Aeooaeuei? i?iaeaie
aeeoy/i? oa i?aee?oeiai? aiaeie?eiieia??” (Oa?e?a, 1995?.), ia
i?aeia?iaeieo neiiic?oiao “O??o?a?/i? i?iaeaie ? aeieia?y” (*a?i?aoe?,
1995?., 1996?.), “Aeooaeuei? ieoaiiy iaaee/ii? aeiiiiiae ianaeaiith”
(*a?i?aoe? — Aiaaeueoieuei, 1996?.).

Ioae?eaoe?? oa ?io? oi?ie ai?iaaaeaeaiiy:

Ca oaiith ?iaioe iioae?eiaaii 16 ?ia?o. Na?aae ieo 4 noaoo? o
oeaio?aeueieo oaoiaeo aeaeaiiyo, 4 ?io? iaoeia? noaoo?, 8 oac.

?acoeueoaoe aeine?aeaeaiue ai?iaaaeaeai? o i?aeoeeo ?iaioe a?aeae?eaiue
*a?i?aaoeueeiai iaeaniiai aiaeie?eiieia?/iiai aeeniaina?o, iniiai?
iieiaeaiiy aeei?enoiaothoueny i?e i?iaaaeaii? i?aeoe/ieo caiyoue c
aiaeie?eiieia?? a Aoeiaeinuee?e aea?aeaai?e iaaee/i?e aeaaeai??.

Ia’?i ? no?oeoo?a aeena?oaoe??: Aeena?oaoe?y aeeeaaeaia ia 200
noi??ieao, i?noeoue anooi, ?icae?ee “Iaeyae e?oa?aoo?e”, “Iaoiaee
aeine?aeaeaiiy”, “Ee?i?/ia oa?aeoa?enoeea ianoaaeaieo oai?eo”, “Io?eiai?
?acoeueoaoe”, “Iaaiai?aiiy io?eiaieo ?acoeueoao?a”, aeniiaee oa
i?aeoe/i? ?aeiiaiaeaoe??, iieaae/ee e?oa?aoo?e. ?iaioa ?ethno?iaaia 40
oaaeeoeyie oa 22 ?enoieaie. Nienie e?oa?aoo?e i?noeoue 289 aeaea?ae.

CI?NO ?IAIOE

Caaaeueia oa?aeoa?enoeea oai?eo ? iaoiaee ?o ianoaaeaiiy

A iniiao ?iaioe iieeaaeaiee iaoa??ae eiiieaeniiai aeine?aeaeaiiy
oee?eaae?aiieo ?eoi?a ooieoe?? ueoiaeaeii? caeice, aene?aoi?ii? ooieoe??
ie?ie o 78 oai?eo ia aeeoociee oiene/iee cia (AeOC), 25 — ia a?iioe?aic,
ye? ciaoiaeeeenue ia e?eoaaii? a *a?i?aaoeueeiio iaeaniiio
aiaeie?eiieia?/iiio aeeniaina?? i?ioyaii 1995 — 1996 ??., oa 20
i?aeoe/ii caei?iaeo in?a, ui neeaee eiio?ieueio a?oio. A a?oio
ianoaaeaieo oa?eoee iaoe??ioe c oe?aioieneeicii ? ia?aeiiei a?iioe?aicii
a noaae?? aeaeiiiainaoe?? aac noiooi?o caoai?thaaiue oa ae?aaeaii?
iaaeinoaoiino? e?iaiia?ao. Aaaee?noue oe?aioieneeico oa a?iioe?aico
anoaiiaethaaeenue ca nooiaiyie i?iyao ee?i?/ieo neiioii?a.

Na?aae oai?eo ia AeOC 26 aoee c oe?aioieneeicii eaaeiai nooiaiy (Oe),
32 — c oe?aioieneeicii na?aaeiueiai nooiaiy aaaeeino? (On), 20 — c
aaaeeei oe?aioieneeicii (Oa); 8 oai?eo ia a?iioe?aic -c eaaeei nooiaiai
aaaeeino? caoai?thaaiiy (Ae), 6 — c na?aaei?i (An), 11 — c aaaeeei
a?iioe?aicii (Aa). A?eueo?noue iaoe??io?a neeaaeaee ae?iee (65 ae?iie oa
13 /ieia?e?a c AeOC oa 20 ae?iie ? 5 /ieia?e?a c a?iioe?aicii).

Aeine?aeaeaiiy ooieoe?iiaeueiiai noaio ueoiaeaeii? caeice i?iaiaeeee ca
aeiiiiiaith aecia/aiiy ai?noo a ne?iaaooe? e?ia? oe?ieneio (O4),
o?eeiaeoe?ii?io (O3), oe?aio?iiiiai ai?iiio (OOA), oe?aiaeiaoe?io (OA).
??aaiue oe?ieneio aecia/aee iaoiaeii ?aae?i?ioiiiai aiae?co ca
aeiiiiiaith iaai?o ??i-O4-?I?, o?eeiaeoe?ii?io — ??i -O3-?I?,
oe?aiaeiaoe?io — ??i — OA 125J ?c aeei?enoaiiyi oe?aiaeiaoe?io, i?/aiiai
eiaeii — 125 (A?ei?onue), oe?aio?iiiiai ai?iiio-?EA-OOA (*ao?y) ia
?aae?i?ioiiiio aiae?caoi?? “Aaiia-12”.

Eiioeaio?aoe?th ?ii?a iao??th ? eae?th a ieaci? e?ia?, a?eo?ioeeoao oa
na/? aecia/aee iaoiaeii oioiiao??? iieoi’y ia “OIE -1”, e?aaoei?io — ca
?aaeoe??th c i?e?eiiaith eeneioith (N.E.?yaia e niaao., 1979) c
?a?no?aoe??th iieaciee?a aenoeioe?? ia oioieaei?eiao?? “EOE — 2” ?
niaeo?ioioiiao?? “NO — 46” (A.E.Ia?cii, 1974).

Oaeaee?noue eeoai/eiai? o?eueo?aoe?? ?ic?aoiaoaaee ca ee??ainii
aiaeiaaiiiai e?aaoei?io. Ae?aoiaoaaee eaiaeueoeaaee o?ainii?o ?ii?a.
Aeey ioe?iee o?ainii?oo aeaeo?ie?o?a a ie?eao aeei?enoiaoaaee iieacieee
ee??aino, aene?aoi?io o?aeoe?th ?ii?a iao??th. ?ic?aoiaoaaee aene?aoe?th
e?aaoei?io, ?ii?a iao??th ? eae?th ca 3, 12, 24 aiaeeie. Ioe?ieo
eaiaeueoeaaiai o?ainii?oo aiaee i?iaiaeeee ca iieacieeaie ?aaani?aoe??
aiaee oa ?? aene?aoi?ii? o?aeoe??.

Oee?eaae?aii? ?eoie ooieoe?? ueoiaeaeii? caeice aea/aee ca aeiiiiiaith
aecia/aiiy ai?noo O3, O4, OOA a ne?iaaooe? e?ia? o?e/? ai?iaeiaae aeiae
(08.00; 16.00; 24.00).Oee?eaae?aii? ?eoie aene?aoi?ii? ooieoe?? ie?ie
aeine?aeaeoaaee oeyoii aecia/aiiy ia’?io na/?, ai?noo ?ii?a iao??th ?
eae?th, e?aaoei?io a 3-aiaeeiieo ii?oe?yo na/? i?ioyaii aeiae.

A aeii ianoaaeaiue oai?? aeio?eioaaeenue noaiaea?oeciaaiiai ?aaeeio
nii-aaaeuei??noue, 4-?aciaiai ciioaiiai ?aoeiiio aac iaiaaeaiiy o
i?eeiii ?iaeeie oa c iiii?iei (aei 10a/aeiao) aaeeaaiiyi eooiiii? niei.

Io?eiai? aeai? ia?iaeai? ca aeiiiiiaith ein?ii?-aiae?co. Aea/aee oae?
ia?aiao?e ?eoio: iaci? (na?aaeiueiaeiaiaee ??aaiue aeine?aeaeoaaiiai
iieacieea), aiie?ooaeo (??cieoeth iaeneiaeueiiai a?aeoeeaiiy a?ae
iaci?o), ae?ioaco (iiiaio /ano, a yeee a?aei?/aeinue iaeneiaeueia
cia/aiiy iieacieea) ? aaoeoaco (iiiaio /ano, a yeee niinoa??aaeinue
i?i?iaeueia cia/aiiy iieacieea).

?acoeueoaoe aeine?aeaeaiue ia?iaeai? ia AII IBM PC 486 DX 4-100 ca
aeiiiiiaith i?ia?aie Microsoft Excel.

O?iii?eoie ooieoe?? ueoiaeaeii? caeice o oai?eo ia aeeoociee oiene/iee
cia oa a?iioe?aic

A oiae? aeine?aeaeaiiy aeyaeaiee aeaneio?iiic ooieoe?? ueoiaeaeii?
caeice o iaoe??io?a c AeOC oa a?iioe?aicii (oaaeeoey 1).

O oai?eo c Oe ca?eueooaaeenue iaci?e oa aiie?ooaee O3 oa O4 (?<0,001), iaci? OOA ciaiooaaany (?<0,001),. aiie?ooaea eiai ia caciaaaea ?noioieo ci?i a?aeiinii eiio?ieth (P>0,05). A?aei?/aany cnoa ae?ioac O3 (ia
4aiae. 44oa.), O4 (ia 8aiae. 40oa.) a a?e aeaiieo oa aa/??i?o aiaeei oa
aaoeoac O3 (ia 8aiae. 34oa.), O4 (ia 8aiae. 48oa.) a a?e ?aieiaeo
aiaeei. Ae?ioaca oa aaoeoaca OOA nooo?ai ia a?ae??ciyeanue a?ae
eiio?ieth.

I?e On iaci?e O3 oa O4 c?inoaee a??ia?aeii ?noioi?oa, i?ae i?e Oe
(?<0,05, ?<0,001 a?aeiia?aeii). Aiie?ooaea O3 ca?eueooaaeanue (?<0,001), O4 - ciaiooaaeanue (?<0,01) uiaei eiio?ieth. Niinoa??aaeinue ciaioaiiy iaci?o (?<0,001) ? aiie?ooaee OOA (?<0,01) ii a?aeiioaiith aei eiio?ieueii? a?oie aac nooo?aeo ci?i uiaei Oe (P>0,05 a?aeiia?aeii).
A?aei?/aany cnoa ae?ioac O3 (ia 5aiae. 11oa.) oa O4 (ia 10aiae. 52oa.) a
a?e aeaiieo oa aa/??i?o aiaeei, i?e/iio aeey O4 a?eueo ae?aaeaiee (ia
2aiae. 12oa.), i?ae i?e Oe, a oaeiae ci?uaiiy aaoeoac iieaciee?a (O3 —
ia 9aiae. 23oa., O4 — ia 9aiae. 28oa.) a a?e ?aieiaeo aiaeei. Ae?ioaca
OOA nooo?ai ia ci?ieeany.

O iaoe??io?a c Oa a?aei?/aeinue nooo?aa ca?eueoaiiy iaci??a O3 (P<0,05 oa P<0,01), O4 (P<0,001 oa P<0,05) a ii??aiyii? c aaee/eiaie oeeo iieaciee?a i?e Oe oa On. Aiie?ooaea O3 c?inea (P<0,001 oa P<0,01), O4 a??ia?aeii ia a?ae??ciyeanue a?ae aeaieo i?e Oe oa On. Iaci? OOA, a oaeiae eiai aiie?ooaea nooo?ai (?>0,05) ia a?ae??ciyeeny a?ae iieaciee?a
i?e ?ioeo nooiaiyo aaaeeino? caoai?thaaiiy. A?aei?/aany cnoa ae?ioac O3
(ia 4aiae. 01oa.) oa O4 (ia 12aiae. 18oa.) uiaei eiio?ieth a a?e aeaiieo
oa aa/??i?o aiaeei, yeee aeey O4 aoa a?eueo ae?aaeaiei, i?ae i?e ?ioeo
oi?iao caoai?thaaiiy (ia 3aiae. 38oa. ii??aiyii c Oe oa ia 1aiae. 19oa.
ii??aiyii c On). A?aeaoaaany cnoa aaoeoac (O3 — ia 8aiae. 17oa. oa O4 —
ia 10aiae. 02oa.) a a?e ?aieiaeo aiaeei uiaei eiio?ieth. Ae?ioaca OOA ia
a?ae??ciyeanue a?ae eiio?ieth.

C?inoaiiy iaci??a O3 oa O4 oe?eeii caeiiii??ii, ine?eueee a?aeaoaa?oueny
ca?eueoaiiy ??aiy oe?ai?aeieo ai?iii?a. Aeieea? ieoaiiy, /iio aiie?ooaea
O4 c?inoa? i?yii, a O3 — iaa?iaii i?iii?oe?eii nooiaith aaaeeino?
caoai?thaaiiy. Oaea iaocaiaeaeai?noue i?ae ?eoiaie iiaea caeaaeaoe a?ae
eiiaa?n?? oeeo ai?iii?a, ui iaoiiaeth?oueny aeoeai?noth 5/-aeaeiaeeiace.
Oea i?eiouaiiy i?aeoaa?aeaeo?oueny ?iaioaie M.Muracami et al. (1988,
1989), a yeeo aeyaeai? o?iii?eoie aeoeaiino? eiaeoe?ii?i —
5/-aeaeiaeeiace c ae?ioacith ii?aii/?. Ciaioaiiy iaci?o OOA
iiynith?oueny cieaeaiiyi ??aiy inoaiiueiai a ieaci? e?ia? i?e ia?aeiiiio
oe?aioieneeic? ca i?eioeeiii cai?ioiiai ca’yceo.

I?e aiae?c? ?eoio ooieoe?iiaeueii? aeoeaiino? a?iio?ca?ii-oe?ai?aeii?
nenoaie i?eaa?oa? oaaao ?ica?aei?noue ca /anii oaeeue iaeneiaeueii?
nae?aoe?? OOA oa oe?ai?aeieo ai?iii?a. A?eueoa oiai, ae?ioaca OOA ia
ia?aaeo? ae?ioacai nae?aoe?? O3 ? O4. I/aaeaeii, oee?eaae?aiiee ?eoi
ai?noo a ieaci? e?ia? O3 ? O4 caeaaeeoue ia o?eueee a?ae OOA-aeoeaiino?.

Cnoa ae?ioac iieaciee?a, ia iaoo aeoieo, iia’ycaiee c ii?ooaiiyi
oe?ai?aeii-ai?o?ca?ieo a?aeiinei i?e i?aeaeuaii? ooieoe?? ueoiaeaeii?
caeice. A?aeiii, ui oe?aioieneeic aeeeeea? ??cea ca?eueoaiiy
eiioeaio?aoe?? iaeaoii?io (ca aeaieie E.A.Aiiaea?aiei (1991) — a 8,5
?ac?a). A naith /a?ao, aeoiaey/e c i?eioeeio cai?ioiiai ca’yceo, ci?ie a
oeoeiiiae?aiiio o?e?, ye? a?aeaoeeny i?e oe?aioieneeic?, aeeeeeaee
aeieeiaiiy aeaneio?iiico ooieoe?? ueoiaeaeii? caeice.

A?aoiaoth/e aeuacacia/ai? ci?ie, iiaeia ae?eoe aeniiaeo, ui caa?? e?ia?
aeey aeine?aeaeaiiy ai?noo oe?ai?aeieo ai?iii?a o iaoe??io?a c AeOC
a?eueo ?ioi?iaoeaii i?iaiaeeoe a ae?oa?e iieiaei? aeiy. Ee?i?/ia
aeine?aeaeaiiy a?aioe? aaaaea?ii iaei?ioi?iaoeaiei, ine?eueee o oai?eo
ia oe?aioieneeic ia ?aieia? aiaeeie i?eiaaeathoue aaoeoace iieaciee?a.

sse aeaeii c oaaeeoe? 1, o iaoe??io?a c Ae niinoa??aaeiny cieaeaiiy ii
a?aeiioaiith aei eiio?ieth iaci?o oa aiie?ooaee O3 (?<0,001) oa O4 (?<0,001, ?<0,01 a?aeiia?aeii), ca?eueoaiiy iaci?o OOA (?<0,001) oa ciaioaiiy eiai aiie?ooaee (?<0,01), cnoa ae?ioace O3 (ia 7aiae. 33oa.) a a?e ?aieiaeo aiaeei, ae?ioace OOA (ia 2aiae. 42oa.) a a?e aa/??i?o aiaeei, oa aaoeoace O3 (ia 7aiae. 53oa.) a a?e aeaiieo aiaeei. I?e An a?aei?/aeinue a?eueo iii?oia, i?ae i?e Ae, cieaeaiiy iaci?o oa aiie?ooaee O3 (?<0,05, ?<0,001 a?aeiia?aeii) ? O4 (?<0,001), i?aeaeuaiiy iaci?o OOA (?<0,05) aac a??ia?aeieo ci?i eiai aiie?ooaee (P>0,05).
A?aeaoaaany cnoa ae?ioace O3 (ia 6aiae. 17oa.) ia ?aieia? aiaeeie,
aaoeoace — ia aeaii? aiaeeie (ia 6aiae. 36oa.), ae?ioace OOA (ia 3aiae.
15oa.) a a?e aa/??i?o aiaeei, iii?oi?oee, i?ae i?e Ae, aaoeoace — a a?e
?aieiaeo aiaeei (ia 4aiae. 00oa.).

O iaoe??io?a c Aa niinoa??aaeinue a?eueoa ciaioaiiy iaci??a O3 (P<0,001) ? O4 (P<0,01) ii??aiyii c Ae ? ia a?aei?/aeinue ?noioieo ci?i a?aeiinii An (P>0,05). Aiie?ooaea OOA cieaeoaaeanue i?iii?oe?eii ?c aaaee?noth
caoai?thaaiiy (P<0,01 a?aeiinii Ae ? P<0,05 a?aeiinii An). Iaci? inoaiiueiai aiaeia?/ii c?inoaa (P<0,01 a?aeiinii Ae oa P<0,05 a?aeiinii An). A?aeaoaaany cnoa ae?ioace O3 (ia 6aiae. 41oa.) ia ?aiie, oa aaoeoace eiai (ia 7aiae. 20oa.) ia aeaiue. Ae?ioaca O4 ?noioii ia ci?ithaaeanue, aaoeoaca i?eiaaeaea ia aeaii? aiaeeie. Niinoa??aaeinue ci?uaiiy ae?ioace OOA o a?e aa/??i?o (ia 4aiae. 20oa.) aiaeei i?iii?oe?eii aaaeeino? caoai?thaaiiy (ia 2aiae.40oa. ii??aiyii c Ae oa ia 1aiae. 05oa. c An). Aaoeoaca OOA cnoioeanue a a?e ?aieiaeo aiaeei (ia 5aiae. 28oa.), a?eueo iii?oii, i?ae i?e ?ioeo nooiaiyo aaaeeino? caoai?thaaiiy (ia 4aiae. 28oa. ii??aiyii c Ae ? ia 1aiae. 28oa. ii??aiyii c An). Ciaioaiiy iaci??a ? aiie?ooae O3 oa O4 iia’ycaia ?c cieaeaiiyi ooieoe?? ueoiaeaeii? caeice. I?aeaeuaiiy iaci?o ? aiie?ooaee OOA a?aeaoaa?oueny ca i?eioeeiii cai?ioiiai ca’yceo. Ciaioaiiy i?/iiai i?eo i?aeeiio ??aiy OOA a ieaci? e?ia?, i/aaeaeii, iia’ycaii c ii?ooaiiyi ?eoi?a a?iioaeai?/ii? ?aaoeyoe??. Ia iaoo aeoieo, cnoa ae?ioac iieaciee?a i?e a?iioe?aic? a?aeaoaa?oueny o ca’yceo c ii?ooaiiyi oe?ai?aeii-ai?o?ca?ieo aca?iia?aeiinei: a?iioe?aic aeeeeea? ?noioia cieaeaiiy eiioeaio?aoe?? iaeaoii?io oa ci?ie a oeoeiiiae?aiiio o?e?, ye?, a naith /a?ao, ca i?eioeeiii cai?ioiiai ca’yceo i?ecaiaeyoue aei ii?ooaiue ?eoi?a ooieoe?? ueoiaeaeii? caeice. Aoaeo iaeaoii?io ?aae?co?oueny /a?ac niaoeeo?/i? ?aoeaioi?e, ui ?ici?uai? ia iaia?ai? oe?ioeeo?a (A.N.?ii-Aiaoneaaneay, 1989). Ine?eueee o iaoe??io?a c a?iioe?aicii ae?ioaca O3 oa O4 i?eiaaea? ia ?aieia? aiaeeie, a aaoeoaca - ia aeaii? aiaeeie, aecia/aiiy ??aiy O3 oa O4 o oai?eo ia a?iioe?aic a?eueo ?ioi?iaoeaii i?iaiaeeoe aaeaiue. Noai aiaeii-nieueiai? ??aiiaaae o oai?eo ia aeeoociee oiene/iee cia oa a?iioe?aic O oai?eo c AeOC ai?no ?ii?a iao??th (149,1+1,22 iIieue/e) a ieaci? e?ia? ia ci?ithaaany uiaei eiio?ieth (146,7+1,45iIieue/e, P>0,05). ??aaiue
?ii?a iao??th a a?eo?ioeeoao aeuee, i?ae o caei?iaeo in?a (a?aeiia?aeii
23,9+0,46iIieue/e ? 19,4+0,59 iIieue/e, P<0,001). I?ioa, iaia?aiiee a?aae??io Na+ieacie/Na+a?eo?ioeeo?a o oeeo oai?eo cia/ii ieae/ee, i?ae a eiio?ieuei?e a?oi? (6,3+0,16 oa 7,6+0,17 a?aeiia?aeii, P<0,001). Ioaea, o a?eueoino? iaoe??io?a iaaeeeoeiai iaeiie/o?oueny iao??e aioo??oiueiee?oeiii i?e iaci?iiiio ai?no? a iicaee?oeii?e ??aeei?. Oea i?ecaiaeeoue aei cia/iiai cieaeaiiy a?aae??ioo Na+ieacie/ Na+a?eo?ioeeo?a. Ai?no ?ii?a eae?th a ieaci? e?ia? o oai?eo ia AeOC (3,9+0,06 iIieue/e) ia a?ae??ciyany a?ae eiai aaee/eie o caei?iaeo in?a (4,1+0,07 iIieue/e, ?>0,05). Eiioeaio?aoe?y eae?th a a?eo?ioeeoao cieaeoaaeany
(85,2+0,76iIieue/e — oai??; 96,1+1,07 iIieue/e — caei?ia?, P<0,001). Iaia?aiiee a?aae??io K+a?eo?ioeeo?a/E+ieacie ia caciaaaa ci?i a aeiaei?e a?oi? ianoaaeaieo oai?eo. Oaeei /eiii, o a?eueoino? oai?eo ia AeOC cieaeoaaany eiao?oe??io K+a?eo?ioeeo?a/Na+a?eo?ioeeo?a ? ??aaiue aioo??oiueiee?oeiiiai eae?th i?e ii?iaeueiiio ai?no? eiai a iicaee?oeii?e ??aeei?. Eiao?oe??io Na+ieacie/K+ieacie aoa a??ia?aeii i?aeaeuaiee (37,2+0,34) ii a?aeiioaiith aei eiio?ieth (34,9(0,33, P<0,001), eiao?oe??io K+a?eo?ioeeo?a/Na+a?eo?ioeeo?a - a??ia?aeii cieaeaiee (3,6+0,11) ii??aiyii ?c ??aiai iieacieea o caei?iaeo in?a (4,9+0,13, P<0,001). Aeiaiaee ae?o?ac a??ia?aeii c?inoaa ii??aiyii ?c eiio?ieai (1080,2+15,41ie/24aiae.) i?e Oe (1492,3+20,32 ie/24aiae, P <0,001) oa On (1369,3+18,55 ie/24aiae., ?<0,001) ? a??ia?aeii cieaeoaaany i?e Oa (857,4+11,24ie/24aiae., ?<0,001). I?e Oe c?inoaa ye aeaiiee, oae ? i?/iee ae?o?ac. Oaeo naio oaiaeaioe?th niinoa??aaee i?e On. I?e Oa aeaiiee oa i?/iee ae?o?ac a??ia?aeii cieaeoaaeenue. Oaeaee?noue eeoai/eiai? o?eueo?aoe?? ii??aiyii ?c eiio?ieai (104,6(1,19ie/oa.) caciaaaea aiaeia?/ieo ci?i (141,2+1,61ie/oa., P<0,001; 119,1+1,43 ie/oa., P<0,01; 72,6+1,05 ie/oa., P<0,001 a?aeiia?aeii). ?aaani?aoe?y aiaee ciaiooaaeanue ii a?aeiioaiith aei eiio?ieth (99,3+0,01%) i?e On ? Oa (99,2+0,01%; 99,2+0,01%, P<0,01). Aeiaiaa aene?aoe?y e?aaoei?io ca?eueooaaeanue ii a?aeiioaiith aei oaei? o caei?iaeo in?a (10,9+0,13 ieI/24aiae.) i?e Oe ? On (16,2+0,22ieI/24 aiae., P<0,001 oa 14,6+0,17ieI/24aiae., ?<0,01) oa ciaiooaaeanue i?e Oa (8,7+0,34ieI/24aiae., P<0,001). I?e Oe c?inoaee ye aeaiiee, oae ? i?/iee e?aaoei?io?ac, i?e On ca?eueooaaany o?eueee aeaiiee. O iaoe??io?a c Oa ciaiooaaeanue ye aeaiia, oae ? i?/ia o?aeoe?y aeiaiaiai e?aaoei?io?aco. Aeiaiaa aene?aoe?y ? o?eueo?aoe?eiee ca?yae ?ii?a iao??th uiaei eiio?ieth (147,4+2,04iI/24aiae.; 15,3+1,09iI/oa a?aeiia?aeii) i?aeaeuoaaeenue i?e Oe (213,5+2,67iI/24aiae., P<0,001; 20,8+1,48iI/oa, P<0,05), ia a?ae??ciyeenue i?e On (138,7+3,75iI/24 aiae., P>0,05,
17,8+1,27iI/oa., P>0,05) oa cieaeoaaeenue i?e Oa (119,6+1,75iI/24 aiae.,
P<0,001, 10,9+0,78iI/oa., P<0,05). A?aei?/aeinue a??ia?aeia c?inoaiiy ye aeaiiiai, oae ? i?/iiai iao??eo?aco a a?oi? oai?eo ia Oe. O iaoe??io?a c On niinoa??aaee a??ia?aeia ciaioaiiy aeaiii? aene?aoe?? iao??th, a oie /an ye i?/ia nooo?ai ia a?ae??ciyeanue a?ae eiio?ieth. I?e Oa aeaiiee ? i?/iee iao??eo?ac a??ia?aeii ciaiooaaeenue. ?aaani?aoe?y ?ii?a iao??th ca?eueooaaeanue a?aeiinii eiio?ieth (14,6+0,89iI/oa.) i?e Oe (20,1+1,28 iI/oa., P<0,01), ia ci?ithaaeanue i?e On ? ciaiooaaeanue i?e Oa (10,2+0,71iI/oa., P<0,05). Aeiaiaa aene?aoe?y ?ii?a eae?th, aeaiiee ? i?/iee eae?eo?ac a??ia?aeii c?inoaee ii??aiyii ?c eiio?ieai (36,6(0,37iI/24aiae; 26,8(0,32iI/12aiae oa 9,8(0,28iI/12aiae a?aeiia?aeii) i?e an?o nooiaiyo aaaeeino? caoai?thaaiiy, iniaeeai i?e On (61,8+0,68iI/24aiae., P<0,001; 44,5+0,43iI/12aiae., P<0,01 oa 17,3+0,32iI/12aiae., P<0,01 a?aeiia?aeii). Ne?ae caoaaaeeoe, ui iaea?eueo ae?aaeai? ci?ie aene?aoi?ii? ooieoe?? ie?ie oa?aeoa?i? aeey Oe (i?aeaeuaiiy ae?o?aco, aene?aoe?? ?ii?a iao??th, eae?th oa e?aaoei?io) oa aeey Oa (cieaeaiiy ae?o?aco, aene?aoe?? ?ii?a iao??th oa e?aaoei?io). Ci?ie aene?aoi?ii? ooieoe?? ie?ie i?e On iaio ae?aaeai?. I?ioa, oea ia icia/a?, ui i?e On aeieea? ii?iae?caoe?y ii?ooaieo ooieoe?e. Iaaiaee, a oeueiio aeiaaeeo iaoieia?/iee i?ioean ? a?eueo iiaeeaeaiei, i?ae i?e Oe ? ? ia?ao?aeiei aoaiii ??cieo noaae?e ooieoe?iiaeueieo ci?i. Ia i?aenoaa? io?eiaieo ?acoeueoao?a caoaaaeeii, ui aeey AeOC oa?aeoa?i? ci?ie ai?noo ?ii?a eae?th ? iao??th a ee?oeiao, a eieeaaiiy ?o ??aiy a iicaee?oeii?e ??aeei? ? aoi?eiieie ? iaiino?eieie. Aaaaea?ii, ui a iniia? iaoiaaiaoe/ieo iaoai?ci?a aeyaeaieo ii?ooaiue iai?io ?ii?a eae?th ? iao??th ? iaaeeeoie oe?ai?aeieo ai?iii?a, yeei aeanoeaa eaoaaie?/ia ae?y, ui i?ecaiaeeoue aei i?aeaeuaiiai ae?eiaaiie?co ? iineeaiiai ?iciaaeo a?ee?a, a aioo??oiueiee?oeiiee eae?e ciaoiaeeoueny o aeaeyae? aoaeaaiaeieo ? a?eeiaeo eiiieaen?a.Aaciina?aaei?e aieea ia ie?ee, ye aoaeoi?iee i?aai oeueiai iai?io, iathoue oe?ai?aei? ai?iiie. Ic oeaieie ie?ie ethaeeie eeiiiaaii ?aoeaioi?e aei oe?ai?aeieo ai?iiiia oeio (2, ui aeaco? ia iayai?noue aeaio /e a?eueoa oi?i ?aoeaioi??a aei ai?iii?a ueoiaeaeii? caeice (A.Nakai et al., 1988). Aieea oe?ai?aeieo ai?iiiia ia iaiiiii i?ioeane a eeioeiao ie?ie coiiaeth? ciiio aeoeaiino? Na+, K+-AOOace (F.Ismail-Beigi et al.,1989), ui a?aeaeca?eaeth?oueny ia ?o ooieoe??. Aaaeeeao ?ieue a iaoiaaiac? ii?ooaiue aeaeo?ie?oiiai iai?io o oai?eo ia AeOC a?ae?a?a? aeeth/aiiy a iaoieia?/iee i?ioean ?ioeo ?aaoeyoi?ieo nenoai. Oae, ia ie?eiai nenoaie o?ainii?oo iao?ith i?e oe?aioieneeici aieeaa? ia?aaena?aeiee iao?ieo?aoe/iee ai?iii (IIOA). I?aeaeuaiiy aene?aoe?? ?ii?a iao??th o oai?eo ia oe?aioieneeic eaaeiai oa na?aaeiueiai nooiaiy, ia iaoo aeoieo, iiaea aooe iia’ycaii ?c c?inoaiiyi ai?noo IIOA (P.W.Ladenson ,1988) a ne?iaaooe? e?ia?. E??i oiai, eaiaeueoeaaee aoeeaeic i?e oe?aioieneeic? ni?ey? i?aeaeuaiith Na+-H+ iai?io, ui noi?iaiaeaeo?oueny iineeaiiyi iao??eo?aco (I.Ae.Ia?aiaethe, 1992). Cieaeaiiy ai?noo ?ii?a iao??th ? ca?eueoaiiy aeae?eaiiy ?ii?a eae?th ?c na/ath, ciaioaiiy a?aae??io?a Na+ieacie/Na+a?eo?ioeeo?a, K+a?eo?ioeeo?a/Na+a?eo?ioeeo?a ? oa?aeoa?ieie iciaeaie i?aeaeuaiiy i?ia?aeiei?oeei?aeii? aeoeaiino? iaaeie?iee?a. Oea i?aeoaa?aeaeo?oueny aeine?aeaeaiiyie nae?aoe?? aeueaeinoa?iio i?e oe?aioieneeic? (M.G.Fullerton, 1990). Cieaeaiiy nae?aoe?? aacii?aneio i?e i?aeaeuaii? ooieoe?? ueoiaeaeii? caeice (W.R.Skowski, 1970) iiynith? ca?eueoaiiy ??aiy ae?o?aco o oai?eo c oe?aioieneeicii eaaeiai ? na?aaeiueiai nooiai?a. Iecueeee ae?o?ac i?e aaaeeiio oe?aioieneeic?, i/aaeaeii, iia’ycaiee c aeae?eaiiyi aaeeei? e?eueeino? ??aeeie c iioii. Iaoiaaiaoe/iee iaoai?ci oeueiai iiaea aooe e ?ioei: i?aeaeuaia aene?aoe?y ?ii?a iao??th i?ecaiaeeoue aei aeoeaaoe?? ?ai?i-aia?ioaicei-aeueaeinoa?iiiai? nenoaie, aiane?aeie oeueiai a?aeaoaa?oueny ia?a?iciiae?e ie?eiaiai e?iaioieo ca i?eioeeiii ooioa O?o?oa, ui cieaeo? eeoai/eiao o?eueo?aoe?th ? ciaioo? ae?o?ac. O iaoe??io?a c a?iioe?aicii e?euee?noue ?ii?a iao??th a ieaci? e?ia? (138,6+0,81iIieue/e) ciaioaia a?aeiinii eiio?ieth (146,7+1,45iIieue/e, P<0,01). Ai?no ?ii?a iao??th a a?eo?ioeeoao (20,9+0,37iIieue/e) i?aeaeuoaaany ii??aiyii c a?oiith caei?iaeo in?a (19,4+0,59 iIieue/e, P<0,05). Iaia?aiiee a?aae??io Na+a?eo?ioeeo?a/Na+ieacie ia caciaaaa ?noioieo ci?i. E?euee?noue ?ii?a eae?th a ieaci? e?ia? (4,53+0,057 iIieue/e) c?inoaea ii??aiyii ?c eiio?ieai (4,1+0,07 iIieue/e, ?<0,05), a a?eo?ioeeoao - ia caciaaaea ?noioieo ci?i. Iaia?aiiee a?aae??io K+a?eo?ioeeo?a/K+ieacie (21,1+0,34iIieue/e) ciaiooaaany ii??aiyii ?c oaeei a eiio?ie? (22,8+0,28iIieue/e, ?<0,01). Eiao?oe??ioe Na+ieacie/K+ieacie, K+a?eo?ioeeo?a/Na+a?eo?ioeeo?a ia iaee a??ia?aeieo ci?i uiaei eiio?ieth. O oai?eo ia a?iioe?aic aeiaiaee ae?o?ac a??ia?aeii cieaeoaaany i?e an?o nooiaiyo aaaeeino? i?ioeano (753,9+13,77 ie/24aiae.; 747,1+14,10ie/24 aiae. ? 727,8+12,69 ie/24aiae., P<0,001 a?aeiia?aeii). I?eaa?oa? oaaao i?aeaeuaiiy i?/iiai ae?o?aco a?aeiinii aeaiiiai i?e An ?, a a?eueo?e i???, i?e Aa, oaiaeaioe?th aei /iai aeyaey?oueny aaea o iaoe??io?a c Ae. Oaeaee?noue eeoai/eiai? o?eueo?aoe?? a??ia?aeii cieaeoaaeanue ii??aiyii ?c eiio?ieai (104,6+1,19ie/oa) i?e Ae (80,9+2,53ie/oa., P<0,001), i?e An - ciaiooaaeanue a?aeiinii eiio?ieth (70,4+2,93 ie/oa., P<0,001) oa a?aeiinii Ae (P<0,05), i?e Aa - a??ia?aeii cieaeoaaeanue a?aeiinii eiio?ieth (67,6+1,54ie/oa., P<0,001), a?aeiinii Ae (P<0,001) oa ia ci?ithaaeanue uiaei An (P(0,05). Aene?aoe?y e?aaoei?io a?aeiinii eiio?ieth (10,9+0,13ieI/24aiae.) ciaiooaaeanue i?e an?o nooiaiyo aaaeeino? caoai?thaaiiy (8,7+0,27ieI/24aiae.; 7,7+0,32ieI/24aiae.; 8,1+0,21ieI/24aiae., P<0,01 a?aeiia?aeii). Ne?ae a?aei?oeoe, ui i?e Ae cieaeoaaeanue naia aeaiia aene?aoe?y e?aaoei?io. I?e An ciaiooaaany aeaiiee ?, a iaio?e i???, i?/iee e?aaoei?io?ac, a o iaoe??io?a c Aa iiieaeoaaany o?eueee aeaiiee e?aaoei?io?ac. Eaiaeueoeaaa ?aaani?aoe?y aiaee ca?eueooaaeanue a?aeiinii eiio?ieth (99,3+0,01%) i?e Ae (99,4+0,01%, P<0,01) oa ia ci?ithaaeanue i?e ?ioeo nooiaiyo aaaeeino? a?iioe?aico Aeiaiaa aene?aoe?y ?ii?a iao??th cieaeoaaeanue ii??aiyii ?c a?oiith caei?iaeo in?a (147,4(2,04iI/24aiae.) i?e an?o nooiaiyo aaaeeino? caoai?thaaiiy (117,0+3,35 iI/24aiae., P<0,01; 98,7+3,52 iI/24aiae., P<0,001; 94,9+2,16iI/24aiae, P<0,001). Aiaeia?/i? ci?ie a?aeiinii eiio?ieth (15,3+1,09iI/oa) oa?aeoa?i? aeey o?eueo?aoe?eiiai ca?yaeo ?ii?a iao??th (11,5+0,82 iI/oa, P<0,05; 9,7+0,62iI/oa, P<0,01; 9,1+0,65 iI/oa, P<0,01 a?aeiia?aeii). O oai?eo ?c An cieaeoaaany o?eueee aeaiiee iao??eo?ac, a oie /an ye i?/iee ia caciaaaa a??ia?aeieo ci?i. I?e Aa niinoa??aaee ci?ie, oa?aeoa?i? aeey Ae: c?inoaiiy i?/iiai oa ciaioaiiy aeaiiiai iao??eo?aco. ?aaani?aoe?y ?ii?a iao??th cieaeoaaeanue ii??aiyii ?c eiio?ieai (14,6+0,89iI/oa) o an?o a?oiao aeine?aeaeoaaieo (10,8+0,77iI/oa, P<0,05; 9,1+0,65 iI/oa, P<0,01; 8,4+0,65iI/oa, P<0,001). Aeiaiaa aene?aoe?y ?ii?a eae?th ca?eueooaaeanue uiaei eiio?ieth (36,6+0,37iI/24 aiae) o oai?eo ia Aa (40,2+0,91 iI/24 aiae., P<0,05) ? ia ci?ithaaeanue i?e Ae ? An (36,6+1,15 iI/24aiae., P>0,05 ?
37,2+1,55iI/24aiae., P>0,05). I?e Aa c?inoa? i?/iee ? ciaioo?oueny
aeaiiee eae?eo?ac.

Ia iaoo aeoieo, iaeiei c iaoai?ci?a aiaeii-nieueiaiai aeenaaeaino i?e
a?iioe?aic? ? iaaeeeoeiaa iaeiie/aiiy o aioo??oi?o i?aaiao eeneeo
ae?eicai?iiae?eai?a, ui iineeththoue a?ae?io?euei?noue niieo/ii? oeaieie
oa aeeeeeathoue cao?eieo iao??th ca iniioe/iei a?aae??ioii.

Ia cao?eieo a oeaieiao ?ii?a iao??th ? aiaee oaeiae iiaea aieeaaoe
iaaeeeoie aacii?aneio. Ia iaoo aeoieo, naia c oeei iia’ycaii a??ia?aeia
ciaioaiiy ae?o?aco aaeaiue ? aeieeiaiiy iiaiai i?eo aene?aoe?? aii/?,
yea a?aei?/aii o iaoe??io?a c a?iioe?aicii.

Ci?ie aiaeii-nieueiaiai iai?io i?e a?iioe?aic? oaeiae iaoiiaeai?
cieaeaiiyi ??aiy IIOA (N.L.Wong et al., 1992). Ioaea, cieaeaiiy
iao??eo?aco iiaea aooe iia’ycaii oaeiae ?c oeei oaeoi?ii.

O?iii?eoie aene?aoi?ii? ooieoe?? ie?ie o oai?eo ia aeeoociee oiene/iee
cia oa a?iioe?aic

Io?eiai? iaie aeai? noiniaii ?eoi?/ii? ae?yeueiino? ie?ie i?e AeOC oa
a?iioe?aic? na?ae/aoue i?i aeaneio?iiic ?o aene?aoi?ii? ooieoe??
(oaaeeoey 2).

O oai?eo ia Oe caieueooaaeenue iaci?e oa c?inoaee aiie?ooaee
na/iaeae?eaiiy (P<0,001), aene?aoe?? ?ii?a iao??th (P<0,001), eae?th (P<0,001) oa e?aaoei?io (P<0,01), aiaeii/aany cnoa ae?ioac, iniaeeai iao?ieo?aco (ia 3 aiae. 29 oa.), aeeae/a aei ?aieiaeo aiaeei, oa aaoeoac a i?ioeeaaeiee a?e. O iaoe??io?a c On iaci? i aiieiooaea na/iaeae?eaiiy a??ia?aeii ca?eueooaaeenue, oaeiae a?aei?/aeinue c?inoaiiy aiie?ooaee e?aaoei?io?aco a?aeiinii eiio?ieueii? a?oie (P<0,01), aea a iaioie ii?i, iiae i?e Oe, ca?eueoaiiy iaci?o ? aiie?ooaee aene?aoe?? ?ii?a eae?th (P<0,001); iaci? oa aiie?ooaea aene?aoe?? ?ii?a iao??th ia caciaaaee ?noioieo ci?i. Oa?aeoa?ia iiaeaeueoa ciiuaiiy ae?ioac ia ?aieia? oa aaoeoac ia aa/??i? aiaeeie. I?e Oa niinoa?iaaeinue cieaeaiiy iaci?ia oa aiieiooae na/iaeaeieaiiy (P<0,01, P<0,05), aene?aoei? ?ii?a iao?ith (P<0,001), ciaioaiiy aiie?ooaee e?aaoeiiio?aco (P<0,05) aac a??ia?aeieo ci?i iaci?o (P>0,05),
a oaeiae c?inoaiiy iaci?o i aiieiooaee aene?aoei? ?ii?a eae?th (P<0,01, P<0,001), cnoa ae?ioac a aie ?aieiaeo aiaeei (aeio?aco ia 5 aiae. 30 oa., ?ii?a eae?th - ia 4 aiae. 47 oa., iao?ith - ia 9 aiae. 29 oa., e?aaoeiiio - ia 5 aiae. 07 oa.), a oaeiae aaoeoac, aieueo iiiioiee, iiae o oai?eo ia Oe oa On. Iaea?eueoeo ci?i caciaaaa o?iii?eoi aene?aoe?? iao??th. Ioaea, o oai?eo ia AeOC a?aeaoaa?oueny ci?uaiiy ae?ioac oa aaoeoac na/iaeae?eaiiy, aene?aoe?? ?ii?a eae?th, iao??th oa e?aaoei?io i?iii?oeieii nooiaith aaaeeinoi caoai?thaaiiy oa ci?iththoueny aaee/eie iaci?ia oa aiieiooae. I?e i?iaaaeaii? ei?aeyoe?eiiai aiae?co aeyaeaiee cai?ioi?e ca’ycie i?ae iaci?aie o?iii?eoi?a ai?noo O3 a e?ia? oa iaci?aie ae?o?aco (R=-0,648, P<0,01), aene?aoe?? ?ii?a iao??th (R=-0,474, P<0,01), a oaeiae cai?ioi?e ca’ycie i?ae iaci?aie O4 oa ae?o?aco (R=-0,579, P<0,01). I?ae aiie?ooaeaie O3 oa ae?o?aco (R=0,604, P<0,05), O3 ? aene?aoe?? ?ii?a iao??th (R=0,604, P<0,05) ?nio? i?yiee ei?aeyoe?eiee ca’ycie, aiie?ooaeaie O4 ? iao??eo?aco (R=-0,324, P<0,01) - oaiaeaioe?y aei i?yiiai ca’yceo. Io?eiai? ?acoeueoaoe na?ae/aoue i?i iaaiee aieea o?iii?eoi?a ooieoe?? ueoiaeaeii? caeice ia o?iii?eoie ooieoe?? ie?ie o oai?eo ia AeOC. O oai?eo ia Ae a?aeaoaaeinue ciaioaiiy iaci??a ae?o?aco (P<0,01) oa aene?aoe?? ?ii?a iao??th (P<0,01) aac a??ia?aeieo ci?i iaci??a eae?eo?aco (P>0,05) oa e?aaoei?io?aco (P>0,05), ciaioaiiy aiie?ooae an?o
iieaciee?a, iniaeeai ae?aaeaia aeey ae?o?aco (P<0,001) ? aene?aoe?? ?ii?a iao??th (P<0,001). A?aei?/aany iacia/iee cnoa ae?ioac ae?o?aco oa aene?aoe?? ?ii?a iao??th a a?e aa/??i?o aiaeei oa a?eueo ae?aaeaiee cnoa ae?ioace aene?aoe?? e?aaoei?io a a?e i?/ieo aiaeei. Aaoeoace o?ainoi?ioaaeenue ia ?aiie. I?e An iaci?e ae?o?aco (P<0,001), aene?aoe?? ?ii?a iao??th (P<0,001) oa e?aaoei?io (P<0,05) ciaiooaaeenue ?noioi?oa, i?ae i?e Ae, aiie?ooaee - a iaio?e i???. A?aei?/aany cnoa ae?ioac iieaciee?a a a?e i?/ieo aiaeei: ae?o?aco - ia 5aiae.20oa, aene?aoe?? ?ii?a iao??th - ia 11 aiae.30 oa., ?ii?a eae?th - ia 12 aiae.00oa., e?aaoei?io - ia 6aiae.27oa., a oaeiae iiaeaeueoa ci?uaiiy aaoeoac. O oai?eo ia Aa niinoa??aaee ciaioaiiy iaci??a oa aiie?ooae ae?o?aco (P<0,001) oa aene?aoe?? ?ii?a iao??th (P<0,001), a?eueo iii?oia, i?ae i?e ?ioeo oi?iao caoai?thaaiiy. A?aei?/aee cnoa ae?ioac a a?e aaoeoac, a aaoeoac a a?e ae?ioac eiio?ieth. A?aei?/ai? ci?ie na?ae/aoue i?i iaeaea iiaio ?iaa?n?th ?eoio aene?aoi?ii? ooieoe?? ie?ie o oai?eo ia a?iioe?aic. I?ioa, aiae?coth/e ii/aoeia?, iaai?ieneiiaai? aeai?, iiaeia a?aei?oeoe “aeaiai?a?noue” e?eaeo o?iii?eoi?a ae?o?aco, aene?aoe?? ?ii?a iao??th, eae?th oa e?aaoei?io o oai?eo ia a?iioe?aic, oiaoi niinoa??aa?oueny aeieeiaiiy iiaeo i?e?a aene?aoe?? iieaciee?a. I?iaaaeaiiy ei?aeyoe?eiiai aiae?co aeyaeei i?yiee ca’ycie i?ae iaci?aie O3 oa ae?o?aco (R=0,418, P<0,01), i?ae aiie?ooaeaie O3 oa ae?o?aco (R=0,605, P<0,05), O4 oa ae?o?aco (R=0,638, P<0,01), ? O4 oa aene?aoe?? ?ii?a iao??th (R=0,659, P<0,05). Ia i?aenoaa? oeueiai iiaeia ae?eoe aeniiaeo, ui o?iii?eoie ooieoe?? ueoiaeaeii? caeice o oai?eo ia a?iioe?aic iaaiith i??ith aieeaathoue ia o?iii?eoie aene?aoi?ii? ooieoe?? ie?ie. Ia iaoo aeoieo, aieiaia ?ieue o aeieeiaii? aeyaeaieo ci?i iaeaaeeoue ii?ooaiith oe?ai?aeii-ai?o?ca?ieo aca?iia?aeiinei o iaoe??io?a c oe?aioieneeicii oa a?iioe?aicii. Ca aeaieie A.I.I?oaea (1985), oeoeiiiae?aia o?ei ? oeaio?aeueiith eaieith ?aaoeyoei? oee?eaaeiaiieo ?eoiia ooieoei? ie?ie. Oaeei /eiii, ci?iaia ooieoe?y oeoeiiiae?aiiai o?ea ni?ey? aeieeiaiith aeaneio?iiico aene?aoi?ii? ooieoe?? ie?ie o oai?eo ia AeOC ? a?iioe?aic. Io?eiai? iaie ?acoeueoaoe na?ae/aoue i?i oa, ui i?e oe?aioieneeic? ? a?iioe?aic? a?aeaoaa?oueny aeaneio?iiic ooieoe?? ueoiaeaeii? caeice, ui, a naith /a?ao, ii?yae c ?ioeie iaoai?ciaie, i?ecaiaeeoue aei ii?ooaiiy o?iii?eoi?a aene?aoi?ii? ooieoe?? ie?ie. Oea ? iane?aeeii iie?aeaiaeoey?ieo aiaeie?eiieo ?iceaae?a. Ea?oeia aeaneio?iiico aene?aoi?ii? ooieoe?? ie?ie ye i?e AeOC, oae ? i?e a?iioe?aic? ? aeineoue oa?aeoa?iith, aeyaey?oueny aaea ia ?aii?o noaae?yo oa iiaeeaeth?oueny ?c c?inoaiiyi aaaeeino? caoai?thaaiue, ia i?aenoaa? /iai iiaeia caeeth/eoe, ui aeine?aeaeaiiy o?iii?eoi?a aene?aoi?ii? ooieoe?? ie?ie o oai?eo ia AeOC oa a?iioe?aic iiaeooue aeei?enoiaoaaoeny ye naiino?ei? ae?aaiinoe/i? oanoe, ye? a?ae??ciythoueny i?inoioith, ia?iaaceai?noth, aeaoaaeciith oa ia iio?aaothoue aeiaeaoeiaiai iaeaaeiaiiy. Ioaea, i?iaaaeaiiy o?iiia?ieia?/iiai aiae?co iieacaei, ui o oai?eo ia AeOC oa a?iioe?aic a?aeaoaathoueny ??ciiiai?oi? ii?ooaiiy ?eoi?a a?iio?ca?ii-oe?ai?aeii? nenoaie oa aene?aoi?ii? ooieoe?? ie?ie i?iii?oe?eii aaaeeino? caoai?thaaiue, ui iiaea na?ae/eoe i?i aeeaeio iaoieia?/iiai i?ioeano. A E N I I A E E O oai?eo ia aeeoociee oiene/iee cia oa a?iioe?aic a?aeaoaa?oueny aeaneio?iiic ooieoe?? ueoiaeaeii? caeice oa aene?aoi?ii? ooieoe?? ie?ie. I?e aeeoociiio oiene/iiio cia? a?aeaoaa?oueny cnoa ae?ioac o?iii?eoi?a ai?noo o?eeiaeoe?ii?io oa oe?ieneio a a?e aeaiieo oa aa/??i?o ? aaoeoac a a?e ?aieiaeo aiaeei, ca?eueoaiiy iaci??a o?eeiaeoe?ii?io oa oe?ieneio ? aiie?ooaee oe?ieneio i?iii?oe?eii ?c aaaee?noth caoai?thaaiiy, a oaeiae ciaioaiiy iaci?o ? aiie?ooaee oe?aio?iiiiai ai?iiio. I?e a?iioe?aic? a?aeaoaa?oueny ciaioaiiy iaci??a o?eeiaeoe?ii?io oa oe?ieneio, ca?eueoaiiy iaci?o oe?aio?iiiiai ai?iiio, ciaioaiiy aiie?ooae o?eeiaeoe?ii?io, oe?ieneio oa oe?aio?iiiiai ai?iiio i?iii?oe?eii ?c aaaee?noth caoai?thaaiiy. O?iii?eoie ooieoe?? ueoiaeaeii? caeice i?e aeeoociiio oiene/iiio cia? oa a?iioe?aic? aieeaathoue ia o?iii?eoie aene?aoi?ii? ooieoe?? ie?ie. O oai?eo ia aeeoociee oiene/iee cia a?aeaoaa?oueny cnoa ae?ioac oa aaoeoac na/iaeae?eaiiy, aene?aoe?? ?ii?a iao??th, eae?th oa e?aaoei?io i?iii?oe?eii ?c aaaee?noth caoai?thaaiiy. O oai?eo ia a?iioe?aic aeieeathoue iia? i?ee ae?o?aco, aene?aoe?? ?ii?a iao??th, eae?th, e?aaoei?io, ciaioaiiy iaci??a ? aiie?ooae a?eueoino? iieaciee?a i?iii?oe?eii c aaaee?noth caoai?thaaiiy, cnoa ae?ioac a a?e aaoeoac, a aaoeoac a a?e ae?ioac eiio?ieth. I?AEOE*I? ?AEIIAIAeAOe?? Caa?? e?ia? aeey i?iaaaeaiiy aeine?aeaeaiiy ai?noo oe?ai?aeieo ai?iii?a a ne?iaaooe? e?ia? oai?eo ia aeeoociee oiene/iee cia a?eueo ?ioi?iaoeaii i?iaiaeeoe a ae?oa?e iieiaei? aeiy (c 14.00 aei 20.00). Caa?? e?ia? aeey aecia/aiiy ??aiy oe?ai?aeieo ai?iii?a o oai?eo ia a?iioe?aic aeioe?eueii i?iaiaeeoe aaeaiue (c 12.00 aei 14.00). Aeine?aeaeaiiy o?iii?eoi?a aene?aoi?ii? ooieoe?? ie?ie o oai?eo ia aeeoociee oiene/iee cia oa a?iioe?aic iiaeooue aeei?enoiaoaaoeny ye naiino?ei? ae?aaiinoe/i? oanoe. Nienie ?ia?o, ui iioae?eiaai? ca oaiith aeena?oaoe?? I?oae A.I., E?eae/ I.A. O?iii?eoie aene?aoi?ii? ooieoe?? ie?ie o oai?eo ia oe?aioieneeic // Aiaeie?eiieia?y, 1996. - O.1. - ? 2. - N. 72-78. E?eae/ I.A., I?oae A.I. Noai aiaeii-nieueiai? ??aiiaaae o oai?eo ia aeeoociee oiene/iee cia oa a?iioe?aic // E?ea?nueea ni?aaa, 1997. -? 4. - N. 110-114. Ieoae A.I., E?eae/ I.A. O?iii?eoiu yene?aoi?iie ooieoeee ii/ae o aieueiuo aeiioe?aicii // Atheeaoaiue yenia?eiaioaeueiie aeieiaee e iaaeeoeeiu, 1998. - O.125. - ? 6. - N. 684-687. E?eae/ I.A. Oee?eaae?aii? ?eoie aene?aoi?ii? ooieoe?? ie?ie i?e a?iioe?aic? // Aoeiaeinueeee iaaee/iee a?niee, 1997. - O.1. - ?1. - N. 35-38. E?eae/ I.A. Aieea ?eoi?/ii? ae?yeueiino? ooieoe?? ueoiaeaeii? caeice ia o?iii?eoie aene?aoi?ii? ooieoe?? ie?ie o oai?eo ia aeeoociee oiene/iee cia // Oeno, 1997. -? 1. - N.104-109. E?eae/ I.A. O?iii?eoie ooieoe?? ueoiaeaeii? caeice a ii?i? ? i?e iaoieia?? // Aeai. a AeIOA Oe?a?ie 04.09.95, ? 2039-Oe95. - 21 n. E?eae/ I.A. O?iii?eoie ooieoe?? ie?ie oa iaoai?cie ?o ?aaoeyoe?? // Aeai. a AeIOA Oe?a?ie 20.12.95, ? 79-Oe96. - 25 n. E?eae/ I.A. Aieea oe?ai?aeieo ai?iii?a ia ooieoe?th ie?ie oa iaoai?cie eiai ?aaoeyoe?? // Aeai. a AeIOA Oe?a?ie 12.10.95, ? 2280-Oe95. - 25 n. E?eae/ I.A. O?iii?eoie ooieoe?? ueoiaeaeii? caeice o oai?eo ia oe?aioieneeic //Aeooaeuei? ieoaiiy iaaee/ii? aeiiiiiae ianaeaiith: Iaoa??aee neiiic?oio. - *a?i?aoe?, 1996. - N. 121-123. E?eae/ I.A. O?iii?eoie ooieoe?? ueoiaeaeii? caeice o oai?eo ia a?iioe?aic //Aeooaeuei? ieoaiiy iaaee/ii? aeiiiiiae ianaeaiith: Iaoa??aee neiiic?oio. - *a?i?aoe?, 1996. - N. 119-121. E?eae/ I.A. Aeeiai?/ia ioe?iea aene?aoi?ii? ooieoe?? ie?ie o oai?eo ia oe?aioieneeic // Aeooaeuei? ieoaiiy ?aaa?e?oaoe?? aano?iaioa?ieia?/ieo oai?eo: Iaoa??aee neiiic?oio. - *a?i?aoe?, 1996. - N. 183. E?eae/ I.A. O?iii?eoie aene?aoi?ii? ooieoe?? ie?ie o oai?eo c iaoieia??th ueoiaeaeii? caeice a aeieia?/ii iani?eyoeeaeo oiiaao // O??o?a?/i? i?iaeaie ? aeieia?y: Iaoa??aee neiiic?oio. - *a?i?aoe?,1995. - N.84. E?eae/ I.A. O?iii?eoie ooieoe?? ueoiaeaeii? caeice i?e ?? iaoieia?? // Neioac, aenia?eiaioaeueia aea/aiiy oa ee?i?/ia canoinoaaiiy /aoaa?oeiieo aiii??aeo niieoe: Iaoa??aee neiiic?oio. - *a?i?aoe?, 1995. - N.35. E?eae/ I.A. Aeeiai?/ia ioe?iea aene?aoi?ii? ooieoe?? ie?ie o oai?eo ia oe?aioieneeic // A?ieia?y, iaaeeoeeia, aeieia?y: Iaoa??aee ia?oi? iaoeiai-i?aeo. eiio. ii/aoeoth/eo iaoeiaoe?a oa iie. a/aieo Aoeiaeie. - *a?i?aoe?, 1996.-N.43. E?eae/ I.A., Eaeoa?i A.I. O?iii?eoie aene?aoi?ii? ooieoe?? ie?ie o oai?eo c oe?aioieneeicii // Aeooaeueiua i?iaeaiu aeaoneie e iiae?inoeiaie yiaeie?eiieiaee: Oacenu aeieeaaeia. - Oa?ueeia, 1995. - N. 62. E?eae/ I.A., I?oae A.I. O?iii?eoie ooieoe?? ueoiaeaeii? caeice a ii?i? ? i?e ?? iaoieia?? // Aeooaeueiua i?iaeaiu aeaoneie e iiae?inoeiaie yiaeie?eiieiaee: Oacenu aeieeaaeia. - Oa?ueeia, 1995. - N. 63. Aiioaoe?y E?eae/ I.A. (O?iii?eoie ooieoe?? ueoiaeaeii? caeice, aene?aoi?ii? ooieoe?? ie?ie o oai?eo ia aeeoociee oiene/iee cia oa a?iioe?aic(. - ?oeiien. Aeena?oaoe?y ia caeiaoooy a/aiiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.14 - aiaeie?eiieia?y. ?inoeooo aiaeie?eiieia?? oa iai?io ?a/iaei ?i. A.I. Eii?na?aiea AII Oe?a?ie, Ee?a, 1998. I?iaaaeaii aeine?aeaeaiiy o?iii?eoi?a ooieoe?? ueoiaeaeii? caeice, aene?aoi?ii? ooieoe?? ie?ie o oai?eo ia aeeoociee oiene/iee cia oa a?iioe?aic. Aeyaeai? iniaeeaino? oee?eaae?aiieo ?eoi?a ooieoe?? ueoiaeaeii? caeice i?e oe?aioieneeic? oa a?iioe?aic?. Aea/aiee noai aene?aoi?ii? ooieoe?? ie?ie o oai?eo c oe?aioieneeicii ? a?iioe?aicii. Aeine?aeaeaia no?oeoo?ia i?aai?caoe?y o?iii?eoi?a aene?aoi?ii? ooieoe?? ie?ie o iaoe??io?a c ii?ooaiiyi ooieoe?? ueoiaeaeii? caeice. Anoaiiaeaiee aieea o?iii?eoi?a ooieoe?? ueoiaeaeii? caeice ia o?iii?eoie aene?aoi?ii? ooieoe?? ie?ie i?e ii?ooaii? ooieoe?? ueoiaeaeii? caeice. ?ic?iaeai? i?eioeeie o?iiiae?aaiinoeee aeine?aeaeaiiy ai?noo oe?ai?aeieo ai?iii?a a e?ia? o oai?eo c oe?aioieneeicii ? a?iioe?aicii. Eeth/ia? neiaa: oee?eaae?aii? ?eoie, oe?aioieneeic, a?iioe?aic, oe?ai?aei? ai?iiie, ie?eiaa aene?aoe?y. Aiiioaoeey E?eae/ I.A. (O?iii?eoiu ooieoeee ueoiaeaeiie aeaeacu, yene?aoi?iie ooieoeee ii/ae o aieueiuo aeeooociui oiene/aneei ciaii e aeiioe?aicii(. - ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.14 - yiaeie?eiieiaey. Einoeooo yiaeie?eiieiaee e iaiaia aauanoa ei. A.I. Eiiena?aiei, Eeaa, 1998. I?iaaaeaii enneaaeiaaiea o?iii?eoiia ooieoeee ueoiaeaeiie aeaeacu, yene?aoi?iie ooieoeee ii/ae o aieueiuo aeeoociui oiene/aneei ciaii e aeiioe?aicii. Auyaeaiu iniaaiiinoe oee?eaaeeaiiuo ?eoiia ooieoeee ueoiaeaeiie aeaeacu i?e oe?aioieneeica e aeiioe?aica. Eco/aii ninoiyiea yene?aoi?iie ooieoeee ii/ae o aieueiuo n oe?aioieneeicii e aeiioe?aicii. Enneaaeiaaia no?oeoo?iay i?aaiecaoeey o?iii?eoiia yene?aoi?iie ooieoeee ii/ae o iaoeeaioia n ia?ooaieai ooieoeee ueoiaeaeiie aeaeacu. Onoaiiaeaii aeeyiea o?iii?eoiia ooieoeee ueoiaeaeiie aeaeacu ia o?iii?eoiu yene?aoi?iie ooieoeee ii/ae i?e ia?ooaiee ooieoeee ueoiaeaeiie aeaeacu. ?ac?aaioaiu i?eioeeiu o?iiiaeeaaiinoeee enneaaeiaaiey niaea?aeaiey oe?aieaeiuo ai?iiiia a e?iae o aieueiuo n oe?aioieneeicii e aeiioe?aicii. Eeth/aaua neiaa: oee?eaaeeaiiua ?eoiu, oe?aioieneeic, aeiioe?aic, oe?aieaeiua ai?iiiu, ii/a/iay aene?aoeey. Annotation Krivich N.V. (The chronorhythms of the function of the thyroid gland, the excretory renal function in the patients with the diffuse toxic goiter and hypothyrosis(. The handwrite. The dissertation in search of the candidate of medicine degree in the speciality 14.01.14 - the endocrinology. The endocrinology and metabolic research institute, Kiev, 1998. The investigation of chronorhythms of the function of the thyroid gland, the excretory renal function in the patients with the diffuse toxic goiter and hypothyrosis has been performed. The peculiares of the circadian rhythms of the thyroid function in thyrotoxicosis and hypothyrosis has been found. The state of excretory renal function in patients with the thyrotoxicosis and hypothyrosis has been studied. The structure organisation of the chronorhythms of the excretory renal function in patients with thyroid dysfunction has been studied. The action of the thyroid functional chronorhythms on the excretory renal functional chronorhythms in thyroid dysfunction has been studied. The principle of the chronodiagnostical examination of the thyroid hormones concentrations in blood of the patients with thyrotoxicosis and hypothyrosis. The key-words: circadian rhythms, thyrotoxicosis, hypothyreosis, thyroid hormones, renal excretoric function. Oaaeeoey 1 O?iii?eoie ai?noo O3, O4 oa OOA a ne?iaaooe? e?ia? o oai?eo ia aeeoociee oiene/iee cia oa a?iioe?aic Iieacieee Eiio?ieue (n=18) Oe (n=13) On (n=14) Oa (n=14) Ae (n=6) An (n=6) Aa (n=7) O3 Iaci? 1,12(0,018 2,61(0,029* 2,84(0,033* 3,34(0,072* 1,06(0,022* 0,57(0,082* 0,41(0,033* (iI\e) Aiie?ooaea 0,29(0,004 2,12(0,032* 1,52(0,018* 0,52(0,014* 0,21(0,006* 0,07(0,001* 0,05(0,004* Ae?ioaca 12051/ 17035/ 18002/ 16052/ 5018/ 6034/ 6010/ Aaoeoaca 23048/ 8022/ 9011/ 8005/ 15055/ 17012/ 16028/ O4 Iaci? 108,60(0,77 152,54(1,621* 189,63(2,890* 209,17(3,931* 55,74(0,972* 27,96(3,494* 16,05(3,526* (iI\e) Aiie?ooaea 21,85(0,180 31,22(0,598* 18,29(0,262* 26,91(2,839* 13,46(0,016* 7,32(0,927* 1,36(0,482 Ae?ioaca 5058/ 14038/ 16050/ 18016/ 7019/ 6028/ 6014/ Aaoeoaca 16010/ 7022/ 6042/ 6008/ 16025/ 16016/ 16005/ OOA Iaci? 2,37(0,098 1,40(0,249* 0,78(0,048* 0,63(0,071* 6,48(0,454* 9,41(0,674* 12,98(0,723* (iIA\e) Aiie?ooaea 2,69(0,111 1,74(0,434 1,45(0,101* 1,23(0,134* 1,31(0,093* 2,82(0,201 1,78(0,098* Ae?ioaca 1024/ 1029/ 0056/ 0038/ 22042/ 22009/ 21004/ Aaoeoaca 12010/ 12030/ 12056/ 12049/ 11010/ 8010/ 6042/ * - a??ia?aei? ci?ie uiaei eiio?ith (? < 0,05) Oaaeeoey 2 O?iii?eoie ae?o?aco, aene?aoe?? Na+, E+ oa e?aaoei?io o oai?eo ia aeeoociee oiene/iee cia oa a?iioe?aic Iieacieee Eiio?ieue (n=20) Oe (n=26) On (n=32) Oa (n=20) Ae (n=8) An (n=6) Aa (n=11) Ae?o?ac Iaci? 135,1(2,32 186,2(4,89* 172,8(2,37* 107,2(3,25* 113,3(1,75* 97,6(1,75* 97,2(1,59* (ie\3 aiae) Aiie?ooaea 51,0(1,06 108,3(3,13* 64,3(1,07* 45,0(1,17* 22,63(0,411* 31,1(0,61* 17,9(0,34* Ae?ioaca 15005/ 14048/ 10005/ 9035/ 19038/ 20025/ 00034/ Aaoeoaca 4000/ 5030/ 2050/ 24000/ 8000/ 8043/ 12000/ Na+ Iaci? 18,42(0,282 23,42(0,352* 17,29(0,523 11,27(0,269* 15,25(0,420* 11,73(0,442* 10,52(0,284* (iI\3 aiae) Aiie?ooaea 11,74(0,188 16,63(0,319* 11,88(0,149 7,24(0,194* 3,02(0,097* 4,71(0,219* 1,72(0,052* Ae?ioaca 15029/ 12000/ 10042/ 6000/ 17014/ 3002/ 2044/ Aaoeoaca 5000/ 1030/ 21030/ 21000/ 7010/ 8030/ 12000/ E+ Iaci? 4,48(0,054 7,18(0,079* 7,73(0,068* 5,53(0,073* 4,74(0,151 4,61(0,218 5,04(0,172* (iI\3 aiae) Aiie?ooaea 3,75(0,048 6,63(0,071* 7,29(0,057* 3,09(0,056* 2,16(0,082* 1,32(0,068* 1,11(0,042* Ae?ioaca 14014/ 12000/ 10053/ 9027/ 13031/ 2020/ 5059/ Aaoeoaca 2030/ 24000/ 21030/ 21026/ 3005/ 18000/ 18008/ E?aaoei?i Iaci? 1,26(0,017 2,03(0,023* 1,82(0,212 1,08(0,096 1,10(0,074 0,71(0,041* 1,08(0,084 (ieI\3aiae) Aiie?ooaea 0,67(0,093 1,34(0,018* 1,24(0,013* 0,26(0,054* 0,46(0,016 0,57(0,037 0,44(0,021 Ae?ioaca 17000/ 15054/ 12000/ 11053/ 24000/ 1027/ 2040/ Aaoeoaca 5048/ 3050/ 24000/ 21025/ 9020/ 12005/ 12000/ * - a??ia?aei? ci?ie uiaei eiio?ieth (? < 0,05) Iai?? ionao. Oe?aae 100 i?ei??iee?a. Caiiae. ?77 Oiia. ae?oe. a?e. - 1. Oi?iao 60o90\16 A?aeae?oeiaaii ia aeoae?eaoi?? 274029, i. *a?i?aoe?, Aaeaea?a 1\33 I?aei?e?inoai (A?o?i(, oae. 7-45-32 PAGE 12

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