.

Цитогенетична та морфофункціональна характеристика ооцитів людини у зв’язку з їх заплідненням in vitro (клініко-експериментальне дослідження): Автореф

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OE?A?INUeEEE IAOEIAEE A?A??I?*IEE OeAIO?

EIAAEAIEI

Oai?ea Aiaoie??aia

OAeE 618.177-089.888.11(048.8)

OeEOIAAIAOE*IA OA II?OIOOIEOe?IIAEUeIA OA?AEOA?ENOEEA IIOeEO?A ETHAeEIE

O CA’ssCEO C ?O CAIE?AeIAIIssI IN VITRO (EE?I?EI-AENIA?EIAIOAEUeIA
AeINE?AeAEAIIss)

03.00.15 – aaiaoeea

Aaoi?aoa?ao aeena?oaoe??

ia caeiaoooy a/aiiai nooiaiy

eaiaeeaeaoa a?ieia?/ieo iaoe

EE?A – 1999

4

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia a Oe?a?inueeiio iaoeiaiio oeaio?? iaaee/ii? aaiaoeee IIC
? IAI Oe?a?ie

Iaoeiaee ea??aiee: eaiaeeaeao a?ieia?/ieo iaoe,
noa?oee iaoeiaee ni?a?ia?oiee

Noaoaiiae/ Aaiia Aieiaeeie??aia

Oe?a?inueeee iaoeiaee oeaio? iaaee/ii? aaiaoeee IIC ? IAI Oe?a?ie,
caa?aeoth/a eaai?aoi???th aaiaoeee ?aiiueiai ?icaeoeo ethaeeie

Io?oe?ei? iiiiaioe: aeieoi? a?ieia?/ieo iaoe,
i?ioani?

Aeai?aeia Na?a?e A?eoi?iae/

Ee?anueeee iaoe?iiaeueiee oi?aa?neoao ?i. Oa?ana Oaa/aiea, caa?aeoth/ee
eaoaae?ith

caaaeueii? oa iieaeoey?ii? aaiaoeee

eaiaeeaeao a?ieia?/ieo iaoe,

Ca?iaa-Ethaeiiaa Oaoyia Aaeoa?ae?aia

Ee?anueea iaaee/ia aeaaeai?y i?neyaeeieiiii? ina?oe ?i. I.E. Ooieea IIC
Oe?a?ie, i?ia?aeiee iaoeiaee ni?a?ia?oiee

I?ia?aeia onoaiiaa: ?inoeooo iieaeoey?ii? a?ieia?? ?
aaiaoeee IAI Oe?a?ie, a?aeae?e aaiaoeee ethaeeie, i. Ee?a

Caoeno a?aeaoaeaoueny “28” o?aaiy 1999 ?. i 1000 aiaeei? ia can?aeaii?
niaoe?ae?ciaaiii? a/aiii? ?aaee Ae26.604.01 Oe?a?inueeiai iaoeiaiai
a?a??i?/iiai oeaio?o, 253660 i. Ee?a-94, aoe. Iiioae?aiea,50

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? Oe?a?inueeiai
iaoeiaiai

a??i?/iiai oeaio?o, i. Ee?a, aoe. Iiioae?aiea,50

Aaoi?aoa?ao ?ic?neaiee “16” ea?oiy

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aiii? ?aaee _____________________ Naeaciueia A.TH.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. Iaoiae caie?aeiaiiy in vitro (in vitro
fertilization, IVF) – iaeia c aeiiii?aeieo ?ai?iaeoeoeaieo oaoiieia?e –
oe?iei ai?iaaaeaeo?oueny a iaaee/io i?aeoeeo aaaaoueio e?a?i na?oo ye
iaoiae e?eoaaiiy aacie?aeaey. Nooue oeueiai iaoiaeo iieyaa? a io?eiaii?
aeic??eeo iioeeo?a ethaeeie i?ney ai?iiiaeueii? noeioeyoe??
noia?iaoeyoe??, caie?aeiaii? ?o iica i?aai?ciii oa ia?aiin? aia??ii?a a
iaoeo ae?iee, aea a?aeaoaa?oueny ?o ?iieaioaoe?y ? iiaeaeueoee ?icaeoie.

Aeaiia?ao?/ia oa ai?aeai?ieia?/ia neooaoe?y a Oe?a?i? a inoaii? ?iee
oa?aeoa?eco?oueny aeaiiioeyoe??th ? aenieei ??aiai aacie?aeaey (a?ey 20%
iiae?oaei?o ia?), ui ia? oaiaeaioe?th aei c?inoaiiy (A?euaiei, 1997).
Oiio iaaoaa? aaeeei? aaae e?eoaaiiy aacie?aeaey, cie?aia ca aeiiiiiaith
iiaeo ?ai?iaeoeoeaieo oaoiieia?e, ye? aeicaieythoue ae??ooaaoe cia/io
e?euee?noue i?iaeai, ui iia’ycai? ye c ae?ii/ei, oae ? c /ieia?/ei
aacie?aeaeyi. Naia iia? ?ai?iaeoeoeai? oaoiieia?? iiaeooue noaoe iaeiei
?c ae??aeo cania?a caa?aaeaiiy aaiioiiaeo Oe?a?ie a oiiaao aeieia?/ii?
e?ece, iineeaii? *i?iiaeeuenueeith eaoano?ioith.

A oaia??oi?e /an a Oe?a?i? ?nio? n?i eaai?aoi??e, ui aeei?enoiaothoue
iaoiae IVF aeey e?eoaaiiy ??cieo oi?i aacie?aeaey. Iacaaaeath/e ia oa,
ui a?o/eciyieie a/aieie oa ee?i?oeenoaie aeei?enoiao?oueny aeina?ae
i?ia?aeieo eaai?aoi??e na?oo, aoaeoeai?noue iaoiaeo ana ua eeoa?oueny
aeineoue iecueeith. C e?oa?aoo?e a?aeiii, ui o cia/ii? /anoeie iioeeo?a,
ye? aoee io?eiai? a noeioeueiaaieo oeeeeao, aeyaeythoueny o?iiiniii?
aiiiae?? (Angell et al, 1986; Plachot et al, 1989; Noaoaiiae/, Aa?eeye,
1994). Iiaeeeai, iaaaea/? e?eoaaiiy aacie?aeaey ca aeiiiiiaith iaoiaeo
IVF iaoiiaeai? iaaieie ii?oiooieoe?iiaeueieie oa?aeoa?enoeeaie iioeeo?a,
a oaeiae o?iiiniiieie aiiiae?yie, ui aeieeathoue i?ae /an aaiaoiaaiaco,
caie?aeiaiiy ? ?aiiueiai aia??iiaeueiiai ?icaeoeo. Aeai? i?i o?iiiniii?
aiiiae?? a aaiaoao oa aei?iieaioaoe?eieo aia??iiao ethaeeie
ciaoiaeyoueny ia noaae?? iaeiie/aiiy.

I?e/eie oa iaoai?cie oaeeo ii?ooaiue eeoathoueny iaei aea/aieie.
I?eionea?oueny, ui ?yae a?ieia?/ieo oa ee?i?/ieo oaeoi??a,
iaeaieiai?oeie c yeeo ? a?e ae?iee, iieacaiiy aei IVF i?ioeaaeo? oa
ai?iiiaeueia noeioeyoe?y noia?iaoeyoe??, iiaeooue aieeaaoe ia
e?euee?ni?, ii?oiooieoe?iiaeuei? oa oeeoiaaiaoe/i? oa?aeoa?enoeee
io?eiaieo iioeeo?a ?, a oe?eiio, ia aoaeoeai?noue i?ioeaaeo?e
caie?aeiaiiy in vitro (Galan et al, 1992; Winston et al, 1993).
Ii?oiooieoe?iiaeueia oa oeeoiaaiaoe/ia aeine?aeaeaiiy iioeeo?a ethaeeie,
ui aeei?enoiaothoueny a IVF i?ia?aiao, ? aeeeth/ii aeooaeueiei ?
aeicaiey? aeyaeoe ii?ooaiiy a yeoeaee?oeiao ae?iie oa anoaiiaeoe aieea
??cieo /eiiee?a ia oa?aeoa?enoeee io?eiaieo iioeeo?a.

Ca’ycie ?iaioe c iaoeiaeie ieaiaie, oaiaie. Aeena?oaoe?eia ?iaioa
aeeiiaia a ?aieao aea?aeaaii? iaoeiai-aeine?aeii? i?ia?aie Caoeno
aaiioiiaeo ianaeaiiy Oe?a?ie, oeo? 01.01.

Iaoith ?iaioe aoei aeine?aeaeaiiy ii?oiooieoe?iiaeueieo oa
oeeoiaaiaoe/ieo oa?aeoa?enoee iioeeo?a ethaeeie oa aieeao ia ieo aeayeeo
ee?i?/ieo oa a?ieia?/ieo oaeoi??a (a?eo ae?iee, ai?iiiaeueii?
noeioeyoe?? oa iieacaiue aei IVF).

Caaea/? aeine?aeaeaiiy:

1. Anoaiiaeoe iniiai? oeie oa ??aaiue oeeoieia?/ieo ? o?iiiniiieo
aiiiae?e, ye? cono??/athoueny a iacaie?aeiaieo iioeeoao ethaeeie.

2. Aeyaeoe aca?iica’ycie i?ae e?euee?nieie ? ii?oieia?/ieie
oa?aeoa?enoeeaie io?eiaieo iioeeo?a oa ??aiai ?o caie?aeiaiiy ? ianoaiiy
aaa?oiino?.

3. Aea/eoe aieea a?eo ae?iee, ai?iiiaeueii? noeioeyoe?? oa iieacaiue
aei canoinoaaiiy IVF ia oa?aeoa?enoeee iioeeo?a.

4. Aeine?aeeoe aieea a?eo, aeic oa noai ai?iiiaeueii? noeioeyoe??
noia?iaoeyoe?? ia ii?oieia?/i? oa oeeoiaaiaoe/i? oa?aeoa?enoeee iioeeo?a
ieoae e?i?? NAA oa i?iaanoe ii??aiyeueiee aiae?c c ?acoeueoaoaie
aeine?aeaeaiiy iioeeo?a ethaeeie.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a.

1. Aia?oa i?iaaaeaii eiiieaenio ioe?ieo e?euee?nieo,
ii?oiooieoe?iiaeueieo oa oeeoiaaiaoe/ieo oa?aeoa?enoee iioeeo?a ethaeeie
a caeaaeiino? a?ae ??cieo a?ieia?/ieo oa ee?i?/ieo oaeoi??a.

2. Aia?oa anoaiiaeaii aca?iica’ycie i?ae ii?oieia?/ieie
oa?aeoa?enoeeaie iioeeo?a, a?aenioeii aiiiaeueiiai ?o caie?aeiaiiy oa
??aiai caie?aeiaiiy iioeeo?a ? ianoaiiy aaa?oiino?.

3. I?iaaaeaii ii??aiyiiy aieeao a?eo, aeic oa noai ai?iiiaeueii?
noeioeyoe?? noia?iaoeyoe?? ia ii?oieia?/i? ? oeeoiaaiaoe/i?
oa?aeoa?enoeee iacaie?aeiaieo iioeeo?a ethaeeie oa iioeeo?a ieo?.

I?aeoe/ia cia/aiiy aeine?aeaeaiiy. Io?eiai? ?acoeueoaoe iiaeooue aooe
aeei?enoai? a ee?i?eao, ui canoiniaothoue iaoiae IVF.

1. Aeine?aeaeaiiy e?euee?nieo ? ii?oieia?/ieo oa?aeoa?enoee iioeeo?a,
io?eiaieo i?ney ai?iiiaeueii? noeioeyoe?? noia?iaoeyoe??, aeicaiey?
i?iaiicoaaoe ??aaiue ?o caie?aeiaiiy oa ianoaiiy aaa?oiino?.

2. Aeai? i?i aieea a?ieia?/ieo ? ee?i?/ieo oaeoi??a ia oa?aeoa?enoeee
iioeeo?a aeicaieyoue ioe?ieoe aeey ie?aii? ae?iee ?iia??i?noue
caie?aeiaiiy oa ianoaiiy aaa?oiino? a caeaaeiino? a?ae ?? a?eo oa
iieacaiue aei IVF.

3. ?acoeueoaoe aeine?aeaeaiiy /anoioe o?iiiniiieo aiiiae?e a
iacaie?aeiaieo iioeeoao aeey ie?aii? ae?iee iiaeooue aooe i?aenoaaith
aeey ?aeiiaiaeaoe?? aeei?enoaiiy yeoeaee?oei aeiii?a.

4. Anoaiiaeaiiy ni?eueieo caeiiii??iinoae i?e aeine?aeaeaii? aieeao
a?eo oa noai ai?iiiaeueii? noeioeyoe?? ia iioeeoe ethaeeie oa ieo? iiaea
i?aeoaa?aeeoe iioeiaeuei?noue aeei?enoaiiy ieoae e?i?? NAA ye
iiaeaeueii? nenoaie aeey aea/aiiy aieeao ??cieo oaeoi??a ia
aoaeoeai?noue IVF i?ioeaaeo?.

Iniaenoee aianie caeiaoaa/a. Aeena?oaioii iniaenoi i?iaaaeaii
i?eaeeoo?aa aeine?aeaeaiiy oa o?enaoe?y iacaie?aeiaieo iioeeo?a,
io?eiaieo a ee?i?oe? Isida IVF ; oeeoiaaiaoe/ia aeine?aeaeaiiy oa
ea??ioeioaaiiy oeeoiaaiaoe/ieo i?aia?ao?a; aenia?eiaioe ii
aeine?aeaeaiith aieeao a?eo oa ai?iiiaeueii? noeioeyoe?? ia iioeeoe
ieoae e?i?? NAA; ?ic?iaeaii aieaoo aeaieo i?i iaoe??ioie, iioeeoe yeeo
aeine?aeaeoaaeenue a oe?e ?iaio?. Aaoi?ii naiino?eii aeeiiaii
noaoenoe/iee aiae?c io?eiaieo ?acoeueoao?a oa i?aeaioiaaii oaeno
aeena?oaoe??.

Aaoi? aeneiaeth? ue?o iiaeyeo aee?aeoi?o Oe?a?inueeiai iaoeiaiai oeaio?o
iaaee/ii? aaiaoeee Aa?eeyeo ?.?. ca iino?eio i?aeo?eieo oa aeiiiiiao
i?ae /an aeeiiaiiy ?iaioe, ni?a?ia?oieeai ee?i?ee Isida IVF oa
?inoeoooo ?ai?iaeoeoeaii? iaaeeoeeie (??I) ca iaaeaiiy iaoa??aeo oa
aeaieo i?i iaoe??ioie, i.i.n. Aanaiei I.I. ca i?eaeeoo?ao ioe?ieo oa
o?enaoe?th iacaie?aeiaieo iioeeo?a, io?eiaieo a ??I, no.i.n. Eae?c? I.A.
ca i?iaaaeaiiy aacaeoii?? naioe?a ieoae e?i?? NAA.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iniiai? iieiaeaiiy ?iaioe
aeiiia?aeaeenue ia iaoeiaiio neiiic?oi? Aanieiaeea: aniiiiaaoaeueiua
?ai?iaeoeoeaiua oaoiieiaee (Ee?a, 1997), ia iaoeiai-i?aeoe/i?e
eiioa?aioe?? Aoaeoeai?noue i?aiaoaeueii? ae?aaiinoeee o i?io?eaeoeoe?
a?iaeaeaii? oa niaaeeiai? iaoieia?? (Oaoeuee, 1998), ia i?aeia?iaeiiio
eiia?an? “The First World Congress of A PART (The International
Assosiation of Privat Assisted Reproductive Technology Clinics and
Laboratories)” (Venice, 1999).

Ioae?eaoe??. Ca oaiith aeena?oaoe?? aoei iioae?eiaaii 9 ae?oeiaaieo
?ia?o, a oiio /ene? 6 noaooae.

Ianya oa no?oeoo?a ?iaioe. Aeena?oaoe?eia ?iaioa aeeeaaeaia ia 126
noi??ieao iaoeiiieniiai oaenoo, neeaaea?oueny ?c anooio, iaeyaeo
e?oa?aoo?e, ?acoeueoao?a aeanieo aeine?aeaeaiue, iaaiai?aiiy,
caeeth/aiiy, aeniiae?a, ia?ae?eo aeei?enoaieo aeaea?ae. Oaeno
aeena?oaoe?? ?ethno?iaaiee 23 oaaeeoeyie oa 16 ?enoieaie. Ia?ae?e
aeei?enoaieo aeaea?ae i?noeoue 216 iaca.

CI?NO ?IAIOE

Iaoa??aee oa iaoiaee

I?ae /an aeeiiaiiy ?iaioe aeine?aeaeoaaeeny iioeeoe, io?eiai? a?ae 214
ae?iie, ye? i?ioiaeeee eo?n e?eoaaiiy aacie?aeaey iaoiaeii caie?aeiaiiy
in vitro o ee?i?oe? “?s?da IVF” oa a ?inoeooo? ?ai?iaeoeoeaii?
iaaeeoeeie (??I), i.Ee?a.

AE?iee aoee iiae?eai? ia a?oie a caeaaeiino? a?ae a?eo (3 a?oie: ? –
aei 26 ?ie?a; ?? – 26-34 ?ie?a; ??? –iiiaae 34 ?iee), oeio aacie?aeaey
(4 a?oie: ? – c o?oaii-ia?eoiiaaeueiei aacie?aeaeyi; ?? – c aiaeie?eiiei
aacie?aeaeyi; ??? – c ?ae?iiaoe/iei aacie?aeaeyi; ?V – c aacie?aeaeyi,
i?e/eiith yeiai aoa /ieia?/ee oaeoi?), noaie ai?iiiaeueii? noeioeyoe??
(3 a?oie: ? – aac aeei?enoaiiy aaii?no?a aiiaaeio?ii?i ??e?c?ia ai?iiio
(Ai?Aa), ?? – Ai?Aa+; ??? – Ai?Aa+const. noaia), ??aiy caie?aeiaiiy (4
a?oie: ? – c ??aiai caie?aeiaiiy 0-25%; ?? – c ??aiai caie?aeiaiiy
26-50%; ??? – c ??aiai caie?aeiaiiy 51-75%).

Aieea a?eo oa noai ai?iiiaeueii? noeioeyoe?? noia?iaoeyoe?? ia
oa?aeoa?enoeee iioeeo?a aea/aee ia iiaeaeuei?e nenoai? – ieoao e?i??
NAA.

Aeey aea/aiiy aieeao a?eo ia noai iioeeo?a aoei aeine?aeaeaii o?e a?oie
ieoae (ii10 oaa?ei a eiaei?e): “iieiaeoiai”, “na?aaeiueiai” oa
“noa?oiai” a?eo. Aeey aeine?aeaeaiiy aieeao ??cieo aeic aaaaeaieo
ai?iii?a aoee aeae?eai? 4 a?oie ieoae a?eii 8-12 oeaei?a (ii10 oaa?ei a
eiaei?e): ? a?oia (eiio?ieue) – iioeeoe io?eioaaee o i?e?iaeiiio oeeee?;
?? a?oia – oaa?eiai aaiaeeee ii 5 II aiiaaeio?ii?i?a; ??? a?oia –
oaa?eiai aaiaeeee ii 10 II aiiaaeio?ii?i?a; ?V a?oia – oaa?eiai aaiaeeee
ii 15 II aiiaaeio?ii?i?a. Aeey aea/aiiy aieeao ??cieo noai ai?iiiaeueii?
noeioeyoe?? ia oa?aeoa?enoeee iioeeo?a aoei aeine?aeaeaii o?e a?oie
ieoae a?eii 8-12 oeaei?a: ? a?oia (eiio?ieue) – iioeeoe io?eioaaee o
i?e?iaeiiio oeeee?; ?? a?oia– noeioeyoe?th i?iaiaeeee ca noaiith
aiiaaeio?ii?i ne?iaaoee aea?aaeo eiaee + oi??ii?/iee aiiaaeio?ii?i
ethaeeie (OAE); ??? a?oia– noeioeyoe?th i?iaiaeeee ca noaiith
iaiiiaocaeueiee aiiaaeio?ii?i ethaeeie + OAE.

Iioeeoe ae?iie io?eioaaee a ee?i?eao oeyoii o?ainaaa?iaeueii? ioieoe??
oa ani??aoe?? i?aiaoeyoi?ieo oie?eoe?a i?ae eiio?ieai oeueo?aniiia?ao??
i?ney ai?iiiaeueii? noeioeyoe?? noia?iaoeyoe??. A?aoiaoaaee oaeee
iieaciee, ye e?euee?noue io?eiaieo iioeeo?a a ?ic?aooieo ia iaeio
ae?ieo, a oaeiae ?acoeueoaoe ?o i?eaeeoo?aiai ii?oieia?/iiai aiae?co:
e?euee?noue aeic??eeo/iaaeic??eeo iioeeo?a oa yeoeaee?oei c iciaeaie
aeaaaia?aoe??. Iacaie?aeiai? iioeeoe aeinoaaeyee o eaai?aoi??th aeey
i?eaeeoo?aiai aeine?aeaeaiiy oa o?enaoe??.

Iaoeyoi?i? iioeeoe ieoae iaea?aeoaaee oeyoii ai?iiiaeueii? noeioeyoe??
noia?iaoeyoe??, yeo i?iaiaeeee ca noaiaea?oiith iaoiaeeeith (Aogan et
al, 1986).

Iacaie?aeiai? iioeeoe ethaeeie oa io?eiai? iioeeoe ieoae i?aeaeaaaee
i?eaeeoo?a?e ii?oieia?/i?e ioe?ioe? (a?aoiaoaaee noai oeeoiieacie:
nooi?iue a?aioeueiaaiino?, u?euei?noue; ia?ea?oae?iiaiai i?inoi?o;
iayai?noue 1-ai iiey?iiai o?eueoey; o?aaiaioaoe??; iciae aeaaaia?aoe??),
ca ?acoeueoaoaie yei? aeae?eyee iioeeoe caaeia?eueii? oa iecueei?
yeino?.

O?enaoe?y iioeeo?a i?iaiaeeeany ca iaoiaeaie Almeida, 1993; Micamo et
al, 1983; Wramsby, 1985.

Aeey ia’?eoea?caoe?? oa i?enei?aiiy o?iiiniiiiai aiae?co aeei?enoiaoaaee
aaoiiaoeciaaio iioeei-aeaeo?iiio nenoaio “Iaoaneai-2” (ni?eueiiai
ae?iaieoeoaa o??ie “Iio?ii” oa Oe?a?inueeiai iaoeiaiai oeaio?o iaaee/ii?
aaiaoeee, i. Ee?a).

On? noaoenoe/i? ?ic?aooiee aeeiioaaee ca aeiiiiiaith niaoe?aeueieo
i?ia?ai ia i?e?ieaeueeoeyoi?? “Aeaeo?ii?ea IE 61”.

?acoeueoaoe aeine?aeaeaiiy oa ?o iaaiai?aiiy

Aeine?aeaeaiiy ooieoe?iiaeueieo oa oeeoiaaiaoe/ieo oa?aeoa?enoee
iioeeo?a ethaeeie

I?iaaaeaia aeine?aeaeaiiy aeaei ciiao ii??aiyoe ooieoe?iiaeuei? oa
oeeoiaaiaoe/i? oa?aeoa?enoeee iioeeo?a ethaeeie, io?eiaieo a ??cieo
oeaio?ao e?eoaaiiy aacie?aeaey: ee?i?oe? ”Isida IVF” oa ?inoeooo?
?ai?iaeoeoeaii? iaaeeoeeie (??I). A eiaei?e c ee?i?e iioeeoe aoee
io?eiai? a?ae 107 ae?iie a?eii a?ae 19 aei 42 ?ie?a, na?aaei?e a?e 30,6
4,5 ?ie?a (??I) oa a?eii a?ae 19 aei 44 ?ie?a, na?aaei?e a?e 31,2 5,1
?ie?a (”Isida IVF”). Na?aaeiy e?euee?noue iioeeo?a ia ae?ieo noaiiaeea
10,6 0,7, ?ica?a 1-33 (??I) oa 10,5 0,6, ?ica?a 3-28 (”Isida IVF”).
E?euee?noue caie?aeiaieo oa iacaie?aeiaieo iioeeo?a ia ae?ieo a iaio
oeaio?ao e?eoaaiiy aacie?aeaey aeinoia??ii ia a?ae??ciyeanue (5,7 0,5
oa 4,8 0,4 a?aeiia?aeii, “Isida IVF” ? 5,1 0,7 oa 5,5 0,7
a?aeiia?aeii, ??I), ui aeicaiey? aiai?eoe i?i iaeaea ?aeaioe/i?
ooieoe?iiaeuei? oa?aeoa?enoeee iioeeo?a, io?eiaieo a ??cieo ee?i?eao.
Io?eiai? iaie ?acoeueoaoe ciaoiaeyoueny a iaaeao iieaciee?a aiaeia?/ieo
aeine?aeaeaiue, i?iaaaeaieo a ??cieo IVF oeaio?ao. ??aaiue caie?aeiaiiy
a iaio aeiaaeeao noaiiaeoue ~50%, ui ocaiaeaeo?oueny c aeaieie ?ioeo
aeine?aeiee?a (Winston et al, 1993) oa aaaaea?oueny ii?iaeueiei
caaaeueiii?eeiyoei ??aiai caie?aeiaiiy i?e IVF i?ioeaaeo?ao.

Oeeoiaaiaoe/iiio aiae?co i?aeeyaaee 288 iacaie?aeiaieo iioeeo?a c ??I oa
204 – c ee?i?ee ”Isida IVF”. ?acoeueoaoe aeine?aeaeaiiy iieacaee, ui
iaeaea on? oa?aeoa?enoeee ?o ciaoiaeyoueny a iaaeao ?acoeueoao?a
aiaeia?/ieo aeine?aeaeaiue. Oae, iniiaia e?euee?noue yeoeaee?oei
ciaoiaeeeany ia noaae?? I ?? iaeico (61,1% ??I oa 57,8% ”Isida IVF”), ui
ocaiaeaeo?oueny c aeaieie, iaaaaeaieie a ?ioeo ?iaioao (Noaoaiiae/ e
ae?., 1995). ??aaiue aeeiei?ae??, aiiiae??, yea aeieea? aiane?aeie
ii?ooaiiy aeae?eaiiy iiey?iiai o?eueoey i?ae /an ia?oiai iiae?eo
aeic??aaiiy, noaiiaea 5,3% (??I) oa 6,9% (”Isida IVF”), ui aeeae/a aei
ieaeiuei? iaae? oeueiai iieacieea (Angell et al, 1986). Iie?iei?ae?y
(e?euee?noue o?iiinii i?eaeecii aei??aithaaea oao?aiei?aeiiio iaai?o
o?iiinii) cono??/aeany a 1,0% (??I) oa 0,5% (”Isida IVF”) yeoeaee?oei.
??aaiue aeaaaia?aoe?? o?iiiniiiiai iaoa??aeo– 20,1% (??I) oa 24,0%
(”Isida IVF). Iacia/ia e?euee?noue iioeeo?a – 1,4% (??I) oa 0,5% (”Isida
IVF”) aoee iaaeic??eeie ? ciaoiaeeeeny ia noaae?? oaeioace ? iaeico.
Aaaaea?oueny, ui yeoeaee?oeie c ia?aae/aniith eiiaeainaoe??th o?iiinii
(IEO) nia?iaoici?ae?a oaeiae iaaeic??e?, oiio ui oey aiiiae?y aeieea?
/a?ac iaaeeeoeiao i?enooi?noue oaeoi?o i?iiioe?? iaeico (Tejada et al,
1992). A iaoiio aeine?aeaeaii? a 12,7% (??I) oa 13,7% (”Isida IVF”)
iioeeo?a, ii?yae c iaoaoaciith ieanoeieith o?iiinii iioeeoo
niinoa??aaeany IEO nia?iaoici?aea. Oiio iiaeia aaaaeaoe, ui caaaeueia
e?euee?noue iaaeic??eeo iioeeo?a noaiiaeoue 13,4%. A oie aea /an
iioeeoe, a yeeo niinoa??aa?oueny IEO nia?iaoici?ae?a, iaeaaeaoue aei
aiiiaeueii caie?aeiaieo yeoeaee?oei (Edwards et al, 1984), ye ?
iie?nia?iii caie?aeiai? iioeeoe (Woll, 1988), /anoioa yeeo neeaaea?, ca
iaoeie aeaieie, 3,5% (??I) oa 1,5% (”Isida IVF”). Oeeoiaaiaoe/iee
aiae?c oaeiae aeyaea 7,6% a ??I oa 5,9% o ee?i?oe? ”Isida
IVF”aia??ii?a, ye? coieieeeny ia ?aii?o noaae?yo ae?iaeaiiy. Oaeei
/eiii, a 21,9% iioeeo?a, ye? aaaaeaeeny iacaie?aeiaieie, a?aeaoeiny
caie?aeiaiiy, i?e/iio a 6,9% oea aoei ii?iaeueia caie?aeiaiiy, aea /a?ac
iaanoaiiaeai? i?e/eie ae?iaeaiiy aia??ii?a i?eieieeiny ia ii/aoeiaeo
noaae?yo, a o 15% – a?aeaoeiny aiiiaeueia caie?aeiaiiy. ??aaiue
niiioaiii? ia?oaiiaaiaoe/ii? aeoeaaoe?? a iaoiio aeine?aeaeaii? noaiiaea
3,8% (??I) oa 2,9% (”Isida IVF”). Oe? oeeo?e aeecuee? aei ?acoeueoao?a
Wojcik et al, 1995 (2,7%). C oaeeo iioeeo?a iiaeooue ?icaeaaoeny
aaiei?aei? aia??iie, /anoeia yeeo aeia i?ae /an ae?iaeaiiy, ia?aae aai
a?ae?aco i?ney ?iieaioaoe??, a aeaye? – ia ii/aoeo i?aaiiaaiaco (De
Sutter, 1992).

Caaaeueia ii??aiyiiy ?acoeueoao?a oeeoiaaiaoe/iiai aiae?co iioeeo?a,
io?eiaieo a aeaio oeaio?ao e?eoaaiiy aacie?aeaey, ia aeyaeei
aeinoia??ieo a?aei?iiinoae o oeeoiaaiaoe/ieo oa?aeoa?enoeeao
iacaie?aeiaieo iioeeo?a. Oiio ie aaaaea?ii, ui iiaeia aiai?eoe i?i
caaaeueio noeoii?noue iioeeo?a, ui aoee io?eiai? i?ae /an IVF
i?ioeaaeo? o ee?i?eao i?noa Ee?aa. E??i oiai, io?eiai? iaie aeai? i?i
ooieoe?iiaeuei? oa oeeoiaaiaoe/i? oa?aeoa?enoeee iacaie?aeiaieo iioeeo?a
? oe?eeii ii??aiyiieie c ?acoeueoaoaie ?ioeo aeine?aeiee?a. Aea, a oie
aea /an, ?niothoue nooo?a? ?ica?aeiino? aeaieo a iaaeao eiaeii? a?oie
iioeeo?a. Oiio iiaeia aiai?eoe, ui ia ?iciiae?e iacaie?aeiaieo iioeeo?a
ca ?o oa?aeoa?enoeeaie iiaeooue aieeaaoe ??ci? oaeoi?e (ee?i?/i?,
a?ieia?/i? oa ?i.), iiaa i?i ye? i?aea ieae/a.

Aeine?aeaeaiiy ii?oieia?/ieo oa?aeoa?enoee iioeeo?a ethaeeie

Iaie aoei anoaiiaeaii, ui a?eueo?noue iacaie?aeiaieo iioeeo?a ethaeeie
ia noaae?? iaoaoace ?? (I??) iaeico iaee caaeia?euei? ii?oieia?/i?
oa?aeoa?enoeee (oaae. 1). Aieea ii?oieia?/ieo oa?aeoa?enoee ia ??aaiue
caie?aeiaiiy aoa iienaiee ?yaeii aeine?aeiee?a (Zenzes et al, 1997, Zhen
et al, 1992). A iaoiio aeine?aeaeaii? aoei iieacaii, ui ii?oieia?/i?
oa?aeoa?enoeee iia’ycai? c ??aiai caie?aeiaiiy, ye ii?iaeueiiai, oae ?
aiiiaeueiiai, oa ia aieeaathoue ia ??aaiue niiioaiii? aeoeaaoe?? (oaae.
2).

Oaae. 1.

Ca’ycie i?ae ii?oieia?/ieie oa oeeoiaaiaoe/ieie oa?aeoa?enoeeaie
iioeeo?a

Oeeoiaaiaoe/i? oa?ae.

Ii?oie. oa?ae.Oaeioaca ?Iaoaoaca
??Aeeiei?-aei?Iie?iei-?aei?Aeaaaia-?aoe?yIioeeoe caaeia?eueii? yeino?, %
50,025,0 78,82,6*53,89,850,025,050,55,1Iioeeoe iecueei? yeino?, %
50,025,0 21,22,646,29,850,025,0 49,55,1*?0,05 I?e ii??aiyii? iioeeo?a
ii?iaeueii? oa iecueei? yeino?

Oaae. 2.

Ca’ycie i?ae ii?oieia?/ieie oa?aeoa?enoeeaie iioeeo?a oa ??aiai
caie?aeiaiiy ? ia?oaiiaaiaoe/ii? aeoeaaoe??

Iieaciee

Ii?oie.oa?aeoa?.Aia??iieIEOIie?nia?i?yIa?oaiiaaiacIioeeoe caaeia?eueii?
yeino?, % 76,57,3*86,44,8*76,911,7*58,811,9Iioeeoe iecueei? yeino?, %
23,57,313,74,823,111,741,211,9*?0,05 I?e ii??aiyii? iioeeo?a ii?iaeueii?
oa iecueei? yeino?

O?iiiniiiee aiae?c iacaie?aeiaieo iioeeo?a ethaeeie

O?iiiniiiee aiae?c iacaie?aeiaieo iioeeo?a ethaeeie ia noaae?? I??
iaeico iieacaa, ui eeoa 47,0% yeoeaee?oei iaee ii?iaeueiee iaa??
o?iiinii (?en. 1). Iniiaiith o?iiiniiiith aiiiae??th a iacaie?aeiaieo
iioeeoao ethaeeie aoea aiaoiei?ae?y, i?e/iio /anoioa a?iiaaiei?ae??
neeaaeaea 39,0%, a a?ia?aaiei?ae?? – 11,0%. A aeine?aeaeoaaieo
iioeeoao aiaoiei?ae?y /ano?oa aoea iia’ycaia c iaaeeeoeii aai
iaaeinoa/ath oe?eeo o?iiinii (78,0%), i?ae o?iiaoeae (18,0%). Aoei
oaeiae c’yniaaii, ui iae/ano?oa aiaoiei?ae?y aeieea? aiane?aeie
ia?icoiaeaeaiiy o?iiinii a?oi A oa G, a /anoioa ia?icoiaeaeaiiy o?iiinii
a?oie A aeinoia??ii ieae/a i/?eoaaii?. *anoioa iie?iei?ae??
a iioeeoao, ui aoee a?ae?a?ai? aeey o?iiiniiiiai aiae?co, neeaaeaea
2,0%. No?oeoo?i? aiiiae?? aoee aeyaeai? a 1,0% yeoeaee?oei.

Aieea a?ieia?/ieo oa ee?i?/ieo oaeoi??a ia oa?aeoa?enoeee iioeeo?a

Aeine?aeaeaiiy aieeao a?eo ae?iee ia ii?oiooieoe?iiaeuei? oa
oeeoiaaiaoe/i? oa?aeoa?enoeee iioeeo?a. A iao?e ?iaio? ie aea/aee ye
ii?oiooieoe?iiaeuei?, oae ? oeeoiaaiaoe/i? oa?aeoa?enoeee iioeeo?a
ethaeeie. Anoaiiaeaii iinooiiaa cieaeaiiy e?eueeino? iioeeo?a ia ae?ieo
c a?eii (13,31,1 i?ioe 10,60,7 oa 8,80,6 a?, ?? ? ??? a?oiao
a?aeiia?aeii, ?

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