Фактори ризику ускладненого перебігу пневмонії та хронізації бронхолегеневого процесу у дітей: Автореф. дис… канд. мед. наук / О.Л. Говдалюк, Крим.

1

I?i?noa?noai ioi?iie caei?ia’y Oe?a?ie

E?einueeee aea?aeaaiee iaaee/iee oi?aa?neoao ?i.N.?.Aai?a??anueeiai

Aiaaeaethe Ieaenaiae? Eaiiiaeiae/

OAeE 616.24-053.2/.6: 575.21:612.017.1:612-015.13:678.048

Oaeoi?e ?eceeo oneeaaeiaiiai ia?aa?ao iiaaiii??

oa o?ii?caoe?? a?iioieaaaiaaiai i?ioeano o ae?oae

14.01.10 — iaae?ao??y

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

N?ioa?iiieue — 1999

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia a E?einueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao?
?i.N.?.Aai?a??anueeiai I?i?noa?noaa ioi?iie caei?ia’y Oe?a?ie

Iaoeiaee ea??aiee — Eiaaoeue Oaoyia Aieiaeeie??aia, aeieoi? iaaee/ieo
iaoe, E?einueeee aea?aeaaiee iaaee/iee oi?aa?neoao
?i.N.?.Aai?a??anueeiai, i?ioani? eaoaae?e aini?oaeueii? iaae?ao???

Iiaa?nueea Aaeaioeia Ieaenaiae??aia, aeieoi? iaaee/ieo iaoe, noa?oee
iaoeiaee ni?a?ia?oiee, canooiiee aee?aeoi?a ii iaoeia?e ?iaio?
Oe?a?inueeiai IAe? aeeoy/i? eo?i?oieiaii oa oiciioa?aiii

Oea/aiei THe?e Iao?iae/, aeieoi? iaaee/ieo iaoe, i?ioani?, caa?aeoaa/
eaoaae?e aini?oaeueii? iaaeiao?i? Caii??cueeiai aea?aeaaiiai iaaee/iiai
oi?aa?neoaoo

I?ia?aeia onoaiiaa: Oe?a?inueeee IAe? ioi?iie caei?ia’y ae?oae oa
i?aee?oe?a, a?aeae?eaiiy aioo??oiuei? iaoieia??, IIC Oe?a?ie, i. Oa?e?a

Caoeno aeena?oaoe?? a?aeaoaeaoueny 25 n?/iy 2000 ?. ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee E 52.600.01 i?e E?einueeiio aea?aeaaiiio
iaaee/iiio oi?aa?neoao? ?i. N.?. Aai?a??anueeiai Iic Oe?a?ie (
95006i.N?ioa?iiieue, aoe.Eai?ia 5/7)

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? E?einueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i. N.?. Aai?a??anueeiai (
95006i.N?ioa?iiieue, aoe.Eai?ia 5/7)

Aaoi?aoa?ao ?ic?neaiee 22 a?oaeiy 1999 ?.

A/aiee nae?aoa?

Niaoe?ae?ciaaii? a/aii? ?aaee

Ae.i.i., i?ioani?
I.O.Iaco?aoeue

Caaaeueia oa?aeoa?enoeea ?iaioe.

Aeooaeuei?noue oaie. Iacaaeath/e ia oni?oe a e?eoaaii? ?anii?aoi?ieo
caoai?thaaiue, iiaaiiiiy ? o?ii?/ia a?iioieaaaiaaa iaoieiaiy o ae?oae
caa??aathoue aenieo aeooaeuei?noue aeey Oe?a?ie. oea coiiaeaii aenieith
caoai?thaai?noth, oaiaeaioe??th aei oneeaaeiaiiai, caoyaeiiai,
?aoeeaeeaoth/iai ia?aa?ao aino?eo i?ioean?a, ui ana /ano?oa noathoue
i?e/eiith oi?ioaaiiy o?ii?/ii? iaoieiaii c? no?eeeie a?aeoeeaiiyie noaio
caei?ia’y ae?oae (Iinoiaee TH.I., 1998). Ca inoaii?ie aeaieie, eeoa 10 %
o?ii?/ieo a?iioieaaaiaaeo caoai?thaaiue coiiaeai? i?e?iaeaeaiith oa
niaaeei?iiith iaoieiai?th (?iciiiaa I.I., 1999). Oea aeiaaa? ?ic?iaee ia
o?eueee iiaeo cania?a e?eoaaiiy, aea e iiaeo cania?a ae?aaiinoeee, ui
aeicaieyoue i?iaiicoaaoe ?icaeoie oa oneeaaeiaiee ia?aa?a iiaaiiiii ia
?aii?o aoaiao ?icaeoeo aeeoeie.

Oey i?iaeaia ia? ? nioe?aeueia cia/aiiy, ai c oai?eie ae?oueie ciooai?
ciaoiaeeoeny iaoa?i, ui i?ecaiaeeoue aei ae?iaie/eo caeoe?a c oei/aniai?
iai?aoeacaeaoiino?.

Aeooaeueiei caeeoa?oueny ieoaiiy i?i cia/aiiy aiaeiaaiieo oaeoi??a
(noaio iioiii? nenoaie, nenoaie i?ioaieico, ia?aeeniiai ieeneaiiy
eiiiae?a (IIE)) a ?icaeoeo ? ia?aa?ao iiaaiiii? (Eioei I.I., Iiiiae/
TH.TH., 1998; Eoaeoe?i A.A. c ni?aaao., 1998). Ia?ae?/ai? nenoaie ?
iniiaieie eiiiiiaioaie, ui aa?ooue o/anoue a iaoiaaiac? a?iioieaaaiaaeo
caoai?thaaiue, ai /a?ac ieo iiina?aaeith?oueny ae?y ?ioaeoe?eiiai
aaaioa, ?ioeo enaiiaaiieo /eiiee?a, a oaeiae aiaeiaaiieo ee?oeiieo ?
aoii?aeueieo oaeoi??a, ui ooieoe?iiothoue ye naiiaaiaoe/ii, oae ?
iaoiaaiaoe/ii.

I?ioaacii-aioei?ioaacia nenoaia (IAN) ? ieneaeaioii-aioeieneaeaioia
(IAI) nenoaia aa?ooue o/anoue a ooeiaeaeaii? niieo/iioeaieiiiai ea?eana
eaaaiue, ?o ia?aioiie, no?oaeoaioa, ae?eicaiiiiae?eai?a, aecia/ath/e
?icaeoie aeano?oeoei?, a iaaeae? — oia?ica, aioicaie, a?iioiaeoac?a.
A?aeiii, ui ia ia?aa?a a?iioieaaaiaai? iaoieiai? ?noioii aieeaathoue
oaiioeiiai aa??aioe -1-iiaiaioi?a i?ioaiiac (-1-?I), aeyaeyth/enue a
aeayeeo aeiaaeeao i?ia?aeiei /eiieeii iaoiaaiaco (Eaiiinueea A.I.,
1978).

Aaaaoioaeoi?i?noue iiaaiiiii ? o?ii?/ieo ianiaoeeo?/ieo caoai?thaaiue
eaaaiue (OICE) aecia/a? aeooaeuei?noue eiiieaeniiai i?aeoiaeo ? aea/aiiy
i?noeaaiai ai?noo -1-?I, ?ioeo eiiiiiaio?a IAN oa IAI, noaio iioiii?
nenoaie, ui neeaaeathoue oaiioei eiie?aoiiai iiaeeaiaeooia, ?c
i?iaeoe??th iaea?aeaieo ?acoeueoao?a ia oae? aeinooii? aaii? ia?ea?e, ye
a?oie e?ia?, a?aoiaoth/e iayai?noue aaiaoe/iiai eiiiiiaioo a noeeueiino?
(aai no?eeinoi) ae?oae aei ianiaoeeo?/ieo caiaeueieo caoai?thaaiue
eaaai?a. A inoaii? ?iee aeyaeaii ca’ycie i?ae noaiii ie?aieo caoenieo
nenoai ? oaiioeiii aeeoeie (Eiaaoeue O.A., 1998), i?ioa, aca?iica’ycie
i?ae noaiii iioiioaoo, ia?aeeniiai ieeneaiiy eiiiae?a, i?ioaieico ?
oaiioeiii ae?oae ia aea/aany. Iiae?aia aeine?aeaeaiiy iiaea aooe
ia?niaeoeaiei, ai i?e aeyaeaii? oaeiai ca’yceo aoaea iaea?aeaia
iiaeeea?noue i?iaiicoaaiiy ii?ooaiue a oeeo nenoaiao ca oaiioeiii
aeeoeie ?c iiiaioo ia?iaeaeaiiy, ine?eueee oae? aaii? ia?ea?e ye a?oie
e?ia? ia ci?iththoueny i?ioyaii onueiai aeeooy. Oea aeicaieeoue ia
o?eueee i?iaiaeeoe oe?eani?yiiaai? i?io?eaeoe/i? caoiaee a a?oiao
?eceeo, aea ? i?ecia/aoe aaeaeaaoio oa?aiith i?e caoai?thaaii? aeeoeie.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie. Aeena?oaoe?eia ?iaioa
aeeiioaaeany a ?aieao iaoeiai? i?ia?aie E?einueeiai aea?aeaaiiai
iaaee/iiai oi?aa?neoaoo (EAIO) ?i. N.?. Aai?ai?anueeiai: «?ic?iaeoe iia?
i?aeoiaee aei ae?aaiinoeee, i?io?eaeoeee ? e?eoaaiiy caiaeueieo
caoai?thaaiue eaaaiue o ae?oae ia iniia? aea/aiiy ooiaeaiaioaeueieo
iaoai?ci?a ?o oi?ioaaiiy, oe?eani?yiiaaii? ei?aeoei? ooieoe?? eaaaiue»,
iiia? aea?aeaaii? ?a?no?aoe?? 01.95. U010153.

Iaoa aeine?aeaeaiiy: aecia/eoe oaeoi?e ?eceeo oneeaaeiaiiai ia?aa?ao
iiaaiiii? oa o?iiicaoei? a?iioieaaaiaaiai i?ioeano o ae?oae.

Caaea/? aeine?aeaeaiiy.

1. Aeaoe ee?i?/io oa?aeoa?enoeeo ae?oae ?c aino?ith iiaaiiii?th aac
oneeaaeiaiue, ?c aeano?oeoeaiith iiaaiiii?th oa c o?ii?/ieie
ianiaoeeo?/ieie caoai?thaaiiyie eaaaiue ?c o?aooaaiiyi a?oi e?ia?
ae?oae.

2. Aecia/eoe ca’ycie i?ae iniaeeainoyie ia?aa?ao iiaaiiii? o ae?oae ?
noaiii ie?aieo eaiie iioiioaoo a ??ci? a?eia? ia??iaee.

3. Aeyaeoe oaeoi?e ?eceeo oneeaaeiaiiai ia?aa?ao iiaaiiii? ? o?iiicaoei?
a?iioieaaaiaaiai i?ioeano a nenoaiao i?ioaieico ? a?eueii?aaeeeaeueiiai
ieeneaiiy.

4. Aeyaeoe ca’ycie i?ae iieacieeaie, ui aeine?aeaeothoueny ? aeayeeie
oaiioeiiaeie oa?aeoa?enoeeaie ae?oae ?c o?aooaaiiyi a?eiaeo
iniaeeainoae.

Iaoeiaa iiaecia. Eiiieaeniee iaoiaeieia?/iee i?aeo?ae aei aea/aiiy
iiaaiiii? ? OICE, — caoai?thaaiue ianiaaeei?iiiai iioiaeaeaiiy, o ae?oae
a ??ci? a?eia? ia??iaee, ui i?noeoue iaeii/ania aea/aiiy ee?i?/ieo
aeaieo, a?io?i?/ieo ? iioiieia?/ieo iieaciee?a, aeicaieea aeyaeoe
/eiieee ?eceeo oneeaaeiaiiai ia?aa?ao iiaaiiii? ? o?iiicaoei?
a?iioieaaaiaaiai i?ioeano a nenoaiao i?ioaieico, a?eueii?aaeeeaeueiiai
ieeneaiiy (A?I), iioiioaoo.

I?iaaaeaia aeine?aeaeaiiy aeicaieeei iieacaoe, ui aino?a iiaaiiiiy
iae/ano?oa ?icaeaa?oueny o ae?oae a ?aiiueiio a?oe? c a?oiith e?ia?
B(III), o oeii/ee?a /ano?oa, i?ae o ae?a/ao. I?ioa o?iiicaoe?y
a?iioieaaaiaaiai i?ioeano iae/ano?oa niinoa??aa?oueny o ae?a/eiie c
a?oiith e?ia? B(III), Rh+, ui aeicaieeei iai aaaaeaoe a?oio e?ia?
B(III), Rh+ ? ae?ii/o noaoue, i?e ?icaeoeo iiaaiiii?, iniaeeai a
?aiiueiio a?oe?, oaeoi?ii ?eceeo o?iiicaoei? i?ioeano.

Aia?oa aeyaeaii, ui o ae?oae, oai?eo ia iiaaiiiith, c a?oiith e?ia?
B(III) a ?aiiueiio a?oe? niinoa??aathoueny iaeieae/? iieacieee
O-eiioioeeo?a (O-e), O-oaeia??a (O-o), a oe?eueiiio – a?eueo cia/oua
cieaeaiiy Ig A o ii??aiyii? c oai?eie c 0(I), A(I?), AB(IV) a?oiaie
e?ia?. Iieacaii, ui o ae?a/aoie, a ii??aiyii? c oeii/eeaie, ieae/a
??aaiue ne?iaaoeiaeo iioiiaeiaoeii?a, a oaeiae a?eueo ae?aaeaia
cieaeaiiy -2-iae?iaeiaoeiio (-2-IA) a a?iioiaeueaaiey?iiio nae?ao?
(AAN), oaiaeaioe?y aei a?eueo aenieeo cia/aiue ia?aeiieo ? aoi?eiieo
i?iaeoeo?a ia?aeeniiai ieeneaiiy eiiiae?a, ui ni?ey? o?iiicaoei?
a?iioieaaaiaaiai i?ioeano.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. Aeae?eaii oaeoi?e ?eceeo c
?icaeoeo aeano?oeoei? ? o?iiicaoei? a?iioieaaaiaaiai i?ioeano o ae?oae.
Anoaiiaeaii iaiao?aei?noue ?aaa?e?oaoe?? aioei?ioaacii?,
aioeieneaeaioii? oa iioiii? nenoai i?e caiaeueieo caoai?thaaiiyo eaaaiia
o ae?oae. Cai?iiiiiaaii aeei?enoiaoaaoe a yeino? i?iaiinoe/ieo e?eoa???a
i?e iiaaiiii? o ae?oae noaoue, a?e, a?oio e?ia? aeeoeie aac
aeiaeaoeiaiai i?iaaaeaiiy iaoiae?a aeine?aeaeaiiy, ye? aei?iai
eiooothoue, ui ia? ?noioia aeiiii?/ia cia/aiiy. Aeya ca’yceo i?ae oeeie
iieacieeaie oa noaiii ie?aieo eaiie ?ioiioaoo, i?ioaieico ? ia?aeiniiai
ieeneaiiy eiiiae?a aeicaiey? e?eoaaoe aeeoeio ?iaeea?aeoaeueii, a ia
oai?iao a oe?eiio, i?iaiicoaaoe oneeaaeiaiee ia?aa?a caoai?thaaiiy,
aeeth/aoe a e?eoaaiiy aaeaeaaoio iaoiaaiaoe/io oa?aiith, oe?eani?yiiaaii
i?iaiaeeoe eo?n i?io?eaeoe/ieo caoiae?a.

Iniaenoee aianie caeiaoaa/a. ?iaioa aeeiiaia ia aac? ioeueiiiieia?/iiai,
o??o?a?/iiai, ?aaiiiaoe?eiiai a?aeae?eaiue ?AeEE i. Niioa?iiiey,
aeeoy/iai a?aeae?eaiiy Oe?EE Niioa?iiieuenueeiai ?aeiio. Aeine?aeaeaiiy
i?iaiaeeeeny ia aac? eaai?aoi??? a?io?i?/ii? aaiaoeee ?AeEE,
iioiieia?/ii? eaai?aoi??? e?ea?i? ?8 i. Niioa?iiiey (caa. eaa. Iaeniiiaa
O.A.), OeIAeE EAeIO ?i. N.?. Aai?ai?anueeiai (caa. eaa. ae.i.i. Eoaeoeii
A.A.).

Ianoaaeaiiy oai?eo, iniiaiee ia’?i eaai?aoi?ieo iaoiae?a aeine?aeaeaiiy,
noaoenoe/ia ia?iaea ?acoeueoao?a, ?o aiae?c aeeiiai? aaoi?ii naiino?eii.
Aaoi?ii aeieacaia a??ia?aei?noue ca’yceo ci?i a nenoaiao i?ioaieico,
IIE, iioiioaoo c oa?aeoa?ii ia?aa?ao caiaeueiiai i?ioeano a eaaaiyo ?
?iaeea?aeoaeueieie iniaeeainoyie aeeoeie.

Ai?iaaaeaeaiiy ?acoeueoao?a ?iaioe a i?aeoeeo. ?acoeueoaoe
aeine?aeaeaiue oi?iaaaeaeai? a ee?i?/io i?aeoeeo i?nueei? aeeoy/i?
e?ea?i? i. ?aiaoi???, ?AeEE i. Niioa?iiiey.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iaoa??aee ?iaioe aeeeaaeaii ia
iaoeiai-i?aeoe/ieo eiioa?aioe?yo a i. Oa?eia? (Oa?e?a, 1995, 1997), i.
Aeooo? (Aeoooa, 1997), ia e?ea?nueeeo eiioa?aioe?yo a naiaoi??yo E?eio
(?aiaoi??y, 1997, sseoa, 1997); ia Aei? iaoee eaoaae?e aini?oaeueii?
iaaeiao?i? EAeIO ?i. N.?. Aai?ai?anueeiai (Niioa?iiieue, 1997); ia
i?aeia?iaeieo eiia?anao: c iioiieiai? (Iineaa, 1997), c oi?o?ai?
(Oaeue-Aaia, 1998). Iniiai? ?acoeueoaoe ai?iaiaai? ia i?aeeaoaae?aeuei?e
eiioa?aioe?? EAeIO ?i. N.?. Aai?ai?anueeiai (Niioa?iiieue, 1999).

Ioae?eaoei?. Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii 8 ?ia?o, na?aae
ieo — 1 noaooy a iaoeiaiio aeo?iae?, aea? ?iaioe a ca??eao iaoeiaeo
i?aoeue, oace a iaoa??aeao c’?cae?a ? eiioa?aioe?e.

No?oeoo?a oa ianya aeena?oaoe??. ?iaioa neeaaea?oueny c? anooio, iaeyaeo
e?oa?aoo?e, 4 ?icae?e?a aeanieo aeine?aeaeaiue, iai??eoaaiiy
?acoeueoao?a, aeniiae?a, i?aeoe/ieo ?aeiiaiaeaoe?e, nieneo e?oa?aoo?e,
yeee aeeth/a? 195 aeaea?ae, iioae?eiaaieo a NIAe, ? 93 ca?oa?aeieo
aeaea?aea e?oa?aoo?e. Aeena?oaoe?y aeeeaaeaia ia 131 noi??ieao, i?noeoue
24 oaaeeoe?, 4 iaethiee.

CI?NO ?IAIOE

Iaoa??aee ? iaoiaee aeine?aeaeaiiy

Aeey ?ica’ycaiiy iinoaaeaieo caaaeaiue aoei ianoaaeaii 144 aeeoeie
e?einueei? iiioeyoei? neia’yinueeeo iaoe?iiaeueiinoae a a?oe? a?ae 1 aei
14 ?ie?a, a /enei yeeo aoiaeeei 54 oai?eo ia aino?o iiaaiiiith aac
oneeaaeiaiue (AI), 37 oai?eo ia iiaaiiiith, oneeaaeiaio aeano?oeoe??th
(AeI) (na?aae ieo 10 c aioo?ioiueieaaaiaaeie oi?iaie, 26 — ?c
eaaaiaai-ieaa?aeueiith oi?iith, 1 c? ci?oaiith oi?iith aeano?oeoei?), 24
oai?eo ia o?ii?/iee a?iio?o ? 29 – ia a?iioiaeoaoe/io oai?iao. Ca
a?o?aieie aeaieie aea/aii 80 inoi??e oai?iae: 61 — ae?oe ?c iiaaiiii?th
aac oneeaaeiaiue, 1 — ?c aeano?oeoeaiith iiaaiiii?th, 6 — c o?ii?/iei
a?iio?oii, 12 — ?c a?iioiaeoaoe/iith oai?iaith. Iaoe??ioe c o?ii?/iei
a?iio?oii ? a?iioiaeoaoe/iith oai?iaith ia i?aenoaa? noaoenoe/ii?
ia?iaee ?acoeueoao?a aeine?aeaeaiiy ? i?iaaaeaiiai ei?aeyoe?eiiai
aiae?co aoee ia’?aeiai? a a?oio OICE.

Ae?aaiic anoaiiaethaaany ca?aeii c eeaneo?eaoe??th ianiaoeeo?/ieo
a?iioieaaaiaaeo caoai?thaaiue o ae?oae, ui cai?iiiiiaaia ia II c’?cae?
ooiciao??a ? ioeueiiiieia?a Oe?a?ie (Ee?a, 1998).

Eaai?aoi?ia ianoaaeaiiy oai?eo i?iaiaeeeiny a aino?iio ia??iae? ? a
ia??iae? ee?i?/iiai iie?ioaiiy. Iaea?aeai? ?acoeueoaoe ii??aithaaeeny c
iieacieeaie caei?iaeo ae?oae e?einueei? iiioeyoei?.

I?e ae??ooaaii? iinoaaeaieo caaaeaiue a?aoiaoaaee a?e, noaoue, a?oie
e?ia? nenoaie AA0, Rhesus.

A?oie e?ia? nenoaie AA0, Rhesus aecia/aeeny noaiaea?oieie ne?iaaoeaie,
ui aeaioiaeaii E?einueeith INIE.

Iioiieia?/ii aeine?aeaeaiiy i?iaiaeeeeny a aeaio a?eiaeo eaoaai??yo:
a?ae 1 aei 6 ?ie?a ? a?ae 7 aei 14 ?ie?a. Iioa?aae i?ae aeine?aeaeaiiyi
a aino?iio ia??iae? ? a ia??iae? aeaeoaeaiiy neeaaeaa 3 oeaei?. Aeey
aecia/aiiy a?aeiinii? ? aaniethoii? e?eueeino? O-eiioioeeo?a oa ?o
noaiiioeyoe?e a e?ia?, o 59 ae?oae (36 oai?eo ia iiaaiiiith ? 23 oai?eo
ia OICE) aeei?enoiaoaaee iaoiae niiioaiiiai ?icaoeiooai?aiiy ?c
a?eo?ioeeoaie aa?aia (A-?oe), o 22 ae?oae (a a?oi? OICE, a?e 7-14 ?ie?a)
— iaoiae iiiieeiiaeueieo aioeo?e. Iaoiaeii A-?oe ii Jondal et al., 1972,
aecia/aee caaaeueio e?euee?noue O-e ? e?euee?noue O-oaioieii?acenoaioieo
(O-oo?, ui iathoue oaeia?io aeoeai?noue) oa O-oaioieii/ooeeaeo (O-oo/, c
noi?ani?iith aeoeai?noth ) eiioioeeo?a — ii A. Shore et al., 1978. A
?aaeoe?? iai?yii? iioiioethi?anoeaioei? (Remherz et al., 1979),
aeei?enoiaoth/e iiiieeiiaeuei? aioeeiioioeeoa?i? aioeo?ea na??? EEI
(EEI90, EEI86, EEI31), aecia/aee aeeoa?aioe?thaaeuei? aioeaaie iaia?aie
ia?eoa?e/ieo O-eiioioeeo?a: CD3 (O-caaaeuei? eiioioeeoe), CD4
(?aaoeyoi?ia noaiiioeyoe?y O-oaeia??a), CD8 (aoaeoi?i? O-eiioioeeoe), ?c
ianooiiei i?ae?aooaaiiyi ia ethiiianoeaioiiio i?e?ineii?.

Ai?no iioiiaeiaoeii?a A, M, G a ne?iaaooe? e?ia? aecia/aee iaoiaeii
?aaeiaeueii? iioiiaeeooci? a aaa?? ii G. Manchini et al., 1965, c
aeei?enoaiiyi aioene?iaaoie ? noaiaea?o?a Ieaeiueiai?iaenueeiai IAe?
aiiaeaiiieiai? oa i?e?iaiieiai?.

Aeey ioe?iee ?ie? i?ioean?a i?ioaieico ? N?I i?e aino??e oa o?ii?/i?e
iaoieiai? eaaaiue aeine?aeaeaii i?noeaaee noai iniiaieo eiiiiiaio?a oeeo
nenoai oeyoii aea/aiiy ai?noo a?iioiaeueaaiey?ieo nae?ao?a, ui a?eueo
niaoeeo?/ii a?aeia?aaeo? o/anoue oeeo nenoai a ?icaeaaii? iaoieiai?.
Ine?eueee caeaaeiino? aeaieo iieaciee?a a?ae a?eo aeyaeaii ia aoei, aiie
aiae?coaaeeny a iaei?e a?eia?e eaoaai??? a?ae 1 aei 14 ?ie?a.
A?iio?aeuei? cieae iaae?aeeny i?ae /an i?yii? a?iioineiii?, ui
i?iaiaeeeany i?ae aa?aioo?aoiei ia?eicii 53 ae?oyi ?c OICE a ia??iae?
caaino?aiiy, 6 ae?oyi ?c iiaaiiii?th aac oneeaaeiaiue oa 28 ae?oyi,
oai?ei ia aeano?oeoeaio iiaaiiiith a aino?iio ia??iae?.

Eiiiiiaioe IAN aeine?aeaeoaaee ca ?icuaieaiiyi neioaoe/ieo noano?ao?a:
aeanoaciiiae?aio aeoeai?noue (AIA) — ca a?ae?ie?cii
N-o-aie-aeaiie-i-iio?ioaiieiaiai ao??o (Iaeiaeiia I.A., 1980),
aioeo?iioe/io aeoeai?noue (AOA) ? -2-IA — i?e?iiaoiaeii ?onaeiaa N.A. ?
Eoaeoeiia A.A., 1995.

C eiiiiiaio?a IAI-nenoaie aeine?aeaeoaaee ia?aeii? i?iaeoeoe IIE —
aei?iia? eii’thaaoe (AeE), oeyoii ?o aeno?aeoei? noi?ooth
aaioai-icii?iiaiie (Aaa?ieia A.A., Iaoei?oaeia I.?., 1983), aoi?eii?
i?iaeoeoe IIE — i?iaeoeoe, ui aeoeai? aei oiiaa?aioo?iai? eeneioe
(OAEAI), ca eieuei?iaith ?aaeoe??th ?c 2-OAE a i?enooiino? iii?a Fe (3+)
(Asakawa T., Matsushita S., 1980). ?acoeueoaoe ae?aaeaee a iaeeieoeyo
iioe/ii? u?eueiino? (A) ia 1 ia eiiiae?a. Eiiiaee aecia/aee
oinoi?ii-aai?e?iiaei iaoiaeii. Aecia/aiiy aioeieenethaaeueiiai
iioaioe?aeo AAN aeeth/aei aeine?aeaeaiiy oea?oeiieaciiio iiaeeo?eiaaiei
iaoiaeii ?aaiia.

Noaoenoe/ia ia?iaea i?iaiaeeeany c aeei?enoaiiyi O-e?eoa??th
No’thaeaioa, ?aa?anieiiai oa ei?aeyoe?eiiai aiae?co ia IBM PC.

?acoeueoaoe aeine?aeaeaiue oa ?o iai??eoaaiiy

I?iaaaeaia aeine?aeaeaiiy aeicaieeei aeyaeoe ca’ycie i?ae
?acenoaioi?noth aeeoy/iai i?aai?cio, caeaoi?noth oi?ioaaiiy aeeoeiith
caoenieo ?aaeoe?e ? eiai oaiioeiiaeie iniaeeainoyie. I?inoaaeaia
caeaaei?noue ci?i a nenoaiao, ui aeine?aeaeoaaeenue, o ae?oae ?c
aino?ith oa o?ii?/iith iaoieiai?th eaaai?a a?ae a?eo, noao?, a?oi e?ia?.
?iciiae?e ianoaaeaieo ae?oae ca a?eii iaaaaeaii ia ?en.1.

Na?aae iaoe??io?a, oai?eo ia iaoneeaaeiaio iiaaiiiith, e?euee?nii
ia?aaaaeaee oeii/eee, ni?aa?aeiioaiiy ca noaooth (oeii/eee/ae?a/aoee)
neeaei 1,3. Iaea?eueo aenieei oeae iieaciee aoa o a?oe? 1-3 ?ie?a, ?
neeaa 2,4 (p<0,05). Na?aae oai?eo ia o?ii?/iee i?ioean a??ia?aeii a?eueoa ae?oae oe?eueiiai a?eo (p<0,001); ae?a/eiee oai??thoue /ano?oa ca oeii/ee?a a a?oe? 4-14 ?ie?a; iacaeaaeii a?ae noao? /ano?oa cono??/a?oueny A(III) a?oia e?ia? ? a aeaa ?ace ??aeoa AA(IV), a ii??aiyii? c? caei?iaeie ? c ae?oueie, oai?eie ia AeI; /anoea Rh-iiceoeaieo ae?oae a?eueoa i?ae a iiioeyoei? caei?iaeo ? a a?oiao AI oa AeI (p<0,001, <0,05, <0,05, a?aeiia?aeii); o 69,8 % ae?oae ?c OICE aia?oa iiaaiii?y ?icaeioeany o a?oe? aei 3 ?ie?a. O?iiicaoei? a?iioieaaaiaaiai i?ioeano ni?ey? iayai?noue ina?aaee?a o?ii?/ii? ?ioaeoe?? (aaeii?eo?a, aaeaii?aeio?a). Na?aae ae?oae oai?eo ia aeano?oeoeaio iiaaiiiith a??ia?aeii ia?aaaaeaee ae?oe ia?oeo o?ueio ?ie?a aeeooy (50 % an?o ae?oae, oa?ieo ia AeI a iao?e aea??oe?), /ano?oa, i?ae na?aae caei?iaeo oa ae?oae, oai?eo ia AI aai OICE cono??/aeany 0(I) a?oia e?ia?, ni?aa?aeiioaiiy ca noaooth (oeii/eee/ae?a/aoee) neeaei 0,9. Aiae?c noaio ee?oeiii? oa aoii?aeueii? eaiie iioiioaoo aeicaieea aeyaeoe ?o caeaaei?noue a?ae iicieia?/ii? oi?ie a?iioieaaaiaaiai i?ioeano, ia??iaeo caoai?thaaiiy, a?eo aeeoeie, noao?, a?oie e?ia?. Oa?aeoa?iei aeey o?ii?/ii? iaoieiai? aoei /eiaea cieaeaiiy ??aiy ne?iaaoeiaiai IgA (a/e) a ia??iae? caaino?aiiy (i?e/iio o ae?oae 7-14 ?ie?a aeaiee iieaciee aeinyaaa aeinoia??ii? cia/ouinoi: 1,070,09, p<0,02), ui oaeiae a?aei?/aeiny ? a noa?o?e a?eia?e a?oi? oai?eo ia iiaaiiiith (0,810,05, p<0,001); i?e/iio iecueeee ??aaiue IgA o ae?oae ?c OICE a noa?o?e a?oi? ia aeinyaaa eiio?ieueieo cia/aiue ? a ia??iae ?aiini? (1,100,08 a/e, p<0,05). O ae?oae, oai?eo ia AI ? OICE a aino?iio ia??iae? ?a?no?oaaeeny ae?aaeai? ci?ie c aieo ee?oeiiiai iioiioaoo ?, ia?aaeon?i O-eiioioeeo?a, O-oaeia??a, a?aeiinia oa aaniethoia e?euee?noue yeeo a ia?eoa?e/iie e?ia? aoea cieaeaia (oaae. 1). A iieiaeo?e a?oi? o an?o ianoaaeaieo ae?oae a aino?iio ia??iae? aoa a??ia?aeii cieaeaiee iioii?aaoeyoi?iee ?iaeaen (I??) (1,720,08, p<0,05). ? oi/a i?e iaeoaeoaaii? e?euee?noue O-e ? O-o i?aeaeuoaaeanue (oaae. 1), aiia ia aeinyaaea eiio?ieueieo cia/aiue; I?? ii?iaeicoaaany. A?aei?/aii, ui oaiie a?aeiiaethaaiiy iieaciee?a ee?oeiii? eaiee caeaaeaee a?ae aaaeeino? iaoieia?/iiai i?ioeano, - i?e a?eueo aaaeeiio ia?aa?ao aiie niia?eueithaaeeny. Oaaeeoey 1 Aeeiai?ea /enea O-eiioioeeo?a ? O-oaeia??a (x109/e) o ae?oae, oai?eo ia aino?o iiaaiiiith oa OICE (M m). A?oia IieacieeAe?oe 1-6 ?ie?aAe?oe 7-14 ?ie?aAI N-15OICE N-5Eiio?ieue N-14AI N-17OICE N-18Eiio?ieue N-25O-ea aino?iio ia??iae?*; ** 1,300,08* 1,300,102,300,08*; ** 0,900,05*; ** 0,840,041,400,03i?e iaeoaeaii?*; ** 1,650,09* 1,610,112,300,08*; ** 1,100,05*; ** 1,130,061,400,03O-oa aino?iio ia??iae?*; ** 0,900,07* 0,900,121,500,06*; ** 0,600,04* 0,500,040,900,02i?e iaeoaeaii?*; ** 1,230,07* 1,100,071,500,06*; ** 0,720,04* 0,750,030,900,02I?ei?oea: * - p<0,05 - 0,001, - aeinoia??i?noue a?aei?iiino? a?ae eiio?ieth. ** - ?<0,05 – 0,01 - aeinoia??i?noue a?aei?iiino? i?ae iieacieeaie a aino?iio ia??iae? oa i?e iaeoaeaii?. Iaea?eueo aaaeeeaei oeae iiiaio ? aeey ae?oae iieiaeoi? a?eiai? a?oie, ine?eueee o ieo iioiiee caoeno caaacia/o?oueny a?eueoith i??ith ca ?aooiie O-ee?oeiii? eaiee (ui i?iyaey?oueny o?c?ieia?/iei eiioioeeoicii), a ?ieue iioiiaeiaoeii?a a caoenieo ?aaeoe?yo ne?iii?oa, ai oi?ioaaiiy Ig G oa Ig A-neioacoth/eo nenoai cae?i/o?oueny i?ae 6-12 ?ie?a. Cieaeaiiy O-oaeia??a a noa?o?e a?oi? niieo/aeiny c iecueeei ??aiai ne?iaaoeiaiai IgA, ui iiaei ni?eyoe caoyaeiiio ia?aa?ao AI, o?iiicaoei? i?ioeano. I?aeaeuaiiy ??aiy ne?iaaoeiaiai Ig M (a/e), ui a?aecia/aeiny o an?o iaoe??io?a a aino?iio ia??iae?, na?ae/eei i?i aeniea aioeaaiia iaaaioaaeaiiy (1-6 ?ie?a: AI 1,230,05, p<0,05, OICE 1,430,17, p<0,05; 7-14 ?ie?a: AI 1,360,05, p<0,01, OICE 1,210,06, p<0,05). I?e iaeoaeaii? ??aaiue Ig M ii?iaeicoaaany, a oie /an ye ??aaiue ne?iaaoeiaiai Ig G a iieiaeo?e a?oi? ?aeiiaae?noeaio?a iiaaiiii? caeeoaany aenieei (12,510,68 a/e, p<0,05), ui eeii?/ii noi?iaiaeaeoaaeiny caaino?aiiyi o?ii?/ieo ina?aaee?a ?ioaeoe?? o oeeo ae?oae oa a?aeia?aaeoaaei aioeaaiia iaaaioaaeaiiy, ui o?eaaei, ine?eueee Ig G ? ae?oaith e?i??th caoenoo i?ney aeniaaeoaaiiy iiaeeeainoae Ig M. Aeyaeaii caeaaei?noue e?eueeino? ia?eoa?e/ieo O-e a?ae a?oie e?ia?. A a?oi? noa?oiai a?eo oai?eo ia iiaaiiiith oea i?iyaeyeiny oiia?eueiaiei oa iaaaeaeaaoiei a?aeiiaeaiiyi /enea O-e o ae?oae c B (III) a?oiith e?ia? (?en. 2). Oae, i?e iaeoaeaii? aaniethoia e?euee?noue O-e aeinoia??ii i?aeaeuoaaeanue o an?o iaoe??io?a (oi/ ? ia aeinyaaea eiio?ieth), e??i ae?oae ?c oaiioeiii A, ui iiaei ni?eyoe caoyaeiiio ia?aa?ao aino?i? iiaaiiii?, o?iiicaoei? a?iioieaaaiaaiai i?ioeano. ?en. 2. Aeeiai?ea O-eiioioeeo?a ia?eoa?e/ii? e?ia? o ae?oae 7-14 ?ie?a, oai?eo ia aino?o iiaaiiiith. O iaoe??io?a noa?oeo 7 ?ie?a c o?ii?/iei caiaeueiei i?ioeanii, /enei O-e (x109/e) a??ia?aeii ieae/a o ae?oae ?c oaiioeiii A (0,730,05, p<0,05), i?ae o ae?oae ?c oaiioeiii 0 aai A (0,900,06 oa 0,950,08 a?aeiia?aeii), ui ei?aeth? c? ca?eueoaiiyi /anoee ae?oae ?c oaiioeiii A na?aae oai?eo OICE (eiao?oe??io ei?aeyoei? r = -0,98). A??ia?aeiino? ??cieoe? i?ae a?oiaie e?ia? ii O-o oa I?? o noa?oeo ae?oae ia aoei, ui iiaeia iia'ycaoe c iaiaaeaiith e?euee?noth aeine?aeaeaiue. Ca'yceo i?ae e?euee?noth O-e oa noaooth aeeoeie ia aeyaeaii, oiae? ye aoii?aeueiee iioiioao caeaaeeoue a?ae a?oie e?ia? ? noao? aeeoeie. A a?oi? OICE aeyaeaii i?yio ei?aeyoe?th na?aaeiueiai nooiaiy i?ae ??aiai Ig M, Ig G ? a?oiaie e?ia? a noa?o?e a?eia?e a?oi? (r =0,541, p<0,05 oa r =0,491, p<0,05 a?aeiia?aeii). Iaeieae/ee ??aaiue Ig A (? a a?oi? oai?eo ia iiaaiiiith, ? a a?oi? OICE) aoa o iaoe??io?a ?c oaiioeiii A, ui ei?aethaaei c? ca?eueoaiiyi /enea ae?oae ?c oaiioeiii A na?aae oai?eo ia OICE: r = -0,999, p<0,01. O oeii/ee?a ??aaiue iioiiaeiaoeii?a a ne?iaaooe? e?ia? aeuee, i?ae o ae?a/ao a iaio a?eiaeo a?oiao. I?e iaoneeaaeiai?e iiaaiiii? o ae?a/aoie ??aaiue Ig G (a/e) aoa a??ia?aeii cieaeaiee a iaio a?eiaeo a?oiao (1-6 ?ie?a: ae?a/eiee - (6,390,59), oeii/eee - (14,021,01), p<0,01; 7-14 ?ie?a: ae?a/eiee - (6,400,78), oeii/eee - (13,691,42), p<0,01), a a noa?o?e a?eia?e a?oi? - ? ??aaiue Ig A (ae?a/eiee - (1,090,02) a/e, oeii/eee - (1,380,08) a/e, p<0,05), ui iiaei ni?eyoe ?aoeeaeeaoaaiith aino?i? iiaaiiii? o ae?a/ao, eeii?/ii noi?iaiaeaeoaaeiny caoyaeiei ia?aa?aii iiaaiiii? oa ca?eueoaiiyi /enea ae?a/aoie na?aae oai?eo ia o?ii?/io a?iioieaaaiaao iaoieiaith. I?ae /an ?icaeiaiiy caiaeaiiy a a?iioao ? eaaaiyo a?aeaoaathoueny i?ioeane, ui noi?iaiaeaeothoueny iaeiie/oaaiiyi i?ioaieioe/ieo oa?iaio?a ? a?eueieo ?aaeeeae?a, caeaoieo ?oeioaaoe niieo/iioeaieiiee ea?ean oa ?io? no?oeoo?i? aeaiaioe eaaaiue, ui iiaea i?ecaiaeeoe aei oi?ioaaiiy o?ii?/ii? iaoieiai?. Aiae?c iieaciee?a i?ioaieico ? N?I a a?iioiaeueaaiey?ieo cieaao ae?oae, ui aoee ianoaaeai? (oaae. 2), aeicaieea aeyaeoe, ui iaea?eueo oa?aeoa?ieie ci?iaie i?e aeano?oeoeaieo i?ioeanao a eaaaiyo o?aaa aaaaeaoe i?aeaeuaiiy aeoeaiino? aeanoaciiiae?aieo i?ioaiiac, iaeiie/oaaiiy ia?aeiieo i?iaeoeo?a ia?aeiniiai ieeneaiiy eiiiae?a ? cieaeaiiy aeoeaiino? oea?oeiieaciiio. I?e o?ii?/iiio caiaeaii? ca?eueoaiiy aeoeaiino? i?ioaiiac a AAN noi?iaiaeaeo?oueny i?eaiiaeaiiyi aioei?ioaiiaciiai iioaioe?aeo, a aeoeaaoe?y ieneaeaioieo i?ioean?a oa?aeoa?eco?oueny ca?eueoaiiyi ye ia?aeiieo, oae ? aoi?eiieo i?iaeoeo?a IIE. Oaaeeoey 2 Ii??aiyeueia oa?aeoa?enoeea i?ioean?a i?ioaieico ? a?eueii-?aaeeeaeueiiai ieeneaiiy a AAN o ae?oae i?e aino??e oa o?ii?/i?e iaoieiaii eaaaiue (M m). Iieacieee A?oieYIA iiieue/iaieiAOA ieiieue/a-2-IA ieiieue/aAeE A232/iaOAEAI iiieue IAeA/iaOeI ia/aAino?a iiaaiii?y N-6 6,251,25 0,550,06* 0,480,05 0,690,45 12,012,72 32,18,8Aeano?oeoeaia iiaaiii?y N-28 6,981,03 0,500,06 0,380,04* 1,210,15 8,131,33* 16,12,0OICE N-53* 9,611,36* 0,310,06* 0,490,04 0,670,05 15,841,50 35,44,4Eiio?ieue N-8 4,641,40 0,680,18 0,330,06 0,370,15 10,802,50 26,25,8I?ei?oea: * - ?1<0,05 –a??ia?aei?noue a?aei?iiino? a?ae eiio?ieth, Aeey ioe?ithaaiiy ca'yceo i?ioean?a i?ioaieico ? N?I ?c aeayeeie aaiaoe/ieie ia?ea?aie ae?oae ?c aino?ith oa o?ii?/iith a?iioieaaaiaaith iaoieiai?th i?iaaaeaii c?noaaeyiiy iaea?aeaieo ?acoeueoao?a caeaaeii a?ae a?oi e?ia?. I?iaaaeaiee aiae?c aeicaieea aeyaeoe a nenoaiao, ui aea/aeeny, iniaeeaino? i?noeaaeo ?aaeoe?e, oa?aeoa?ieo aeey ?icaeoeo aino?i? aeano?oeoeaii? iiaaiiii? oa o?ii?/iiai ianiaoeeo?/iiai caiaeueiiai i?ioeano. I?e aino??e aeano?oeoeai?e iiaaiiii? iaea?eueo ae?aaeai? ci?ie niinoa??aathoueny o oai?eo c II ? III a?oiaie e?ia? (?en. 3). Oea i?aeoaa?aeaeo?oueny iayai?noth i?yiiai ei?aeyoe?iiiai ca'yceo (r =+0,45, p<0,05) aeey AeE c a?oiaie e?ia?, - c i?aeaeuaiiyi oeueiai iieacieeo a a?oi? B(III) ?, iniaeeai, A(II); a oaeiae aeinoia??iith ei?aeyoe??th (r =+0,42, p<0,05) c a?oiaie e?ia? ??aiy -2-iae?iaeiaoeiia, ?c i?i?iaeueiei eiai cia/aiiyi o ae?oae ?c A(II) ?, iniaeeai, AA(IV) a?oiith. O iaoe??io?a c III a?oiith e?ia? a?aecia/athoueny iaea?eueo aenie? oeeo?e aeoeaiino? aeanoace (14,216,21 iiieue/iaoiii), ui ia?aaeuothoue eiio?ieue a o?e ?ace, ? cieaeaia aioeo?eioe/ia aeoeai?noue AAN. O oai?eo c AA(IV) a?oiith AOA aeoeai?noue aoea iaioith, i?ae a eiio?ie? iaeaea a 3,5 ?ace (0,200,02 ieiieue/a, p<0,05). O oie aea /an, c aieo IAI-nenoaie iaea?eueo aenie? cia/aiiy ia?aeiieo i?iaeoeo?a ia?aeeniiai ieeneaiiy a?aecia/ai? o oai?eo ?c A(II) a?oiith e?ia?: eiioeaio?aoe?y AeE a AAN oeeo ae?oae cia/ii aeua, i?ae a AAN ae?oae c ?ioeie a?oiaie e?ia?, oa ia?aaeuo? eiio?ieue a 4 ?ace (1,620,27 A232/ia, p<0,01). A oe?e aea a?oi? a?aei?/aeeny ? iaea?eueo aenie? cia/aiiy aoi?eiieo i?iaeoeo?a ia?aeeniiai ieeneaiiy, iaea?eueo iecuee? cia/aiiy oea?oeiieaciiia. A a?oi? oai?eo ia aeano?oeoeaio iiaaiiiith c 0(I) a?oiith e?ia? i?aeaeuaiiy AeE oaeiae aeinyaaei a??ia?aeiino? ??cieoe? c eiio?ieai (0,910,20 A232/ia, p<0,05). Iaeiie/oaaiiy ioea ia?aeiieo i?iaeoeo?a IIE a AAN oa?aeoa?ii ? aeey iaoe??io?a ?c A(III) a?oiith e?ia?, ??aaiue AeE o yeeo ia?aaeuoaaa eiio?ieue a 3 ?ace. Oe? aeai? aeicaieythoue i?eionoeoe, ui a?eueo ae?aaeai? ci?ie a cacia/aieo nenoaiao ni?eythoue oi?ioaaiith aeano?oeoei? o oai?eo c A(II) ? B(III) a?oiaie e?ia?. Iaea?aeai? ?acoeueoaoe (?c o?aooaaiiyi aeaieo ii OICE) oaeiae aeicaieythoue noaa?aeaeoaaoe, ui aeinaaeain a nenoai? IAI ? IAN ? naia o ae?oae ?c A(III), ?, iaioith i??ith, o ae?oae c A(II) a?oiith e?ia? i?e/eiith a?eueo aaaeeiai ia?aa?ao eaaaiaai? aeano?oeoei? c oi?ioaaiiyi ii?oieia?/iiai noano?aoo aeey o?ii?/iiai i?ioeano. I?e o?ii?/iiio caiaeaii? a eaaaiyo (?en. 4) iaea?eueo aenie? oeeo?e AIA a?aei?/ai? o oai?eo ?c 0(I) a?oiith e?ia? (15,12,5 iiieue/iaoiii, p<0,01). O oeeo aea oai?eo a?aei?/athoueny a 2 ?ace ieae/? ca eiio?ieuei? cia/aiiy aioeo?eioe/ii? aeoeaiino? AAN. I?ioa a?eueo aeeaiea i?eaiiaeaiiy i?noeaaiai aioeo?eioe/iiai iioaioe?aeo niinoa??aa?oueny o oai?eo ?c A(II) ? B(III) a?oiaie e?ia? (0,270,06 ieiieue/a a iaio a?oiao, p<0,05), ui ? iaea?eueo ?noioiei iiiaioii o?iiicaoei? caiaeaiiy. C ?ioiai aieo, iaeaeu? cia/aiiy i?iaeoeo??a ia?aeeniiai ieeneaiiy eiiiae?a a?aecia/ai? oaeiae o oai?eo ?c A(II) oa B(III) a?oiaie e?ia?. Aei?iia? eii'thaaoe o oai?eo ?c B(III) a?oiith ia?aaeuothoue eiio?ieue a 2 ?ace (0,850,12 A-232/ia, p<0,05), ? a?eueoa i?ae a 1,5 ?ace i?aeaeuai? aoi?eii? i?iaeoeoe IIE. ??aaiue OAEAI iaeneiaeueiee o iaoe??io?a ?c oaiioeiii A (17,92,3 iiieue Iaea/ia, p<0,05). O oai?eo ?c B (III) a?oiith e?ia? ia oii? i?aeaeuaieo iieaciee?a IIE e?euee?noue OeI ia?aaoaa? ia ??ai? eiio?ieth. Noaoenoe/iee aiae?c iieacaa iayai?noue iii??ii? i?yii? ei?aeyoe?? iieaciee?a i?ioaacii-iiaiaioi?ii? nenoaie, ui aeine?aeaeothoueny (eiao?oe??io iiiaeeiii? ei?aeyoei? r =0,451), ? iieaciee?a IAI-nenoaie (eiao?oe??io iiiaeeiii? ei?aeyoei? r =0,337) c a?oiaie e?ia? ae?oae, oai?eo ia OICE. I?aeaeuaiiy ??aiy AeE ? cieaeaiiy aioeo?eioe/ii? aeoeaiino? a AAN oai?eo c B(III) a?oiith e?ia? o ii??aiyii? c ae?oueie ?ioeo a?oi e?ia? ei?aethaaei c? ca?eueoaiiyi /anoee ae?oae ?c oaiioeiii B a iao?e aea??oe? (/anoea A(III) a?oie e?ia? a aea??oe? - 29,6 %, a eiio?ieuei?e a?oi? - 17,9 %, ??cieoey d=+11,7%): eiao?oe??io ei?aeyoei? i?ae ??aiai AOA ? ??cieoeath a iaeia?e o/ano? a?oi e?ia? r = -0,540, eiao?oe??io ei?aeyoei? i?ae ??aiai AeE ? ??cieoeath a iaeia?e o/ano? a?oi e?ia? r =+0,646. Oaeei /eiii, ci?uaiiy ??aiiaaae o iai?yi? ia?aaaaeaiiy oai?eo ?c B(III) ? A(II) a?oiaie e?ia? na?aae oai?eo ia o?ii?/io iaoieiaith eaaaiue oa?aeoa?eco?oueny iaea?eueo ae?aaeaieie o ieo c?ooaiiyie a nenoai? i?ioaieico ? N?I, oa ei?aeth? ?c oeeie c?ooaiiyie. sseui a oe?eiio aeey o?ii?/ii? a?iioieaaaiaai? iaoieiai? oa?aeoa?ia i?eaiiaeaiiy aioei?ioaaciiai iioaioe?aeo ? iaeiie/oaaiiy ia?aeiieo oa aoi?eiieo i?iaeoeo?a IIE, oi iaea?eueo ae?aaeai? ci?ie aeaieo iieaciee?a a?aei?/ai? a a?oiao oai?eo ?c A(II) i B(III) a?oiaie e?ia?. Aeyaeaii iaai? ci?ie a i?ioeanao i?ioaieico ? a?eueii-?aaeeeaeueiiai ieeneaiiy a AAN ae?oae caeaaeii a?ae noao?. I?e aeano?oeoeai?e iiaaiiii? o ae?a/aoie, a ii??aiyii? c oeii/eeaie, a?aei?/aii aeu? cia/aiiy iioeiaeaeoth/i? eaiee iaio nenoai (AIA (ii/iaxiii): ae?a/eiee 7,402,65, oeii/eee 6,531,95; ? AeE (A232/ia): ae?a/eiee 1,250,28, oeii/eee 1,180,17, oi/ a??ia?aeiino? oey ??cieoey ia aeinyaaea), ? ieae/? cia/aiiy iiaiaioi?ii? eaiee (AOA (ieI/a): ae?a/eiee 0,440,09, oeii/eee 0,540,08, p>0,05; -2-IA (ieI/a): ae?a/eiee 0,300,06, oeii/eee 0,450,04,
p<0,05), ui oa?aeoa?eco? iaea?eueo oeiia? ci?ie i?e aeai?e iaoieiai?. I?e o?ii?/i?e iaoieiai? o ae?a/aoie a?aei?/aii ieae/? cia/aiiy -2-IA (ieI/a: ae?a/eiee 0,370,04, oeii/eee 0,640,08, p<0,01), ? oaiaeaioe?y aei a?eueo aenieeo cia/aiue ia?aeiieo oa aoi?eiieo i?iaeoeo?a IIE, o ii??aiyii? c oeii/eeaie. I?ae ai?noii -2-IA ? noaooth i?e OICE anoaiiaeaii aeinoia??iee iii??iee i?yiee ei?aeyoe?eiee ca'ycie: r =+0,39 (?<0,01). Iiaeia i?eionoeoe, ui a?eueo ae?aaeai? o ae?a/eiie ci?ie a i?ioeanao i?ioaieico ? a?eueii-?aaeeeaeueiiai ieeneaiiy ni?eythoue /ano?oiio ?icaeoeo o ieo aeano?oeoeaieo i?ioean?a oa o?iiicaoei? a?iioieaaaiaaiai i?ioeano. sse iieacaei i?iaaaeaia aeine?aeaeaiiy, cieaeaiiy ?acenoaioiinoi ae?oae iia'ycaii, ia?aaeon?i, c ii?ooaiiyie ooieoe?iioaaiiy ie?aieo aaiieo eiiieaen?a a nenoai? aaiioeio. Ae?oe, ui ia iathoue iiae?aieo ii?ooaiue, iaea?eueo no?ee? aei aieeao oe?aeeeaeo aiaei- ? aeciaaiieo /eiiee?a, iiaaiiiiy (a ?ac? ?? ?icaeoeo) i?io?ea? o ieo aac oneeaaeiaiue. Ae?oe, ui iathoue ii?ooaiiy a nenoai? aaiioeio, ia o?eueee aaae/a oai??thoue ia iiaaiiiith, yea iiaea i?io?eaoe o ieo c ?icaeoeii aeano?oeoei?, aea ? noeeuei? aei ?icaeoeo a?iioiaeoac?a. Oiaoi, ae?oe, yeeo ianoaaeaii iaie, aoee aaoa?iaaii? ca nai?ie oa?aeoa?enoeeaie, ? ia?aa?a iiaaiiii? o ieo ii/anoe caeaaeaa a?ae ?o oaiioeiiaeo oa?aeoa?enoee (noao?, a?oie e?ia?, ?acon-oaeoi?a), ui aecia/athoue aiaeiaaiio noeeuei?noue aei iiaaiiii?, yea (noeeuei?noue) ?aae?co?oueny i?ae aieeaii /eiiee?a na?aaeiaeua. Ioaea, iiaaiiiiy iineoue ?ene ioeueoi-oaeoi?iaeueiinoi. A ??ciiiai?oia niieo/aiiy aiaei- ? aeciaaieo /eiiee?a aecia/a? ee?i?/i? oi?ie ?anii?aoi?ieo caoai?thaaiue o ae?oae. I?e/iio, yeui i?ia?aeio ?ieue a ?icaeoeo iiaaiiii? o aeeoeie a?athoue aaiaoe/i? oaeoi?e, - caoai?thaaiiy i?io?ea? aaaeei, c ?icaeoeii oneeaaeiaiue, noeeuei?noth aei o?iiicaoei? a?iioieaaaiaaiai i?ioeano ? ?icai?oa?oueny a a?eueo ?aiiueiio a?oe?. I?e i?ia?aei?e ?ie? a aaiac? iiaaiiii? /eiiee?a na?aaeiaeua, caoai?thaaiiy i?io?ea? eaaoa, aac ?icaeoeo oneeaaeiaiue. Oe? a?oie ae?oae a?ae??ciythoueny iaeia a?ae iaeii? ca oaiioeiiaeie oa?aeoa?enoeeaie, ye ? a?ae a?oie caei?iaeo ae?oae. Oae, ae?oe c aenieei ?eceeii ?icaeoeo OICE oa?aeoa?ecothoueny oaiioeiii A, Rh+, aia?oa caoai?ththoue AI ia ia?oiio (iae/ano?oa) ?ioe? aeeooy, /anoi oai??thoue ia ?anii?aoi?i? caoai?thaaiiy, aeey ieo oa?aeoa?ia iayai?noue ina?aaee?a o?ii?/ii? ?ioaeoe??, ae?ii/a noaoue. O ae?oae ?c oaiioeiii 0 a ia?o? aeaa ?iee aeeooy aenieee ?ecee ?icaeoeo aino?i? aeano?oeoeaii? iiaaiiii?, a ?icaeoie aeano?oeoeaii? iiaaiiii? o ae?oae c a?oiith e?ia? B(III) ? oaeoi?ii ?eceeo o?iiicaoei?. Oaeei /eiii, ae?oe ?c aeanoaaieicaoe??th ooieoe?? nenoai, ui aaiaoe/ii aeaoa?i?iiaai?, iathoue i?aeaeuaio ?iia??i?noue ?icaeoeo iiaaiiii?, oneeaaeiaiiai ?? ia?aa?ao, o?iiicaoei? a?iioieaaaiaaiai i?ioeano. Aeae?eyoe oeeo ae?oae a a?oie ?eceeo c ianooiiei i?iaaaeaiiyi oe?eani?yiiaaieo i?io?eaeoe/ieo caoiae?a iaaecae/aeii aaaeeeai aeey cieaeaiiy ?eceeo ?icaeoeo o?ii?/iiai a?iioieaaaiaaiai i?ioeano o aeaiiai eiioeiaaioo ae?oae. AENIIAEE 1. Ia?aa?a a?iioieaaaiaai? iaoieiai? o ae?oae ia? caeiiii??iinoi o aeaeyae? ?icaeoeo aeano?oeoei? aai o?iiicaoei? i?ioeano a caeaaeiino? a?ae noaio aeayeeo eaiie iioiioaoo, i?ioean?a i?ioaieico, ia?aeeniiai ieeneaiiy eiiiae?a ? oaiioeiiaeo iciae. 2. Aino?a iaoneeaaeiaia iiaaiiiiy /ano?oa cono??/a?oueny o ae?oae ia?oeo o?ueio ?ie?a aeeooy, o oeii/ee?a a 2,4 ?ace /ano?oa i?ae o ae?a/eiie. Aeano?oeoeaia iiaaiiiiy /ano?oa cono??/a?oueny a ia?o? 2 ?iee aeeooy o ae?oae c 0(I) a?oiith e?ia?, aea aaae/a i?io?ea? ? /ano?oa o?iiico?oueny o ae?oae ?c A(III) a?oiith e?ia?, o oeii/ee?a oa ae?a/eiie c iaeiaeiaith /anoioith. O?ii?/i? ianiaoeeo?/i? caoai?thaaiiy eaaaiue /ano?oa cono??/athoueny a oe?eueiiio a?oe? o ae?a/eiie c a?oiith e?ia? B(III), Rh+. 3. Iaa?aeiia?aei?noue ee?i?/iiai aeaeoaeaiiy ? ii?iae?caoe?? iioiieiai/ieo iieaciee?a (O-ee?oeiii? eaiee ? IgA) i?e iiaaiiii? iaea?eueo ae?aaeaii o ae?oae ?c A(III) a?oiith e?ia? ? iiaea ni?eyoe o ieo ?aoeeaeeaoaaiith i?ioeano. 4. A ?aiiueiio a?oe? oneeaaeiaiiio ia?aa?ao iiaaiiii? o ae?oae ?c oaiioeiii A ni?ey? iecueeee ??aaiue O-eiioioeeo?a, a oe?eueiiio - cieaeaiiy ne?iaaoeiaiai IgA, o ii??aiyii? c ae?oueie ?c oaiioeiii 0 ? A. 5. Aeano?oeoeaiee i?ioean a eaaaiyo o ae?oae noi?iaiaeaeo?oueny i?aeaeuaiiyi aeanoaciiiae?aii? aeoeaiino?, iaeiie/oaaiiyi ia?aeiieo i?iaeoeo?a ia?aeeniiai ieeneaiiy eiiiae?a ? cieaeaiiyi aeoeaiino? oea?oeiieaciiio a a?iioiaeueaaiey?iiio nae?ao?. Aeey o?ii?/iiai caiaeaiiy oa?aeoa?ii i?noeaaa ca?eueoaiiy aeoeaiino? i?ioaiiac, ui noi?iaiaeaeo?oueny i?eaiiaeaiiyi aioei?ioaaciiai iioaioe?aeo, ? aeoeaaoe?y ieneaeaioieo i?ioean?a c? ca?eueoaiiyi ye ia?aeiieo, oae ? aoi?eiieo i?iaeoeo?a ia?aeeniiai ieeneaiiy. Ia?ae?/ai? ii?ooaiiy iaea?eueo ae?aaeai? o ae?oae ?c A(II) i A(III) a?oiaie e?ia?. 6. A?eueo iecueeee ??aaiue ne?iaaoeiaeo iioiiaeiaoeii?a o ae?a/ao, cieaeaiiy o ieo -2-IA a a?iioiaeueaaiey?iiio nae?ao?, oaiaeaioe?y aei a?eueo aenieeo cia/aiue ia?aeiieo oa aoi?eiieo i?iaeoeo?a ia?aeeniiai ieeneaiiy, o ii??aiyii? c oeii/eeaie, ni?ey? /ano?oiio ?icaeoeo o ieo aeano?oeoeaieo i?ioean?a oa o?iiicaoei? a?iioieaaaiaaiai i?ioeano. I?AEOE*I? ?AEIIAIAeAOe?? 1. Ae?a/aoa c a?oiith e?ia? B(III), Rh+, ui caoai??ee ia aino?o iiaaiiiith, iniaeeai a ?aiiueiio a?oe? oa ?c aeano?oeoeaieie oneeaaeiaiiyie, iiaeii? aooe aeae?eai? a a?oie ?eceeo ca ?icaeoeii o?ii?/iiai a?iioieaaaiaaiai i?ioeano ?c i?iaaaeaiiyi oe?eani?yiiaaieo i?io?eaeoe/ieo caoiae?a. 2. Ae?a/aoai, iniaeeai oe?eueiiai a?eo, oai?ei ia aino?o iiaaiiiith iieacaia ye oa?aiiy aioeieneaeaioaie ? iieiaaeaioieie iiaiaioi?aie i?ioaieico, oae ? a?aeiiaeaiiy ??aiy iioiiaeiaoeiia A. 3. ?icaeoie aino?i? iiaaiiii? o ae?oae ?c oaiioeiii B a ?aiiueiio a?oe? aaaea aei iaiao?aeiino? aeeth/aiiy a eiiieaen e?eoaaeueieo caoiae?a iioiiiiaeoeyoei? O-ee?oeiii? eaiee, a oe?eueiiio a?oe? - cai?nii? oa?aii? i?aia?aoaie c aenieei ai?noii IgA (a ?ac? a?aenooiino? ia?aeiiiai aeaoaeoo aioeo?eiooai?aiiy). Iieacaia aioeieneaeaioia oa?aiiy. 4. Ae?oe, ui oai??thoue ia o?ii?/iee a?iio?o aai a?iioiaeoaoe/io oai?iao, iio?aaothoue ?aaa?e?oaoe?? ?ia?a?oi?iiai oa aioeieneaeaioiiai iioaioe?aeo, iniaeeai iaoe??ioe c oaiioeiii A ? A, aeey yeeo a?eueo aaaeeeaa i?noeaaa (aioo??oiueia?iio?aeueia) ni?yiiaai?noue cacia/aieo caoiae?a. Oe? ae ae?oe iio?aaothoue ?ioiiiiaeoeyoe?? c oaeia?iith ni?yiiaai?noth. 5. An?i ae?oyi, ui ia?aoai??ee ia aino?o iiaaiiiith, iiaeii? i?iaiaeeoeny ?aaaieioaoe?ei? caoiaee ia iaio i?ae 6 i?nyoe?a, a ca'yceo c iaa?aeiia?aei?noth ee?i?/iiai aeaeoaeaiiy ? ii?iae?caoe?? iieaciee?a caoenieo nenoai, cie?aia, iioiii?. NIENIE ?IA?O, IIOAE?EIAAIEO CA OAIITH AeENA?OAOe?? 1) Eiaaoe O.A., Ai?iiei N.I., Aiaaeaethe A.E. Eiioiiaaiaoe/aneea aniaeou ?acaeoey e oa/aiey ino?ie iiaaiiiee o aeaoae // I?iaeaiu, aeinoeaeaiey e ia?niaeoeau ?acaeoey iaaeeei-aeieiae/aneeo iaoe e i?aeoe/aneiai cae?aaiio?aiaiey: O?oaeu E?uineiai iaaeeoeeineiai einoeoooa. – Neioa?iiieue, 1995. – O.131. – N.285-289. 2) Aiaaeaethe A.E. ?ieue oaiioeia, i?ioaacii-aioei?ioaaciie, ieneaeaioii-aioeieneaeaioiie nenoai i?aaiecia a ?acaeoee e oa/aiee ino?ie iiaaiiiee o aeaoae // Iaaeeoeeineay ?aaaeeeoaoeey, eo?i?oieiaey, oeceioa?aiey. – 1998. - ?3(15). – N.40-42. 3) Aiaaeaethe A.E. Naycue iaaeaeo iieacaoaeyie i?ioaieeoe/aneie, ieneaeaioii-aioeieneaeaioiie nenoai e a?oiiaie e?iae o aeaoae n o?iie/aneie a?iioie?ai/iie iaoieiaeae // I?iaeaiu, aeinoeaeaiey e ia?niaeoeau ?acaeoey iaaeeei-aeieiae/aneeo iaoe e i?aeoe/aneiai cae?aaiio?aiaiey: O?oaeu E?uineiai ainoaea?noaaiiiai iaaeeoeeineiai oieaa?neoaoa ei. N.E. Aai?aeaaneiai. – Neioa?iiieue, 1998. – O.134, /anoue ??. – N.258-262. 4) ?aaaeeeoaoeey aeaoae n iiaoi?iie ino?ie iiaaiiieae n o/?oii eo oaiioeie/aneeo iniaaiiinoae / O.A.Eiaaoe, N.I.Ai?iiei, A.E.Aiaaeaethe, A.A.Eoauoeei // Iiaua aeinoeaeaiey a ?aiiae aeeaaiinoeea ainiaeeoaeueiuo caaieaaaiee i?aaiia aeuoaiey…: Iaoa?eaeu iao/ii-i?aeoe/aneie eiioa?aioeee. – Oa?ueeia, 1995. – N.26. 5) Aiaaeaethe A.E. Oaeoi?u ?enea ?acaeoey o?iie/aneiai a?iioie?ai/iiai i?ioeanna o aeaoae // ?ieue caaaeueiii?aeoeeoth/iai e?ea?y o ?ica’ycaii? i?iaeai i?io?eaeoeee ia?ioaeoe?eieo caoai?thaaiue: Iaoa?. iaoe. i?aoeue ?ani. iaoeiai-i?aeo. eiio. – Oa?e?a, 1997. – N. 19. 6) Eoauoeei A.A., Aiaaeaethe A.E., Eiaaoe O.A. Naycue iaaeaeo /eneii O-eeioioeeoia e a?oiiaie e?iae, iannie e aeeeiie oaea i?e ?iaeaeaiee aeaoae n ino?ie iiaaiiieae // Aeooaeueiua aii?inu nia?aiaiiie iaaeeao?ee: Iaoa?eaeu iaaeaeoia?iaeiie eiioa?aioeee. – Na?aoia, 1997. – N.14. 7) Iainiiaaiea iiaeoiaeia e ?aaaeeeoaoeee aioei?ioaaciie e aioeieneaeaioiie nenoai i?e ainiaeeoaeueiuo caaieaaaieyo e?aeeo / A.A.Eoauoeei, A.I.Nioaeia, A.E.Aiaaeaethe, N.I.Ai?iiei, N.I.O?ioei/oe, I.A.*aaioa // International Journal on immunorehabilitation. – 1997. - ?4. – N.73. 8) Immunologic reactivity of children with different phenotypic indications / T.Kobez, M.Ivanova, A.Govdalyuk, I.Usachenko, N.Lagunova // Wounds, burns, dressings: International surgery congress. – Tel-Aviv, 1998. – P.75. ae?oe, iiaaiii?y, ?ioi?oao, i?ioaie?c, ia?aeenia ieeneaiiy e?i?ae?a, oaiioei. aeaoe, iiaaiiiey, eiioieoao, i?ioaieec, ia?aeeniia ieeneaiea eeieaeia, oaiioei. children, pneumonia, immunity, proteolysis, peroxide oxidation of lipids, phenotype. I?aaenoaaeaii ?acoeueoaoe ianoaaeaiiy 224 ae?oae, na?aae yeeo 115 oai?eo ia iiaaiii?th aac oneeaaeiaiue, 38 oai?eo ia aeano?oeoeaio iiaaiii?th, 71 – c OICE. I?iaiae?ciaaii noai ieneaeaioii-aioeieneaeaioii? oa i?ioaacii-aioei?ioaacii? nenoaie a a?iioiaeueaaiey?iiio nae?ao?, a oaeiae noai ee?oeiii? oa aoii?aeueii? eaiie ?ioi?oaoo. Aeey eiaeii? iicieia?/ii? oi?ie aeyaeaii iaiaeiaeiaee ca neeith ca’ycie oa?aeoa?ieo ii?ooaiue a oeeo nenoaiao c a?eii, noaooth, a?oiaie e?ia?, ?acon-iaeaaei?noth ae?oae. Iaea?eueoa ei?aeyoe?y ii?ooaiue a?aei?/aia c A(???) a?oiith e?ia?, Rh+, ae?ii/ith noaooth, a?eii aei 3 ?ie?a. Oea aeicaiey? aeae?eyoe na?aae oai?eo ia iiaaiii?th a?oie ?eceeo ca ?icaeoeii aeano?oeoe?? oa o?ii?caoe?? i?ioeano, a oaeiae ?aeiiaiaeoaaoe ?iaeea?aeoaeueio ni?yiiaai?noue e?eoaaeueieo ? i?io?eaeoe/ieo caoiae?a. I?aaenoaaeaiu ?acoeueoaou ianeaaeiaaiey 224 aeaoae, n?aaee eioi?uo 115 aieueiuo iiaaiiieae aac ineiaeiaiee, 38 aieueiuo aeano?oeoeaiie iiaaiiieae, 71 – n OICE. I?iaiaeece?iaaii ninoiyiea ieneaeaioii-aioeieneaeaioiie e i?ioaacii-aioei?ioaaciie nenoaiu a a?iioiaeueaaiey?iuo nae?aoao, a oaeaea ninoiyiea eiioiiie nenoaiu a aeeiaieea a aeaoo aic?anoiuo eaoaai?eyo. Aeey eaaeaeie iicieiae/aneie oi?iu auyaeaia ?aciay ii neea naycue oa?aeoa?iuo ia?ooaiee a yoeo nenoaiao n aic?anoii, iieii, a?oiiaie e?iae, ?acon i?eiaaeeaaeiinoueth aeaoae. Iaeaieueoay ei??aeyoeey ia?ooaiee ioia/aia n A(???) a?oiiie e?iae, Rh+, aeaineei iieii, aic?anoii aei 3 eao. Yoi iicaieyao auaeaeyoue n?aaee aieueiuo iiaaiiieae a?oiiu ?enea ii ?acaeoeth aeano?oeoeee e o?iiecaoeee i?ioeanna, a oaeaea ?aeiiaiaeiaaoue eiaeeaeaeoaeueioth iai?aaeaiiinoue ea/aaiuo e i?ioeeaeoe/aneeo ia?ii?eyoee. There are presented the results of examining 224 children, 115 of which are the patients with pneumonia without complications, 38 ones with destructive pneumonia, 71 – with chronic non-specific lung diseases. The state of oxidant-antioxidant and protease-antiprotease system in bronchoalveolar secretions as well as of cellular and humoral links of immunity have been analyzed. For each nosologic form different by the force connection of failures in these systems with the age, sex, blood group, rhesus appertaining of children has been revealed. The greatest correlation of failures with B(III) blood group, Rh+, female sex, age till 3 years has been marked. It allows to single out among the patients with pneumonia risk groups according to the development of destructions and chronization of process and to recommend individual orientation of medical and prophylactic measures.

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